CN103861203A - Ultrasonic cavitation cloud transport device and method - Google Patents
Ultrasonic cavitation cloud transport device and method Download PDFInfo
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Abstract
The invention relates to an ultrasonic cavitation cloud transport device and method. The device comprises a transducer and a reflective surface, wherein the transducer is used for converting electrical energy into vibration energy and transmitting the vibration energy to fluid through a radiating surface; first ultrasound waves are formed after the vibration energy and the fluid are reacted; the reflective surface is used for receiving the first ultrasound waves and reflecting the first ultrasound waves to the fluid; second ultrasound waves are formed after the reflected first ultrasound waves and the fluid are reacted; the second ultrasound waves and the first ultrasound waves form a standing wave sound field; the standing wave sound field acts on the fluid to form cavitation cloud, and thus particles entering the cavitation cloud move in the cavitation cloud along the direction determined by the standing wave sound field. By applying the ultrasonic cavitation cloud transport device and method, transporting of the particles can also be completed under the condition that the surrounding fluid is still; the particles can be precisely transported along a specific direction and released on specific destinations. Drugs can be delivered to the site of lesion by the ultrasonic cavitation cloud transport device, so the ultrasonic cavitation cloud transport device has an important application value in the medical field.
Description
Technical field
The present invention relates to mass transfer field, relate in particular to a kind of ultrasonic cavitation cloud feeding device and method.
Background technology
Nowadays to realize, the orientation of medicine is carried and fixed point is released to object targeted therapy and has become medical science, the especially study hotspot of the interventional therapy to tumor, and the ultrasonic technology that transports is carried and fixed point is released to object targeted therapy field and has potential, huge application prospect in the orientation to realize medicine.
Existing is the mode that ultrasound microbubble contrast agent combines with gene and medicine.Ultrasound microbubble contrast agent is the microvesicle that includes gas, and outer shell component can be albumin, lipid, surfactant and macromolecule polymer etc.Gene and medicine can stick to microvesicle surface or be wrapped in microvesicle inside.By intravenous injection, microvesicle can reach target organ or target tissue.Carry out ultrasonic irradiation at affected area, ultrasonic cavitation effect makes gene or medicine that the permeability of cell membrane, microvesicle carry enter histiocyte, thereby reaches the object for the treatment of.But this mode positioning performance is strong not, because the scope of ultrasonic irradiation is wider, the microvesicle really playing a role at affected area is also few.And utilize cavitation cloud to transport technology can to improve the positioning precision of drug conveying, increasing action, in the microvesicle quantity of affected area, improves drug conveying efficiency, improves therapeutic effect.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, a kind of ultrasonic cavitation cloud feeding device and method are provided, this device and method sends to by vibrational energy the standing-wave sound field that the ultrasound wave of ultrasound wave after fluid and reflecting surface reflection forms by transducer, standing-wave sound field acts on the cavitation cloud that fluid forms, the position of adjusting transducer and reflecting surface and phase place are adjusted position and the direction of standing-wave sound field, thereby the particulate matter that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field, realize under the state that fluid is static around and still can complete transporting of particulate matter, and can exactly particulate matter directed transport and fixed point be discharged into destination.
For achieving the above object, first aspect present invention provides a kind of ultrasonic cavitation cloud feeding device, and this device comprises: transducer, for converting electrical energy into vibrational energy, by radiating surface, vibrational energy is sent to fluid, after vibrational energy and fluid effect, generate the first ultrasound wave; Reflecting surface, be used for receiving the first ultrasound wave, by the first ultrasonic reflections to fluid, the first ultrasound wave and fluid effect after reflection generate the second ultrasound wave, the second ultrasound wave and the first ultrasound wave form standing-wave sound field, standing-wave sound field acts on fluid and forms cavitation cloud, thereby the particulate matter that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field.
Preferably, the operating frequency of transducer is 10kHz-50MHz.
Preferably, the amplitude of standing-wave sound field is 50kPa-200kPa.
Preferably, standing-wave sound field acts on fluid and forms cavitation cloud and specifically comprise: the structure of cavitation cloud is sound Lichtenberg's figures structure.
Preferably, particulate matter is solid particle, bubble, is insoluble to drop and the acoustic contrast agent of fluid.
Second aspect present invention provides a kind of ultrasonic cavitation cloud transportation method, and the method comprises: transducer converts electrical energy into vibrational energy, by radiating surface, vibrational energy is sent to fluid; After vibrational energy and fluid effect, generate the first ultrasound wave; Reflecting surface receives the first ultrasound wave, by the first ultrasonic reflections to fluid; The first ultrasound wave and fluid effect after reflection generate the second ultrasound wave; The second ultrasound wave and the first ultrasound wave form standing-wave sound field; Standing-wave sound field acts on fluid and forms cavitation cloud, thereby the particulate matter that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field.
Preferably, the second ultrasound wave and the first ultrasound wave form standing-wave sound field and specifically comprise: the position and the phase place that regulate transducer and reflecting surface, thereby regulate the first ultrasound wave and the second hyperacoustic phase place and direction, determine that thus the first ultrasound wave and the second ultrasound wave form position and the direction of standing-wave sound field.
Preferably, the particulate matter entering in cavitation cloud moves and specifically comprises in cavitation cloud along the determined direction of standing-wave sound field: the particulate matter entering in cavitation cloud moves to the high pressure amplitude region direction of standing-wave sound field along the low-pressure amplitude region of standing-wave sound field in cavitation cloud.
The beneficial effect that the present invention brings is: ultrasonic cavitation cloud feeding device provided by the invention and method have realized under the state that fluid is static around still can complete transporting of particulate matter, and can exactly particulate matter directed transport and fixed point be discharged into destination, therefore this device can conduct drugs to affected area, there is important using value at medical field, the interventional therapy of tumor is had to potential application prospect.
Brief description of the drawings
The ultrasonic cavitation cloud feeding device that Fig. 1 provides for the embodiment of the present invention one is applied to the schematic diagram of targeted therapy;
The ultrasonic cavitation cloud feeding device schematic diagram that Fig. 2 provides for the embodiment of the present invention two;
The ultrasonic cavitation cloud feeding device that Fig. 3 provides for the embodiment of the present invention two produces the schematic diagram of cavitation cloud;
Fig. 4 is the schematic diagram that in the embodiment of the present invention two, ultrasonic cavitation cloud feeding device forms cavitation cloud;
Fig. 5 is the structure chart of the embodiment of the present invention two cavitation clouds;
Fig. 6 is the movement locus of particulate matter in cavitation cloud in the embodiment of the present invention two;
The ultrasonic cavitation cloud transportation method flow chart that Fig. 7 provides for the embodiment of the present invention.
Detailed description of the invention
Below by drawings and Examples, technical scheme of the present invention is described in further detail.
The invention discloses a kind of ultrasonic cavitation cloud feeding device and method, ultrasonic cavitation cloud feeding device of the present invention sends to by vibrational energy the standing-wave sound field that the ultrasound wave of ultrasound wave after fluid and reflecting surface reflection forms by transducer, standing-wave sound field acts on the cavitation cloud that fluid forms, regulate position and the phase place of transducer and reflecting surface to adjust position and the direction of standing-wave sound field, thereby the particulate matter that makes to enter in cavitation cloud move in cavitation cloud along the determined direction of standing-wave sound field.Realized under the state that fluid is static around, this ultrasonic cavitation cloud feeding device still can complete transporting of particulate matter.This device is widely used in medical field, can conduct drugs to affected area.
The ultrasonic cavitation cloud feeding device that Fig. 1 provides for the embodiment of the present invention one is applied to the schematic diagram of targeted therapy.As shown in Figure 1, the fluid 13 in embodiment mono-is blood, and particulate matter is acoustic contrast agent.Transducer 11 converts electrical energy into vibrational energy, by the radiating surface of transducer 11, vibrational energy is sent to blood, after vibrational energy and blood effect, generates the first ultrasound wave; Reflecting surface 12 receives the first ultrasound wave, by the first ultrasonic reflections to blood, the first ultrasound wave and blood effect after reflection generate the second ultrasound wave, the second ultrasound wave and the first ultrasound wave form standing-wave sound field, standing-wave sound field acts on blood and forms cavitation cloud, and the contrast agent now entering in cavitation cloud arrives affected area along the determined direction of standing-wave sound field.
The ultrasonic cavitation cloud feeding device schematic diagram that Fig. 2 provides for the embodiment of the present invention two.As shown in Figure 2, transducer 11 is mainly used in, by radiating surface, vibrational energy is sent to fluid 13, after 13 effects of vibrational energy and fluid, generate the first ultrasound wave, reflecting surface 12 is for receiving the first ultrasound wave from fluid 13, and by the first ultrasonic reflections this process to fluid 13.
The ultrasonic cavitation cloud feeding device that Fig. 3 provides for the embodiment of the present invention two produces the schematic diagram of cavitation cloud.As shown in Figure 3, the ultrasonic cavitation cloud feeding device that the embodiment of the present invention two provides need to be immersed in 13 li of fluids completely, transducer in a ultrasonic cavitation cloud feeding device 11 at least one, reflecting surface 12 at least one.
In conjunction with Fig. 2 and Fig. 3, ultrasonic cavitation cloud feeding device is described, this device comprises: transducer 11 and reflecting surface 12.
Because the too little meeting of the second ultrasonic energy causes forming standing wave, so the border of reflecting surface 12 is preferably bounds, can make like this second hyperacoustic energy attenuation less.Transducer 11 can be focused transducer as the case may be, and reflecting surface 12 can be concave surface, because energy centralization effect increases the first ultrasound wave and the second ultrasonic energy.In the ultrasonic cavitation cloud feeding device providing in the embodiment of the present invention two, reflecting surface 12 can be glass container, and transducer 11 is immersed in the glass container that fluid 13 is housed completely, and glass container wall is exactly reflecting surface 12.
Transducer 11, for converting electrical energy into vibrational energy, sends to fluid 13 by radiating surface by vibrational energy, after vibrational energy and fluid 13 effects, generates the first ultrasound wave.
Particularly, transducer 11 specifically also comprises radiating surface, and transducer 11, for converting electrical energy into vibrational energy, sends to aqueous solution by radiating surface by vibrational energy, after vibrational energy and aqueous solution effect, generates the first ultrasound wave.The operating frequency of transducer 11 is 10kHz-50MHz.Because the standing-wave sound field amplitude that forms cavitation cloud is at least 50kPa, the amplitude that cavity is repelled in high pressure amplitude region is at least 200kPa, so the amplitude of standing-wave sound field is 50kPa-200kPa.
Reflecting surface 12, be used for receiving the first ultrasound wave, by the first ultrasonic reflections to fluid 13, the first ultrasound wave after reflection and fluid 13 effects generate the second ultrasound wave, the second ultrasound wave and the first ultrasound wave form standing-wave sound field, standing-wave sound field acts on fluid 13 and forms cavitation cloud, thereby the particulate matter that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field.
Particularly, reflecting surface 12 is for receiving the first ultrasound wave from fluid 13, again by the first ultrasonic reflections to fluid 13, now, the second ultrasound wave after containing the vibrational energy being sent by transducer 11 in fluid 13 and acting on rear the first ultrasound wave forming of fluid 13 and reflecting surface 12 and act on by the first ultrasonic reflections reflux 13 and with fluid 13, then the second ultrasound wave and the stack of the first ultrasound wave form standing-wave sound field, and standing-wave sound field acts on fluid 13 and forms cavitation cloud.
Fig. 4 is the schematic diagram that in the embodiment of the present invention two, ultrasonic cavitation cloud feeding device forms cavitation cloud.Fig. 5 is the structure chart of the embodiment of the present invention two cavitation clouds.As shown in Figure 4, standing-wave sound field acts on fluid 13 and forms cavitation cloud, and the structure of cavitation cloud is sound Lichtenberg's figures structure particularly.As shown in Figure 5, the structure of cavitation cloud is sound Lichtenberg's figures structure, also be dendritic morphology, cavitation cloud periphery a bit, as any point in A point B point C point D point or E point, throw in a small particulate matter, particulate matter moves to F point along the dendritic morphology of cavitation cloud under the active force of standing-wave sound field.
Fig. 6 is the movement locus of particulate matter in cavitation cloud in the embodiment of the present invention two.As shown in Figure 6, particulate matter dendritic morphology along cavitation cloud under the active force of standing-wave sound field moves to from A point the trajectory diagram that F is ordered, the particulate matter that enters into cavitation cloud moves at the cavitation cloud of sound Lichtenberg's figures structure along the determined direction of standing-wave sound field, wherein the determined direction that transports of standing-wave sound field is from low-pressure amplitude region to high pressure amplitude regional movement, so particulate matter is from low-pressure amplitude region to high pressure amplitude regional movement.Particulate matter is the material that solid, gas or liquid etc. are insoluble to fluid 13 in this ultrasonic cavitation cloud feeding device, for example: bubble, drop, acoustic contrast agent.So this device can pass through to regulate position and the phase place of transducer 11 and reflecting surface 12, thereby regulate the first ultrasound wave and the second hyperacoustic phase place and direction, determine that thus the first ultrasound wave and the second ultrasound wave form position and the direction of standing-wave sound field.
In the ultrasonic cavitation cloud feeding device providing in the embodiment of the present invention two, transducer 11 at least one, reflecting surface 12 at least one, in the time that transducer 11 and reflecting surface 12 are all several, by regulating position and the phase place of several transducers 11 and several reflectings surface 12, thereby regulate the first ultrasound wave and the second ultrasound wave to form position and the direction of standing-wave sound field, further determine the motion path that enters the particulate matter in cavitation cloud.
Simultaneously, in ultrasonic cavitation cloud feeding device, the transducer 11 of two same frequencys also can form cavitation cloud, two ultrasound wave stack formation standing-wave sound fields that transducer 11 sends, position or the phase place of now adjusting two transducers 11 realize the position and the direction that regulate standing-wave sound field, also can add more than 11 reflecting surface 12 of transducer of multiple same frequencys to realize the control to standing-wave sound field position and direction.
For example, transducer 11 is attached on skin, on skin, smear some couplants, how ultrasonic wave energy is propagated in body, there are two or more such same frequency transducers 11, in the blood vessel of specifying, form standing wave like this, determine lesions position and cavitation cloud node location by modes such as B ultrasonic, adjust transducer 11 positions and phase place and adjust cavitation cloud node location, cavitation cloud node location is overlapped with lesions position.Inject acoustic contrast agent to internal blood vessel, contrast agent is many microvesicles, these microvesicles constantly expand and shrink under the effect of sound field, because the second order Bjerknes power between the main Bjerknes power of sound field and microvesicle, because the interaction force between suffered sound field power and the microvesicle of microvesicle forms cavitation cloud, cavitation cloud by microvesicle together with stick on microvesicle surface or be wrapped in microvesicle inside DNA or drug conveying to affected area.
Therefore, the ultrasonic cavitation cloud feeding device that the embodiment of the present invention two provides, by transducer 11, vibrational energy is sent to the standing-wave sound field that ultrasound wave that ultrasound wave after fluid 13 and reflecting surface 12 reflect forms, standing-wave sound field acts on the cavitation cloud that fluid 13 forms, adjust position and the direction of standing-wave sound field by the position and the phase place that regulate transducer 11 and reflecting surface 12, thereby determine and enter the path that the particulate matter in cavitation cloud moves in cavitation cloud.Under the state that fluid 13 is static so around, particulate matter still can arrive destination automatically, and the positioning performance of this device is accurate.
The ultrasonic cavitation cloud transportation method flow chart that Fig. 7 provides for the embodiment of the present invention.This ultrasonic cavitation cloud transportation method is the ultrasonic cavitation cloud feeding device providing based on the embodiment of the present invention.As shown in Figure 7, the present embodiment specifically comprises the following steps:
Step 201, transducer 11 convert electrical energy into vibrational energy, by radiating surface, vibrational energy are sent to fluid 13.
Particularly, fluid 13 is the liquid of mobility, and in embodiments of the present invention, fluid 13 is preferably aqueous solution.Transducer 11 specifically also comprises radiating surface, and transducer 11 converts electrical energy into vibrational energy, by radiating surface, vibrational energy is sent to aqueous solution, after vibrational energy and aqueous solution effect, generates the first ultrasound wave.
After step 202, vibrational energy and fluid 13 effects, generate the first ultrasound wave.Transducer 11 sends to the vibrational energy of aqueous solution and aqueous solution effect to generate the first ultrasound wave.
Step 203, reflecting surface 12 receive the first ultrasound wave, by the first ultrasonic reflections to fluid 13.
Particularly, in the device providing in the embodiment of the present invention, transducer 11 is immersed in the glass container that aqueous solution is housed completely, and glass container wall is exactly reflecting surface 12.Reflecting surface 12 receives the first ultrasound wave from aqueous solution, then by the first ultrasonic reflections to aqueous solution.
The first ultrasound wave after step 204, reflection and fluid 13 effects generate the second ultrasound wave.Glass container wall to aqueous solution, and generates the second ultrasound wave with aqueous solution effect by the first ultrasonic reflections.
Step 205, the second ultrasound wave and the first ultrasound wave form standing-wave sound field.
Particularly, behind step 203 and 204, in aqueous solution, there are two different ultrasound wave, the vibrational energy that the first ultrasound wave sends from transducer 11 acts on the sound wave forming after aqueous solution, the second ultrasound wave from glass container wall by the first ultrasonic reflections backwater solution and with aqueous solution effect after sound wave, then the second ultrasound wave and the first ultrasound wave stack formation standing-wave sound field.By regulating position and the phase place of transducer 11 and reflecting surface 12, thereby regulate the first ultrasound wave and the second hyperacoustic phase place and direction, determine that thus the first ultrasound wave and the second ultrasound wave form position and the direction of standing-wave sound field.
Step 206, standing-wave sound field act on fluid 13 and form cavitation cloud, thereby the particulate matter that makes to enter in cavitation cloud moves in cavitation cloud along the determined direction of standing-wave sound field.
Particularly, standing-wave sound field acts on aqueous solution and forms cavitation cloud, and the structure of cavitation cloud is sound Lichtenberg's figures structure.The particulate matter that enters into cavitation cloud moves at the cavitation cloud of sound Lichtenberg's figures structure along the determined direction of standing-wave sound field, wherein the determined direction that transports of standing-wave sound field is from low-pressure amplitude region to high pressure amplitude regional movement, so particulate matter is from low-pressure amplitude region to high pressure amplitude regional movement.
Therefore, the ultrasonic cavitation cloud transportation method that the embodiment of the present invention provides, by transducer, vibrational energy is sent to the standing-wave sound field that ultrasound wave that ultrasound wave after fluid 13 and reflecting surface 12 reflect forms, standing-wave sound field acts on the cavitation cloud that fluid 13 forms, adjust position and the direction of standing-wave sound field by the position and the phase place that regulate transducer and reflecting surface 12, thereby determine and enter the path that the particulate matter in cavitation cloud moves in cavitation cloud.The method has realized under the state that fluid 13 is static around, and particulate matter still can arrive destination automatically.The method is widely used in medical field, and the method positioning performance is accurate, directed medicine conveying and fixed point can be discharged into affected area, and the interventional therapy of tumor is had to potential application prospect.
Professional should further recognize, unit and the algorithm steps of each example of describing in conjunction with embodiment disclosed herein, can realize with electronic hardware, computer software or the combination of the two, for the interchangeability of hardware and software is clearly described, composition and the step of each example described according to function in the above description in general manner.These functions are carried out with hardware or software mode actually, depend on application-specific and the design constraint of technical scheme.Professional and technical personnel can realize described function with distinct methods to each specifically should being used for, but this realization should not thought and exceeds scope of the present invention.
The software module that the method for describing in conjunction with embodiment disclosed herein or the step of algorithm can use hardware, processor to carry out, or the combination of the two is implemented.Software module can be placed in the storage medium of any other form known in random access memory (RAM), internal memory, read only memory (ROM), electrically programmable ROM, electrically erasable ROM, depositor, hard disk, moveable magnetic disc, CD-ROM or technical field.
Above-described detailed description of the invention; object of the present invention, technical scheme and beneficial effect are further described; institute is understood that; the foregoing is only the specific embodiment of the present invention; the protection domain being not intended to limit the present invention; within the spirit and principles in the present invention all, any amendment of making, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. a ultrasonic cavitation cloud feeding device, is characterized in that, described device comprises:
Transducer, for converting electrical energy into vibrational energy, sends to fluid by radiating surface by described vibrational energy, after described vibrational energy and described fluid effect, generates the first ultrasound wave;
Reflecting surface, be used for receiving described the first ultrasound wave, by extremely described fluid of described the first ultrasonic reflections, described the first ultrasound wave and described fluid effect after reflection generate the second ultrasound wave, described the second ultrasound wave and described the first ultrasound wave form standing-wave sound field, described standing-wave sound field acts on described fluid and forms cavitation cloud, thereby the particulate matter that makes to enter in described cavitation cloud moves in described cavitation cloud along the determined direction of described standing-wave sound field.
2. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that, the operating frequency of described transducer is 10kHz-50MHz.
3. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that, the amplitude of described standing-wave sound field is 50kPa-200kPa.
4. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that, described standing-wave sound field acts on described fluid formation cavitation cloud and specifically comprises: the structure of described cavitation cloud is sound Lichtenberg's figures structure.
5. ultrasonic cavitation cloud feeding device according to claim 1, is characterized in that, described particulate matter is solid particle, bubble, be insoluble to drop and the acoustic contrast agent of described fluid.
6. a ultrasonic cavitation cloud transportation method, is characterized in that, described method comprises:
Transducer converts electrical energy into vibrational energy, by radiating surface, described vibrational energy is sent to fluid;
After described vibrational energy and described fluid effect, generate the first ultrasound wave;
Reflecting surface receives described the first ultrasound wave, by extremely described fluid of described the first ultrasonic reflections;
Described the first ultrasound wave and described fluid effect after reflection generate the second ultrasound wave;
Described the second ultrasound wave and described the first ultrasound wave form standing-wave sound field;
Described standing-wave sound field acts on described fluid and forms cavitation cloud, thereby the particulate matter that makes to enter in described cavitation cloud moves in described cavitation cloud along the determined direction of described standing-wave sound field.
7. ultrasonic cavitation cloud transportation method according to claim 6, it is characterized in that, described the second ultrasound wave and described the first ultrasound wave form standing-wave sound field and specifically comprise: the position and the phase place that regulate described transducer and described reflecting surface, thereby regulate described the first ultrasound wave and described the second hyperacoustic phase place and direction, determine that thus the first ultrasound wave and the second ultrasound wave form position and the direction of standing-wave sound field.
8. ultrasonic cavitation cloud transportation method according to claim 6, it is characterized in that, described in the particulate matter that enters in described cavitation cloud move and specifically comprise in described cavitation cloud along the determined direction of described standing-wave sound field: the particulate matter entering in described cavitation cloud moves to the high pressure amplitude region direction of described standing-wave sound field along the low-pressure amplitude region of described standing-wave sound field in described cavitation cloud.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138736A (en) * | 2014-08-19 | 2014-11-12 | 中国科学院声学研究所 | Ultrasonic cavitation device |
| CN107907373A (en) * | 2017-11-29 | 2018-04-13 | 中国科学院声学研究所 | A kind of particulate matter sampler and its system |
| CN111773177A (en) * | 2020-07-16 | 2020-10-16 | 南京大学 | Method for realizing fixed-point release of drug particles by using acoustic radiation force |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020082666A1 (en) * | 2000-12-22 | 2002-06-27 | Eilaz Babaev | Wound treatment method and device with combination of ultrasound and laser energy |
| CN102095796A (en) * | 2010-11-12 | 2011-06-15 | 中国科学院声学研究所 | Device and method for detecting fluid cavitation by combining active ultrasonic with passive acoustics |
| CN102548614A (en) * | 2009-04-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | Tumor treatment using ultrasound cavitation |
| CN203861768U (en) * | 2014-03-19 | 2014-10-08 | 中国科学院声学研究所 | Ultrasonic cavitation cloud transporting device |
-
2014
- 2014-03-19 CN CN201410103085.6A patent/CN103861203B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020082666A1 (en) * | 2000-12-22 | 2002-06-27 | Eilaz Babaev | Wound treatment method and device with combination of ultrasound and laser energy |
| CN102548614A (en) * | 2009-04-15 | 2012-07-04 | 皇家飞利浦电子股份有限公司 | Tumor treatment using ultrasound cavitation |
| CN102095796A (en) * | 2010-11-12 | 2011-06-15 | 中国科学院声学研究所 | Device and method for detecting fluid cavitation by combining active ultrasonic with passive acoustics |
| CN203861768U (en) * | 2014-03-19 | 2014-10-08 | 中国科学院声学研究所 | Ultrasonic cavitation cloud transporting device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138736A (en) * | 2014-08-19 | 2014-11-12 | 中国科学院声学研究所 | Ultrasonic cavitation device |
| CN107907373A (en) * | 2017-11-29 | 2018-04-13 | 中国科学院声学研究所 | A kind of particulate matter sampler and its system |
| CN111773177A (en) * | 2020-07-16 | 2020-10-16 | 南京大学 | Method for realizing fixed-point release of drug particles by using acoustic radiation force |
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| CN103861203B (en) | 2016-05-04 |
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