CN103961424B - A kind of treat the Chinese medicine formula of cervical spondylosis and the preparation method of capsule preparations thereof - Google Patents
A kind of treat the Chinese medicine formula of cervical spondylosis and the preparation method of capsule preparations thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, it is specifically related to a kind of Chinese medicinal capsule preparation and its preparation method for the treatment of cervical spondylosis. Solve the problem of the result for the treatment of difference for the treatment of cervical spondylosis Chinese patent medicine used at present, adopt technical scheme be: by the root of kudzu vine, Ligusticum wallichii, the Radix Astragali, Radix Angelicae Sinensis, the root of herbaceous peony, Root of Sixpetal Clematis, the bark of eucommia, Yunnan Caulis Spatholobi, the red sage root, cassia twig, safflower, Radix Glycyrrhizae composition raw material by described quality proportioning through immersion, reflux, sedimentation, filter, it is condensed into fluid extract, after oven dry, pulverizes into powder, add dispersion agent and other auxiliary material in proportion, fill and be prepared into capsule. The medicine of the present invention has function promoting blood circulation and removing blood stasis, anti-inflammatory analgetic, liver and kidney tonifying of dispelling rheumatism, mend. Clinical observation on the therapeutic effect shows that it is to all kinds of cervical spondylosis good effect, and instant effect, rehabilitation thoroughly without recurrence, can reach the object treated both principal and secondary aspect of disease. With current like product ratio, clinical effective rate of the present invention and curative ratio are all higher than other products.
Description
Technical field
The present invention relates to Chinese medicine and preparing technical field thereof, it is specially and a kind of treats the Chinese medicine formula of cervical spondylosis and the preparation method of capsule preparations thereof.
Background technology
Cervical spondylosis (CcrvicalSpondylosis) is also known as cervical syndrome, it it is international frequently-occurring disease, it it is the common disease that harm the elderly is healthy, due to the increase of time to bend over one's desk working and kind, popularizing of computer, private car increase in a large number and high pillow, to sleep soft bed etc. all multifactor, and become the occupational illness being engaged in the industry staff such as electronics, science and technology, culture and education for a long time. Calculate to have at least 5,000 ten thousand to 1 hundred million people being subject to the torment of cervical spondylosis by existing population is conservative. Not only bring great pain to patient, and bring heavy burden to family and society. Therefore, the clinical study for the treatment of of cervical spondylopathy has important society and economic implications. Before this, for the treatment of cervical spondylosis, due to operation more complicated, have a big risk, and in art and post-operative complication still difficulty avoid completely. Therefore except a few symptoms seriously affects normal operation and life, it is necessary to outside adopting operative treatment, in principle based on non-operative treatment. Owing to Western medicine mainly plays anti-inflammatory analgetic in the treatment of this disease, expanding the effect of blood vessel, therefore curative effect usually can not be satisfactory, and easily repeatedly, side effect is bigger. Therefore, utilization treatment by Chinese herbs cervical spondylosis is effective and the most conventional method, has great advantage in this disease for the treatment of. The determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of cervical spondylosis is achieved gratifying achievement by modern Chinese medicine Chinese medicine on the basis inheriting forefathers. The patent of invention of the Traditional Chinese medicine formula preparation application of existing many treatment cervical spondylosiss in recent years, wherein oral Chinese medicine preparation just nearly 20 remainders, the treatment cervical spondylosis Chinese medicine preparation (patent No. 201010503733.9) of the refined flat invention of such as Liu; The Chinese medicinal tablet of Li Qiurong invention and capsule preparations (patent No. 201110084433.6); The Chinese medicine preparation (patent No. 200510119090.7) of ten thousand precious full inventions; The middle medicine composite preparation (patent No. 201210039614.1) of letter good fortune river invention; Open the Chinese medicinal capsule preparation (patent No. 201010579309.2) etc. of people's invention. Above-mentioned formula is different, and curative effect also has notable difference, and the Chinese patent medicine specific aim of the treatment cervical spondylosis of listing is not strong yet at present, and curative effect is not very good yet, and therefore people expect that can develop one treats the more effective Chinese medicine preparation of cervical spondylosis. But, traditional Chinese herbal decoction treatment cervical spondylosis clinical efficacy is definite, but it is longer to take the course for the treatment of, it may also be useful to comparatively bother.
Summary of the invention
The present invention is in order to problem that to solve the treatment by Chinese herbs effect of existing treatment cervical spondylosis undesirable, it provides a kind of treat the Chinese medicine formula of cervical spondylosis and the preparation method of capsule preparations thereof.
The present invention adopts following technical scheme to realize:
Treat a Chinese medicine formula for cervical spondylosis, it is made up of following component and mass fraction proportioning: the root of kudzu vine 15��30 parts, Ligusticum wallichii 20��30 parts, the Radix Astragali 15��25 parts, Radix Angelicae Sinensis 15��25 parts, the root of herbaceous peony 12��25 parts, 15��30 parts, Root of Sixpetal Clematis, the bark of eucommia 12��25 parts, Yunnan Caulis Spatholobi 20��30 parts, the red sage root 10��20 parts, cassia twig 10��25 parts, 10��20 parts, safflower, 10��20 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis, comprises the steps:
(1), each component raw material medicine is taken by formula;
(2), by above-mentioned raw materials medicine it is broken into 20��40 object meal, the alcohol immersion with the 50��70% of 4��8 times amount 18��24 hours, reflux 2��4 hours, collects an extracting solution;
(3), add 2 again��50��70% alcohol heating reflux of 4 times amount 2��3 hours, collect secondary raffinate;
(4), merging and filter after above-mentioned secondary raffinate, add 0.1��0.5% sinking agent, filter after stirring in filtrate, concentrating under reduced pressure becomes fluid extract, dries afterwards and obtain dry extract at 50��60 DEG C;
(5) add medicine dispersion agent and auxiliary material after being pulverized by dry extract, fill and be prepared into capsule.
Numerous and diverse post-processing step that above-mentioned preparation method and Measures compare that is traditional and document, the alcohol precipitation of eliminating over and water sink, makes production technique more simplify, and production cost obviously reduces. Therefore the method have easy and simple to handle, facility investment is little, the feature of high financial profit.
The present invention is under the reality of the deficiency of the Chinese medicine preparation existence drawing more existing treatment cervical spondylosiss, develops a kind of good effect, and instant effect, not easily recurs, and can reach and treat both principal and secondary aspect of disease, and Chinese medicinal capsule preparation easy to carry and use. This Chinese patent medicine preparation has effect promoting blood circulation and removing blood stasis, anti-inflammatory analgetic, liver and kidney tonifying of dispelling rheumatism, mend. Clinical observation on the therapeutic effect shows that it is definite to the curative effect of all kinds of cervical spondylosis.
The root of kudzu vine: be the block root of vine elegant jessamine; Cool in nature, taste is pungent, sweet, returns spleen, stomach warp. Energy expelling pathogenic factors from muscles for reducing heat, treating measles, promotes the production of body fluid to quench thirst, and rises sun antidiarrheal. If exterior syndrome due to wind-cold, disease sees that aversion to cold is lossless, stiff nape and back, often joins Chinese ephedra, cassia twig etc., such as GEGEN TANG. " herbal classic ": " master quenches one's thirst, high fever of the body, vomiting, all numbness, plays cloudy gas, separates all poison. " " not Lu ": " cold apoplexy of curing the wound is had a headache, and separates flesh and delivers, perspire, loosing the interspaces of skin and muscles. "
Radix Angelicae Sinensis: warm in nature, taste is pungent, sweet, return liver, the heart, the spleen channel. Can enrich blood invigorate blood circulation, menstruction regulating and pain relieving, ease constipation. Cold solidifying and wound is had concurrently, the pain of wind-damp numbness for blood stagnancy due to deficiency of QI. Dispelling the wind and dampness pathogens numbness pain, numb limbs and tense tendons. " scape high mountain pandect ": " Radix Angelicae Sinensis, its taste is sweet and weighs, therefore specially can enrich blood; Its gas is light and pungent, therefore again can promoting circulation of blood: bowl spares has, has benefit in row, is really the gas medicine in blood, and also the panacea in blood is also ".
The Radix Astragali: slightly warm in nature, taste are sweet, returns spleen, lung channel. Have tonifying Qi and lifting yang, benefit defends solid table, effect of inducing diuresis to remove edema, holder sore myogenic. To the not all right numbness pain of blood stagnancy due to deficiency of QI, numb or hemiplegia, can tonifying Qi row stagnant. " pearl sac ": " the sweet Wen Chunyang of the Radix Astragali, it is with having five: mending all empty not enough, one also; Benefit vigour, two also: strong taste, and three also; Going flesh heat, four also; Apocenosis pain relieving, raw blood of invigorating blood circulation, the cloudy subcutaneous ulcer of Neto is persons particularly liable to develop skin infection's panacea ".
Ligusticum wallichii (formal name used at school: Ligusticumchuanxiong): warm in nature, taste is pungent, returns liver, courage, pericardium warp. Function blood-activating and qi-promoting, wind-expelling pain-stopping. The pungent loose temperature of this product lead to, can invigorate blood circulation but can promoting the circulation of qi, be gas medicine in blood, for the pain disease of stagnation of QI and blood. The pungent temperature rise of this product is fallen apart, and energy " upper wardrobe order ", wind-expelling pain-stopping, forefathers have saying of " headache not being from Ligusticum wallichii ". Dispelling the wind and dampness pathogens bi Zheng, limbs pain are numb, and this product can " bypass passages through which vital energy circulates " expelling wind and activating blood circulation pain relieving. " book on Chinese herbal medicine converge with speech ": " the pungent property sun of taste, gas is apt to walk and is altered and without the state of the solidifying viscous of the moon, though entering blood system, can go again a wind cutting, adjusting all gas. "
Yunnan Caulis Spatholobi: be the dry rattan stem of leguminous plants spatholobus suberectus (Root or stem of Smoothfruit Ventilago, three leaf Yunnan Caulis Spatholobis, nine layers of wind); Warm in nature, bitter, sweet. Return Liver Channel. Promoting circulation of blood enriching blood, menstruation regulating, stimulates the circulation of the blood and cause the muscles and joints to relax. This product energy nourshing blood and promoting blood circulation and stimulate the circulation of the blood and cause the muscles and joints to relax, dispelling the wind and dampness pathogens numbness pain, arthrodynia, numb limbs and tense tendons, join medicine for rheumatism with use. " A Supplement to the Compendium of Materia Medica ": " its rattan is invigorated blood circulation most, warm waist knee wind phlegm. " rattan glue " strong muscles and bones, caproic acid pain, and wine clothes, punish-old people's deficient qi and blood, the diseases such as numb in every limb paralysis ".
The red sage root: cold nature, bitter. The thoughts of returning home, Liver Channel. Effect: promoting blood flow to regulate menstruation, cool blood disappears carbuncle, calms the nerves. This product is key medicine promoting blood circulation and removing blood stasis. Dispelling the wind and dampness pathogens numbness pain, then join the medicine for rheumatisms such as windproof, bark of ash with using. " with China's son book on Chinese herbal medicine ": " sedate of reposing, logical profit Guan pulse. Controlling cold and hot labor, arthralgia, four limbs are unsuccessful. "
Root of Sixpetal Clematis: the rhizome of ranunculaceae plant Root of Sixpetal Clematis, Clematis hexapetala or northeast clematis etc.; Warm in nature, taste is pungent, salty. Return bladder warp. Effect: wind-damp dispelling, the meridian dredging, the bone that disappears is choked. Its pungent loose temperature is led to, and property is apt to walk suddenly, the current twelve regular channels, can wind-damp dispelling, can stimulate the menstrual flow again stopping numbness pain. All rheumatic arthralgia, apathetic, no matter all can use up and down, be rheumatic arthralgia key medicine. " medicineization justice ": " spirit is celestial, and property is suddenly anxious, is apt to walk and do not keep, logical 12 channels and collaterals of a surname. Cure mainly in wind, wet, stagnant channels and collaterals of phlegm harmony, cause into gout and walk note, arthralgia, or swollen, or numb. " modern study: this product has analgesia, antidiuretic activity.
Radix Glycyrrhizae: property is flat, taste is sweet. The thoughts of returning home, lung, spleen, stomach warp. Effect: benefit gas bowl spares, clearing heat and detoxicating, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine. " book on Chinese herbal medicine is just ": " property that must neutralize, has the merit adjusting benefits, therefore poison obtains it separates its poison, and firm medicine obtains its property of sum, outside what medicine administered to bring out the cold obtained help it, put in poison slow it is fast. Enter gas with gas medicine, enter blood with blood medicine, without toward can not, therefore claim state old. Modern study: this medicine has anti-inflammation, anti-allergic effects.
The bark of eucommia: formal name used at school EucommiaulmoidesOliver, has another name called bakelite is Eucommiaceae plant; Warm in nature, taste is sweet. Return liver, kidney channel. There is invigorating the liver and kidney, strengthening the bones and muscles effect. Being used for the treatment of lumbago due to renal deficiency, muscles and bones is unable and the illness such as hypertension.
Safflower (Classification system CarthamustinctoriusL.): composite family, safflower platymiscium, warm in nature, taste is pungent. The thoughts of returning home, Liver Channel. There is promoting blood circulation to restore menstrual flow, effect of blood stasis removing analgesic. Being used for the treatment of lump in the abdomen lump in the abdomen, Obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, chest side of body shouting pain, injury from falling down and sore such as swell and ache at the illness.
Cassia twig, rectification of name: Chinese cassia tree (formal name used at school: CinnamomumcassiaPresl), has another name called beautiful osmanthus, cassia bark etc., belongs to buttercup order, the medium megaphanerophyte of Lauraceae; Warm in nature, taste is pungent, sweet. The thoughts of returning home, lung, bladder warp. There is sweating solution flesh, promoting the flow of QI-blood by warming the meridian, effect of the peaceful gas that spins of supporing yangization gas. For common cold caused by wind-cold, coldness and pain in the epigastrium, arthralgia, phlegm and retained fluid, oedema, palpitaition and the illnesss such as globefish of running quickly.
The root of herbaceous peony: i.e. root of herbaceous peony medicine (formal name used at school: PaeonialactifloraPall.) is Ranunculaceae Chinese herbaceous peony platymiscium; Cold nature, bitter, acid, return Liver Channel. There is nourishing blood to suppress the hyperactive liver, pain relieving in slow, hold back cloudy receipts sweat, nourish blood and receive effect of the moon. Cure mainly chest and abdomen pain over the hypochondriac region, brothers' spasm pain, alliteration, headache, dizzy, tinnitus, irritated irritability, spontaneous sweating, fever due to yin deficiency.
The traditional Chinese medical science is thought, deficiency of both the liver and kidney, muscles and bones is lost and supported is the internal cause of this disease, and wound is strained, wind-cold damp pathogen is the external cause of this disease, under the impact of external cause, wind-cold damp pathogen invades sun warp, causes sun operation to be defended and becomes estranged, QI-blood circulation is not smooth, passages through which vital energy circulates is retarded by silt, thus produces stiff nape and back, and shoulder arm numbness " dizzy " headache waits the disease of deficiency in origin and excess in superficiality. All belonging to the categories such as traditional Chinese medicine syndrome of blood stasis bi Zheng, Chinese traditional treatment cervical spondylosis is with promoting blood circulation and removing blood stasis, and loose wind dehumidifying, removes obstruction in channels to relieve pain, and the strong bone of relaxing muscles and tendons is main. The root of kudzu vine in side, cool in nature, taste is pungent, sweet, its effect solution flesh promoting blood circulation and stopping pain, is apt to control stiff nape and back, and energy born fluid, Ru Yangjinmai, and its contraction of relaxing, it is the key medicine for the treatment of cervical spondylosis pain, also it is medicine the most used in treatment, side reuses the root of kudzu vine and can rise the gas that sun separates flesh, the logical gv of a surname, it is apt to control person's back unfavorable through acupoint, and on priming, row reaches disease institute, improvement headache effect is excellent. Radix Angelicae Sinensis is warm in nature, and taste is pungent, sweet, returns liver, the heart, the spleen channel, and having enriches blood invigorates blood circulation, anti-inflammatory analgetic, effect of protection kidney. " scape high mountain pandect book on Chinese herbal medicine is just ": " Radix Angelicae Sinensis, its taste is sweet and weighs, therefore specially can enrich blood; Its gas is light and pungent, therefore again can promoting circulation of blood. Bowl spares has, has benefit, the gas medicine in sincere blood in row, and also the panacea in blood is also. Its effect, for enriching blood, is invigorated blood circulation, pain relieving, and the two is monarch's medicine altogether. The bark of eucommia, warm in nature, taste is sweet, returns liver kidney channel, can invigorating the liver and kidney, strengthening the bones and muscles. Red sage root cold nature, bitter, the thoughts of returning home, Liver Channel, have scattered silt of invigorating blood circulation, swelling and pain relieving, help liver. Two medicines share can mend liver and kidney tonifying, and invigorating blood circulation is become silted up, and stimulates the circulation of the blood and cause the muscles and joints to relax, anti-inflammatory analgetic. Yunnan Caulis Spatholobi property is put down, and taste is sweet, returns spleen, stomach, bladder warp, and energy blood-supplementing blood-nourishing, stimulates the circulation of the blood and cause the muscles and joints to relax, promoting blood circulation to remove blood stasis, and nourishing disney and strengthening bone is inducing meastruation to relieve menalgia, is control from void opinion. Safflower is warm in nature, and taste is pungent, the thoughts of returning home, Liver Channel, promoting blood circulation to restore menstrual flow, blood stasis removing analgesic, and this is ministerial drug, and principal drug assistance is strengthened promoting blood circulation and removing blood stasis, promoting the circulation of QI to relieve pain, mends liver and kidney tonifying, strong muscles and bones. Root of Sixpetal Clematis, warm in nature, taste is pungent, property is apt to walk, can wind-damp dispelling, the meridian dredging, stopping numbness pain, kind dispelling the wind and dampness pathogens brachialgia, numb limbs and tense tendons, joint joint stuffiness person; Cassia twig, warm in nature, taste is pungent, sweet, its effect warming the meridian for promoting the flow of YANG QI, separates flesh and delivers, and upper limb shoulder brachialgia is the most suitable; Root of herbaceous peony cold nature, bitter, acid, sweet, its effect nourishing blood to suppress the hyperactive liver, relieving spasm to stop pain, with Radix Glycyrrhizae with better with analgesic effect; Above three medicines are adjutant. Radix Glycyrrhizae, property is put down, and taste is sweet, effect coordinating the actions of various ingredients in a prescription, with for making medicine. This Chinese medicine preparation based on promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, invigorate blood circulation and not blood trouble, residence is mended in logical, and tonification and purgation in combination, has eliminating evil and does not hinder positive prescription feature. Said preparation goes its internal cause with the dehumidifying of loose wind, with Zhi Qiben promoting blood circulation and removing blood stasis, controls its mark with relaxing muscles and tendons pain relieving, thus reaches the object for the treatment of cervical spondylosis.
Theory of traditional Chinese medical science thinks " have a Zhu Nei and must shape all outer ". Symptom, the sign of cervical spondylosis are varied, and patient's subjective symptoms is more, and symptom presents parallel dependency with sign with the severity of cervical spondylosis. Although Chinese medicine can not change spur, dissolve nucleus pulposus, CT or MRI morphology even can not be made to change, but its alleviating pain, there is the effect improving clinical symptom and sign, it is the not mediocre fact doubted.
The cure mechanism of this Chinese medicine preparation is as follows:
(1), improve microcirculation, eliminate local congestion and edema.
The clinical symptom of cervical spondylosis and body card can have projection extruding or lead and draw neural axon and anterior horn cell to cause, it is also possible to wears due to extruding or pia vessels clump makes nervous tissue microcirculation disturbance, ischemic, anoxic and expand infringement. Meanwhile, mechanical pressure can affect the axoplasma flow in nerve root, and what cause the neurohumour interior vescular bed of running obstacle, particularly nerve is subject to pressure deformity, result in trophicity blood flow in nerve root and is obstructed, causes microcirculation disturbance. A large amount of Clinical and experimental study shows that microcirculation disturbance plays comparatively vital role in the pathological change process of this disease. This disease is relevant with microcirculation and hemorheology obstacle. Local inflammatory response, hyperemia, oedema cause that blood fortune is obstructed, histanoxia, venous return obstacle and microcirculation disturbance occurs, meta-bolites is made to organize inner accumulated, the local content concn of algogenic substance (inflammatory mediator) raises, particularly cause gathering and radiculitis exudate of nervous tissue intracellular metabolite product, the major reason that inflammatory mediator gathers. The release of the inflammation induced pain factor and pain occurs. Modern medicine thinks that cervical spondylosis causes vasospasm owing to sclerotin stimulates the concentration with meta-bolites (such as endothelin) to increase, affect blood to supply, congestion and edema around horizontal prominent hole, horizontal prominent hole is diminished relatively, extruding nerve root, vertebra intervertebral disk sex change, horizontal prominent pitch smaller, make neural and blood circulation resistance increase around it own, sludging. The understanding of this disease interpretation of the cause, onset and process of an illness is consistent with the traditional Chinese medical science by this. When caused by liver and kidney deficiency, insufficiency of vital energy and blood, sense wind-cold damp pathogen or chronic strain cause wind chill blockage blood vessels, even qi depression to blood stasis, passages through which vital energy circulates not smooth again. This research shows, this product Chinese medicine preparation has the effect improving microcirculation, and its effect is mainly manifested in following two aspect: l, improves micro-blood flow. Achieve the goal by releasing vasospasm and reduce blood viscosity resistance of blood flow. After treatment, microcirculation improves, and first shows as micro-improving blood flow, makes flowing micro-blood flow acceleration slowly. 2, capillary permeability reduces. While accelerating blood flow, do not reduce the effective constituent of blood, do not reduce the osmotic pressure,effective even increasing Ink vessel transfusing, ooze blood around capillary blood vessel and reduce or disappear.
(2) effect of hemorheological property, is improved
Hemorheology is mobility and the viscosity of research blood, and microcirculation has close contact. There is abnormal, slow blood flow in the viscosity such as blood, causes general or locality cycle penalty, organize and ischemic, anoxic just can occur, cause physiological function unbalance, irreversible pathological change even occurs. It is exactly the pathological change of microcirculation from macroscopically saying. Therefore the developing of hemorheology and numerous disease, change and have close contacting. Experimental result finds the blood viscosity of cervical spondylosis patient, and pcv all increases than normal people, and a large amount of data shows that again the improvement of hemorheology has parallel dependency with the remission of cervical spondylosis. This product has the improvement whole blood viscosity of significance and the effect of pcv.
In a word, nerve root symptom modern study thinks the compressing due to physical property, the inflammation of chemical, the immune response of local more, stimulates the generation symptom such as infringement that makes nerve root hyperemia, oedema, microcirculation disturbance or nerve. The experimental research achievements passed through, recognize why Chinese medicine has good therapeutic action, just because of it can improve the blood circulation of nerve root, eliminate oedema, stop the release of local inflammation medium, algogenic substance around nerve root, penetration enhancement makes it be dissipated, and facilitates neural regeneration and the recovery of function.
The acute and chronic toxicity test of this Chinese medicine preparation is as follows:
The various traditional Chinese medicinal components that the present invention selects all meet the regulation of the Drug Administration Law of People's Republic of China, and said preparation is harmless to human non-toxic. Showing that underproof animal is showed no any toxic reaction through the acute and chronic toxicity test of animal, its main organs has no significant change, and therefore said preparation is safe and reliable.
The observation of curative effect of this Chinese medicine preparation is reported as follows:
JINGFUKANG KELI is the main product of the treatment cervical spondylosis of listing at present, is also the product that market sales volume is best in like product at present. In order to show that medicine of the present invention is to the result for the treatment of of treatment cervical spondylosis, by as follows to medicine of the present invention and JINGFUKANG KELI clinical experiment result comparitive study:
(1), Case definition: tcm diagnosis standard, macroscopic test: nape pain, upper myasthenia of limbs, point numb, lower limb are weak, difficulty in walking, dizziness, Nausea and vomiting, even blurring of vision, tachycardia and dysphagia etc., doctor trained in Western medicine film making checks, makes a definite diagnosis as cervical spondylosis according to x-ray fluoroscopy or CT detection.
(2), methods for the treatment of: capsule of the present invention is provided by Shanxi Normal University's pharmaceutical preparation room. Specification is 0.25 gram/60. Instructions of taking: daily 3 times, 15th is a course for the treatment of, generally took for 2��3 courses for the treatment of by each 3.
(3) curative effect judging standard
Clinical cure: original symptom and sign disappear, neck, limb functional recover normal operation.
Effective: main symptom is obviously alleviated, sign major part disappears, and function recovers normal substantially, can participate in routine work.
Effective: original symptom alleviates, neck, limb function part recover normal.
Invalid: treat front and back symptom, sign is without improvement or increases the weight of.
(4) test-results
Curing 59 examples in cervical spondylosis 75 example, effective 9 examples, effective 5 examples, invalid 2 examples, curative ratio 78.6%, always has efficiency 97.3%. " JINGFUKANG KELI " comparitive study that this product and document are reported is in table 1.
The observation of curative effect that this product of table 1 treats cervical spondylosis with JINGFUKANG KELI compares
[1] old peace, JINGFUKANG KELI coordinates Manipulation therapy treatment cervical spondylosis 33 example, medicine forward position, 2013.19:194.
[2] Miao Tonghe, JINGFUKANG KELI treatment cervical spondylotic radiculopathy 56 example, Hunan Journal of Traditional Chinese Medicine, 2011.27(5): 36.
[3] Ma Zhengming, JINGFUKANG KELI treatment cervical spondylotic radiculopathy 197 example clinical observation on the therapeutic effect, Chinese Medicine guide, 2012.10(21): 237-238.
[4] Ma little Jun, brilliant profit. JINGFUKANG KELI treatment ankylosing spondylitis cervical pain 60 example. practical tcm internal medicine magazine, 2011.25(2): 67-68.
As can be seen from Table 1, this product treatment cervical spondylosis is evident in efficacy, treat both principal and secondary aspect of disease, and no matter is curative ratio or has efficiency all higher than like product JINGFUKANG KELI.
Inventive design is reasonable, above-mentioned Chinese medicine material is selected to carry out combining and adopt modern technologies that the effective constituent in Chinese medicine and elite part have been extracted and refined, gained capsule preparations has promoting blood circulation and removing blood stasis, relieving inflammation and relaxing pain, the strong kidney of tonifying liver, improves the effect of microcirculation, thus improve the blood circulation of neck portion, elimination oedema, stoping the release of local inflammation medium, algogenic substance around neck portion, penetration enhancement makes it be dissipated, and facilitates neural regeneration and the recovery of function. Therefore the combination of the formula of medicine of the present invention be reasonably, science, effective, the capsule preparations treatment cervical spondylosis good effect developed, instant effect, not easily recurs, and treats both principal and secondary aspect of disease, and easy to carry and use.
Model case is as follows:
1, Mr. Zhu, man, 43 years old, Shanxi province Yicheng County area just outside a city gate people from town, in long-term startup procedure, gradually felt that neck hardens and turns sour, CT examination is made a definite diagnosis as making a definite diagnosis cervical vertebra hyperplasia for 2007. After increase the weight of gradually, develop in one's hands numb, vision is fuzzy. In March, 2013 starts to take this product, feels that neck is brisk after taking medicine 3 days, and after 1 course for the treatment of, neck rotates flexibly, 2 the course for the treatment of hand fiber crops sensation obviously alleviate, eyes are also felt not felt bad, see thing also clear how, after 3 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, have no recurrence.
2, Mrs Qiao, 43 years old, Shanxi province Linfen city people from Yaodu District, in April, 2003 prominent sense hand is numb, CT examination is made a definite diagnosis as cervical curvature straightens, after develop into neck and harden, arm is numb, to such an extent as to right hand finger joint style can not stretch, cannot normally go to work, rest of can only being in. Adopting multiple mode to treat, effect is not obvious. In April, 2013 starts to take this product, takes medicine after 1 course for the treatment of, and symptom is alleviated to some extent, and suddenly sensation whole body is comfortable brisk in the 5th day of the 2nd course for the treatment of, and neck is flexible, and the feeling of hand fiber crops alleviates. After 3rd course for the treatment of, right hand articulations digitorum manus can stretch, and the sensation of hand and arm fiber crops obviously alleviates, and feels good day by day subsequently, and after 4 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, have no recurrence.
3, Mr. Li, 48 years old, Shanxi province Linfen city people from Yaodu District, started morbidity for 2006, and sensation headache, vision is fuzzy. CT examination is made a definite diagnosis as cervical internal disc herniation. Rear development is in one's hands numb swells, and evening, pain cannot be fallen asleep, and in May, 2013 starts to take this product, and having a headache after 1 course for the treatment of obviously alleviates, and eyes are much more comfortable, sees that thing is also seen clear, and after 2 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, have no recurrence.
4, Mr. Wang, 59 years old, Shanxi province makes the county prosperous Lvliang City people, feel in March, 2013 neck harden, have a headache, dizzy, feel sick, CT examination is made a definite diagnosis as osteoproliferation, by Duo Jia hospital and pharmacological agent all without effect, after starting to take 1 course for the treatment of of this product in April, 2013, neck hardens, symptom dizzy, that feel sick obviously is alleviated, and after 2 courses for the treatment of, all symptoms all disappear, follow up a case by regular visits to, have no recurrence.
5, Mrs Li, 42 years old, your household services company worker was liked in Beijing, within 2012, gradually felt that neck is felt bad and hardened, and CT examination is made a definite diagnosis as cervical vertebra hyperplasia, after increase the weight of gradually to develop into shoulder pain, impact is normally gone to work. In May, 2013 starts to take this product, feels after the course for the treatment of, and neck rotates much more flexible, and both shoulders pain relief, after 2 courses for the treatment of, all symptoms all disappear, and follow up a case by regular visits to, have no recurrence.
Embodiment
Below specific embodiments of the invention are described in detail.
Embodiment 1
Treat a Chinese medicine formula for cervical spondylosis, it is made up of following component and mass fraction proportioning: (every part of 1g)
The root of kudzu vine 20 parts, Ligusticum wallichii 25 parts, the Radix Astragali 18 parts, Radix Angelicae Sinensis 15 parts, the root of herbaceous peony 20 parts, 25 parts, Root of Sixpetal Clematis, the bark of eucommia 25 parts, Yunnan Caulis Spatholobi 20 parts, the red sage root 18 parts, cassia twig 20 parts, 10 parts, safflower, 17 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), each bulk drug is taken by proportion by weight;
(2), by above-mentioned raw materials medicine it is broken into 20 object meal, the alcohol immersion with the 60% of 5 times amount 24 hours, reflux 3 hours, collects an extracting solution;
(3) alcohol heating reflux of the 60% of the times amount that adds 2, again 2 hours, collects secondary raffinate;
(4), merging and filter after above-mentioned secondary raffinate, add ZTC-�� natural clarifying agent by 0.2%, filter after fully stirring in filtrate, concentrating under reduced pressure becomes fluid extract, dries afterwards and obtain dry extract at 60 DEG C;
(5) add medicine dispersion agent and auxiliary material after dry extract being broken into 100 object fine powders, fill and be prepared into capsule.
Embodiment 2
Treat a Chinese medicine formula for cervical spondylosis, it is made up of following component and mass fraction proportioning: (every part of 10g)
The root of kudzu vine 25 parts, Ligusticum wallichii 20 parts, the Radix Astragali 25 parts, Radix Angelicae Sinensis 23 parts, the root of herbaceous peony 25 parts, 20 parts, Root of Sixpetal Clematis, the bark of eucommia 18 parts, Yunnan Caulis Spatholobi 25 parts, the red sage root 15 parts, cassia twig 10 parts, 20 parts, safflower, 15 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), each bulk drug is taken by proportion by weight;
(2), by above-mentioned raw materials medicine it is broken into 20 object meal, the alcohol immersion with the 65% of 4 times amount 18 hours, reflux 4 hours, collects an extracting solution;
(3) alcohol heating reflux of the 70% of the times amount that adds 4, again 2 hours, collects secondary raffinate;
(4), merging and filter after above-mentioned secondary raffinate, add ZTC-III natural clarifying agent by 0.1%, filter after fully stirring in filtrate, concentrating under reduced pressure becomes fluid extract, dries afterwards and obtain dry extract at 50 DEG C;
(5) add medicine dispersion agent and auxiliary material after dry extract being broken into 80 object fine powders, fill and be prepared into capsule.
Embodiment 3
Treat a Chinese medicine formula for cervical spondylosis, it is made up of following component and mass fraction proportioning: (every part of 15g)
The root of kudzu vine 30 parts, Ligusticum wallichii 30 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 25 parts, the root of herbaceous peony 18 parts, 15 parts, Root of Sixpetal Clematis, the bark of eucommia 12 parts, Yunnan Caulis Spatholobi 22 parts, the red sage root 10 parts, cassia twig 13 parts, 15 parts, safflower, 20 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), each bulk drug is taken by proportion by weight;
(2), by above-mentioned raw materials medicine it is broken into 20 object meal, the alcohol immersion with the 70% of 5 times amount 16 hours, reflux 3 hours, collects an extracting solution;
(3) alcohol heating reflux of the 60% of the times amount that adds 2, again 2 hours, collects secondary raffinate;
(4), merging and filter after above-mentioned secondary raffinate, add ZTC-II natural clarifying agent and 0.3%ZTC-IV natural clarifying agent by 0.2%, filter after fully stirring in filtrate, concentrating under reduced pressure becomes fluid extract, dries afterwards and obtain dry extract at 60 DEG C;
(5) add medicine dispersion agent and auxiliary material after dry extract being broken into 100 object fine powders, fill and be prepared into capsule.
Embodiment 4
Treat a Chinese medicine formula for cervical spondylosis, it is made up of following component and mass fraction proportioning: (every part of 20g)
The root of kudzu vine 15 parts, Ligusticum wallichii 22 parts, the Radix Astragali 20 parts, Radix Angelicae Sinensis 20 parts, the root of herbaceous peony 12 parts, 20 parts, Root of Sixpetal Clematis, the bark of eucommia 20 parts, Yunnan Caulis Spatholobi 15 parts, the red sage root 20 parts, cassia twig 15 parts, 18 parts, safflower, 10 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), each bulk drug is taken by proportion by weight;
(2), by above-mentioned raw materials medicine it is broken into 30 object meal, the alcohol immersion with the 60% of 6 times amount 24 hours, reflux 3 hours, collects an extracting solution;
(3) alcohol heating reflux of the 60% of the times amount that adds 3, again 3 hours, collects secondary raffinate;
(4), merging and filter after above-mentioned secondary raffinate, add ZTC-III natural clarifying agent of 0.2% and the ZTC-�� natural clarifying agent of 0.2%, filter after fully stirring in filtrate, concentrating under reduced pressure becomes fluid extract, dries afterwards and obtain dry extract at 55 DEG C;
(5) add medicine dispersion agent and auxiliary material after dry extract being broken into 80 object fine powders, fill and be prepared into capsule.
Embodiment 5
Treat a Chinese medicine formula for cervical spondylosis, it is made up of following component and mass fraction proportioning: (every part of 20g)
The root of kudzu vine 25 parts, Ligusticum wallichii 20 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 20 parts, the root of herbaceous peony 20 parts, 20 parts, Root of Sixpetal Clematis, the bark of eucommia 20 parts, Yunnan Caulis Spatholobi 15 parts, the red sage root 15 parts, cassia twig 15 parts, 10 parts, safflower, 10 parts, Radix Glycyrrhizae.
The preparation method of the Chinese medicinal capsule preparation of above-mentioned treatment cervical spondylosis is as follows:
(1), each bulk drug is taken by proportion by weight;
(2), by above-mentioned raw materials medicine it is broken into 30 object meal, the alcohol immersion with the 60% of 6 times amount 24 hours, reflux 3 hours, collects an extracting solution;
(3) alcohol heating reflux of the 60% of the times amount that adds 3, again 3 hours, collects secondary raffinate;
(4), merging and filter after above-mentioned secondary raffinate, add ZTC-IV natural clarifying agent of 0.1% and the ZTC-�� natural clarifying agent of 0.3%, filter after fully stirring in filtrate, concentrating under reduced pressure becomes fluid extract, dries afterwards and obtain dry extract at 55 DEG C;
(5) add medicine dispersion agent and auxiliary material after dry extract being broken into 80 object fine powders, fill and be prepared into capsule.
Claims (2)
1. treat the Chinese medicine composition of cervical spondylosis for one kind, it is characterised in that: it is made up of following component and quality proportioning:
The root of kudzu vine 15��30 parts, Ligusticum wallichii 20��30 parts, the Radix Astragali 15��25 parts, Radix Angelicae Sinensis 15��25 parts, the root of herbaceous peony 12��25 parts, 15��30 parts, Root of Sixpetal Clematis, the bark of eucommia 12��25 parts, Yunnan Caulis Spatholobi 15��25 parts, the red sage root 10��20 parts, cassia twig 10��20 parts, 10��20 parts, safflower, 10��20 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of cervical spondylosis according to claim 1, it is characterised in that: it is made up of following component and quality proportioning:
The root of kudzu vine 25 parts, Ligusticum wallichii 20 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 20 parts, the root of herbaceous peony 20 parts, 20 parts, Root of Sixpetal Clematis, the bark of eucommia 20 parts, Yunnan Caulis Spatholobi 15 parts, the red sage root 15 parts, cassia twig 15 parts, 10 parts, safflower, 10 parts, Radix Glycyrrhizae.
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| CN104383018A (en) * | 2014-09-22 | 2015-03-04 | 林军庭 | Lumbar degenerative pathological change treating traditional Chinese medicine composition plaster |
| CN104857322A (en) * | 2015-05-20 | 2015-08-26 | 李念虎 | Chinese material medicine preparation for treating sympathetic nervous cervical spondylosis and preparation method |
| CN105456748A (en) * | 2015-12-29 | 2016-04-06 | 张利 | Traditional Chinese medicine composition for treating cervical spondylosis |
| CN108785497A (en) * | 2018-09-03 | 2018-11-13 | 刘亚莉 | A kind of ointment and preparation method thereof for treating bone and joint diseases |
| CN110151858A (en) * | 2019-07-10 | 2019-08-23 | 杜黎明 | A kind of Chinese materia medica preparation for treating cervical spondylosis |
| CN110269906A (en) * | 2019-08-07 | 2019-09-24 | 河南省神州神药业有限公司 | A kind of dedicated liquid medicine alleviated and promote rehabilitation of osteopathy |
| CN114668801A (en) * | 2022-04-14 | 2022-06-28 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating cervical spondylosis and preparation method and application thereof |
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