CN103948453A - Degradable magnesium alloy membranous stent and membranous stent system - Google Patents
Degradable magnesium alloy membranous stent and membranous stent system Download PDFInfo
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- CN103948453A CN103948453A CN201410161298.4A CN201410161298A CN103948453A CN 103948453 A CN103948453 A CN 103948453A CN 201410161298 A CN201410161298 A CN 201410161298A CN 103948453 A CN103948453 A CN 103948453A
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- magnesium alloy
- degradable magnesium
- overlay film
- film frame
- membranous
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Abstract
The invention discloses a degradable magnesium alloy membranous stent and a membranous stent system and belongs to the field of medical science. The degradable magnesium alloy membranous stent and the membranous stent system comprise a membrane and a degradable magnesium alloy bare stent, wherein the membrane is coated on the outer surface of the degradable magnesium alloy bare stent. The degradable magnesium alloy membranous stent system comprises the degradable magnesium alloy membranous stent, a balloon and a balloon catheter, wherein the degradable magnesium alloy membranous stent is arranged on the outer wall of the balloon, and the balloon is arranged on the balloon catheter. The degradable magnesium alloy membranous stent and the membranous stent system have the advantages of being simple in operation, low in price, low in embolism causing performance and inflammatory response, safe and reliable, and are suitable for pathological changes of intracranial aneurysm, carotid-cavernous sinus fistula, arteriovenous fistula, thoracic aortic aneurysm, abdominal aortic aneurysm and the like.
Description
Technical field
The present invention relates to medical domain, relate in particular to a kind of degradable magnesium alloy overlay film frame and overlay film frame system that is used for the treatment of intracranial aneurysm.
Background technology
Intracranial aneurysm subarachnoid hemorrhage is one of common cerebrovascular, about 8-16 example/100,000 of annual morbidity people.After aneurysm rupture, mortality rate reaches 40%, and disability rate is up to 33%.According to the relevent statistics, China intracranial aneurysm patient is up to 6,000 ten thousand for root, approximately has the 200000 routine intracranial aneurysms hemorrhage patient of breaking every year, and therefore aneurysm is just as staying " the variable interval bomb " of intracranial and jeopardize at any time patient's life.
The method for the treatment of intracranial aneurysm mainly contains at present: the mode of aneurysm inner spring circle embolotherapy, the treatment of Willis overlay film frame and surgery operation of opening cranium is treated.
Wherein, the most frequently used method is aneurysm inner spring circle embolotherapy, but this technology treatment behavior is in aneurysm cavity, still there is fine and close filling rate lower (35% – 76.8%), relapse rate higher (≈ 30%), occupy-place effect, complicated operation, the defect such as expensive.
The mode Therapeutic Method complexity that adopts surgery operation of opening cranium, wound is larger, normal with serious complication, and patient is usually difficult to accept.
Willis overlay film frame is comparatively ideal treatment method of acute cranium section aneurysm, but still has the support difficulty that puts in place, and internal fistula incidence rate is high, and endothelialization such as delays at the problem.The low areola support of Pipeline of foreign latest development has good compliance, can be transported to the position that microtubular arrives, but it is not suitable for subarachnoid hemorrhage patient, exists at once the aneurysm cavity rate of entirely shutting low, and endothelialization such as delays at the defect.
Summary of the invention
There is the support difficulty that puts in place for solving at present for acute cranium section aneurysm treatment in the present invention, internal fistula incidence rate is high, and endothelialization such as delays at the problem, thereby the technical scheme of a kind of degradable magnesium alloy overlay film frame and overlay film frame system is provided.
A kind of degradable magnesium alloy overlay film frame of the present invention, comprising: overlay film and degradable magnesium alloy bare bracket, described overlay film is coated in the outer surface of described degradable magnesium alloy bare bracket.
Preferably, described degradable magnesium alloy bare bracket is mainly formed by stacking by multiple corrugated metal racks, and the end of described overlay film frame is circular.
Preferably, adjacent two the corrugated metal racks of described degradable magnesium alloy bare bracket connect by connecting rod.
Preferably, every two described corrugated metal racks that close on differ half period.
Preferably, described degradable magnesium alloy bare bracket structure is cylindrical-shaped structure.
Preferably, described overlay film is for manually blood vessel covered.
A kind of degradable magnesium alloy overlay film frame system, comprising: degradable magnesium alloy overlay film frame, sacculus and foley's tube, and described degradable magnesium alloy overlay film frame is arranged on described sacculus outer wall, and described sacculus is arranged on described foley's tube.
Preferably, described foley's tube is made up of a guidewire lumen and fluid injection chamber.
Preferably, described foley's tube comprises catheter proximal end, catheter body and distal end of catheter,
Described catheter proximal end is provided with injection port, in order to connect syringe;
Described distal end of catheter is provided with described fluid injection chamber;
The inner chamber of described catheter body is described guidewire lumen, and described distal end of catheter is seal wire entrance, and described catheter proximal end is seal wire outlet;
On the outer wall in described fluid injection chamber, be provided with the aperture being communicated with described sacculus.
Beneficial effect of the present invention:
The present invention utilizes the degradable characteristic of magnesium alloy, and taking degradable magnesium alloy bare bracket as basis, preparation has the overlay film frame of degradable characteristic.Under room temperature, by the coated artificial blood vessel's overlay film outer surface at degradable magnesium alloy bare bracket, build degradable magnesium alloy overlay film frame.When use, degradable magnesium alloy overlay film frame is compressed on sacculus, then sacculus is delivered to target vessel position along seal wire, Filled Balloon, struts overlay film frame, and artificial blood vessel's overlay film and tunica intima are closely linked, and also aneurysm mouth is sealed simultaneously.About half a year, degradable magnesium alloy bare bracket is degradable, thereby has reached the object of curing intracranial aneurysm, has accelerated again the formation of endothelialization.The present invention has advantages of simple to operate, cheap, lowly causes bolt, low inflammatory reaction and safe and reliable, is applicable to the pathological changes such as intracranial aneurysm, carotid-cavernous fistula, arteriovenous fistula, breast and abdominal aortic aneurysm.
Brief description of the drawings
Fig. 1 is the structural representation of degradable magnesium alloy bare bracket of the present invention;
Fig. 2 is the structural representation of degradable magnesium alloy overlay film frame system of the present invention;
Fig. 3 is the structural representation of degradable magnesium alloy overlay film frame being delivered to injury of carotid artery place along seal wire;
Fig. 4 is the structural representation that after degradable magnesium alloy bare bracket is degraded voluntarily, overlay film is retained in tumor mouth place.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, the invention will be further described, but not as limiting to the invention.
Fig. 1 is the structural representation of degradable magnesium alloy bare bracket of the present invention, and degradable magnesium alloy overlay film frame comprises: overlay film 5 and degradable magnesium alloy bare bracket 1, overlay film 5 is coated in the outer surface of degradable magnesium alloy bare bracket 1.
Adopt degradable magnesium alloy bare bracket 1 to reach low inflammatory reaction, ensured patient's safety, and accelerate the object of endothelialization effect.
In a preferred embodiment, degradable magnesium alloy bare bracket 1 is mainly formed by stacking by multiple corrugated metal racks, and the end of overlay film 5 supports is circular.
In a preferred embodiment, the metal rack of adjacent two wave bands of degradable magnesium alloy bare bracket 1 connects by connecting rod.
In a preferred embodiment, every two corrugated metal racks that close on differ half period.
In a preferred embodiment, degradable magnesium alloy bare bracket 1 structure is cylindrical-shaped structure.
In a preferred embodiment, overlay film 5 is artificial blood vessel covered 5.
Fig. 2 is the structural representation of degradable magnesium alloy overlay film frame system, this system comprises: degradable magnesium alloy overlay film frame 2, sacculus 3 and foley's tube 4 in above-described embodiment, degradable magnesium alloy overlay film frame 2 is arranged on sacculus 3 outer walls, and sacculus 3 is arranged on foley's tube 4.
In a preferred embodiment, foley's tube 4 is made up of a guidewire lumen 41 and fluid injection chamber.
In a preferred embodiment, foley's tube 4 comprises catheter proximal end, catheter body and distal end of catheter,
Catheter proximal end is provided with injection port, in order to connect syringe;
Distal end of catheter is provided with fluid injection chamber;
The inner chamber of catheter body is guidewire lumen 41, and distal end of catheter is seal wire entrance, and catheter proximal end is seal wire outlet;
On the outer wall in fluid injection chamber, be provided with the aperture being communicated with sacculus 3.
Be positioned on the tube wall of wire leading pipe at hollow sacculus 3 positions and be embedded with gauge point.
Fig. 3 is for to deliver to carotid artery 6 injury regions by degradable overlay film 5 supports along seal wire, degradable magnesium alloy overlay film frame 2 strutted with sacculus 3, makes degradable magnesium alloy overlay film frame 2 cover tumor mouth, by the schematic diagram of tumor mouth sealing.
Fig. 4 is the wall of 6 months rear neck arteries 6 while healing completely, and degradable degradable magnesium alloy overlay film frame 2 is degraded voluntarily, and blood vessel covered 5 are retained in tumor mouth place by the schematic diagram of tumor mouth sealing.
The foregoing is only preferred embodiment of the present invention; not thereby limit embodiments of the present invention and protection domain; to those skilled in the art; the scheme that being equal to of should recognizing that all utilizations description of the present invention and diagramatic content done replaces and apparent variation obtains, all should be included in protection scope of the present invention.
Claims (9)
1. a degradable magnesium alloy overlay film frame, is characterized in that, comprising: overlay film and degradable magnesium alloy bare bracket, described overlay film is coated in the outer surface of described degradable magnesium alloy bare bracket.
2. a kind of degradable magnesium alloy overlay film frame as claimed in claim 1, is characterized in that, described degradable magnesium alloy bare bracket is mainly formed by stacking by multiple corrugated metal racks, and the end of described overlay film frame is circular.
3. a kind of degradable magnesium alloy overlay film frame as claimed in claim 2, is characterized in that, adjacent two the corrugated metal racks of described degradable magnesium alloy bare bracket connect by connecting rod.
4. a kind of degradable magnesium alloy overlay film frame as claimed in claim 2, is characterized in that, every two described corrugated metal racks that close on differ half period.
5. a kind of degradable magnesium alloy overlay film frame as claimed in claim 2, is characterized in that, described degradable magnesium alloy bare bracket structure is cylindrical-shaped structure.
6. a kind of degradable magnesium alloy overlay film frame as claimed in claim 1, is characterized in that, described overlay film is for manually blood vessel covered.
7. a degradable magnesium alloy overlay film frame system, it is characterized in that, comprise: degradable magnesium alloy overlay film frame, sacculus and foley's tube as described in claim 1-6, described degradable magnesium alloy overlay film frame is arranged on described sacculus outer wall, and described sacculus is arranged on described foley's tube.
8. a kind of degradable magnesium alloy overlay film frame system as claimed in claim 7, is characterized in that, described foley's tube is made up of a guidewire lumen and fluid injection chamber.
9. a kind of degradable magnesium alloy overlay film frame system as claimed in claim 8, is characterized in that, described foley's tube comprises catheter proximal end, catheter body and distal end of catheter,
Described catheter proximal end is provided with injection port, in order to connect syringe;
Described distal end of catheter is provided with described fluid injection chamber;
The inner chamber of described catheter body is described guidewire lumen, and described distal end of catheter is seal wire entrance, and described catheter proximal end is seal wire outlet;
On the outer wall in described fluid injection chamber, be provided with the aperture being communicated with described sacculus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410161298.4A CN103948453A (en) | 2014-04-21 | 2014-04-21 | Degradable magnesium alloy membranous stent and membranous stent system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410161298.4A CN103948453A (en) | 2014-04-21 | 2014-04-21 | Degradable magnesium alloy membranous stent and membranous stent system |
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| CN103948453A true CN103948453A (en) | 2014-07-30 |
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| CN201410161298.4A Pending CN103948453A (en) | 2014-04-21 | 2014-04-21 | Degradable magnesium alloy membranous stent and membranous stent system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016176804A1 (en) * | 2015-05-04 | 2016-11-10 | 聂绍平 | Biodegradable polymer film monolayer metal covered stent |
| CN107440817A (en) * | 2017-08-21 | 2017-12-08 | 北京赛铂医药科技有限公司 | A kind of carotid artery flow controls support |
| CN107744415A (en) * | 2017-11-29 | 2018-03-02 | 成都创客之家科技有限公司 | A kind of titanium alloy carries medicine intravascular stent |
| CN108463190A (en) * | 2016-01-12 | 2018-08-28 | W.L.戈尔及同仁股份有限公司 | The implantable devices of energy degradation selectivity |
| CN112638322A (en) * | 2018-04-23 | 2021-04-09 | 恩朵罗杰克斯有限责任公司 | Modulation of inflammatory responses following intravascular treatment |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060253185A1 (en) * | 2005-05-09 | 2006-11-09 | Medtronic Vascular, Inc. | Catheter for stent delivery having expanded inner member |
| CN2936196Y (en) * | 2006-06-02 | 2007-08-22 | 中国科学院金属研究所 | Metal magnesium implanted rack capable of absorbing |
| CN101385875A (en) * | 2007-09-12 | 2009-03-18 | 中国科学院金属研究所 | Complete degradable absorbent medicine slow-release magnesium alloy bracket and use thereof |
| US20100262221A1 (en) * | 2005-09-19 | 2010-10-14 | Cook Incorporated | Graft with bioabsorbable support frame |
| CN102488932A (en) * | 2011-12-22 | 2012-06-13 | 哈尔滨工程大学 | Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating |
| CN102805893A (en) * | 2011-06-01 | 2012-12-05 | 上海市第六人民医院 | Hollow balloon catheter not blocking blood/air flow |
| CN203458679U (en) * | 2013-09-13 | 2014-03-05 | 维科医疗器械(苏州)有限公司 | Blood vessel dilating balloon |
-
2014
- 2014-04-21 CN CN201410161298.4A patent/CN103948453A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060253185A1 (en) * | 2005-05-09 | 2006-11-09 | Medtronic Vascular, Inc. | Catheter for stent delivery having expanded inner member |
| US20100262221A1 (en) * | 2005-09-19 | 2010-10-14 | Cook Incorporated | Graft with bioabsorbable support frame |
| CN2936196Y (en) * | 2006-06-02 | 2007-08-22 | 中国科学院金属研究所 | Metal magnesium implanted rack capable of absorbing |
| CN101385875A (en) * | 2007-09-12 | 2009-03-18 | 中国科学院金属研究所 | Complete degradable absorbent medicine slow-release magnesium alloy bracket and use thereof |
| CN102805893A (en) * | 2011-06-01 | 2012-12-05 | 上海市第六人民医院 | Hollow balloon catheter not blocking blood/air flow |
| CN102488932A (en) * | 2011-12-22 | 2012-06-13 | 哈尔滨工程大学 | Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating |
| CN203458679U (en) * | 2013-09-13 | 2014-03-05 | 维科医疗器械(苏州)有限公司 | Blood vessel dilating balloon |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016176804A1 (en) * | 2015-05-04 | 2016-11-10 | 聂绍平 | Biodegradable polymer film monolayer metal covered stent |
| CN108463190A (en) * | 2016-01-12 | 2018-08-28 | W.L.戈尔及同仁股份有限公司 | The implantable devices of energy degradation selectivity |
| CN108463190B (en) * | 2016-01-12 | 2021-03-09 | W.L.戈尔及同仁股份有限公司 | Selectively degradable implantable devices |
| CN107440817A (en) * | 2017-08-21 | 2017-12-08 | 北京赛铂医药科技有限公司 | A kind of carotid artery flow controls support |
| CN107744415A (en) * | 2017-11-29 | 2018-03-02 | 成都创客之家科技有限公司 | A kind of titanium alloy carries medicine intravascular stent |
| CN112638322A (en) * | 2018-04-23 | 2021-04-09 | 恩朵罗杰克斯有限责任公司 | Modulation of inflammatory responses following intravascular treatment |
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Application publication date: 20140730 |
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