CN103896878B - A kind of Purification decolorization method of cinepazide - Google Patents
A kind of Purification decolorization method of cinepazide Download PDFInfo
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- CN103896878B CN103896878B CN201210570975.9A CN201210570975A CN103896878B CN 103896878 B CN103896878 B CN 103896878B CN 201210570975 A CN201210570975 A CN 201210570975A CN 103896878 B CN103896878 B CN 103896878B
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- Prior art keywords
- cinepazide
- dichloromethane
- salt
- aqueous solution
- product
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- A kind of 1. Purification decolorization method of cinepazide, it is characterised in that:Comprise the following steps,(1)Obtained cinepazide slightly produces The dichloromethane solution of product;(2)Washing, then the salt cinepazide maleate aqueous solution is obtained by extraction with watery hydrochloric acid;(3)Regulating step(2) In the obtained pH value of the salt cinepazide maleate aqueous solution to 7~8;(4)System temperature is reduced to less than 0 DEG C, half of stirring insulation Hour;(5)By step(4)In obtain mixture filtering, collect filter cake, obtain salt cinepazide maleate;(6)By step(5)In To cinepazide be dissolved in dichloromethane, wash dichloromethane phase, dry after, remove dichloromethane produce cinepazide decolouring Purifying product;The step(2)The middle molar concentration for adding watery hydrochloric acid is 3~5mol/L;The step(3)It is middle to use 3~6% hydrogen Aqueous solution of sodium oxide adjusts the pH value of the cinepazide aqueous solution.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210570975.9A CN103896878B (en) | 2012-12-26 | 2012-12-26 | A kind of Purification decolorization method of cinepazide |
Applications Claiming Priority (1)
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CN201210570975.9A CN103896878B (en) | 2012-12-26 | 2012-12-26 | A kind of Purification decolorization method of cinepazide |
Publications (2)
Publication Number | Publication Date |
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CN103896878A CN103896878A (en) | 2014-07-02 |
CN103896878B true CN103896878B (en) | 2018-02-09 |
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CN201210570975.9A Active CN103896878B (en) | 2012-12-26 | 2012-12-26 | A kind of Purification decolorization method of cinepazide |
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CN (1) | CN103896878B (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3634411A (en) * | 1968-04-03 | 1972-01-11 | Delalande Sa | Derivatives of 1-(3 4 5-trimethoxy cinnamoyl)-piperazine and process for their preparation |
CN101717382A (en) * | 2008-10-10 | 2010-06-02 | 齐鲁制药有限公司 | Method for synthesizing cinepazide |
CN101768140A (en) * | 2010-01-13 | 2010-07-07 | 安徽金太阳生化药业有限公司 | Preparation method of cinepazide maleate |
CN101774983A (en) * | 2010-01-21 | 2010-07-14 | 海南美兰史克制药有限公司 | Cinepazide maleate compound with novel route |
CN102229583A (en) * | 2011-05-13 | 2011-11-02 | 江苏神龙药业有限公司 | Method for synthesizing cinepazide |
-
2012
- 2012-12-26 CN CN201210570975.9A patent/CN103896878B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3634411A (en) * | 1968-04-03 | 1972-01-11 | Delalande Sa | Derivatives of 1-(3 4 5-trimethoxy cinnamoyl)-piperazine and process for their preparation |
CN101717382A (en) * | 2008-10-10 | 2010-06-02 | 齐鲁制药有限公司 | Method for synthesizing cinepazide |
CN101768140A (en) * | 2010-01-13 | 2010-07-07 | 安徽金太阳生化药业有限公司 | Preparation method of cinepazide maleate |
CN101774983A (en) * | 2010-01-21 | 2010-07-14 | 海南美兰史克制药有限公司 | Cinepazide maleate compound with novel route |
CN102229583A (en) * | 2011-05-13 | 2011-11-02 | 江苏神龙药业有限公司 | Method for synthesizing cinepazide |
Non-Patent Citations (1)
Title |
---|
一种简化的马来酸桂哌齐特的合成方法;金晓峰 等;《黑龙江大学工程学报》;20110228;第2卷(第1期);第58页 1.2.1 * |
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Publication number | Publication date |
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CN103896878A (en) | 2014-07-02 |
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GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: 221004 No. 6, Yang Shan Road, Jinshan Development Zone, Jiangsu, Xuzhou Co-patentee after: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Patentee after: JIANGSU WANBANG BIOPHARMACEUTICAL GROUP CO.,LTD. Address before: 221004 No. 6, Yang Shan Road, Jinshan Development Zone, Jiangsu, Xuzhou Co-patentee before: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Patentee before: Jiangsu Wan Bang Biochemical Medicine Co.,Ltd. Address after: 221004 No. 6, Yang Shan Road, Jinshan Development Zone, Jiangsu, Xuzhou Co-patentee after: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Patentee after: Jiangsu Wan Bang Biochemical Medicine Co.,Ltd. Address before: 221004 No. 6, Yang Shan Road, Jinshan Development Zone, Jiangsu, Xuzhou Co-patentee before: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Patentee before: JIANGSU WANBANG BIOPHARMACEUTICALS Co.,Ltd. |
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CP01 | Change in the name or title of a patent holder | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180126 Address after: 221004 No. 6, Yang Shan Road, Jinshan Development Zone, Jiangsu, Xuzhou Patentee after: JIANGSU WANBANG BIOPHARMACEUTICAL GROUP CO.,LTD. Address before: 221004 No. 6, Yang Shan Road, Jinshan Development Zone, Jiangsu, Xuzhou Co-patentee before: SHANGHAI FOSUN PHARMACEUTICAL(GROUP)CO., Ltd. Patentee before: JIANGSU WANBANG BIOPHARMACEUTICAL GROUP CO.,LTD. |
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TR01 | Transfer of patent right |