CN103908693A - Bionic alginate composite antimicrobial dressing and preparation method thereof - Google Patents
Bionic alginate composite antimicrobial dressing and preparation method thereof Download PDFInfo
- Publication number
- CN103908693A CN103908693A CN201410149677.1A CN201410149677A CN103908693A CN 103908693 A CN103908693 A CN 103908693A CN 201410149677 A CN201410149677 A CN 201410149677A CN 103908693 A CN103908693 A CN 103908693A
- Authority
- CN
- China
- Prior art keywords
- alginic acid
- bionic
- component
- dressing
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention belongs to the field of biomedical materials, and particularly relates to bionic alginate composite antimicrobial dressing and a preparation method thereof. The bionic alginate composite antimicrobial dressing is prepared from the following raw materials: alginate components, chitosan components and silver ion components. The method is characterized by comprising the following steps: adding deionized water to agitate a solvent after mixing the raw materials, so as to obtain mixed water gel; repeatedly thawing, freezing and drying the mixed water gel to obtain a product, wherein the product comprises the following raw materials by weight percent: 60-90% of alginate components, 9.8-39% of chitosan components and 0.2-1% of silver ion components. The process system disclosed by the invention is controllable in temperature and condition, the problems of residues such as a toxic cross-linking agent or an assistant and the like do not exist, the safety risk of clinical application is greatly reduced, and the bionic alginate composite antimicrobial dressing has good product transformation feasibility.
Description
(1) technical field
The invention belongs to biomedical materials field, particularly a kind of bionic-type alginic acid base composite antibiotic dressing and preparation method thereof.
(2) background technology
Along with the raising that people require for medical effect, infection control and healing acceleration more and more become the key factor that is related to all kinds of surgical clinical operation prognosis quality.Especially the damage of special environment as battlefield wound or large wound surface, depth wound first aid in, quick-acting haemostatic powder, effectively antiinflammatory and promote healing can be to save life to provide powerful guarantee.The market value of U.S.'s wound care in 2003 and disposable product has reached 47.6 hundred million U.S. dollars, mainly comprises the wound control products such as biological skin and dressing, the wet wound healing product of alginate, adhesive bandage, and the wound closed product such as sealer.Also there are the multiple Wound care products such as multiple collagen-based, chitosan-based, Sargassum acidic group, cellulose base and fibrin, platelet rich plasma in China, for dissimilar wound healing.
Along with the development of regeneration medicine technology, research and develop advanced Wound care products and always be clinical and hot issue basic research common concern.This field has many Related products, research or patent, but still has many problems constantly to improve, such as penetrating fluid absorption, mechanical performance, anti-microbial property and original position repairing performance etc.
Sargassum acidic group biomaterial early has historical records for wound care, just has people to treat wound with Sargassum at ancient rome era, and Sargassum was once once used for wound hemostasis by sailor.Since nineteen eighty-three, first case alginate casting product put goods on the market, Related product is in the clinical practice history of existing 30 years, and its safety and effectiveness are fully confirmed.Chitosan-based biomaterial had been proved performances such as having good hemostasis, anti, inhibiting bacteria and diminishing inflammation, analgesia, promoting healing already, was widely used in the fields such as organizational project, medicament slow release, health care of food.Silver ion also obtains clinical confirmation as its effectiveness of broad spectrum antimicrobicide and safety.So far, existing many alginic acid research report, product patent and product relevant with chitosan-based antiseptic dressing, becomes one of focus of achievements conversion in bio-medical material.
Current existing patent and product are to adopt the materials such as alginic acid/chitosan/active carbon by spraying or the mode such as immersion is prepared the antiseptic dressing of silver ion mostly, and technique is simple effective but long-acting releasing effect is not good.Patent CN102406957, CN1935268A, CN102505461A, CN10450222A etc. also disclose the method for preparing in several ways Sargassum acidic group antiseptic dressing, but all there is some difference with the method for patent of the present invention.
(3) summary of the invention
The present invention, in order to make up the deficiencies in the prior art, provides bionic-type alginic acid base composite antibiotic dressing that a kind of preparation technology is simple, feasibility is good and preparation method thereof.
The present invention is achieved through the following technical solutions:
The dressing of a kind of bionic-type alginic acid base composite antibiotic, taking alginic acid component, chitosan component and silver ion component as raw material, it is characterized in that: after raw material is mixed, add deionized water and stirring solvent, obtain mixing water gel, mixing water gel obtains product through multigelation, lyophilization; The percentage by weight of each raw material is, alginic acid component 60-90%, chitosan component 9.8-39%, silver ion component 0.2-1%.
The present invention's use Sargassum acidic group and chitosan-based material are as the slow-released carrier of silver ion, be cross-linked the bionic-type adjuvant that obtains again satisfactory mechanical property through lyophilization by secondary physical, and can discharge gradually silver ion along with swelling, the degraded of dressing matrix, reach the effect of long acting antibiotic.Sargassum acidic group biomaterial in dressing matrix material has good mechanical performance, fluid absorbent and gelling performance, chitosan material has good antibacterial activity, anthemorrhagic performance, easing pain and diminishing inflammation and promotes the effects such as healing, after the two and silver ion chelating, form good crosslinked stable three dimensional structure through multigelation, can realize the long-acting slow-release of silver ion, thereby reach the object of long acting antibiotic.In addition, because this kind of silver ion mode of loading is reliable and stable, therefore can alleviate due to prominent and release the toxicity causing, the breadth of the concentration of silver ions of loading with is higher than traditional approach.
More excellent technical scheme of the present invention is:
The weight proportion of described each raw material is, alginic acid component 75-90%, chitosan component 9.8-38.7%, silver ion component 0.5-1%.
Described alginic acid component is grouped into by two kinds of one-tenth: the salt that salt, alginic acid and the bivalent metal ion that alginic acid and valent metal ion form forms, and wherein, the former is one or more in sodium alginate, potassium alginate and ammonium alginate, the latter is calcium alginate; The mass ratio of the two is 10-3:1, preferably 5-8:1.
Alginic acid component is made up of the alginic acid Base Metal salt of two kinds of different prices, can form gradually the stable hydrogel network of metal ion crosslinked between the two, and cross-linking process is slow, controllability good, and the hydrogel network mechanical performance of formation significantly strengthens.
Described chitosan component is water solublity, is one or more in carboxymethyl chitin, carboxymethyl chitosan, Chitofilmer, hydroxypropyl chitosan, ethoxyl chitin and hydroxyethyl chitosan.Owing to having introduced chitosan component, there is good anthemorrhagic performance and have antibacterial, antiinflammatory, analgesia function concurrently and can promote wound healing, also can form chelate structure with silver ion, make in the three-dimensional net structure that is present in material that silver ion component is stable, long-acting, can disengage gradually the fungistatic effect that reaches long-acting, stable after being applied to wound surface.
Described silver ion component is one or more in nitrate, silver chloride, silver sulfate, nanometer silver and silver sulfadiazine.Silver ion compositional range is wider, as silver nitrate, is also applicable to water-insoluble silver ion donor as silver sulfadiazine etc. applicable to water-soluble silver ionic compound.
The preparation method of bionic-type alginic acid base composite antibiotic of the present invention dressing, is characterized in that: alginic acid component, chitosan component are mixed with silver ion component, add deionized water, stirring at room temperature 0.5-5h, obtains mixing water gel; Mixing water gel is placed in to freezing 12h at-20 DEG C, take out thaw after stirring and evenly mixing, then be placed in freezing 12h at-20 DEG C, so multigelation 1-5 time, lyophilization obtains product.
Preferred version is: described raw material adds after deionized water, stirring at room temperature 0.5-4h; Described mixing water gel multigelation number of times is 2-4 time.
For further improving hygrometric state mechanical performance and the fluid absorbent of dressing, the present invention adopts multigelation method to carry out secondary physical to dressing and is cross-linked.Be cross-linked for related twice and all do not introduce other chemical substances or inorganic ions, do not relate to the residual equivalent risk control problem of cross-linking agent, there is good safety and operability.In addition, technique of the present invention is simply controlled, has significantly reduced the difficulty of preparation process risk management, has good product and transforms feasibility.
Product of the present invention except as conventional dressing for clinical, mechanical strength, antibiotic property, haemostatic effect and healing quality are also strengthened, not only greatly improve the repairing effect of common wound, the wound more for chronic ulcer, diabetic foot, decubital ulcer and the hemorrhage amount of coming to a head also has good therapeutical effect, significantly improve patient's compliance, expanded clinical application range.
(4) detailed description of the invention
Adopt specific embodiment to be used for elaborating compound antiseptic dressing of the present invention and preparation process thereof below.
Embodiment 1:
The preparation process of a kind of bionic-type alginic acid of the present invention base composite antibiotic dressing is as follows:
Adopt alginic acid component to be formed by sodium alginate and calcium alginate; Chitosan component is carboxymethyl chitosan; Silver ion component is silver nitrate.Wherein, the molecular weight of sodium alginate, calcium alginate and carboxymethyl chitosan is respectively 80,000,30,000,200,000 dalton.
Take alginic acid component 9g(sodium alginate: the mass ratio of calcium alginate is 8:1), carboxymethyl chitosan 0.9g, silver nitrate 0.1g, after above-mentioned three kinds of powder are mixed, add deionized water 300ml, stirring at room temperature 3h fully mixes, and silver ion is fully sequestered on polysaccharide molecule chain; The mixing water gel of gained is placed in to-20 DEG C of multigelations 3 times; Last lyophilization obtains bionic-type alginic acid base composite antibiotic dressing sponge.
Embodiment 2:
The preparation process of a kind of bionic-type alginic acid of the present invention base composite antibiotic dressing is as follows:
Adopt alginic acid component to be formed by potassium alginate and calcium alginate; Chitosan component is carboxymethyl chitin; Silver ion component is nanometer silver.Wherein, the molecular weight of potassium alginate, calcium alginate and carboxymethyl chitin is respectively 100,000,20,000,150,000 dalton.
Take alginic acid component 8g(potassium alginate: the mass ratio of calcium alginate is 5:1), carboxymethyl chitin 1.5g, silver nitrate 0.5g, after above-mentioned three kinds of powder are mixed, add deionized water 300ml, stirring at room temperature 2h fully mixes, and silver ion is fully sequestered on polysaccharide molecule chain; The mixing water gel of gained is placed in to-20 DEG C of multigelations 2 times; Last lyophilization obtains bionic-type alginic acid base composite antibiotic dressing sponge.
Embodiment 3:
The preparation process of a kind of bionic-type alginic acid of the present invention base composite antibiotic dressing is as follows:
Adopt alginic acid component to be formed by sodium alginate and calcium alginate; Chitosan component is hydroxypropyl chitosan; Silver ion component is silver sulfadiazine.Wherein, the molecular weight of sodium alginate, calcium alginate and hydroxypropyl chitosan is respectively 80,000,30,000,100,000 dalton.
Take alginic acid component 7.5g(sodium alginate: the mass ratio of calcium alginate is 5:1), hydroxypropyl chitosan 1.5g, silver nitrate 1.0g, after above-mentioned three kinds of powder are mixed, add deionized water 300ml, stirring at room temperature 4h fully mixes, and silver ion is fully sequestered on polysaccharide molecule chain; The mixing water gel of gained is placed in to-20 DEG C of multigelations 4 times; Last lyophilization obtains bionic-type alginic acid base composite antibiotic dressing sponge.
Embodiment 4:
The preparation process of a kind of bionic-type alginic acid of the present invention base composite antibiotic dressing is as follows:
Adopt alginic acid component to be formed by sodium alginate and calcium alginate; Chitosan component is carboxymethyl chitosan; Silver ion component is the two components of silver sulfadiazine and silver nitrate.Wherein, the molecular weight of sodium alginate, calcium alginate and carboxymethyl chitosan is respectively 120,000,30,000,200,000 dalton.
Take alginic acid component 8.4g(sodium alginate: the mass ratio of calcium alginate is 6:1), carboxymethyl chitosan 0.9g, silver nitrate 0.2g, silver sulfadiazine 0.5g, after above-mentioned several powder are mixed, add deionized water 300ml, stirring at room temperature 3h fully mixes, and silver ion is fully sequestered on polysaccharide molecule chain; The mixing water gel of gained is placed in to-20 DEG C of multigelations 3 times; Last lyophilization obtains bionic-type alginic acid base composite antibiotic dressing sponge.
The above; it is only preferred embodiment of the present invention; not that the present invention is done to other forms of restriction; any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations; but do not depart from technical solution of the present invention content; any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. bionic-type alginic acid base composite antibiotic dressing, taking alginic acid component, chitosan component and silver ion component as raw material, it is characterized in that: after raw material is mixed, add deionized water and stirring solvent, obtain mixing water gel, mixing water gel obtains product through multigelation, lyophilization; The percentage by weight of each raw material is, alginic acid component 60-90%, chitosan component 9.8-39%, silver ion component 0.2-1%.
2. bionic-type alginic acid base composite antibiotic according to claim 1 dressing, is characterized in that: the weight proportion of described each raw material is, alginic acid component 75-90%, chitosan component 9.8-38.7%, silver ion component 0.5-1%.
3. bionic-type alginic acid base composite antibiotic according to claim 1 dressing, it is characterized in that: described alginic acid component is grouped into by two kinds of one-tenth: the salt that salt, alginic acid and the bivalent metal ion that alginic acid and valent metal ion form forms, wherein, the former is one or more in sodium alginate, potassium alginate and ammonium alginate, and the latter is calcium alginate; The mass ratio of the two is 10-3:1.
4. bionic-type alginic acid base composite antibiotic according to claim 1 dressing, it is characterized in that: described chitosan component is water solublity, is one or more in carboxymethyl chitin, carboxymethyl chitosan, Chitofilmer, hydroxypropyl chitosan, ethoxyl chitin and hydroxyethyl chitosan.
5. bionic-type alginic acid base composite antibiotic adjuvant according to claim 1, is characterized in that: described silver ion component is one or more in nitrate, silver chloride, silver sulfate, nanometer silver and silver sulfadiazine.
6. bionic-type alginic acid base composite antibiotic according to claim 3 dressing, is characterized in that: the mass ratio of described alginic acid monovalent salt and divalent salts is 5-8:1.
7. the preparation method of bionic-type alginic acid base composite antibiotic according to claim 1 dressing, is characterized in that: alginic acid component, chitosan component are mixed with silver ion component, add deionized water, stirring at room temperature 0.5-5h, obtains mixing water gel; Mixing water gel is placed in to freezing 12h at-20 DEG C, take out thaw after stirring and evenly mixing, then be placed in freezing 12h at-20 DEG C, so multigelation 1-5 time, lyophilization obtains product.
8. the preparation method of bionic-type alginic acid base composite antibiotic according to claim 7 dressing, is characterized in that: described raw material adds after deionized water, stirring at room temperature 0.5-4h.
9. the preparation method of bionic-type alginic acid base composite antibiotic according to claim 7 dressing, is characterized in that: described mixing water gel multigelation number of times is 2-4 time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410149677.1A CN103908693B (en) | 2014-04-15 | 2014-04-15 | A kind of bionic-type alginic acid base composite antibiotic dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410149677.1A CN103908693B (en) | 2014-04-15 | 2014-04-15 | A kind of bionic-type alginic acid base composite antibiotic dressing and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103908693A true CN103908693A (en) | 2014-07-09 |
| CN103908693B CN103908693B (en) | 2015-10-28 |
Family
ID=51034894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410149677.1A Active CN103908693B (en) | 2014-04-15 | 2014-04-15 | A kind of bionic-type alginic acid base composite antibiotic dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103908693B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474535A (en) * | 2014-12-10 | 2015-04-01 | 成都新际生物活性胶原开发有限公司 | Water-soluble gel for treating diabetic foot |
| CN105107008A (en) * | 2015-09-16 | 2015-12-02 | 中南民族大学 | Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster |
| CN105288698A (en) * | 2015-11-19 | 2016-02-03 | 广东泰宝医疗科技股份有限公司 | Calcium alginate composite medical surgical dressing and preparation method thereof |
| EP3011981A1 (en) * | 2014-10-24 | 2016-04-27 | Histocell, S.L. | A biomaterial scaffold for regenerating the oral mucosa |
| CN106380609A (en) * | 2016-09-19 | 2017-02-08 | 天津科技大学 | Antibacterial carboxymethyl chitosan hydrogel and preparation method thereof |
| CN107714299A (en) * | 2017-12-04 | 2018-02-23 | 广东泰宝医疗科技股份有限公司 | A kind of medical dressing is dispelled pain patch |
| CN108478874A (en) * | 2018-04-25 | 2018-09-04 | 信阳师范学院 | A kind of preparation method of the nano combined bone holder material of hydroxyethyl chitosan |
| CN109847097A (en) * | 2018-12-10 | 2019-06-07 | 安徽徽科生物工程技术有限公司 | Intrinsic bioremediation film, preparation method and application |
| TWI693929B (en) * | 2018-06-27 | 2020-05-21 | 南六企業股份有限公司 | Antibacterial wound dressing |
| CN112295008A (en) * | 2020-11-10 | 2021-02-02 | 北京深核智能科技有限公司 | Bioactive dressing with anti-inflammatory and hemostatic functions |
| CN112451738A (en) * | 2020-11-30 | 2021-03-09 | 西安交通大学 | Silver ion polysaccharide polymer antibacterial dressing and preparation method and application thereof |
| WO2021237094A1 (en) * | 2020-05-22 | 2021-11-25 | Mig Usa, Llc | Antimicrobial compositions and methods of use and for making same |
| CN114409973A (en) * | 2022-02-23 | 2022-04-29 | 北京工业大学 | Bio-based blending material and preparation method thereof |
| CN115591008A (en) * | 2021-12-31 | 2023-01-13 | 上海炫鑫医药科技有限公司（Cn） | Spray-type liquid wound-protecting dressing and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109942839B (en) * | 2019-03-25 | 2021-07-30 | 四川大学 | In-situ free radical polymerization gel with antibacterial and self-adhesive properties, and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2370226A (en) * | 2000-09-21 | 2002-06-26 | Acordis Speciality Fibres Ltd | Wound dressing |
| CN1583838A (en) * | 2004-06-02 | 2005-02-23 | 武汉大学 | Preparing method for macroporous konjaku gel |
| CN1810298A (en) * | 2006-01-17 | 2006-08-02 | 武汉理工大学 | Bacteriostatic porous polyelectrolyte material and its prepn process |
| CN101602814A (en) * | 2009-07-09 | 2009-12-16 | 上海交通大学 | Carboxymethyl curdlan gum physical hydrogel and preparation method thereof |
| KR20110114195A (en) * | 2010-04-13 | 2011-10-19 | (주)글로벌첼린지 | Hydrogel patch mixed inorganic materials for pets, and their process |
| CN103469365A (en) * | 2013-09-22 | 2013-12-25 | 山东颐诺生物科技有限公司 | Alginic acid-chitosan composite fiber for tranma repairing and preparation method thereof |
-
2014
- 2014-04-15 CN CN201410149677.1A patent/CN103908693B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2370226A (en) * | 2000-09-21 | 2002-06-26 | Acordis Speciality Fibres Ltd | Wound dressing |
| CN1583838A (en) * | 2004-06-02 | 2005-02-23 | 武汉大学 | Preparing method for macroporous konjaku gel |
| CN1810298A (en) * | 2006-01-17 | 2006-08-02 | 武汉理工大学 | Bacteriostatic porous polyelectrolyte material and its prepn process |
| CN101602814A (en) * | 2009-07-09 | 2009-12-16 | 上海交通大学 | Carboxymethyl curdlan gum physical hydrogel and preparation method thereof |
| KR20110114195A (en) * | 2010-04-13 | 2011-10-19 | (주)글로벌첼린지 | Hydrogel patch mixed inorganic materials for pets, and their process |
| CN103469365A (en) * | 2013-09-22 | 2013-12-25 | 山东颐诺生物科技有限公司 | Alginic acid-chitosan composite fiber for tranma repairing and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| ELBADAWY A. KAMOUN等: ""Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications：Characterization and bio-evaluation"", 《ARABIAN JOURNAL OF CHEMISTRY》 * |
| 王华明等: ""壳聚糖伤口敷料的研究进展"", 《华南热带农业大学学报》 * |
| 谢玮玮等: ""壳聚糖与聚乙烯醇磁性水凝胶的制备与性能研究"", 《塑料》 * |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11241516B2 (en) | 2014-10-24 | 2022-02-08 | Histocell, S.L. | Biomaterial scaffold for regenerating the oral mucosa |
| EP3011981A1 (en) * | 2014-10-24 | 2016-04-27 | Histocell, S.L. | A biomaterial scaffold for regenerating the oral mucosa |
| WO2016062862A1 (en) * | 2014-10-24 | 2016-04-28 | Histocell, S.L. | A biomaterial scaffold for regenerating the oral mucosa |
| CN107073170A (en) * | 2014-10-24 | 2017-08-18 | 赫斯特细胞有限公司 | Biomaterial scaffolds for regenerating oral mucosa |
| CN104474535A (en) * | 2014-12-10 | 2015-04-01 | 成都新际生物活性胶原开发有限公司 | Water-soluble gel for treating diabetic foot |
| CN105107008A (en) * | 2015-09-16 | 2015-12-02 | 中南民族大学 | Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster |
| CN105288698A (en) * | 2015-11-19 | 2016-02-03 | 广东泰宝医疗科技股份有限公司 | Calcium alginate composite medical surgical dressing and preparation method thereof |
| CN106380609A (en) * | 2016-09-19 | 2017-02-08 | 天津科技大学 | Antibacterial carboxymethyl chitosan hydrogel and preparation method thereof |
| CN107714299A (en) * | 2017-12-04 | 2018-02-23 | 广东泰宝医疗科技股份有限公司 | A kind of medical dressing is dispelled pain patch |
| CN108478874A (en) * | 2018-04-25 | 2018-09-04 | 信阳师范学院 | A kind of preparation method of the nano combined bone holder material of hydroxyethyl chitosan |
| TWI693929B (en) * | 2018-06-27 | 2020-05-21 | 南六企業股份有限公司 | Antibacterial wound dressing |
| CN109847097A (en) * | 2018-12-10 | 2019-06-07 | 安徽徽科生物工程技术有限公司 | Intrinsic bioremediation film, preparation method and application |
| WO2021237094A1 (en) * | 2020-05-22 | 2021-11-25 | Mig Usa, Llc | Antimicrobial compositions and methods of use and for making same |
| CN112295008A (en) * | 2020-11-10 | 2021-02-02 | 北京深核智能科技有限公司 | Bioactive dressing with anti-inflammatory and hemostatic functions |
| CN112295008B (en) * | 2020-11-10 | 2021-08-10 | 广州图微科创生物科技有限公司 | Bioactive dressing with anti-inflammatory and hemostatic functions |
| CN112451738A (en) * | 2020-11-30 | 2021-03-09 | 西安交通大学 | Silver ion polysaccharide polymer antibacterial dressing and preparation method and application thereof |
| CN115591008A (en) * | 2021-12-31 | 2023-01-13 | 上海炫鑫医药科技有限公司（Cn） | Spray-type liquid wound-protecting dressing and preparation method thereof |
| CN114409973A (en) * | 2022-02-23 | 2022-04-29 | 北京工业大学 | Bio-based blending material and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103908693B (en) | 2015-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103908693B (en) | A kind of bionic-type alginic acid base composite antibiotic dressing and preparation method thereof | |
| CN101502667B (en) | Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof | |
| KR101377569B1 (en) | Antimicrobial Wound Dressing and Preparing Method of the Same | |
| AU2015246140B2 (en) | Hemostatic Devices | |
| Daunton et al. | A history of materials and practices for wound management | |
| CN103536954B (en) | A kind of crosslinked alginic acid-bacteria cellulose sponges and preparation method thereof | |
| CN110694102A (en) | 3D printing hydrogel wound dressing with long-acting antibacterial effect | |
| Wiegand et al. | Polymer‐based biomaterials as dressings for chronic stagnating wounds | |
| CN103599558B (en) | A kind of quick hemostatic dressing and preparation method thereof | |
| CN100427149C (en) | Nano silver bionic dressing and its preparing method | |
| CN101954117A (en) | Hemostatic bacteriostatic biological dressing and preparation method thereof | |
| CN103469365A (en) | Alginic acid-chitosan composite fiber for tranma repairing and preparation method thereof | |
| CN103690989B (en) | A kind of medical chitosan bleeding-stopping dressing | |
| Cao et al. | Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair | |
| CN105597144A (en) | Absorbable collagen styptic powder and preparing method thereof | |
| CN103012836A (en) | Preparation method of polysaccharide sponge for material dressing | |
| CN101564549A (en) | Traditional Chinese medicine dressing for antibacterium and hematischesis and production method thereof | |
| CN102406957A (en) | Preparation method of nano silver-containing sodium alginate wound dressing | |
| CN108478846A (en) | A kind of medical hemostatic antiseptic dressing and preparation method thereof | |
| CN101244286A (en) | Hydrogel dressings and preparation thereof | |
| KR101366417B1 (en) | Covering material for antimicrobial moist wound and Method of manufacturing the same | |
| CN209392452U (en) | A kind of micro-nano magnesium hydride antibacterial anti-inflammatory wound dressing | |
| CN109395154A (en) | A kind of high porosity carries the preparation method of medicine wound dressing | |
| CN112546286A (en) | Antibacterial hemostatic dressing | |
| CN105688271A (en) | Propolis dressing for healing wounds and preparation method of propolis dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |