CN103948909A

CN103948909A - Traditional Chinese medicine preparation for lowering blood pressure

Info

Publication number: CN103948909A
Application number: CN201410233289.1A
Authority: CN
Inventors: 张军
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-29
Filing date: 2014-05-29
Publication date: 2014-07-30

Abstract

The invention discloses a traditional Chinese medicine preparation for lowering blood pressure, which is prepared from taraxacum, gardenia, small fennel, lawn pennywort, acanthopanax bark, dangshen, epimedium, dried ginger, balsamine, uncaria, figwort, honeysuckle flower, radish seed, corydalis tuber, cassia twig, phellodendron bark, henbane, fenugreek, radix angelicae, Reed Rhizome, tetrandra root, Cortex Fraxini, radix ligustici sinensis, green tangerine orange peel, Mangnolia officinalis and amomum fruit. The preparation can achieve the goals of favorable curative effect and no side effect when being used for treating hypertension, and all the active pharmaceutical ingredients are cheap and accessible.

Description

A kind of Chinese medicine preparation of blood pressure lowering

Technical field

The present invention relates to technical field of Chinese medicines, specifically refer to a kind of Chinese medicine preparation of blood pressure lowering.

Background technology

Hypertension is a kind ofly to take arteriotony and continue to raise be the chronic disease of main manifestations, one of main pathogenic factor is due to human peripheral arteriolospasm, human peripheral small artery resistance is strengthened, thereby cause blood pressure to increase, form hypertension, often cause the pathological changes of the vitals such as the heart, brain, kidney and occur corresponding consequence.Long-term hypertension can cause cardiovascular disease as myocardial infarction, coronary heart disease etc., can also cause renal arteriosclerosis, thereby causes renal insufficiency, uremia etc.

In hypertensive treatment, people are being widely used various Western medicine depressor.Antihypertensive drugs has: (one) angiotensin converting enzyme inhibitor: apply at present captopril, enalapril.(2) calcium antagonist: be that one group of chemical constitution is different, the medicine that mechanism of action is also not quite similar.Owing to suppressing calcium ion by the interior stream of calcium channel on cell membrane, thereby be called calcium-channel antagonists.Common drug has verapamil, diltiazem and nifedipine, nitrendipine.(3) vasodilation: the vascular smooth muscle that directly relaxes, blood vessel dilating, reduces blood pressure.Common drug has: 1. sodium nitroprusside.2. Minoxidil.3. Aiselazine.(4) act on the depressor of sympathetic nervous system.1. central sympathetic nerve depressant: (1) clonidine.(2) methyldopa.2. sympathetic block agent.Dust head has arfonad, for the treatment of hypertensive encephalopathy.3. blocker after sympathetic ganglion.Make the slightly middle norepinephrine in sympathetic nerve end store exhaustion, and reach the object of blood pressure lowering.Common drug has: (1) guanethidine.(2) reserpine.4. adrenergic receptor blocker.(1) beta-blocker; Labetalol is the depressor that WHO recommends.Acebutolol.(2) α receptor blocking agent: dust head has prazosin.Doxazosin.(5) diuretic antihypertensive medicine.1. thiazide: be most widely used oral diuretic antihypertensive medicine, hydrochlorothiazide.2. chlortalidone.3. furosemide.4. triamterene.

Though Western medicine can meet general blood pressure lowering requirement, also has obvious side effect.Because Western medicine blood pressure lowering is all to take blood vessel dilating as main, and blood vessel dies down and hardens at continuous process of expansion Elastic, therefore makes the people of life-time service depressor easily cause sclerosis of blood vessels and break, and causes the diseases such as cerebral vessels embolism, apoplexy.Therefore, Western medicine is not suitable for permanent use.

Summary of the invention

The object of this invention is to provide a kind of hypertensive Chinese medicine preparation for the treatment of, the present invention is achieved by the following technical solutions:

A kind of Chinese medicine preparation of blood pressure lowering, Chinese crude drug by following weight portion is made: Herba Taraxaci 5-20 part, Fructus Gardeniae 5-15 part, Fructus Foeniculi 5-15 part, Herba Hydrocotyles 5-11 part, Cortex Acanthopancis 5-11 part, Radix Codonopsis 2-6 part, Herba Epimedii 2-6 part, Rhizoma Zingiberis 2-6 part, Flos Impatientis 2-6 part, Ramulus Uncariae Cum Uncis 2-6 part, Radix Scrophulariae 2-4 part, Flos Lonicerae 2-4 part, Semen Raphani 2-4 part, Rhizoma Corydalis 2-4 part, Ramulus Cinnamomi 1-3 part, Cortex Phellodendri 1-3 part, Semen Hyoscyami 1-3 part, Semen Trigonellae 1-3 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Phragmitis 1-3 part, Radix Stephaniae Tetrandrae 1-3 part, Cortex Fraxini 1-3 part, Rhizoma Ligustici 1-3 part, Pericarpium Citri Reticulatae Viride 1-3 part, Cortex Magnoliae Officinalis 1-3 part, Fructus Amomi 1-3 part.

Preferably, a Chinese medicine preparation for blood pressure lowering, is made by the Chinese crude drug of following weight portion: 12 parts of Herba Taraxacis, 10 parts of Fructus Gardeniaes, 10 parts of Fructus Foeniculi, 8 parts of Herba Hydrocotyleses, 8 parts of Cortex Acanthopanciss, 4 parts of Radix Codonopsis, 4 parts of Herba Epimedii, 4 parts of Rhizoma Zingiberiss, 4 parts of Flos Impatientiss, 4 parts of Ramulus Uncariae Cum Uncis, 3 parts of Radix Scrophulariaes, 3 parts of Flos Loniceraes, 3 parts of Semen Raphanis, 3 parts of Rhizoma Corydalis, 2 parts of Ramulus Cinnamomi, 2 parts of Cortex Phellodendris, 2 parts of Semen Hyoscyamis, 2 parts of Semen Trigonellaes, 2 parts of the Radixs Angelicae Dahuricae, 2 parts of Rhizoma Phragmitiss, 2 parts of Radix Stephaniae Tetrandrae, 2 parts of Cortex Fraxinis, 2 parts of Rhizoma Ligusticis, 2 parts, Pericarpium Citri Reticulatae Viride, 2 parts of Cortex Magnoliae Officinalis, 2 parts of Fructus Amomis.

The preparation method of the Chinese medicine preparation of above-mentioned blood pressure lowering: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds the clean water that meets drinking water standard, and it is degree that amount of water be take over powder 2-3cm; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use again slow fire boiling half an hour instead, remove medicinal residues, get decoction.

The instructions of taking of Chinese medicine preparation of the present invention is: potion on the one, potion is taken at twice, within seven days, is a course for the treatment of.

The present invention is comprised of Chinese medicine, has suppressing the hyperactive liver to relieve the wind syndrome, alleviates the effect of periphery arteriolospasm, thereby the QI and blood of containing was declined, reach the object of blood pressure lowering, the object that can play good effect, have no side effect for hypertensive treatment, and raw materials used medicine is all cheap and easy to get.

the specific embodiment:

Below in conjunction with embodiment and case, the present invention is further illustrated.

Embodiment 1

Take Herba Taraxaci 5g, Fructus Gardeniae 15g, Fructus Foeniculi 5g, Herba Hydrocotyles 11g, Cortex Acanthopancis 5g, Radix Codonopsis 6g, Herba Epimedii 2g, Rhizoma Zingiberis 6g, Flos Impatientis 2g, Ramulus Uncariae Cum Uncis 6g, Radix Scrophulariae 2g, Flos Lonicerae 4g, Semen Raphani 2g, Rhizoma Corydalis 4g, Ramulus Cinnamomi 1g, Cortex Phellodendri 3g, Semen Hyoscyami 1g, Semen Trigonellae 3g, Radix Angelicae Dahuricae 1g, Rhizoma Phragmitis 3g, Radix Stephaniae Tetrandrae 1g, Cortex Fraxini 3g, Rhizoma Ligustici 1g, Pericarpium Citri Reticulatae Viride 3g, Cortex Magnoliae Officinalis 1g, Fructus Amomi 3g puts into drug-decocting appliance, add the clean water that meets drinking water standard, it is degree that amount of water be take over powder 2-3cm; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use again slow fire boiling half an hour instead, remove medicinal residues, get the Chinese medicine preparation that decoction obtains blood pressure lowering.

The instructions of taking of above-mentioned Chinese medicine preparation is: potion on the one, potion is taken at twice, within seven days, is a course for the treatment of.

Embodiment 2

Take Herba Taraxaci 20g, Fructus Gardeniae 5g, Fructus Foeniculi 15g, Herba Hydrocotyles 5g, Cortex Acanthopancis 11g, Radix Codonopsis 2g, Herba Epimedii 6g, Rhizoma Zingiberis 2g, Flos Impatientis 6g, Ramulus Uncariae Cum Uncis 2g, Radix Scrophulariae 4g, Flos Lonicerae 2g, Semen Raphani 4g, Rhizoma Corydalis 2g, Ramulus Cinnamomi 3g, Cortex Phellodendri 1g, Semen Hyoscyami 3g, Semen Trigonellae 1g, Radix Angelicae Dahuricae 3g, Rhizoma Phragmitis 1g, Radix Stephaniae Tetrandrae 3g, Cortex Fraxini 1g, Rhizoma Ligustici 3g, Pericarpium Citri Reticulatae Viride 1g, Cortex Magnoliae Officinalis 3g, Fructus Amomi 1g puts into drug-decocting appliance, add the clean water that meets drinking water standard, it is degree that amount of water be take over powder 2-3cm; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use again slow fire boiling half an hour instead, remove medicinal residues, get the Chinese medicine preparation that decoction obtains blood pressure lowering.

Embodiment 3

Take Herba Taraxaci 12g, Fructus Gardeniae 10g, Fructus Foeniculi 10g, Herba Hydrocotyles 8g, Cortex Acanthopancis 8g, Radix Codonopsis 4g, Herba Epimedii 4g, Rhizoma Zingiberis 4g, Flos Impatientis 4g, Ramulus Uncariae Cum Uncis 4g, Radix Scrophulariae 3g, Flos Lonicerae 3g, Semen Raphani 3g, Rhizoma Corydalis 3g, Ramulus Cinnamomi 2g, Cortex Phellodendri 2g, Semen Hyoscyami 2g, Semen Trigonellae 2g, Radix Angelicae Dahuricae 2g, Rhizoma Phragmitis 2g, Radix Stephaniae Tetrandrae 2g, Cortex Fraxini 2g, Rhizoma Ligustici 2g, Pericarpium Citri Reticulatae Viride 2g, Cortex Magnoliae Officinalis 2g, Fructus Amomi 2g puts into drug-decocting appliance, add the clean water that meets drinking water standard, it is degree that amount of water be take over powder 2-3cm; Enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice; After boiling with high heat, use again slow fire boiling half an hour instead, remove medicinal residues, get the Chinese medicine preparation that decoction obtains blood pressure lowering.

Clinical testing data:

For checking therapeutic effect of the present invention, choose the routine patients with hypertension in Hefei ,Anhui 120, the range of age 43 ~ 67 years old, 55 years old mean age, male's 65 examples wherein, women's 55 examples.120 routine patients are equally divided into four groups at random, are respectively treatment group 1, treatment group 2, treatment group 3 and matched group, every group of 30 routine patients.Diagnostic criteria: systolic pressure is equal to or higher than 160mmHg(21.3kPa), diastolic pressure is equal to or higher than 95mmHg(12.721.3kPa), both have 1 through examining, and can make a definite diagnosis.

Therapeutic Method:

Matched group adopts FUFANG JIANGYA PIAN, oral, one time 2,3 times on the one; Treatment group 1 adopts the Chinese medicine for lowering blood pressure preparation of the embodiment of the present invention 1 to treat, every day potion, potion is taken at twice; Treatment group 2 adopts the Chinese medicine for lowering blood pressure preparation of the embodiment of the present invention 2 to treat, every day potion, potion is taken at twice; Treatment group 3 adopts the Chinese medicine for lowering blood pressure preparation of the embodiment of the present invention 3 to treat, every day potion, potion is taken at twice; Treat respectively 7 days for above four groups.

Criterion of therapeutical effect:

Effective: 1. diastolic pressure decline 10mmHg(1.3kPa) more than, and reach normal range; Though 2. diastolic pressure is not near normal, 20 mmHg(2.7kPa have declined) or more than, must possess wherein 1;

Effective: 1. diastolic pressure declines not as good as 10mmHg(1.3kPa), but reach normal range; 2. diastolic pressure is treated front decline 10～19 mmHg(1.3～2.5kPa), but do not reach normal range; 3. systolic pressure is treated front decline 30 mmHg(4kPa); Must possess wherein 1;

Invalid: not reach above standard.

Therapeutic effect:

Matched group: effective 10 examples, account for 33.3%; Effective 15 examples, account for 50%; Invalid 5 examples, account for 16.7%; Total effective rate 83.3%;

Treatment group 1: effective 15 examples, account for 50%; Effective 15 examples, account for 50%; Invalid 0 example; Total effective rate 100%;

Treatment group 2: effective 18 examples, account for 60%; Effective 12 examples, account for 40%; Invalid 0 example; Total effective rate 100%;

Treatment group 3: effective 28 examples, account for 93.3%; Effective 2 examples, account for 6.7%; Invalid 0 example; Total effective rate 100%.

Above-mentioned therapeutic effect demonstration, treatment group curative effect is obviously better than matched group, and wherein the effect for the treatment of group 3 is best.

Claims

1. the Chinese medicine preparation of a blood pressure lowering, it is characterized in that: the Chinese crude drug by following weight portion is made: Herba Taraxaci 5-20 part, Fructus Gardeniae 5-15 part, Fructus Foeniculi 5-15 part, Herba Hydrocotyles 5-11 part, Cortex Acanthopancis 5-11 part, Radix Codonopsis 2-6 part, Herba Epimedii 2-6 part, Rhizoma Zingiberis 2-6 part, Flos Impatientis 2-6 part, Ramulus Uncariae Cum Uncis 2-6 part, Radix Scrophulariae 2-4 part, Flos Lonicerae 2-4 part, Semen Raphani 2-4 part, Rhizoma Corydalis 2-4 part, Ramulus Cinnamomi 1-3 part, Cortex Phellodendri 1-3 part, Semen Hyoscyami 1-3 part, Semen Trigonellae 1-3 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Phragmitis 1-3 part, Radix Stephaniae Tetrandrae 1-3 part, Cortex Fraxini 1-3 part, Rhizoma Ligustici 1-3 part, Pericarpium Citri Reticulatae Viride 1-3 part, Cortex Magnoliae Officinalis 1-3 part, Fructus Amomi 1-3 part, preparation method is: the Chinese crude drug that takes described weight portion is put into drug-decocting appliance, adds the clean water that meets drinking water standard, and it is degree that amount of water be take over powder 2-3cm, enter to decoct front immersion half an hour, make it fully moistening, fully fried in order to medicine juice, after boiling with high heat, use again slow fire boiling half an hour instead, remove medicinal residues, get decoction.