CN103877620A - Oral cavity basement membrane and preparation method thereof - Google Patents
Oral cavity basement membrane and preparation method thereof Download PDFInfo
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- CN103877620A CN103877620A CN201410103682.9A CN201410103682A CN103877620A CN 103877620 A CN103877620 A CN 103877620A CN 201410103682 A CN201410103682 A CN 201410103682A CN 103877620 A CN103877620 A CN 103877620A
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- orabase
- film
- oral cavity
- poly
- basement membrane
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Abstract
The invention provides an oral cavity basement membrane and a preparation method thereof, belonging to the field of medical biodegradable filling material preparation methods. A matrix of the oral cavity basement membrane is formed by mixing 75-89.5% of polylactic acid polymer (PDLLA), 10.5-13% of acetyl tributyl citrate (ATBC) and 0-12% of poly-L-lactic acid (PLLA). The oral cavity basement membrane has a three-layer structure and comprises a top layer (1), a middle layer (2) and a bottom layer (3), wherein through holes (4) are formed in each layer. The defects that existing periodontal disease treatment technology lacks biodegradable matrix materials so that success in bone grafting treatment can not be ensured are overcome by adopting the oral cavity basement membrane and the preparation method. The oral cavity basement membrane provided for people has good tissue adhesion, can promote cell reproduction and can be completely biodegraded in a certain time.
Description
technical field:
The preparation method field that the invention belongs to medical biodegradable packing material, is specifically related to a kind of orabase film and preparation method thereof.
background technology:
Mankind's alveolar bone is the most active osseous tissue of human body, and in life in absorption trend, once absorb, technology there is no its reverse hypertrophy of decree at present.Tooth is rooted in alveolar bone, and it is the main cause that senile mistake tooth and masticatory function are lost that alveolar bone absorbs naturally.In addition, alveolar bone that periodontal disease causes destroys, and because not impelling at present the technical method of alveolar bone hypertrophy, except controlling periodontal disease inflammation, only has an alveolar bone destroyed and tooth is all come off.
Although multiple bone-grafting material and bone grafting method are applied in other positions of body and obtain successfully, but in periodontal disease therapeutic, bone grafting treatment is always unsuccessful, reason mainly contains 3 points: 1. bone grafting isolated material tissue apposition is poor, can not prevent epithelium and the connective tissue osseous tissue of growing into, thereby skeletonization is bad, treat unsuccessfully; 2. because whole body administration can not directly arrive bone graft area, chronic inflammatory disease that can not permanently effective control periodontal, causes treating unsuccessfully; 3. the artificial material of implanting can not controlled (time, amount and the mode of absorption) degraded and absorbed, finally can not form the alveolar bone take the new bone from bulk-growth as main body, causes bone grafting to be treated unsuccessfully.
Up to now do not have biodegradable orabase film to come out.
summary of the invention:
The object of the invention is to overcome in existing periodontal disease therapeutic technology, lack biodegradable host material, can not guarantee that bone grafting treats the defect succeeding, for people provide a kind of tissue apposition good, can promote cell proliferation, and orabase film that within a certain period of time can complete biodegradable and preparation method thereof.
Orabase film of the present invention is characterized in that the base material of orabase film is mixed by polylactic acid polymer (PDLLA), tributyl 2-acetylcitrate (ATBC) and Poly-L-lactic acid (PLLA), wherein polylactic acid polymer is 75 ~ 89.5%, tributyl 2-acetylcitrate is 10.5 ~ 13%, and Poly-L-lactic acid is 0 ~ 12%.
In such scheme, described polylactic acid polymer molecular weight is 200,000, and Poly-L-lactic acid molecular weight is 5 ~ 80,000.
In such scheme, described orabase film is three-decker, i.e. upper strata (1), middle level (2) and bottom (3), and every layer is all provided with through hole (4).
In such scheme, through hole (4) length of described upper strata (1) and bottom (3) is 100～600 μ m, wide is 100 μ m～400 μ m, distance between Kong Yukong is 100 μ m～300 μ m, wherein even column and odd column align respectively, and line space is 100 μ m～200 μ m, and the through hole (4) of middle level (2) is circular hole, the diameter of circular hole is 50 μ m～150 μ m, and the distance between Kong Yukong is 50 μ m～200 μ m.
In such scheme, the preparation method of described orabase film is as follows: in proportion polylactic acid polymer, tributyl 2-acetylcitrate are put into together with Poly-L-lactic acid to torque rheometer rubber plastic mixing arrangement, reinforced without successively requirement, at 100 ~ 150 ℃ of blend 5 ~ 20min, blend composition is hot-forming in pressure forming machine, hot pressing condition is that pressure is at 0.25 ~ 10Mpa, temperature is 100 ~ 150 ℃, time is 5min, hot pressing or laser boring become sheet material with holes, finally three-layer tablet material is colded pressing or bonding forming again, obtain orabase film.
The present invention is the technical scheme of inventor's science practicality of starting out by long-term practice, and the orabase membrane tissue tack providing is good, can promote cell proliferation, and within a certain period of time can complete biodegradable.This film has good elasticity and certain hardness, conveniently fill between alveolar bone and the gap of tooth, fixing teeth on the one hand, give on the other hand near Growth of Cells space along with the biodegradation of this packing material, thereby form new cementum on the former root face being exposed in periodontal pocket, and have periodontal membrane fiber to imbed, and form paradenlal tissue regeneration, form new tack healing.Through hole on orabase film can pass through nutrient substance, provides growing space to Growth of Cells, for tissue repair provides physical plane.
Orabase film of the present invention is without toxic side effect, and safety meets GB/T16886 series standard.
Orabase membrane preparation method of the present invention is simple for process, and equipment cost is cheap, can fully guarantee product quality.
In sum, the present invention has overcome in existing periodontal disease therapeutic technology, lack biodegradable host material, can not guarantee that bone grafting treats the defect succeeding, the orabase film providing for people and preparation method thereof tissue apposition is good, can promote cell proliferation, and within a certain period of time can complete biodegradable.
Accompanying drawing explanation
Fig. 1 is schematic diagram of the present invention.
In accompanying drawing, the implication of each numeral is: 1: upper strata; 2: middle level; 3: bottom; 4: through hole.
The specific embodiment
The invention is further illustrated by the following examples, and the present invention is not limited only to described embodiment.
Embodiment mono-
The base material of this routine orabase film is mixed by polylactic acid polymer (PDLLA), tributyl 2-acetylcitrate (ATBC) and Poly-L-lactic acid (PLLA), wherein polylactic acid polymer is 77%, tributyl 2-acetylcitrate is 13%, and Poly-L-lactic acid is 10%.
Polylactic acid polymer molecular weight is 200,000, and Poly-L-lactic acid molecular weight is 5 ~ 80,000.PDLLA molecular weight is conducive to machine-shaping in 200,000 left and right, adds the physical strength that act as reinforcing membrane of PLLA, and PLLA degradation time is slower than PDLLA, so its molecular weight is lower, contributes to degraded.The intrinsic viscosity >1.0dl/g of final orabase film base material.
Orabase film is three-decker, i.e. upper strata 1, middle level 2 and bottom 3, and every layer is all provided with through hole 4.
Through hole 4 length of upper strata 1 and bottom 3 are 100～600 μ m, wide is 100 μ m～400 μ m, distance between Kong Yukong is 100 μ m～300 μ m, wherein even column and odd column align respectively, line space is 100 μ m～200 μ m, the through hole 4 in middle level 2 is circular hole, and the diameter of circular hole is 50 μ m～150 μ m, and the distance between Kong Yukong is 50 μ m～200 μ m.
The preparation method of orabase film is as follows: in proportion polylactic acid polymer, tributyl 2-acetylcitrate are put into together with Poly-L-lactic acid to torque rheometer rubber plastic mixing arrangement, reinforced without successively requirement, at 100 ~ 150 ℃ of blend 5 ~ 20min, blend composition is hot-forming in pressure forming machine, hot pressing condition is that pressure is at 0.25 ~ 10Mpa, temperature is 100 ~ 150 ℃, time is 5min, hot pressing or laser boring become sheet material with holes, finally three-layer tablet material is colded pressing or bonding forming again, obtain the orabase film that the compound rear thickness of trilamellar membrane is 0.5mm ~ 0.7mm.
Embodiment bis-
It is polylactic acid polymer 89.5% that this routine orabase film removes base material component ratio, tributyl 2-acetylcitrate 10.5%, and outside Poly-L-lactic acid 0, all the other are with embodiment mono-.
Embodiment tri-
It is polylactic acid polymer 75% that this routine orabase film removes base material component ratio, tributyl 2-acetylcitrate 13%, and outside Poly-L-lactic acid 12%, all the other are with embodiment mono-.
Embodiment tetra-
It is polylactic acid polymer 87% that this routine orabase film removes base material component ratio, tributyl 2-acetylcitrate 13%, and outside Poly-L-lactic acid 0, all the other are with embodiment mono-.
Embodiment five
It is polylactic acid polymer 78% that this routine orabase film removes base material component ratio, tributyl 2-acetylcitrate 12%, and outside Poly-L-lactic acid 10%, all the other are with embodiment mono-.
Embodiment six
It is polylactic acid polymer 80% that this routine orabase film removes base material component ratio, tributyl 2-acetylcitrate 12%, and outside Poly-L-lactic acid 8%, all the other are with embodiment mono-.
Claims (5)
1. an orabase film, the base material that it is characterized in that orabase film is mixed by polylactic acid polymer, tributyl 2-acetylcitrate and Poly-L-lactic acid, wherein polylactic acid polymer is 75 ~ 89.5%, and tributyl 2-acetylcitrate is 10.5 ~ 13%, and Poly-L-lactic acid is 0 ~ 12%.
2. orabase film according to claim 1, is characterized in that described polylactic acid polymer molecular weight is 200,000, and Poly-L-lactic acid molecular weight is 5 ~ 80,000.
3. orabase film according to claim 1, is characterized in that described orabase film is three-decker, i.e. upper strata (1), middle level (2) and bottom (3), and every layer is all provided with through hole (4).
4. orabase film according to claim 3, through hole (4) length that it is characterized in that described upper strata (1) and bottom (3) is 100～600 μ m, wide is 100 μ m～400 μ m, distance between Kong Yukong is 100 μ m～300 μ m, wherein even column and odd column align respectively, and line space is 100 μ m～200 μ m, and the through hole (4) of middle level (2) is circular hole, the diameter of circular hole is 50 μ m～150 μ m, and the distance between Kong Yukong is 50 μ m～200 μ m.
5. orabase film according to claim 1, the preparation method that it is characterized in that described orabase film is as follows: in proportion by polylactic acid polymer, tributyl 2-acetylcitrate is put into torque rheometer rubber plastic mixing arrangement together with Poly-L-lactic acid, reinforced without successively requirement, at 100 ~ 150 ℃ of blend 5 ~ 20min, blend composition is hot-forming in pressure forming machine, hot pressing condition is that pressure is at 0.25 ~ 10Mpa, temperature is 100 ~ 150 ℃, time is 5min, hot pressing or laser boring become sheet material with holes, finally three-layer tablet material is colded pressing or bonding forming again, obtain orabase film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410103682.9A CN103877620B (en) | 2014-03-20 | 2014-03-20 | Orabase film and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410103682.9A CN103877620B (en) | 2014-03-20 | 2014-03-20 | Orabase film and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103877620A true CN103877620A (en) | 2014-06-25 |
| CN103877620B CN103877620B (en) | 2016-09-14 |
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| CN201410103682.9A Active CN103877620B (en) | 2014-03-20 | 2014-03-20 | Orabase film and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237388A (en) * | 2016-08-11 | 2016-12-21 | 武汉大学 | A kind of bionic laminar support for periodontal tissue defect reparation and preparation method thereof |
| CN110314248A (en) * | 2019-07-24 | 2019-10-11 | 上海典范医疗科技有限公司 | A kind of oral cavity self-bone grafting regeneration membrane and preparation method thereof |
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| WO1992007555A1 (en) * | 1990-10-30 | 1992-05-14 | Alza Corporation | Drug delivery system and method |
| WO1992015340A1 (en) * | 1991-03-04 | 1992-09-17 | Guidor Ab | Bioresorbable material and an article of manufacture made of such material for medical use |
| CN1332016A (en) * | 2000-06-28 | 2002-01-23 | A·J·舒克拉 | Biodegradable carrier and biodegradable transfer system |
| CN101141987A (en) * | 2005-02-23 | 2008-03-12 | Hi-Lex株式会社 | Medical material, artificial tooth root and method of producing material for clinical use |
| CN103349797A (en) * | 2013-07-22 | 2013-10-16 | 广西医科大学 | Absorbable polylactic acid film for enhancing airtightness of absorbable root canal post of deciduous tooth |
-
2014
- 2014-03-20 CN CN201410103682.9A patent/CN103877620B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992007555A1 (en) * | 1990-10-30 | 1992-05-14 | Alza Corporation | Drug delivery system and method |
| WO1992015340A1 (en) * | 1991-03-04 | 1992-09-17 | Guidor Ab | Bioresorbable material and an article of manufacture made of such material for medical use |
| CN1332016A (en) * | 2000-06-28 | 2002-01-23 | A·J·舒克拉 | Biodegradable carrier and biodegradable transfer system |
| CN101141987A (en) * | 2005-02-23 | 2008-03-12 | Hi-Lex株式会社 | Medical material, artificial tooth root and method of producing material for clinical use |
| CN103349797A (en) * | 2013-07-22 | 2013-10-16 | 广西医科大学 | Absorbable polylactic acid film for enhancing airtightness of absorbable root canal post of deciduous tooth |
Non-Patent Citations (2)
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| （日）西久保忠臣: "《高分子化学》", 31 January 2013, 北京：北京大学出版社 * |
| 刘明华: "《生物质的开发与利用 》", 31 October 2012, 北京：化学工业出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237388A (en) * | 2016-08-11 | 2016-12-21 | 武汉大学 | A kind of bionic laminar support for periodontal tissue defect reparation and preparation method thereof |
| CN106237388B (en) * | 2016-08-11 | 2019-05-10 | 武汉大学 | A kind of bionic laminar bracket and preparation method thereof for periodontal tissue defect reparation |
| CN110314248A (en) * | 2019-07-24 | 2019-10-11 | 上海典范医疗科技有限公司 | A kind of oral cavity self-bone grafting regeneration membrane and preparation method thereof |
| CN110314248B (en) * | 2019-07-24 | 2021-11-02 | 上海典范医疗科技有限公司 | Oral bone induction regeneration membrane and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103877620B (en) | 2016-09-14 |
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Effective date of registration: 20161207 Address after: 510663 Guangzhou hi tech Industrial Development Zone, Guangdong Province, No. 17 Xiang Shan Road, B6-1 Patentee after: GUANGZHOU HONG JIAN BIO-MEDICAL PRODUCTS AND TECHNOLOGY CO., LTD. Address before: 610000 Chengdu City, Wuhou District province people's Road South, No. three, No. 13, building 3, unit 9, No. 24 Patentee before: Zhu Xiaoming |