CN103932673B - A kind of arthroscope system based on multimode spectral technique - Google Patents
A kind of arthroscope system based on multimode spectral technique Download PDFInfo
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- CN103932673B CN103932673B CN201410166357.7A CN201410166357A CN103932673B CN 103932673 B CN103932673 B CN 103932673B CN 201410166357 A CN201410166357 A CN 201410166357A CN 103932673 B CN103932673 B CN 103932673B
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Abstract
The present invention relates to a kind of arthroscope system based on multimode spectral technique, it is characterized in that: comprise LED lamp cold light source, optical fiber, arthroscope probe, CCD image sensor, femto second optical fiber laser, can be optical signal lead fiber switch, Raman spectrometer, visible spectrophotometer, the computer control processing unit of different fiber. The present invention is reasonable in design, is skillfully constructed, and has vast potential for future development and larger dissemination.
Description
Technical field
The present invention relates to medical instruments field, especially a kind of arthroscope system based on multimode spectral technique.
Background technology
Arthroscope is the important optical instrument of current diagnosis and treatment joint disease. Doctor can carry out complete observation to articular cavity inner structure by arthroscope, and the pathology in many articular cavities can directly be diagnosed and treat. But the suspicious focus that can not make a definite diagnosis arthroscope, also needs by a series of processes such as biopsy, pathological analysis, has so just wasted valuable treatment time. Therefore development had not only had existing Arthroscopic function but also can realize that suspicious focus is carried out to quantitative analysis is following Arthroscopic prior development direction with the new technology of making a definite diagnosis, and was again Key Scientific And Technical Problems in the urgent need to address in medical advance.
As everyone knows, in articular cavity, mainly formed by osteocyte, extracellular matrix and bone component. Therefore, can realize the analysis of the information such as these composition variations and quantification are had to great clinical value to the diagnosis of joint disease. But clinical detection technique all cannot realize analysis and the quantification to these information at present.
In recent years, microspectrum technology has obtained applying more and more widely owing to having without wound, the advantage such as simple, quick, efficient in biomedicine. Particularly micro-nonlinear optical spectral technology, it is the linear optics effect of utilizing the inherent interaction between component of femtosecond laser and cell and extracellular matrix to occur, can effectively analyze the situation of change with quantization cell function and extracellular matrix composition. In addition, micro Raman spectra technology, by the scattering spectrum different from incident light frequency analyzed, can provide inorganic and organic principle information, comprises the feature such as mineral lattice and collagen secondary structure information, in bone tissue research, has important application. In brief, micro Raman spectra technology can provide a kind of accurate quantification means for bone component.
But at present, in arthroscope, still there is no the micro-nonlinear optical spectral technology of fine application and micro Raman spectra technology. If, arthroscope can be gathered the advantage of micro-nonlinear optical spectral technology and micro Raman spectra technology, to obtain the quantitative information of osteocyte, extracellular matrix and bone component variation etc., further improve diagnosis arthropathy and the assessment accuracy of function of joint and the accuracy rate of operation and success rate.
Therefore, design a kind of multimode arthroscope system that micro-nonlinear optical spectral technology, micro Raman spectra technology are combined with arthroscope extremely urgent.
Summary of the invention
In view of the deficiencies in the prior art, the invention provides a kind of arthroscope system based on multimode spectral technique, can further improve diagnosis arthropathy and the assessment accuracy of function of joint and the accuracy rate of operation and success rate.
Technical program of the present invention lies in:
Based on an arthroscope system for multimode spectral technique, it is characterized in that: comprise LED lamp cold light source, optical fiber, arthroscope probe, CCD image sensor, femto second optical fiber laser, can be optical signal lead fiber switch, Raman spectrometer, visible spectrophotometer, the computer control processing unit of different fiber; Described optical fiber comprises first, second, third, fourth, the 5th, six fibers; Described LED lamp cold light source forms the first input path through the first optical fiber and described arthroscope probe, and described arthroscope probe forms the first reflected light path through the second optical fiber and described imageing sensor; Described femto second optical fiber laser forms the second input path by the 3rd optical fiber and described arthroscope probe, and described endoscope probe forms wherein second reflected light path on a road by the 4th optical fiber, fiber switch, the 5th optical fiber and described Raman spectrometer successively; Described endoscope probe forms second reflected light path on another road successively by the 4th optical fiber, fiber switch, six fibers and described visible spectrophotometer; Described computer control processing unit is connected with described LED lamp cold light source, described femto second optical fiber laser, described imageing sensor, described Raman spectrometer, described visible spectrum instrument circuit respectively.
Wherein, described arthroscope probe is made up of a miniscanning device, a microcobjective and four optical fiber that are connected with first, second, third, fourth optical fiber respectively.
More than described LED lamp cold light source illumination reaches 300LUX in working range.
Described femto second optical fiber laser is the ultrashort pulse laser of a high repetition frequency, and frequency reaches 76MHz, and ultrashort pulse is 60fs, and wavelength is 780nm, and power output is 60mW.
Described Raman spectrometer is made up of a notch filter sheet, high-quality reflecting grating and high sensitivity TE refrigeration temperature control ccd array, and spectral resolution can reach 5cm-1, spectral coverage 175-3500cm-1; The described optical fiber being connected with Raman spectrometer, diameter is 100 μ m.
Described visible spectrophotometer is made up of a short pass filter sheet of KP650 type, two dispersing prisms and an enhancement mode CCD, and spectral resolution can reach 1nm, the wave-length coverage 350-650nm of detection; The described six fibers being connected with visible spectrophotometer, diameter is 200 μ m.
The invention has the advantages that: the present invention adopts LED lamp cold light source, more than illumination reaches 300LUX in working range, color is close to daylight, and the image of acquisition is more true to nature, clear, has the advantages such as cost is low, the life-span long, light, compact; Fiber switch can be the optical signal different optical fiber that leads, thereby can realize the switching of light path; Femto second optical fiber laser is not only as measuring the light source of micro Raman spectra but also as the light source of measuring micro-non-linear spectral, and have that cost is low, miniaturization, the advantage such as intensive; Based on the arthroscope system of multimode spectral technique, can realize analysis and the quantification that can realize again the information such as biochemical component variation of articular cavity surface and bone to the demonstration of articular cavity inner disease foci and location; This system provides new method and new technology for realizing arthropathy diagnosis, significant to improving diagnosis arthropathy and the assessment accuracy of function of joint and the accuracy rate of operation and success rate. The present invention is reasonable in design, is skillfully constructed, and has vast potential for future development and larger dissemination.
Brief description of the drawings
Fig. 1 is System Construction schematic diagram of the present invention.
Detailed description of the invention
For above-mentioned feature and advantage of the present invention can be become apparent, special embodiment below, and coordinate accompanying drawing, be described in detail below.
With reference to figure 1, the present invention relates to the invention provides a kind of arthroscope system based on multimode spectral technique, comprise cold light source: LED lamp 1, the first optical fiber 2, arthroscope probe 3, the second optical fiber 4, CCD image sensor 5, femto second optical fiber laser 6, the 3rd optical fiber 7, the 4th optical fiber 8, fiber switch 9, the 5th optical fiber 10, Raman spectrometer 11, six fibers 12, visible spectrophotometer 13, computer control processing unit 14.
Described cold light source: the light that LED lamp 1 sends incides in described arthroscope probe 3 by described the first optical fiber 2, thereby to articular cavity surface, the reflected light signal producing is from described arthroscope probe 3 outputs, then by described the second optical fiber 4, the reflected light signal described imageing sensor 5 that leads is surveyed, the signal detecting is inputted described computer control processing unit 14 by described imageing sensor, obtain White-light image, thereby determine the particular location of articular cavity surface focus, determining after the particular location of articular cavity surface focus, the near-infrared ultrashort pulse light that described femto second optical fiber laser 6 sends arrives in described arthroscope probe 3 by described the 3rd optical fiber 7, thereby arrive the focus on articular cavity surface, the optical signalling producing is exported from described endoscope probe 3, then incide described fiber switch 9 by described the 4th optical fiber 8, then survey by regulating and controlling described fiber switch 9 optical signal guiding the 5th optical fiber 10 and inciding described Raman spectrometer 11 by described the 5th optical fiber 10, the optical signal detecting is inputted described computer control processing unit 14 by described Raman spectrometer 11, obtain micro Raman spectra, thereby realize the measurement of micro Raman spectra.
Realizing after micro Raman spectra measurement, by regulating and controlling described fiber switch 9 lead six fibers 12 incide described visible spectrophotometer 13 by described six fibers 12 and survey of optical signal, the optical signal detecting is inputted described computer control processing unit 14 by described visible spectrophotometer 13, obtain micro-non-linear spectral, thereby realize the measurement of micro-non-linear spectral.
Preferably, described endoscope probe is made up of four optical fiber, a miniscanning device and a microcobjective; Described cold light source: LED lamp, more than illumination reaches 300LUX in working range, color is close to daylight, and the image of acquisition is more true to nature, clear, has the advantages such as cost is low, the life-span long, light, compact; Described femto second optical fiber laser is the ultrashort pulse laser of a high repetition frequency, and frequency reaches 76MHz, and ultrashort pulse is 60fs, and wavelength is 780nm, and power output is about 60mW, has that cost is low, a miniaturization, the advantage such as intensive; Described Raman spectrometer is made up of a notch filter sheet, high-quality reflecting grating and high sensitivity TE refrigeration temperature control ccd array, and spectral resolution can reach 5cm-1, spectral coverage 175-3500cm-1; The described optical fiber being connected with Raman spectrometer, diameter is 100 μ m, has the function as detecting pinhole; Described visible spectrophotometer is made up of a short pass filter sheet (KP650), two dispersing prisms and an enhancement mode CCD, and spectral resolution can reach 1nm, the wave-length coverage 350-650nm of detection; The described optical fiber being connected with visible spectrophotometer, diameter is 200 μ m.
The present invention diagnoses new method and new technology is provided for arthropathy, significant to improving diagnosis arthropathy and the assessment accuracy of function of joint and the accuracy rate of operation and success rate.
The foregoing is only preferred embodiment of the present invention, all equalizations of doing according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (1)
1. the arthroscope system based on multimode spectral technique, is characterized in that: comprise LED lamp cold light source, optical fiber, arthroscope probe, CCD image sensor, femto second optical fiber laser, can be optical signal lead fiber switch, Raman spectrometer, visible spectrophotometer, the computer control processing unit of different fiber, described optical fiber comprises first, second, third, fourth, the 5th, six fibers, described LED lamp cold light source forms the first input path through the first optical fiber and described arthroscope probe, and described arthroscope probe forms the first reflected light path through the second optical fiber and described imageing sensor, described femto second optical fiber laser forms the second input path by the 3rd optical fiber and described arthroscope probe, and described arthroscope probe forms wherein second reflected light path on a road by the 4th optical fiber, fiber switch, the 5th optical fiber and described Raman spectrometer successively, described arthroscope probe forms second reflected light path on another road successively by the 4th optical fiber, fiber switch, six fibers and described visible spectrophotometer, described computer control processing unit is connected with described LED lamp cold light source, described femto second optical fiber laser, described imageing sensor, described Raman spectrometer, described visible spectrum instrument circuit respectively, the light that described LED lamp cold light source sends incides in described arthroscope probe by described the first optical fiber, thereby to articular cavity surface, the reflected light signal producing is from the output of described arthroscope probe, then by described the second optical fiber, the reflected light signal described imageing sensor that leads is surveyed, the signal detecting is inputted described computer control processing unit by described imageing sensor, obtain White-light image, thereby determine the particular location of articular cavity surface focus, determining after the particular location of articular cavity surface focus, in the near-infrared ultrashort pulse light that described femto second optical fiber laser sends is popped one's head in to described arthroscope by described the 3rd optical fiber, thereby arrive the focus on articular cavity surface, the optical signal producing is from the output of described arthroscope probe, then incide described fiber switch by described the 4th optical fiber, then survey by regulating and controlling described fiber switch optical signal guiding the 5th optical fiber and inciding described Raman spectrometer by described the 5th optical fiber, the optical signal detecting is inputted described computer control processing unit by described Raman spectrometer, obtain micro Raman spectra, thereby realize the measurement of micro Raman spectra, realizing after micro Raman spectra measurement, by regulating and controlling described fiber switch lead six fibers incide described visible spectrophotometer by described six fibers and survey of optical signal, the optical signal detecting is inputted described computer control processing unit by described visible spectrophotometer, obtain micro-non-linear spectral, thereby realize the measurement of micro-non-linear spectral, described femto second optical fiber laser is the ultrashort pulse laser of a high repetition frequency, frequency reaches 76MHz, ultrashort pulse is 60fs, wavelength is 780nm, power output is 60mW, described arthroscope is popped one's head in by a miniscanning device, one microcobjective and respectively with first, second, the 3rd, the four optical fiber compositions that the 4th optical fiber connects, more than described LED lamp cold light source illumination reaches 300LUX in working range, described Raman spectrometer is by a notch filter sheet, high-quality reflecting grating and high sensitivity TE refrigeration temperature control ccd array composition, spectral resolution can reach 5cm-1, spectral coverage 175-3500cm-1; The described optical fiber being connected with Raman spectrometer, diameter is 100 μ m, and described visible spectrophotometer is made up of a short pass filter sheet of KP650 type, two dispersing prisms and an enhancement mode CCD, and spectral resolution can reach 1nm, the wave-length coverage 350-650nm of detection; The described six fibers being connected with visible spectrophotometer, diameter is 200 μ m.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171227A (en) * | 1997-05-14 | 1998-01-28 | 上海雷硕医疗器械有限公司 | Natural fluoroscopic image and spectrodiagnostic apparatus for malignant tumor |
| CN1251290A (en) * | 1999-11-13 | 2000-04-26 | 福建师范大学 | Coaxle low-light fluorescent diagnosing and positioning instrument for cancer of lung |
| US6069689A (en) * | 1997-04-16 | 2000-05-30 | Derma Technologies, Inc. | Apparatus and methods relating to optical systems for diagnosis of skin diseases |
| KR20030048522A (en) * | 2001-12-12 | 2003-06-25 | 박경순 | Apparatus of fluorescence endoscope, spectrum analysis and diagnosing method of cancer using the same |
| CN1493250A (en) * | 2002-10-31 | 2004-05-05 | ƽ | Device using endoscope to diagnose precancer affection |
| CN103315699A (en) * | 2013-06-13 | 2013-09-25 | 福建师范大学 | Endoscopic system applicable to positioning and recognition of Barrett's esophagus |
| CN103705201A (en) * | 2014-01-16 | 2014-04-09 | 福建师范大学 | Multimode spectrum analysis system suitable for detecting alimentary canal pathologic changes |
-
2014
- 2014-04-24 CN CN201410166357.7A patent/CN103932673B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069689A (en) * | 1997-04-16 | 2000-05-30 | Derma Technologies, Inc. | Apparatus and methods relating to optical systems for diagnosis of skin diseases |
| CN1171227A (en) * | 1997-05-14 | 1998-01-28 | 上海雷硕医疗器械有限公司 | Natural fluoroscopic image and spectrodiagnostic apparatus for malignant tumor |
| CN1251290A (en) * | 1999-11-13 | 2000-04-26 | 福建师范大学 | Coaxle low-light fluorescent diagnosing and positioning instrument for cancer of lung |
| KR20030048522A (en) * | 2001-12-12 | 2003-06-25 | 박경순 | Apparatus of fluorescence endoscope, spectrum analysis and diagnosing method of cancer using the same |
| CN1493250A (en) * | 2002-10-31 | 2004-05-05 | ƽ | Device using endoscope to diagnose precancer affection |
| CN103315699A (en) * | 2013-06-13 | 2013-09-25 | 福建师范大学 | Endoscopic system applicable to positioning and recognition of Barrett's esophagus |
| CN103705201A (en) * | 2014-01-16 | 2014-04-09 | 福建师范大学 | Multimode spectrum analysis system suitable for detecting alimentary canal pathologic changes |
Non-Patent Citations (1)
| Title |
|---|
| 鼻咽癌组织及细胞的拉曼光谱检测与分析;李永增;《中国博士学位论文全文数据库 医药卫生科技辑》;20130115(第01期);正文19-30 * |
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