CN103936660A - Preparation method and application of micron acicular-structure N-methyl-2-phenyl-3,4-fullerenylpyrrolidine - Google Patents
Preparation method and application of micron acicular-structure N-methyl-2-phenyl-3,4-fullerenylpyrrolidine Download PDFInfo
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- CN103936660A CN103936660A CN201410190434.2A CN201410190434A CN103936660A CN 103936660 A CN103936660 A CN 103936660A CN 201410190434 A CN201410190434 A CN 201410190434A CN 103936660 A CN103936660 A CN 103936660A
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- Prior art keywords
- phenyl
- methyl
- soccerballene
- toluene
- solution
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims abstract description 60
- 238000000034 method Methods 0.000 claims abstract description 17
- 239000003054 catalyst Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims abstract description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 176
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 69
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 57
- 238000006243 chemical reaction Methods 0.000 claims description 52
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 28
- 239000000126 substance Substances 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 23
- -1 phenyl aldehyde Chemical class 0.000 claims description 18
- 238000000926 separation method Methods 0.000 claims description 16
- 238000005406 washing Methods 0.000 claims description 16
- 229910052786 argon Inorganic materials 0.000 claims description 14
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 9
- 238000010025 steaming Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- VWLYRQOJEIIHMO-UHFFFAOYSA-N 4-aminophenol nitrobenzene Chemical compound [N+](=O)([O-])C=1C=CC=CC1.NC1=CC=C(C=C1)O VWLYRQOJEIIHMO-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000013019 agitation Methods 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 7
- 238000004440 column chromatography Methods 0.000 claims description 7
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 7
- 238000004821 distillation Methods 0.000 claims description 7
- 239000003480 eluent Substances 0.000 claims description 7
- 239000007789 gas Substances 0.000 claims description 7
- 238000001291 vacuum drying Methods 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000005554 pickling Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 abstract description 5
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 abstract 2
- 108010077895 Sarcosine Proteins 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 229940043230 sarcosine Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 61
- 229910003472 fullerene Inorganic materials 0.000 description 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 10
- 239000002086 nanomaterial Substances 0.000 description 7
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000005984 hydrogenation reaction Methods 0.000 description 4
- 239000011259 mixed solution Substances 0.000 description 4
- WSDQIHATCCOMLH-UHFFFAOYSA-N phenyl n-(3,5-dichlorophenyl)carbamate Chemical compound ClC1=CC(Cl)=CC(NC(=O)OC=2C=CC=CC=2)=C1 WSDQIHATCCOMLH-UHFFFAOYSA-N 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 238000006736 Huisgen cycloaddition reaction Methods 0.000 description 3
- BZVNRJRSPKWGGE-UHFFFAOYSA-N NC1=CC=C(C=C1)O.ClC1=C(C=CC=C1)[N+](=O)[O-] Chemical compound NC1=CC=C(C=C1)O.ClC1=C(C=CC=C1)[N+](=O)[O-] BZVNRJRSPKWGGE-UHFFFAOYSA-N 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 238000006114 decarboxylation reaction Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- BQVXQIAWQMNASF-UHFFFAOYSA-N C(Cl)(Cl)(Cl)Cl.C=N.C=N.C=N.C=N Chemical compound C(Cl)(Cl)(Cl)Cl.C=N.C=N.C=N.C=N BQVXQIAWQMNASF-UHFFFAOYSA-N 0.000 description 2
- AJTMKGZNXQVIHO-UHFFFAOYSA-N CC1=CC=CC=C1.C=N.C=N.C=N.C=N Chemical compound CC1=CC=CC=C1.C=N.C=N.C=N.C=N AJTMKGZNXQVIHO-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 125000000168 pyrrolyl group Chemical group 0.000 description 2
- 238000010408 sweeping Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
- 0 *C(C=C=C1)=CC=C1ON(C1=CCCC=C1)O Chemical compound *C(C=C=C1)=CC=C1ON(C1=CCCC=C1)O 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 238000010958 [3+2] cycloaddition reaction Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 150000001989 diazonium salts Chemical class 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 125000006575 electron-withdrawing group Chemical group 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 230000005311 nuclear magnetism Effects 0.000 description 1
- 238000005935 nucleophilic addition reaction Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0244—Nitrogen containing compounds with nitrogen contained as ring member in aromatic compounds or moieties, e.g. pyridine
-
- B01J35/50—
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
Abstract
The invention relates to a micron acicular-structure N-methyl-2-phenyl-3,4-fullerenylpyrrolidine, and a preparation method and application thereof. The fullerene C60, benzaldehyde and sarcosine are used as raw materials to prepare the N-methyl-2-phenyl-3,4-fullerenylpyrrolidine and N-methyl-2-phenyl-3,4-fullerenylpyrrolidine in a micron acicular structure; and the micron acicular-structure N-methyl-2-phenyl-3,4-fullerenylpyrrolidine is used as a support to prepare the catalyst for preparing p-aminophenol from nitrobenzene by catalytic hydrogenation. The product prepared by the technique has the advantages of high yield and high purity; and the prepared catalyst has the advantages of high activity and long service life.
Description
Technical field
The present invention relates to a kind of preparation method and application thereof of fullerene derivate, more particularly, relate to a kind of N-methyl-2-phenyl-3, preparation method and the application of 4-soccerballene base tetramethyleneimine.
Background technology
Aspect modern science and engineering science and technology, compared with the same material that the material being made up of at the nanoparticle in nano-scale range particle diameter forms with conventional particle, be very different at aspect of performance, this material has more advantage in physics, chemical property, has potential application prospect at the aspect such as catalyzer and opto-electronic device.Soccerballene based nano-material has very important optical, electrical, magnetic, catalytic performance, and therefore scientists is striving to find different methods, and to preparing, pattern is identical, the uniform soccerballene based nano-material of size distribution.Bokare and Patnaik directly utilize C
60cS
2solution obtains C through self-assembly
60nanoparticle, and find that the particle dia obtaining is with C
60the increase of strength of solution and reducing.C
60the crystal form of other pattern is also produced out, as: nanowhisker, nano wire, nanometer rod, nanotube etc.
[3+2] cycloaddition reaction is the classical reaction of of fullerene synthesis derivative, 1,3-dipole is diversified, as ylide compounds, diazonium compound and other 1,3-dipole, dipole both can original position produce, and also can prepare in advance, method is easy, and transformation efficiency and the productive rate of general reaction are all higher.Azomethine ylide be a class common 1,3-dipole, its production method is varied, adding thermal condensation decarboxylation by aldehydes or ketones and a-amino acid, to form azomethine ylide be wherein the most frequently used method, that is: a-amino acid can make Azomethine Ylide (Prato reacts) after decarboxylation and dehydration with aldehyde reaction, Maggini has reported this class reaction, sarkosine, formaldehyde and C the earliest
60in reflux in toluene, make N-methyl fulleropyrrolidine derivative, especially by selecting different aldehyde, ketone or amino acid easily the molecule of bio-active group or tool specific physical and electrical properties to be introduced to soccerballene, synthetic multiple tetramethyleneimine also, fullerene derivate, reacts as follows.Be commonly used to functionalized C with [3+2] cycloaddition of 1,3 dipole and other reagent
60, 1996, the research group of Prato and Mart í n independently reported first C simultaneously
60-TTF compound.Under heating condition, the TTF derivative with aldehyde radical and a-amino acid generation nucleophilic addition form Azomethine Ylide, afterwards and C after decarboxylation and dehydration
60there is 1,3-Dipolar Cycloaddition and obtain compound.
C
60the preparation method of base and derivative nano material thereof is a lot, can artificially arbitrarily control the C being evenly distributed but will obtain structure, form, yardstick
60base and derivative nano material thereof are still quite difficult.
" C
60the control of pyrrolidin derivatives micro-nano structure is synthesized and is characterized " (Huang Fei, in May, 2010, China's excellent MA theses full-text database) synthetic N-methyl-2-phenyl-3 are disclosed, 4-soccerballene base tetramethyleneimine, and this product is made to solvent with toluene, add tensio-active agent, its crystal form pattern is controlled.
" N-methyl-2-pentafluorophenyl group-3, the preparation of 4-soccerballene base tetramethyleneimine and two-dimensional nano material thereof " (Huang Fei, Wei Xianwen, " Huangshan University journal ", in June, 2013, the 15th the 3rd phase of volume, 17-21 page) a kind of N-methyl-2-pentafluorophenyl group-3 are disclosed, the preparation of 4-soccerballene base tetramethyleneimine and two-dimensional nano material thereof, utilize 1,3-Dipolar Cycloaddition (Prato reaction), successfully strong electron-withdrawing group is rolled into a ball to pentafluorophenyl group and receive C
60on carbon cage, study the impact of reaction conditions on single adduct, synthesized N-methyl-2-pentafluorophenyl group-3,4-soccerballene base tetramethyleneimine.
CN103242217A discloses a kind of fullerene derivate micron film and preparation method thereof, and micron film is by soccerballene C
60derivative composition, particularly soccerballene C
60derivative is N-methyl-2-[4-dimethylamino of sheet] phenyl-3,4-soccerballene base tetramethyleneimine, its length of a film be 2～4 μ m, sheet high be 1～3 μ m, the thick 70～80nm of being of sheet, it is single crystalline structure; N-methyl-2-[4-dimethylamino that method is is first 0.75～2.0g/L by concentration] phenyl-3, after the cetyl trimethylammonium bromide aqueous isopropanol that 4-soccerballene base tetramethyleneimine toluene solution is 3～7mmol/L with concentration mixes, stir at least 20min, obtain mixed solution, wherein, N-methyl-2-[4-dimethylamino] phenyl-3, the volume ratio of 4-soccerballene base tetramethyleneimine toluene solution and cetyl trimethylammonium bromide aqueous isopropanol is 1:1～6, to the hocket processing of solid-liquid separation and washing of mixed solution, make fullerene derivate micron film again.
CN103319397A also discloses a kind of fullerene derivate micron film and preparation method thereof, and micro-flowers is by soccerballene C
60derivative composition, particularly soccerballene C
60derivative is spherical flower-shaped N-methyl-2-[4-dimethylamino] phenyl-3,4-soccerballene base tetramethyleneimine, the micron film that spherical flower is the high mutual cross stand that is 1～3 μ m, the thick 20～30nm of being of sheet of 3～5 μ m, sheet by length of a film forms, and it is single crystalline structure; Method is for first by N-methyl-2-[4-dimethylamino] phenyl-3, after mixing with cetyl trimethylammonium bromide aqueous isopropanol, stirs 4-soccerballene base tetramethyleneimine carbon tetrachloride solution, obtain mixed solution, wherein, N-methyl-2-[4-dimethylamino] phenyl-3, the volume ratio of 4-soccerballene base tetramethyleneimine carbon tetrachloride solution and cetyl trimethylammonium bromide aqueous isopropanol is 1:1～6, then to the hocket processing of solid-liquid separation and washing of mixed solution, makes fullerene derivate micro-flowers.
But the target product that the technique of existing fullerene synthesis derivative makes, it is lower that ubiquity products collection efficiency, and purity is not high, adopts above-mentioned fullerene derivate to apply simultaneously, for example, as support of the catalyst, has the problems such as catalytic conversion is low.
Summary of the invention
In order to overcome problems of the prior art, the invention provides a kind of fullerene derivate and synthetic method thereof, the fullerene derivate productive rate that makes is high, purity is high, it is high to be converted into the catalytic conversion efficiency of p-aminophenol as support of the catalyst catalysis oil of mirbane.
A kind of N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
(1), under argon shield, the ratio that is first 1:6 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 1-2h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60in toluene solution, add respectively phenyl aldehyde and the sarkosine of new distillation, and be placed on the 2-3h that refluxes at 120 DEG C, obtain reaction solution, wherein, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively hexanaphthene drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and hexanaphthene mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 2-3 time, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
N-methyl-2-phenyl-3 that adopt aforesaid method to make, 4-soccerballene base tetramethyleneimine structural formula is:
N-methyl-2-phenyl-3 of a kind of micron of acicular structure, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
To N-methyl-2-phenyl-3 of above-mentioned gained, 4-soccerballene base tetramethyleneimine is processed, taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, and its concentration in toluene is 0.75mg-0.85mg/mL, then adds tensio-active agent, wherein tensio-active agent is that sodium laurylsulfonate is dissolved in and makes in methyl alcohol, the amount of substance concentration 3-7mmol/L of described tensio-active agent; The volume ratio of methyl alcohol and toluene is 5-6:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min; Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine is applied in By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed.
The catalyzer of a kind of By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed, wherein said support of the catalyst is N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine, described active ingredient is group VIII metal, wherein N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine accounts for 3% (weight) of catalyst content, adopts pickling process to make, and preferably described active ingredient is Pt.
Useful technique effect, N-methyl-2-phenyl-3 that aforesaid method of the present invention makes, 4-soccerballene base tetramethyleneimine, make compared to existing technology N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine, there is higher productive rate and purity, can be reached for respectively 45% and 97%; N-methyl-2-phenyl-3 of micron acicular structure prepared by aforesaid method, 4-soccerballene base tetramethyleneimine is used for By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed as catalyzer, N-methyl-2-phenyl-3 that catalyzer makes compared to existing technology, catalyzer prepared by 4-soccerballene base tetramethyleneimine is for By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed, active high, the life-span is long.
Brief description of the drawings
Fig. 1 is to N-methyl-2-phenyl-3, the infrared spectrogram that infrared spectra (FTIR) instrument that 4-soccerballene base tetramethyleneimine use model is VECTOR22FT-IR characterizes;
Fig. 2 is to N-methyl-2-phenyl-3, the hydrogen spectrogram that the nuclear magnetic resonance analyser that 4-soccerballene base tetramethyleneimine use model is BrukerAV300 characterizes;
Fig. 3 is N-methyl-2-phenyl-3 to micron acicular structure, one of scanning electron microscope (SEM) photograph that 4-soccerballene base tetramethyleneimine use surface sweeping Electronic Speculum (SEM) characterizes;
Fig. 4 is N-methyl-2-phenyl-3 to micron acicular structure, two of the scanning electron microscope (SEM) photograph that 4-soccerballene base tetramethyleneimine use surface sweeping Electronic Speculum (SEM) characterizes;
For Fig. 1, characterize through infrared spectra (KBr compressing tablet), 1462,1182,575,527cm
-1belong to C
60on characteristic absorbance, 729,896,907,996,1045,1166cm
-1belong to the absorption of vibrations of phenyl ring, 2976,2920,2843,2775cm
-1the stretching vibration that belongs to C-H absorbs.
For Fig. 2, process
1h nuclear magnetic resonance spectrum, wherein nuclear-magnetism
1belong to-N-CH of H NMR2.82 (s, 3H)
3, 4.08 (d, 1H) and 4.99 (d, 1H) are pyrrole ring C
60-CH
2-N, 4.95 is pyrrole ring C
60-CH (Ph) N, 7.17-7.47 (m, 5H) is C
6h
5.
Embodiment
Embodiment 1 (S1)
N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
(1), under argon shield, the ratio that is first 1:6 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 1h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60in toluene solution, add respectively phenyl aldehyde and the sarkosine of new distillation, and be placed on the 2h that refluxes at 120 DEG C, obtain reaction solution, wherein, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively hexanaphthene drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and hexanaphthene mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 2 times, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
Embodiment 2 (S2)
N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
(1), under argon shield, the ratio that is first 1:6 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 2h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60in toluene solution, add respectively phenyl aldehyde and the sarkosine of new distillation, and be placed on the 3h that refluxes at 120 DEG C, obtain reaction solution, wherein, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively hexanaphthene drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and hexanaphthene mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 3 times, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
Comparative example 1 (SD1)
N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
(1), under argon shield, the ratio that is first 1:7 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 1h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60in toluene solution, add respectively phenyl aldehyde and the sarkosine of new distillation, and be placed on the 2h that refluxes at 120 DEG C, obtain reaction solution, wherein, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively hexanaphthene drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and hexanaphthene mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 2 times, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
Comparative example 2 (SD2)
N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
(1), under argon shield, the ratio that is first 1:7 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 1h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60what in toluene solution, add respectively new distillation enters phenyl aldehyde and sarkosine, and is placed on the 2h that refluxes at 120 DEG C, obtains reaction solution, wherein, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:5:3;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively hexanaphthene drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and hexanaphthene mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 2 times, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
Comparative example 3 (SD3)
N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, its step comprises:
(1), under argon shield, the ratio that is first 1:7 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 1h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60in toluene solution, add respectively phenyl aldehyde and the sarkosine of new distillation, and be placed on the 2h that refluxes at 120 DEG C, obtain reaction solution, wherein, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:5:3;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively sherwood oil drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and sherwood oil mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 2 times, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
Table 1
Table 1 is N-methyl-2-phenyl-3 that embodiment 1 and comparative example 1-3 are made, and 4-soccerballene base tetramethyleneimine carries out the analytical test of productive rate and purity, and wherein productive rate refers to N-methyl-2-phenyl-3 that obtain, 4-soccerballene base tetramethyleneimine product quality and raw material soccerballene C
60, phenyl aldehyde and sarkosine three quality sum ratio.As shown in Table 1, the present invention finds by great many of experiments, as soccerballene C
60be dissolved in new steaming toluene, employing molar ratio is 1:6; In reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4; Finally adopt hexanaphthene to rinse; N-methyl-2-phenyl-3 that now obtain, 4-soccerballene base tetramethyleneimine has the highest productive rate and purity, is respectively 45% and 97%; Learn by analysis, as soccerballene C
60be dissolved in new steaming toluene, employing molar ratio is 1:6, now soccerballene C
60in toluene, there is the highest solubleness, in reaction, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4, with this understanding, each component has the highest transformation efficiency; The flushing of coupling collar hexane, above-mentioned many factors coordinative role, obtains the highest productive rate and product purity.
Embodiment 3 (M3)
To N-methyl-2-phenyl-3 of embodiment 1 gained, 4-soccerballene base tetramethyleneimine is processed, taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, and its concentration in toluene is 0.75mgmg/mL, then adds tensio-active agent, wherein tensio-active agent is that sodium laurylsulfonate is dissolved in and makes in methyl alcohol, the amount of substance concentration 3mmol/L of described tensio-active agent; The volume ratio of methyl alcohol and toluene is 5:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min.Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
Embodiment 4 (M4)
To N-methyl-2-phenyl-3 of embodiment 1 gained, 4-soccerballene base tetramethyleneimine is processed,
Taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, its concentration in toluene is 0.85mg/mL, add again tensio-active agent, wherein tensio-active agent is that sodium laurylsulfonate is dissolved in and makes in methyl alcohol, the amount of substance concentration 7mmol/L of described tensio-active agent; The volume ratio of methyl alcohol and toluene is 6:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min.Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
Embodiment 5 (M5)
To N-methyl-2-phenyl-3 of embodiment 2 gained, 4-soccerballene base tetramethyleneimine is processed, taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, and its concentration in toluene is 0.8mg/mL, then adds tensio-active agent, wherein tensio-active agent is that sodium laurylsulfonate is dissolved in and makes in methyl alcohol, the amount of substance concentration 6mmol/L of described tensio-active agent; The volume ratio of methyl alcohol and toluene is 6:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min.Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
Comparative example 4 (MD4)
To N-methyl-2-phenyl-3 of embodiment 3 gained, 4-soccerballene base tetramethyleneimine is processed,
Taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, its concentration in toluene is 0.75/mL, add again tensio-active agent, wherein tensio-active agent is that cetyl trimethylammonium bromide is dissolved in and makes in Virahol, the amount of substance concentration 5mmol/L of described tensio-active agent; The volume ratio of Virahol and toluene is 4:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min.Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
Comparative example 5 (MD5)
To N-methyl-2-phenyl-3 of embodiment 3 gained, 4-soccerballene base tetramethyleneimine is processed,
Taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, its concentration in toluene is 0.75/mL, add again tensio-active agent, wherein tensio-active agent is that cetyl trimethylammonium bromide is dissolved in and makes in methyl alcohol, the amount of substance concentration 5mmol/L of described tensio-active agent; The volume ratio of methyl alcohol and toluene is 4:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min.Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
N-methyl-2-phenyl-3 of the micron acicular structure that employing embodiment 3-5 makes, 4-soccerballene base tetramethyleneimine is as support of the catalyst, N-methyl-2-phenyl-3 that comparative example 4-5 makes, 4-soccerballene base tetramethyleneimine and gac are respectively as support of the catalyst, active ingredient Pt is carried in described support of the catalyst, carry out By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed with described catalyzer, concrete preparation method and reaction conditions are as follows: N-methyl-2-phenyl-3 that take the micron acicular structure that 300g embodiment 3-5 makes, 4-soccerballene base tetramethyleneimine is done N-methyl-2-phenyl-3 that carrier or comparative example 4-5 make, 4-soccerballene base tetramethyleneimine as carrier or with gac as carrier, H
2ptCl
6solution (1.85mgPt/mL, 5.40mL) is platinum source, adopts preparation catalyst, and at room temperature after hydrazine hydrate reduction, in 110 DEG C of dry 4h, for subsequent use, makes the catalyzer of Pt Chong amount Han Liang≤2%.Hydrogenation reaction is carried out under normal pressure, in 10% sulfuric acid medium, in three neck Erlenmeyer flasks, add 0.1g catalyzer, 35mL distilled water, the 3.5mL vitriol oil, 10mL tensio-active agent (0.1g/mL), and with the air in nitrogen replacement system, then with hydrogen exchange nitrogen, temperature is risen to 90 DEG C, add the oil of mirbane of half amount to start reaction, after reaction 30min, add second half oil of mirbane, while continuing to react to 90min, stopped reaction, carries out product analysis, and reaction equation is as follows, catalyst recirculation is used for 5 times simultaneously, investigate its work-ing life.
Table 2
Adopting as shown in Table 2 embodiment 3-5 product is that the catalyzer prepared of raw material is in hydrogenation of chloronitrobenzene p-aminophenol reaction processed, reactive behavior is respectively 25% left and right, and the comparative example 4-5 product catalyzer that to be raw material prepare is in hydrogenation of chloronitrobenzene p-aminophenol reaction processed, reactive behavior is 11% left and right, and reactive behavior obviously improves as can be seen here; And after circulation 5 times, adopting embodiment 3-5 product is that catalyst activity prepared by raw material reduces seldom, and it is nearly 50% to adopt comparative example 4-5 product to be that catalyst activity prepared by raw material reduces, and the life-span is obviously different.Embodiment 3-5 product be the catalyzer prepared of raw material in hydrogenation of chloronitrobenzene p-aminophenol reaction processed, the catalyst activity that reactive behavior is also carrier than conventional gac is high.
Claims (6)
1. N-methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, is characterized in that, step comprises:
(1), under argon shield, the ratio that is first 1:6 according to amount of substance ratio is by soccerballene C
60be dissolved in new steaming toluene, and stir 1-2h, obtain soccerballene C
60toluene solution;
(2) to described soccerballene C
60in toluene solution, add respectively phenyl aldehyde and the sarkosine of new distillation, and be placed on the 2-3h that refluxes at 120 DEG C, obtain reaction solution, wherein, three kinds of raw material soccerballene C
60, phenyl aldehyde and sarkosine amount of substance than being 1:6:4;
(3) in reaction solution, pass into argon gas, it is cooled to after room temperature, it is filtered, is concentrated and column chromatography for separation, obtain reacting concentrated solution;
(4) use successively hexanaphthene drip washing to fall the soccerballene C that does not participate in reaction to reaction concentrated solution
60, be 1:3 by volume ratio toluene and hexanaphthene mixes again eluent drip washing residuum, obtain product solution, afterwards, first product solution is carried out successively solid-liquid separation and uses washed with methanol 2-3 time, again to its vacuum-drying 24h, obtain target product, i.e. N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine.
2. N-methyl-2-phenyl-3 that made by method described in claim 1,4-soccerballene base tetramethyleneimine, is characterized in that, its structural formula is:
3. the N-of micron acicular structure methyl-2-phenyl-3, the preparation method of 4-soccerballene base tetramethyleneimine, is characterized in that, its step comprises:
To N-methyl-2-claimed in claim 2 phenyl-3,4-soccerballene base tetramethyleneimine is processed, taking toluene as solvent, described N-methyl-2-phenyl-3,4-soccerballene base tetramethyleneimine is dissolved in toluene, and its concentration in toluene is 0.75mg-0.85mg/mL, then adds tensio-active agent, wherein tensio-active agent is that sodium laurylsulfonate is dissolved in and makes in methyl alcohol, the amount of substance concentration 3-7mmol/L of described tensio-active agent; The volume ratio of methyl alcohol and toluene is 5-6:1, and temperature is 15 DEG C, and the magnetic agitation time is 20min; Centrifugal through whizzer again, the rotating speed of whizzer is 5000r/min, and centrifugation time is 10min, remove upper solution, with dehydrated alcohol cleaning 3 times, after whizzer is centrifugal, be placed under normal temperature and dry 10min, can obtain N-methyl-2-phenyl-3 of micron acicular structure, 4-soccerballene base tetramethyleneimine.
4. N-methyl-2-phenyl-3 of the micron acicular structure that a method according to claim 3 makes, the application of 4-soccerballene base tetramethyleneimine in By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed.
5. the catalyzer of a By Catalytic Hydrogenation of Nitrobenzene p-aminophenol processed, it is characterized in that described support of the catalyst is N-methyl-2-phenyl-3 of the micron acicular structure that makes of method claimed in claim 3,4-soccerballene base tetramethyleneimine, described active ingredient is group VIII metal, wherein group VIII metal accounts for catalyst content ≤2% (weight), adopts pickling process to make.
6. catalyzer as claimed in claim 5, is characterized in that, described active ingredient is Pt.
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