CN103861083A - 一种更稳定的棘白菌素类抗真菌剂的药用组合物 - Google Patents
一种更稳定的棘白菌素类抗真菌剂的药用组合物 Download PDFInfo
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- CN103861083A CN103861083A CN201210544628.9A CN201210544628A CN103861083A CN 103861083 A CN103861083 A CN 103861083A CN 201210544628 A CN201210544628 A CN 201210544628A CN 103861083 A CN103861083 A CN 103861083A
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- caspofungin
- esters
- pharmaceutical composition
- echinocandin
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
时间(min) | 流动相A(%) | 流动相B(%) |
0 | 65.5 | 34.5 |
14.5 | 65.5 | 34.5 |
35 | 50 | 50 |
45 | 35 | 65 |
50 | 20 | 80 |
52 | 20 | 80 |
53 | 65.5 | 34.5 |
66 | 65.5 | 34.5 |
时间(min) | 流动相A(%) | 流动相B(%) |
0 | 65.5 | 34.5 |
14.5 | 65.5 | 34.5 |
35 | 50 | 50 |
45 | 35 | 65 |
50 | 20 | 80 |
52 | 20 | 80 |
53 | 65.5 | 34.5 |
66 | 65.5 | 34.5 |
时间(min) | 流动相A(%) | 流动相B(%) |
0 | 65.5 | 34.5 |
14.5 | 65.5 | 34.5 |
35 | 50 | 50 |
45 | 35 | 65 |
50 | 20 | 80 |
52 | 20 | 80 |
53 | 65.5 | 34.5 |
66 | 65.5 | 34.5 |
编号 | 0个月时含量% | 12个月时含量% | 24个月时含量% |
实施例1 | 99.82 | 99.64 | 99.47 |
实施例2 | 99.85 | 99.60 | 99.43 |
实施例3 | 99.83 | 99.65 | 99.48 |
实施例4 | 99.83 | 99.58 | 99.41 |
实施例5 | 99.85 | 99.70 | 99.53 |
实施例6 | 99.84 | 99.67 | 99.50 |
实施例7 | 99.81 | 99.57 | 99.40 |
实施例8 | 99.85 | 99.71 | 99.54 |
实施例9 | 99.84 | 99.52 | 99.35 |
实施例10 | 99.86 | 99.72 | 99.55 |
实施例11 | 99.84 | 99.78 | 99.61 |
实施例12 | 99.83 | 99.75 | 99.58 |
实施例13 | 99.83 | 99.74 | 99.57 |
实施例14 | 99.83 | 99.74 | 99.57 |
实施例15 | 99.81 | 99.73 | 99.56 |
实施例16 | 99.81 | 99.72 | 99.55 |
实施例17 | 99.84 | 99.71 | 99.54 |
实施例18 | 99.82 | 99.69 | 99.52 |
实施例19 | 99.83 | 99.67 | 99.50 |
实施例20 | 99.84 | 99.66 | 99.49 |
实施例21 | 99.82 | 99.57 | 99.40 |
实施例22 | 99.81 | 99.56 | 99.39 |
实施例23 | 99.82 | 99.54 | 99.37 |
实施例24 | 99.81 | 99.45 | 99.28 |
对比例1 | 99.82 | 99.52 | 99.05 |
对比例2 | 99.82 | 99.42 | 98.83 |
对比例3 | 99.84 | 98.95 | 98.68 |
对比例4 | 99.82 | 98.82 | 98.35 |
对比例5 | 99.83 | 98.86 | 98.43 |
对比例6 | 99.82 | 98.63 | 97.06 |
编号 | 0个月时杂质总量% | 12个月时杂质总量% | 24个月时杂质总量% |
实施例1 | 0.25 | 0.41 | 0.64 |
实施例2 | 0.26 | 0.42 | 0.65 |
实施例3 | 0.24 | 0.40 | 0.63 |
实施例4 | 0.25 | 0.44 | 0.67 |
实施例5 | 0.25 | 0.34 | 0.57 |
实施例6 | 0.24 | 0.36 | 0.59 |
实施例7 | 0.26 | 0.44 | 0.67 |
实施例8 | 0.25 | 0.33 | 0.56 |
实施例9 | 0.26 | 0.48 | 0.71 |
实施例10 | 0.27 | 0.31 | 0.54 |
实施例11 | 0.24 | 0.28 | 0.51 |
实施例12 | 0.25 | 0.31 | 0.54 |
实施例13 | 0.24 | 0.31 | 0.54 |
实施例14 | 0.26 | 0.30 | 0.53 |
实施例15 | 0.24 | 0.30 | 0.53 |
实施例16 | 0.25 | 0.31 | 0.54 |
实施例17 | 0.24 | 0.36 | 0.59 |
实施例18 | 0.25 | 0.37 | 0.60 |
实施例19 | 0.24 | 0.40 | 0.63 |
实施例20 | 0.25 | 0.41 | 0.64 |
实施例21 | 0.26 | 0.43 | 0.66 |
实施例22 | 0.25 | 0.44 | 0.67 |
实施例23 | 0.24 | 0.47 | 0.70 |
实施例24 | 0.27 | 0.58 | 0.81 |
对比例1 | 0.24 | 0.73 | 1.18 |
对比例2 | 0.26 | 0.69 | 1.15 |
对比例3 | 0.25 | 1.18 | 1.81 |
对比例4 | 0.24 | 1.33 | 2.56 |
对比例5 | 0.25 | 1.07 | 1.93 |
对比例6 | 0.26 | 2.21 | 5.05 |
Claims (16)
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CN201210544628.9A CN103861083B (zh) | 2012-12-14 | 2012-12-14 | 一种更稳定的棘白菌素类抗真菌剂的药用组合物 |
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CN201210544628.9A CN103861083B (zh) | 2012-12-14 | 2012-12-14 | 一种更稳定的棘白菌素类抗真菌剂的药用组合物 |
Publications (2)
Publication Number | Publication Date |
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CN103861083A true CN103861083A (zh) | 2014-06-18 |
CN103861083B CN103861083B (zh) | 2016-03-30 |
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CN201210544628.9A Active CN103861083B (zh) | 2012-12-14 | 2012-12-14 | 一种更稳定的棘白菌素类抗真菌剂的药用组合物 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024088301A1 (zh) * | 2022-10-25 | 2024-05-02 | 江苏恒瑞医药股份有限公司 | 一种棘白素类似物的药物组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102488887A (zh) * | 2011-01-31 | 2012-06-13 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂卡泊芬净的药用组合物及其制备方法和用途 |
CN102512669A (zh) * | 2011-12-13 | 2012-06-27 | 北京同仁堂健康药业股份有限公司 | 一种女性美白养颜的组合物 |
CN103040852A (zh) * | 2012-12-12 | 2013-04-17 | 中国人民解放军第二军医大学 | 赖氨酸作为增效剂在制备抗真菌药物中的应用 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102488887A (zh) * | 2011-01-31 | 2012-06-13 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂卡泊芬净的药用组合物及其制备方法和用途 |
CN102512669A (zh) * | 2011-12-13 | 2012-06-27 | 北京同仁堂健康药业股份有限公司 | 一种女性美白养颜的组合物 |
CN103040852A (zh) * | 2012-12-12 | 2013-04-17 | 中国人民解放军第二军医大学 | 赖氨酸作为增效剂在制备抗真菌药物中的应用 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024088301A1 (zh) * | 2022-10-25 | 2024-05-02 | 江苏恒瑞医药股份有限公司 | 一种棘白素类似物的药物组合物及其制备方法 |
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CN103861083B (zh) | 2016-03-30 |
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