CN103875657A - Uvioresistant farm-oriented water dispersible granule containing natamycin and preparation method of water dispersible granule - Google Patents
Uvioresistant farm-oriented water dispersible granule containing natamycin and preparation method of water dispersible granule Download PDFInfo
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- CN103875657A CN103875657A CN201410131731.XA CN201410131731A CN103875657A CN 103875657 A CN103875657 A CN 103875657A CN 201410131731 A CN201410131731 A CN 201410131731A CN 103875657 A CN103875657 A CN 103875657A
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Abstract
The invention belongs to the field of farm-oriented antibacterial agents, and specifically discloses an uvioresistant farm-oriented water dispersible granule containing natamycin and a preparation method of the water dispersible granule. The water dispersible granule comprises the following components in percentage by weight: 10%-30% of a natamycin slow release agent, 1%-10% of a dispersing agent, 20%-45% of a wetting agent, 0.5%-5% of a binding agent, 1%-20% of a disintegrating agent and 20%-40% of blue-green algae powder. The uvioresistant farm-oriented water dispersible granule containing the natamycin, which is provided by the invention, has the characteristics that the uvioresistant farm-oriented water dispersible granule is green and environment-friendly, efficient and stable, long in lasting period, safe to use. resistant to ultraviolet rays and the like; the uvioresistant farm-oriented water dispersible granule containing natamycin is used for fields such as field planting, long-distance transportation, storage preservation and the like of agricultural products.
Description
Technical field
The present invention relates to a kind of agricultural antibacterial agent, particularly a kind of have protective effect to agricultural cultivation, transport and preservation, and the uvioresistant agricultural water dispersible granule containing natamycin of good light stability and preparation method thereof.
Background technology
Water dispersible granules is a kind of pesticides new formulation of the eighties in last century exploitation, and because its safety is good, containing organic solvent, without dust, packaging, transport, the advantage such as easy to use are developed rapidly.As an important development direction of novel agrochemical environmental protection formulation, water dispersible granules has become the leading formulation of agricultural chemicals of recent domestic.
Natamycin (Natamycin) is a kind of natural antifungal compound being produced by streptomycete fermentation, belong to polyene macrolides, rely on the sterol compound effect on its lactonic ring structure and fungal cell membrane, form antibiotic-sterol compound, thereby destroy the structure of the cytoplasma membrane of fungi.The hydrophilic segment (many alcohol moieties) of macrocyclic lactone forms water hole on film, damaging cells membrane permeability, and then cause amino acid in bacterium, the materials such as electrolyte ooze out, thalline death.In the time there is not sterol compound on certain micro-organisms cell membrane, natamycin just to it without effect, therefore natamycin both can extensively effectively suppress various moulds, saccharomycetic growth, generation that again can Antifungi toxin, natamycin belongs to biological species antimicrobial product simultaneously, there is good biological safety, be can be used as food preservative by Food Additives Used in China standard chemical technical committee official approval natamycin, be widely used at present the fresh-keeping and antifungal therapy of food antiseptic.
Fungal disease is a class maximum in plant disease, accounts for 70～80% of plant disease, and much harm is heavy, widespread plant disease is all fungus-caused.Within 1970, american corn leaf blight is popular, makes 16,500,000,000 kilograms of the corn underproduction; Within 1980, helminthosporium maydis is popular, makes 1,700,000,000 kilograms of the corn underproduction; Within 1974, Rice In Asian Cultivated Rice seasonal febrile diseases are popular, make 6,000,000,000 kilograms of rice yield losses.In addition, wheat rust, corn smut, potato late blight, cotton spoting verticillium wilt etc. are all also fungal diseases.Natamycin does not obtain propagation and employment widely as the antifungal substance of efficient green in agricultural production, wherein one of important reason is that it has ring-type chemical constitution, comparatively responsive to ultraviolet ray, in the use procedure of field, easily decompose inactivation, the drug effect duration is not long, thus limited it as green high-efficient antibacterial agent the propagation and employment at agriculture field.
Summary of the invention
In order to overcome above-mentioned the deficiencies in the prior art, the invention provides a kind of uvioresistant agricultural water dispersible granule containing natamycin and the method for preparation thereof.Can solve natamycin in agriculture field application process, meet light and easily decompose, the shortcoming that biologically active reduces, extends life cycle.And be processed into water dispersible granules, not with an organic solvent, active constituent content is up to 10～50%, disperse, suspension stability is good, and has slow releasing function, the lasting period can reach 25～30 days, suspensibility can reach more than 90%, and the grain fineness after dispersion reaches 1～20 micron, and drug effect and commodity performance are good.
The present invention is achieved by the following technical solutions:
Containing a uvioresistant agricultural water dispersible granule for natamycin, its component by following percentage by weight forms: natamycin sustained release agent 10～30%, dispersant 1～10%, wetting agent 20～45%, binding agent 0.5～5%, disintegrant 1～20%, blue algae powder 20～40%.
Water dispersible granules is generally made up of active component, wetting agent, dispersant, disintegrant, stabilizing agent, binding agent and carrier etc., and particle diameter 200～5000um enters disintegration rapidly, dispersion after water, forms higher suspension dispersion.In water dispersible granules, the content of wetting agent is 2～8% under normal circumstances; And in invention for the content of wetting agent in the water dispersible granules of natamycin up to 20～45%, be preferably 20～30%.
Described natamycin sustained release agent composition comprises: 20～35% natamycins, 60～80% blue algae powders and 1～2% carbomer resin.The preparation method of described natamycin sustained release agent, comprises the following steps:
Under S1.25 DEG C of room temperature, prepare natamycin methanol solution, add dry blue algae powder, in the gas bath oscillator under 25～30 DEG C of constant temperature, vibration is soaked 20～30 hours, and rotary evaporation is dry, prepares natamycin-blue algae powder.
S2. natamycin-blue algae powder is added in the carbomer resin alcoholic solution of magnetic agitation, rotary evaporation, except desolventizing, through air-flow crushing, makes natamycin sustained release agent.
Described dispersant comprises one or more mixing in T-2700, NNO, T-2020, KY-555, SHQ-1.
Described wetting agent comprises aliphatic alcohol sulfate, alkyl sulfate, alkylol polyoxyethylene groups ether sodium sulfate, alkylphenol-polyethenoxy base ether sodium sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, one or more mixing in sodium alkyl sulfonate, alkylbenzenesulfonate, alkylnaphthalene sulfonate, dialkyl succinylsuccinate sulfonate, monoalkyl phenyl polyoxyethylene ether succinic acid sodium sulfonate, fatty alcohol ethylene oxide adduct sulfonate, alkylphenol formaldehyde condensation product ethylene oxide adduct sulfonate, alkane phthalein amido taurate, T-1004, K12.
Described binding agent comprises xanthans, carboxymethyl cellulose, soluble starch, bentonite, one or more mixing in polyethylene glycol.
Described disintegrant comprises one or more mixing in ammonium sulfate, sodium sulphate, sodium chloride, urea, soluble starch.
The preparation method of the uvioresistant agricultural water dispersible granule containing natamycin as above, carries out according to the following steps:
Under S1.25 DEG C of room temperature, prepare natamycin methanol solution, add dry blue algae powder, in the gas bath oscillator under 25～30 DEG C of constant temperature, vibration is soaked 20～30 hours, and rotary evaporation is dry, prepares natamycin-blue algae powder.
S2. natamycin-blue algae powder is added in the carbomer resin alcoholic solution of magnetic agitation, rotary evaporation, except desolventizing, through air-flow crushing, makes natamycin sustained release agent.
S3. by formula rate as above, after natamycin sustained release agent, dispersant, wetting agent, binding agent, disintegrant, blue algae powder are uniformly mixed, pulverizing obtains 500～800 order fine powders, in fine powder, adds suitable quantity of water, mixes rear extruder grain, dries, sieves and obtains water dispersible granules.
The invention has the beneficial effects as follows:
Water dispersible granules is since the eighties in 20th century; become gradually an important development direction of novel agrochemical environmental protection formulation; a large amount of water dispersible granules for different activities composition are also disclosed in prior art; but compared with general water dispersible granules; the present invention preparation containing the process of the uvioresistant agricultural water dispersible granule of natamycin in order to overcome natamycin easy problem of decomposition failure under ultraviolet ray; by adding blue algae powder for the protection of natamycin; and add carbomer resin, effective life, extends to 25～30 days.
The present invention is scattered in natamycin in water with the particle of miniaturization, has following characteristics: 1, product cost is not high, easily packed and transported.2, taking water as matrix, organic solvent-free, without dust, environmental pollution is little, to producing and user's safety.3, after said preparation spraying, be scattered in uniformly the surface of crop and product with fine particle, good anti-bacterial effect, is difficult for illumination and decomposes, and the antibacterial cycle is long.
Embodiment
Further describe the present invention below in conjunction with specific embodiment.Unless stated otherwise, reagent, the equipment that the present invention adopts is the conventional reagent of the art and equipment.
Embodiment 1
First weigh each component of preparing natamycin sustained release agent: 20% natamycin, 79% blue algae powder and 1% carbomer resin.Prepare natamycin sustained release agent according to the following steps: 1) under 25 DEG C of room temperatures, prepare natamycin methanol solution, add dry blue algae powder, in the gas bath oscillator under 25～30 DEG C of constant temperature, 20-30 hour, rotary evaporation are soaked in vibration, dry, prepare natamycin-blue algae powder.2) natamycin-blue algae powder is added in the carbomer resin alcoholic solution of magnetic agitation, rotary evaporation, except desolventizing, through air-flow crushing, makes natamycin sustained release agent.
Secondly weigh preparation each component containing the uvioresistant agricultural water dispersible granule of natamycin: natamycin sustained release agent 10%, dispersant (T-2700) 5%, wetting agent (T-1004) 30%, binding agent xanthans 2%, disintegrant sodium sulphate 13%, blue algae powder 40%.Above-mentioned raw materials is prepared according to the following steps:
After natamycin sustained release agent, dispersant, wetting agent, binding agent, disintegrant, blue algae powder are uniformly mixed according to the above ratio, pulverizing obtains 500～800 order fine powders, in fine powder, add suitable quantity of water, mix rear extruder grain, dry, sieve and obtain water dispersible granules.
Embodiment 2
First weigh each component of preparing natamycin sustained release agent: 30% natamycin, 68% blue algae powder and 2% carbomer resin.Prepare natamycin sustained release agent according to the following steps: 1) under 25 DEG C of room temperatures, prepare natamycin methanol solution, add dry blue algae powder, in the gas bath oscillator under 25～30 DEG C of constant temperature, 20-30 hour, rotary evaporation are soaked in vibration, dry, make natamycin-blue algae powder.2) natamycin-blue algae powder is added in the carbomer resin alcoholic solution of magnetic agitation, rotary evaporation, except desolventizing, through air-flow crushing, makes natamycin sustained release agent.
Secondly weigh preparation each component containing the uvioresistant agricultural water dispersible granule of natamycin: natamycin sustained release agent 20%, dispersant NNO 5%, wetting agent (K12) 25%, binding agent bentonite 5%, disintegrant sodium chloride 15%, filler blue algae powder 30%.Above-mentioned raw materials is prepared according to the following steps: after natamycin sustained release agent, dispersant, wetting agent, binding agent, disintegrant, blue algae powder are uniformly mixed according to the above ratio, pulverizing obtains 500～800 order fine powders, in fine powder, add suitable quantity of water, mix rear extruder grain, dry, sieve and obtain water dispersible granules.
The performance of the uvioresistant agricultural water dispersible granule containing natamycin described in mensuration embodiment 1～2, result is as follows: the water dispersible granules that the present invention prepares, not with an organic solvent, active constituent content is up to 10～50%, disperses, suspension stability is good, and has slow releasing function, lasting period can reach 25～30 days, suspensibility can reach more than 90%, and the grain fineness after dispersion reaches 1～20 micron, and drug effect and commodity performance are good.And through the UV-irradiation of 4 hours, the natamycin content that embodiment 1～2 prepares water dispersible granules only reduced by 20%, control sample (natamycin) has reduced by 50%.
Claims (8)
1. containing a uvioresistant agricultural water dispersible granule for natamycin, it is characterized in that, formed by the component of following percentage by weight: natamycin sustained release agent 10～30%, dispersant 1～10%, wetting agent 20～45%, binding agent 0.5～5%, disintegrant 1～20%, blue algae powder 20～40%.
2. the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1, is characterized in that, described natamycin sustained release agent composition comprises: 20～35% natamycins, 60～80% blue algae powders and 1～2% carbomer resin.
3. the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1 and 2, is characterized in that, the preparation method of natamycin sustained release agent is:
Under S1.25 DEG C of room temperature, prepare natamycin methanol solution, add dry blue algae powder, in the gas bath oscillator under 25～30 DEG C of constant temperature, vibration is soaked 20～30 hours, and rotary evaporation is dry, prepares natamycin-blue algae powder;
S2. natamycin-blue algae powder is added in the carbomer resin alcoholic solution of magnetic agitation, rotary evaporation, except desolventizing, through air-flow crushing, makes natamycin sustained release agent.
4. the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1, is characterized in that, described dispersant comprises one or more mixing in T-2700, NNO, T-2020, KY-555, SHQ-1.
5. the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1, it is characterized in that, described wetting agent comprises aliphatic alcohol sulfate, alkyl sulfate, alkylol polyoxyethylene groups ether sodium sulfate, alkylphenol-polyethenoxy base ether sodium sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, sodium alkyl sulfonate, alkylbenzenesulfonate, alkylnaphthalene sulfonate, dialkyl succinylsuccinate sulfonate, monoalkyl phenyl polyoxyethylene ether succinic acid sodium sulfonate, fatty alcohol ethylene oxide adduct sulfonate, alkylphenol formaldehyde condensation product ethylene oxide adduct sulfonate, alkane phthalein amido taurate, T-1004, one or more mixing in K12.
6. the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1, is characterized in that, described binding agent comprises xanthans, carboxymethyl cellulose, soluble starch, bentonite, one or more mixing in polyethylene glycol.
7. the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1, is characterized in that, described disintegrant comprises one or more mixing in ammonium sulfate, sodium sulphate, sodium chloride, urea, soluble starch.
8. the preparation method of the uvioresistant agricultural water dispersible granule containing natamycin according to claim 1, it is characterized in that, by formula rate claimed in claim 1, after natamycin sustained release agent, dispersant, wetting agent, binding agent, disintegrant, blue algae powder are uniformly mixed, pulverizing obtains 500～800 order fine powders, in fine powder, add suitable quantity of water, mix rear extruder grain, dry, sieve and obtain water dispersible granules.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019021250A1 (en) | 2017-07-27 | 2019-01-31 | Sawant Arun Vitthal | Novel crop fortification, nutrition and crop protection composition |
| CN109310093A (en) * | 2016-04-18 | 2019-02-05 | Arec作物保护有限公司 | Natamycin composition and application thereof |
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| CN102273449A (en) * | 2011-06-27 | 2011-12-14 | 上海师范大学 | Avermectin-cyanobacteria anti-ultraviolet sustained-release microcapsule water dispersible granules, and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109310093A (en) * | 2016-04-18 | 2019-02-05 | Arec作物保护有限公司 | Natamycin composition and application thereof |
| WO2019021250A1 (en) | 2017-07-27 | 2019-01-31 | Sawant Arun Vitthal | Novel crop fortification, nutrition and crop protection composition |
| EP3658166B1 (en) * | 2017-07-27 | 2024-03-06 | Sawant, Arun Vitthal | Crop nutrition composition |
| EP4339179A3 (en) * | 2017-07-27 | 2024-06-12 | Sawant, Arun Vitthal | Novel crop fortification, nutrition and crop protection composition |
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| CN103875657B (en) | 2016-01-20 |
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