CN103936878B - A kind of method of sequential simulated mobile chromatograph (SSMB) purification oligomeric isomaltose - Google Patents
A kind of method of sequential simulated mobile chromatograph (SSMB) purification oligomeric isomaltose Download PDFInfo
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- CN103936878B CN103936878B CN201410173390.2A CN201410173390A CN103936878B CN 103936878 B CN103936878 B CN 103936878B CN 201410173390 A CN201410173390 A CN 201410173390A CN 103936878 B CN103936878 B CN 103936878B
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- oligomeric isomaltose
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- sequential simulated
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- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 title claims abstract description 73
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 title claims abstract description 73
- 238000000746 purification Methods 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000006188 syrup Substances 0.000 claims abstract description 29
- 235000020357 syrup Nutrition 0.000 claims abstract description 29
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 239000011347 resin Substances 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 230000002378 acidificating effect Effects 0.000 claims abstract description 4
- 150000001768 cations Chemical class 0.000 claims abstract description 4
- 238000001228 spectrum Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 235000008504 concentrate Nutrition 0.000 claims description 14
- 239000012141 concentrate Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 13
- 238000007599 discharging Methods 0.000 claims description 12
- 238000004088 simulation Methods 0.000 claims description 9
- 238000010612 desalination reaction Methods 0.000 claims description 7
- 239000003463 adsorbent Substances 0.000 claims description 6
- 238000005352 clarification Methods 0.000 claims description 6
- 230000001839 systemic circulation Effects 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 239000012043 crude product Substances 0.000 claims description 3
- 241000209140 Triticum Species 0.000 claims description 2
- 235000021307 Triticum Nutrition 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000011112 process operation Methods 0.000 abstract description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 238000005265 energy consumption Methods 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 12
- 238000004587 chromatography analysis Methods 0.000 description 10
- 235000000346 sugar Nutrition 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000186016 Bifidobacterium bifidum Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- ZCLAHGAZPPEVDX-UHFFFAOYSA-N D-panose Natural products OC1C(O)C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC1COC1C(O)C(O)C(O)C(CO)O1 ZCLAHGAZPPEVDX-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 238000011097 chromatography purification Methods 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- DBTMGCOVALSLOR-AXAHEAMVSA-N galactotriose Natural products OC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](CO)O[C@@H](O[C@H]3[C@@H](O)[C@H](O)O[C@@H](CO)[C@@H]3O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O DBTMGCOVALSLOR-AXAHEAMVSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- FBJQEBRMDXPWNX-FYHZSNTMSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)C(O)O2)O)O1 FBJQEBRMDXPWNX-FYHZSNTMSA-N 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- ZCLAHGAZPPEVDX-MQHGYYCBSA-N panose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@@H]1CO[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ZCLAHGAZPPEVDX-MQHGYYCBSA-N 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 150000004043 trisaccharides Chemical class 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 238000007445 Chromatographic isolation Methods 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- -1 dextrinose Chemical class 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000003153 isomaltose group Chemical group 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
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- Saccharide Compounds (AREA)
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CN201410173390.2A CN103936878B (en) | 2014-04-28 | 2014-04-28 | A kind of method of sequential simulated mobile chromatograph (SSMB) purification oligomeric isomaltose |
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CN201410173390.2A CN103936878B (en) | 2014-04-28 | 2014-04-28 | A kind of method of sequential simulated mobile chromatograph (SSMB) purification oligomeric isomaltose |
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CN103936878A CN103936878A (en) | 2014-07-23 |
CN103936878B true CN103936878B (en) | 2016-09-14 |
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CN109438583B (en) * | 2018-11-26 | 2021-07-13 | 黑龙江八一农垦大学 | Method for purifying resistant dextrin by sequential simulated mobile chromatography |
CN114213477B (en) * | 2021-12-21 | 2023-08-15 | 黑龙江八一农垦大学 | Starch syrup decoloring method based on simulated mobile chromatography |
CN115960273B (en) * | 2022-12-20 | 2024-05-07 | 黑龙江八一农垦大学 | Method for purifying Phellinus linteus polysaccharide by simulated mobile chromatography |
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FI20020936A (en) * | 2002-05-17 | 2003-11-18 | Finnfeeds Finland Oy | Chromatographic separation |
CN1320122C (en) * | 2005-06-02 | 2007-06-06 | 江南大学 | Process for extracting xylose and xylitol from a xylose mother liquor or a xylose digest |
CN101284851A (en) * | 2007-04-13 | 2008-10-15 | 山东福田药业有限公司 | Process for separating maltitol liquor by sequential simulated moving bed |
CN102559810B (en) * | 2012-01-19 | 2013-11-06 | 保龄宝生物股份有限公司 | Method for preparing high-purity isomaltooligosacharide from wheat starch |
CN102850408B (en) * | 2012-09-12 | 2015-06-17 | 黑龙江八一农垦大学 | Method for preparing xylose and arabinose by using simulated moving chromatography |
CN103555794A (en) * | 2013-10-15 | 2014-02-05 | 山东百龙创园生物科技有限公司 | isomaltose hypgather cleaning and production method |
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Inventor after: Li Liangyu Inventor after: Jia Pengyu Inventor after: Li Chaoyang Inventor after: Lv Huozhu Inventor after: Wang Xuequn Inventor after: Zhang Liping Inventor after: Cao Longkui Inventor before: Li Liangyu Inventor before: Li Chaoyang Inventor before: Jia Pengyu Inventor before: Lv Huozhu Inventor before: Wang Xuequn Inventor before: Zhang Liping Inventor before: Cao Longkui |
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Effective date of registration: 20230418 Address after: 152000 Economic Development Zone, Beilin District, Suihua City, Heilongjiang Province Patentee after: HEILONGJIANG HAOTIAN CORN DEVELOPMENT Co.,Ltd. Address before: 163000 Heilongjiang Bayi Agricultural Reclamation University, High tech Zone, Daqing City, Heilongjiang Province Patentee before: HEILONGJIANG BAYI AGRICULTURAL University |
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Granted publication date: 20160914 |