CN103919714B - Lightening compositions - Google Patents
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- CN103919714B CN103919714B CN201410183089.XA CN201410183089A CN103919714B CN 103919714 B CN103919714 B CN 103919714B CN 201410183089 A CN201410183089 A CN 201410183089A CN 103919714 B CN103919714 B CN 103919714B
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Abstract
The invention discloses a kind of lightening compositions, formed by following component by percentage to the quality: niacinamide: 1-20%, ursin: 1-5%, carnitine: 1-10%, Angelica roots: 0.1-1%, Cortex Mori extract: 0.1-1%, Peony Root extract: 0.1-1%, bletilla striata root extract: 0.1-1%, Poria cocos root extract: 0.01-0.5%, bighead atractylodes rhizome root extract: 0.01-0.5%, Margarita extract: 0.01-0.5%, glycerine: 10-50%, surplus is water. The present invention also provides the application of above-mentioned lightening compositions in cosmetics. The present invention, respectively from melanic formation, arrives melanic transfer, then to multiple directions effects such as melanic decomposition and eliminatings, thereby reach collaborative whitening effect, there is excellent whitening and softening skin effect, and energy moisturizing and nourishing skin, long-term use has crease-resistant effect.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of lightening compositions and application thereof.
Background technology
Cosmetics refer to smear, and spray or other similar approach, intersperse among any position of human body surface, as skinSkin, hair, refers to toenail, lips and teeth etc., to reach clean, maintenance, beauty treatment, modifies and changes outward appearance, or revising human scent, protectsHold chemical industrial product or fine chemical product that kilter is object. At present, general skin-whitening agents is exactly by suppressingTyrosinase activity or blocking-up tyrosine generate melanic oxidative pathway, reach whitening skin thereby reduce melanic generationThe effect of skin. As skin-whitening agents mainly contains ursin, kojic acid and derivative thereof, licoflavone, hydroquinones, Tretinoin, reallyAcid, azelaic acid and various herb extracts. Adopt and make an addition in cosmetics single above-mentioned whitening agent or compound, to reachRestraint of tyrosinase is lived as direct effect mechanism. The permeability that this single inhibition mechanism is added active matter is undesirable, makesThe effect that obtains these whitening products is poor.
Summary of the invention
For the deficiencies in the prior art, the object of the present invention is to provide a kind of lightening compositions, described lightening compositionsFrom melanic formation, to melanic transfer, then to multiple directions effects such as melanic decomposition and eliminatings, thereby reachTo collaborative whitening effect, there is excellent whitening and softening skin effect, and energy moisturizing and nourishing skin, long-term use has crease-resistant effect.
Realizing object of the present invention can be by taking following technical scheme to reach:
A kind of lightening compositions, is characterized in that, is made up of: niacinamide: 1-following component by percentage to the quality20%, ursin: 1-5%, carnitine: 1-10%, Angelica roots: 0.1-1%, Cortex Mori extract: 0.1-1%, Chinese herbaceous peonyRoot extract: 0.1-1%, bletilla striata root extract: 0.1-1%, Poria cocos root extract: 0.01-0.5%, bighead atractylodes rhizome root extract:0.01-0.5%, Margarita extract: 0.01-0.5%, glycerine: 10-50%, surplus is water.
Preferably, lightening compositions is made up of following component by percentage to the quality: niacinamide: 5-10%, and ursin:2-5%, carnitine: 3-8%, Angelica roots: 0.3-0.6%, Cortex Mori extract: 0.3-0.6%, Peony Root extract:0.3-0.6%, bletilla striata root extract 0.3-0.6%, Poria cocos root extract: 0.1-0.3%, bighead atractylodes rhizome root extract: 0.1-0.3%, Margarita extract: 0.1-0.3%, glycerine: 20-40%, surplus is water.
Preferably, lightening compositions is made up of following component by percentage to the quality: niacinamide: 10%, and ursin:2%, carnitine: 5%, Angelica roots: 0.5%, Cortex Mori extract: 0.5%, Peony Root extract: 0.5%, bletilla striata rootExtract: 0.5%, Poria cocos root extract: 0.2%, bighead atractylodes rhizome root extract: 0.3%, Margarita extract: 0.3%, glycerine:25%, surplus is water.
Above-mentioned raw materials all can be buied from market.
Extract of the present invention refer to by by the wish material that obtains extract soak or be mixed in institute in solventThe solution extracting and obtain. Leaching process can carry out under the help of selecting applicable solvent, as: water, ethanol, ethanol/water is mixedCompound, methyl alcohol, propyl alcohol, butanols, chloroform, acetone or other organic solvents, and by segregation, diafiltration, decocts, counter-current extraction is superSound wave, microwave, the method for supercritical fluid extraction obtains extract, and extract is evaporation and concentration further, obtains medicinal extract and dryDry extract.
Niacinamide: traditional safe whitening agent is also multi-functional vitamin simultaneously, has moisturizing, skin barrier reparationWith the effect such as anti-aging.
Ursin: extraction, from the leaf of black bearberry, can be accelerated melanic decomposition and excretion, thus it is heavy to reduce skin pigmentLong-pending, dispelling stain and freckle also have sterilization, the effect of anti-inflammatory simultaneously.
Carnitine: beta-hydroxy acid, can promotion accelerated ageing cutin as mild as a dove come off, and improve water content of stratum corneum,Keep the soft water of skin tender.
Angelica roots: ventilation arteries and veins, moisturizing is dry, nti-freckle, anti-wrinkle, anti-ageing, activating blood circulation, clearing and activating the channels and collaterals, beauty treatment is dispelledSpot.
Cortex Mori extract: can effectively reduce the topmost high activity composition of tyrosinase, and the formation of check melanin.
Peony Root extract: treat acne for cosmetics, and delay the aging of body tissue.
Bletilla striata root extract: Compendium of Material Medica is said: " wash one's face black, nti-freckle. " it is mainly moisturizing fine flour, goes the scar of going out, andCan cure rhagadia manus et pedis etc.
Poria cocos root extract: " Bencao Pinhui Jingyao " said: " PORIA ALBA for end, close honey and, on flush coat, treat face sore and puerpera blackBlister is as sparrow ovum. " PORIA ALBA can de-black fine flour, is one of ancient prescription eight white raw materials.
Bighead atractylodes rhizome root extract: there is antioxidation, can effectively suppress lipid peroxidation, reduce and organize lipid peroxyThe content of compound, avoids the destruction of harmful substance to histocyte 26S Proteasome Structure and Function.
Margarita extract: have good white-skinned face function, its mainly come from composition in pearl can suppress tyrosine andThe activity of tyrosinase, stops it to send and forms melanic signal, reaches effect that check melanin forms.
The present invention also provides the application of above-mentioned lightening compositions in cosmetics.
A kind of skin-lightening cosmetic, described cosmetics contain above-mentioned lightening compositions, and described lightening compositions is in described cosmeticWeight percent consumption in product is 0.5%～10%.
Preferably, the weight percent consumption of described lightening compositions in described cosmetics is 4%～5%.
Beneficial effect of the present invention is:
Whitening compound action principle of the present invention:
1, check melanin forms: 1) ursin, and Cortex Mori extract can restraint of tyrosinase activity; 2) Peony Root is carriedGet thing, bletilla striata root extract, Poria cocos root extract, bighead atractylodes rhizome root extract: contain flavonoids, Polyphenols natural materials, has veryGood whitening effect, suppresses dopachrome isomerase activity;
2, check melanin transfer of granules is to horn cell: the niacinamide mechanism of action is: 1) by check melanin particleFormation; 2) effective check melanin is to horn cell transmission; 3) renewal speed of acceleration Skin Cell promotes melaniferous thinBorn of the same parents come off;
3, niacinamide, carnitine, as skin exfoliation agent, can come off by accelerator angle cell plastid mesocuticle;
4, the signal transduction pathway in blocking-up melanogenesis process: because the composition in the pearl of Margarita extract can press downThe activity of tyrosine processed and tyrosinase, stops it to send and forms melanic signal, reaches effect that check melanin forms;
5, Angelica roots can activating blood circulation, clearing and activating the channels and collaterals, face-beautifying and spot-removing, and ruddy skin, highlights skin, thereby reachesTo the effect of whitening and moistening skin.
Being used in conjunction with of above-mentioned raw materials, respectively from melanic formation, to melanic transfer, then to melanic decompositionWith the multiple directions effect such as eliminating, thereby reach collaborative whitening effect, there is excellent whitening and softening skin effect, and can moisturizingNourish skin, long-term use has crease-resistant effect.
Detailed description of the invention
Below, in conjunction with detailed description of the invention, the present invention is described further:
Embodiment 1:
A kind of lightening compositions, is made up of following component by percentage to the quality: niacinamide: 20%, and ursin: 5%,Carnitine: 10%, Angelica roots: 1%, Cortex Mori extract: 1%, Peony Root extract: 1%, bletilla striata root extract:1%, Poria cocos root extract: 0.5%, bighead atractylodes rhizome root extract: 0.5%, Margarita extract: 0.5%, glycerine: 50%, surplus isWater.
The preparation method of lightening compositions: above-mentioned raw materials is mixed, stir.
Embodiment 2:
A kind of lightening compositions, is made up of following component by percentage to the quality: niacinamide: 10%, and ursin: 2%,Carnitine: 5%, Angelica roots: 0.5%, Cortex Mori extract: 0.5%, Peony Root extract: 0.5%, bletilla striata root extractsThing: 0.5%, Poria cocos root extract: 0.2%, bighead atractylodes rhizome root extract: 0.3%, Margarita extract: 0.3%, glycerine: 25%, more thanAmount is water.
The preparation method of described composition is identical with embodiment 1.
Embodiment 3:
A kind of lightening compositions, is made up of following component by percentage to the quality: niacinamide: 1%, and ursin: 1%,Carnitine: 1%, Angelica roots: 0.1%, Cortex Mori extract: 0.1%, Peony Root extract: 0.1%, bletilla striata root extractsThing: 0.1%, Poria cocos root extract: 0.01%, bighead atractylodes rhizome root extract: 0.01%, Margarita extract: 0.01%, glycerine: 10%,Surplus is water. The preparation method of described composition is identical with embodiment 1.
Test implementation example 1: the impact that different materials generates check melanin.
1, reagent and instrument:
RPMI1640, Gibco company; Calf serum (FCS), Hangzhou Chinese holly company; Lactic dehydrogenase enzyme reagent kit, NanjingBuild up company; B16 cell, new drug center during China Medicine University is new;
BBHF-16CO2 incubator, Shanghai power Shengong department; TDL80-2B centrifuge, Anting Scientific Instrument Factory, Shanghai; 96 holesCulture plate, Corning company; DG5031 enzyme-linked immunosorbent assay instrument, East China Electronics Co., Ltd pipe factory.
2, method of testing:
Select the same generation cell of exponential phase, conventional trypsinization is processed after-blow and is broken into single cell suspension cell countQuantitatively be inoculated in 96 orifice plates. After 24 hours, abandoning supernatant, adds respectively the nutrient solution that contains test material shown in following table 1.At 37 DEG C, under the saturated moist condition of the CO2 of volume fraction 5%, to cultivate, control wells adds RPMI1640 nutrient solution, cultivates three days, inBetween change and once cultivate liquid. Abandoning supernatant, after conventional trypsinization is processed, counting cells density, the centrifugal cell precipitation that obtains,Rinse twice with PBS, centrifugal abandoning supernatant, quantitatively adds the NaOH liquid containing the 1N of 10% DMSO, 80 DEG C of water-baths 50 minutes, soAfter ELIASA 450nm place measure light absorption value.
The inhibiting rate (%)=100 (absorbance of the absorbance/control group of each test material) that melanin generates, specifically knotFruit is in table 1.
Table 1
| Test material | The inhibiting rate (%) that melanin generates |
| Niacinamide | 29.8 3 --> |
| Ursin, Cortex Mori extract | 30 |
| Ursin, Cortex Mori extract, niacinamide | 33 |
| Certain brand cosmetics of buying on market | 29.5 |
| Composition described in embodiment 1 | 40.2 |
| Composition described in embodiment 2 | 59.8 |
| Composition described in embodiment 3 | 33.4 |
As can be seen from Table 1, on check melanin generates, ursin, Cortex Mori extract, niacinamide is used in conjunction withEffect more more excellent than their independent uses, there is good complementary and synergy. Composition described in embodiment 1-3The effect using is more more excellent than similar cosmetics on market, and described in embodiment 2, the result of use of composition is best.
Test implementation example 2: to the whitening effect of human body skin
In order to verify the whitening effect on human body skin, 50 healthy males and women are carried out to following experiment: will be bothHaving six diameters is the upper arm that the opaque adhesive tape of 1.5cm through hole is additional to each tester, then attached to every bit test personAdd part and carry out ultraviolet radiation, the dosage of radiation is minimum erythema dose 1.5 times, induction skin darkening. At ultraviolet wire spokeAfter penetrating, will impose on by the position of radiation as the composition in table 2 respectively. And after two months, with colorimeter (market purchase) surveyAmount skin color.
Represent that by determining " L " value of skin brightness and darkness judges the effect of each component, in the present invention " L " valueProofread and correct by on-gauge plate, and repeatedly measure a part, evenly to measure pigment deposition part. Start to applyThe time point of composition to the skin color poor (Δ L) completing between the time point that applies composition calculates according to following formula: Δ L=The brightness L-testing after two months tests the brightness L while beginning. The results are shown in Table 2. Wherein, evaluating by Δ L valueWhen whitening effect, in the time that Δ L value is approximately 2, represent that pigmentation obviously alleviates, there is whitening effect if exceed 1.5 expressions.
Table 2
As can be seen from Table 2, aspect whitening, Peony Root extract, bletilla striata root extract, Poria cocos root extract is whiteThe effect being used in conjunction with of art root extract is used in combination all more excellent than their independent uses or both, have significantlySynergistic function, the effect of the use of composition is more more excellent than similar cosmetics on market described in embodiment 1-3, andDescribed in embodiment 2, the result of use of composition is best.
Test implementation example 3: to the moistening effect of human body skin
Keratoderma hydration rate test: operation principle is taking capacitor as instrument probe, because water is medium on skinThe material of constant maximum, in the time that skin moisture content changes, the capacitance of skin also changes, so can be by surveyingDetermine skin capacitance, analyzing skin surface moisture content. Conventional instrument is CorneometerCM825. Use by measurementBefore and after product, the variation of water content of stratum corneum is weighed in the variation of keratoderma capacitance, thereby evaluates the moisturizing of cosmeticsThis kind of method of effect carried out quantification to the moisture of keratoderma, can react delicately the change of skin moisture contentChange, and favorable reproducibility, be one of conventional method of current moisture-keeping cosmetics effect evaluation.
Experimental technique: bend at candidate left and right forearm the square Experimental Area that side marks 3 × 3cm2 size, do with left armFor the test zone of moisturizer, the corresponding symmetrical region of right arm is blank, then with CorneometerCM825 test inspectionSurvey the moisture at each test position, repeat respectively 5 times, draw mean value. By formula (1) calculated hydration rate.
Hydration rate=(test value-blank value)/blank value × 100% formula (1)
The detection of moistening effect, result is as shown in table 3:
Table 3
| Time | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| 1h | 78％ | 78％ | 78％ |
| 2h | 60％ | 65％ | 58％ |
| 4h | 42％ | 49％ | 38％ |
| 6h | 40％ | 48％ | 34％ |
| 8h | 39％ | 48％ | 30％ |
As can be seen from Table 3, aspect moisturizing, the effect of the use of composition is all very excellent described in embodiment 1-3, andDescribed in embodiment 2, the result of use of composition is best.
For a person skilled in the art, can be according to technical scheme described above and design, make that other is eachPlant corresponding change and distortion, and these all changes and distortion all should belong to the protection model of the claims in the present inventionWithin enclosing.
Claims (3)
1. lightening compositions, is characterized in that, is made up of: niacinamide: 1-20%, black bearberry following component by percentage to the qualityGlycosides: 1-5%, carnitine: 1-10%, Angelica roots: 0.1-1%, Cortex Mori extract: 0.1-1%, Peony Root extract:0.1-1%, bletilla striata root extract: 0.1-1%, Poria cocos root extract: 0.01-0.5%, bighead atractylodes rhizome root extract: 0.01-0.5%,Margarita extract: 0.01-0.5%, glycerine: 10-50%, surplus is water.
2. lightening compositions according to claim 1, is characterized in that being made up of following component by percentage to the quality:Niacinamide: 5-10%, ursin: 2-5%, carnitine: 3-8%, Angelica roots: 0.3-0.6%, Cortex Mori extract:0.3-0.6%, Peony Root extract: 0.3-0.6%, bletilla striata root extract 0.3-0.6%, Poria cocos root extract: 0.1-0.3%, bighead atractylodes rhizome root extract: 0.1-0.3%, Margarita extract: 0.1-0.3%, glycerine: 20-40%, surplus is water.
3. lightening compositions according to claim 1 and 2, is characterized in that the following component group by by percentage to the qualityBecome: niacinamide: 10%, ursin: 2%, carnitine: 5%, Angelica roots: 0.5%, Cortex Mori extract: 0.5%, Chinese herbaceous peonyRoot extract: 0.5%, bletilla striata root extract: 0.5%, Poria cocos root extract: 0.2%, bighead atractylodes rhizome root extract: 0.3%, pearlExtract: 0.3%, glycerine: 25%, surplus is water.
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104523528A (en) * | 2014-12-31 | 2015-04-22 | 李春茂 | Moisture mask and preparation method thereof |
| CN105456089A (en) * | 2015-12-04 | 2016-04-06 | 青岛讯达捷电子科技有限公司 | Skin whitening cosmetic product containing arbutin, tangerine powder and juicy peach powder |
| CN108366952A (en) * | 2015-12-14 | 2018-08-03 | 帝斯曼知识产权资产管理有限公司 | The composition for including niacinamide and alpha-arbutin for skin lightening |
| CN105456123A (en) * | 2015-12-17 | 2016-04-06 | 青岛讯达捷电子科技有限公司 | Whitening cosmetic containing arbutin, mulberry leaf extract and juicy peach powder |
| CN108403538A (en) * | 2017-09-14 | 2018-08-17 | 上海珍雪生物科技有限公司 | A kind of Chinese prescription beauty treatment composite extract and preparation method thereof |
| CN107595756A (en) * | 2017-11-01 | 2018-01-19 | 蒋冰冰 | A kind of whitening is dispelled black compound |
| CN108078861B (en) * | 2018-01-29 | 2020-11-10 | 广州天然国度生物科技有限公司 | Whitening essence composition and preparation method thereof |
| CN109464326A (en) * | 2018-11-26 | 2019-03-15 | 庄雪芸 | A kind of formula of cosmetic composition |
| CN112107522A (en) * | 2019-06-19 | 2020-12-22 | 东莞圣幸健康科技有限公司 | Whitening composition, whitening mask and preparation method thereof |
| CN110664698A (en) * | 2019-11-21 | 2020-01-10 | 樊瑞 | Composition with whitening effect and preparation method thereof |
| CN112807255A (en) * | 2020-03-23 | 2021-05-18 | 上海铮信生物科技有限公司 | Anti-wrinkle composition and application thereof in cosmetics |
| CN112022766A (en) * | 2020-09-15 | 2020-12-04 | 广州科盈化妆品有限公司 | Whitening and acne removing composition and preparation method and application thereof |
| CN112294718A (en) * | 2020-10-14 | 2021-02-02 | 广州悦瑞生物科技有限公司 | Brightening and skin-refreshing essence and preparation method and application thereof |
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| CN1915370A (en) * | 2005-08-19 | 2007-02-21 | 彭小航 | Massage cream of Chinese herbal medicine for removing spots and whitening skin |
| CN102000016A (en) * | 2010-11-23 | 2011-04-06 | 珈侬生化科技(中国)有限公司 | Dispersing powder compound extract, preparation method and application thereof |
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| JP2004189645A (en) * | 2002-12-10 | 2004-07-08 | Kanebo Ltd | Cosmetic |
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| CN1915370A (en) * | 2005-08-19 | 2007-02-21 | 彭小航 | Massage cream of Chinese herbal medicine for removing spots and whitening skin |
| CN102000016A (en) * | 2010-11-23 | 2011-04-06 | 珈侬生化科技(中国)有限公司 | Dispersing powder compound extract, preparation method and application thereof |
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Effective date of registration: 20160926 Address after: 510000 Guangdong Province, Huadu District of Guangzhou City Xinya Street Yingchun Road No. 3 Patentee after: GUANGZHOU PINHE BIOLOGICAL TECHNOLOGY CO., LTD. Address before: Jiahe Street crane in Baiyun District of Guangzhou City, Guangdong province 510000 village Songyuan fine self A1 Patentee before: GUANGZHOU Q-MAX COSMETICS CO., LTD. |