CN103906760B - 用作抗原掩蔽剂的人乳铁蛋白衍生肽 - Google Patents
用作抗原掩蔽剂的人乳铁蛋白衍生肽 Download PDFInfo
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- CN103906760B CN103906760B CN201080070362.8A CN201080070362A CN103906760B CN 103906760 B CN103906760 B CN 103906760B CN 201080070362 A CN201080070362 A CN 201080070362A CN 103906760 B CN103906760 B CN 103906760B
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- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Marine Sciences & Fisheries (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
天 | A | B | A+B | 对照 |
0 | 0.5ml | 0.5ml | 0.5ml | 无剂量 |
7 | 0.5ml | 0.5ml | 0.5ml | 无剂量 |
14 | 0.5ml | 0.5ml | 0.5ml | 无剂量 |
21 | 0.5ml | 0.5ml | 0.5ml | 无剂量 |
天 | 备注 |
0 | 施用前的剂量 |
6 | |
13 | |
20 | |
27 | 处死 |
Claims (9)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2010/068302 WO2012069089A1 (en) | 2010-11-26 | 2010-11-26 | Human lactoferrin derived peptide for use as an antigen masking agent |
Publications (2)
Publication Number | Publication Date |
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CN103906760A CN103906760A (zh) | 2014-07-02 |
CN103906760B true CN103906760B (zh) | 2017-02-22 |
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CN201080070362.8A Active CN103906760B (zh) | 2010-11-26 | 2010-11-26 | 用作抗原掩蔽剂的人乳铁蛋白衍生肽 |
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US (1) | US9724422B2 (zh) |
EP (1) | EP2643344B1 (zh) |
JP (1) | JP6073239B2 (zh) |
KR (1) | KR101765364B1 (zh) |
CN (1) | CN103906760B (zh) |
AU (1) | AU2010364538B2 (zh) |
BR (1) | BR112013012811B8 (zh) |
CA (1) | CA2818951C (zh) |
ES (1) | ES2627960T3 (zh) |
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HU (1) | HUE033501T2 (zh) |
IL (1) | IL226198B (zh) |
MX (1) | MX348337B (zh) |
PL (1) | PL2643344T3 (zh) |
RU (1) | RU2573422C2 (zh) |
SI (1) | SI2643344T1 (zh) |
WO (1) | WO2012069089A1 (zh) |
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CA2950339C (en) | 2014-05-28 | 2022-03-29 | Evonik Rohm Gmbh | Coated calcium phosphate nanoparticles comprising a cationic polymer layer |
CN108697798A (zh) * | 2016-02-16 | 2018-10-23 | 达纳-法伯癌症研究所有限公司 | 免疫疗法组合物及方法 |
DE102016008601B4 (de) | 2016-07-14 | 2019-05-23 | Giesecke+Devrient Currency Technology Gmbh | Sicherheitselement mit reversibel veränderbarem Farbbereich |
WO2018160791A1 (en) | 2017-03-03 | 2018-09-07 | Massachusetts Institute Of Technology | Antimicrobial constructs and uses thereof |
CN107226860B (zh) * | 2017-07-06 | 2020-04-10 | 浙江辉肽生命健康科技有限公司 | 一种生物活性多肽skhssldcvl及其制备方法和应用 |
WO2019214939A1 (en) | 2018-05-08 | 2019-11-14 | Evonik Röhm Gmbh | Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide |
Citations (1)
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CN101395180A (zh) * | 2005-12-30 | 2009-03-25 | 赢创罗姆有限责任公司 | 用作细胞穿膜肽的肽 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
US5977337A (en) | 1997-06-03 | 1999-11-02 | Connaught Laboratories Limited | Lactoferrin receptor genes of Moraxella |
US6423509B1 (en) | 1998-07-15 | 2002-07-23 | Samyang Genex Corporation | Pichia pastoris strain for producing lactoferrin and methods of use |
JP2000045182A (ja) | 1998-07-23 | 2000-02-15 | Peptide Science:Kk | 抗菌性繊維および繊維・皮革用抗菌加工剤 |
US20070259007A1 (en) * | 1999-10-19 | 2007-11-08 | Kruzel Marian L | Lactoferrin: an adjuvant for vaccines |
RU2165769C1 (ru) | 2000-07-13 | 2001-04-27 | Якубовская Раиса Ивановна | Антибактериальный, антиоксидантный, иммуномодулирующий и антиканцерогенный препарат и способ его применения |
AU2003284187B2 (en) | 2002-10-25 | 2009-10-01 | Techlab, Inc. | Inflammatory bowel disease and irritable bowel syndrome IBD-first chek diagnostic panel |
WO2004052305A2 (en) | 2002-12-10 | 2004-06-24 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
DE102005051366A1 (de) | 2005-10-25 | 2007-04-26 | Degussa Gmbh | Drug Delivery Systeme |
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2010
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- 2010-11-26 WO PCT/EP2010/068302 patent/WO2012069089A1/en active Application Filing
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- 2010-11-26 HU HUE10784307A patent/HUE033501T2/en unknown
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- 2010-11-26 AU AU2010364538A patent/AU2010364538B2/en active Active
- 2010-11-26 US US13/988,829 patent/US9724422B2/en active Active
- 2010-11-26 CN CN201080070362.8A patent/CN103906760B/zh active Active
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2013
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2014
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Patent Citations (1)
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CN101395180A (zh) * | 2005-12-30 | 2009-03-25 | 赢创罗姆有限责任公司 | 用作细胞穿膜肽的肽 |
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MX2013005820A (es) | 2013-07-12 |
JP2014501723A (ja) | 2014-01-23 |
MX348337B (es) | 2017-06-07 |
AU2010364538A1 (en) | 2013-07-11 |
EP2643344A1 (en) | 2013-10-02 |
WO2012069089A1 (en) | 2012-05-31 |
BR112013012811A2 (pt) | 2016-09-13 |
KR20130119955A (ko) | 2013-11-01 |
BR112013012811B1 (pt) | 2021-07-06 |
JP6073239B2 (ja) | 2017-02-01 |
AU2010364538B2 (en) | 2016-04-14 |
CN103906760A (zh) | 2014-07-02 |
US20130302342A1 (en) | 2013-11-14 |
CA2818951A1 (en) | 2012-05-31 |
IL226198A0 (en) | 2013-07-31 |
HUE033501T2 (en) | 2017-12-28 |
BR112013012811B8 (pt) | 2022-07-05 |
CA2818951C (en) | 2018-03-13 |
PL2643344T3 (pl) | 2017-09-29 |
RU2013128884A (ru) | 2015-01-10 |
SI2643344T1 (sl) | 2017-07-31 |
KR101765364B1 (ko) | 2017-08-08 |
IL226198B (en) | 2019-01-31 |
EP2643344B1 (en) | 2017-03-22 |
RU2573422C2 (ru) | 2016-01-20 |
HK1196379A1 (zh) | 2014-12-12 |
ES2627960T3 (es) | 2017-08-01 |
US9724422B2 (en) | 2017-08-08 |
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