CN103861062A - Traditional Chinese medicine composition for treating rheumatoid diseases and preparation method thereof - Google Patents

Abstract

A disclosed traditional Chinese medicine composition for treating rheumatoid diseases is composed of the following raw materials in percent by mass: 22%-23% of radix saposhnikoviae, 10%-23% of herba schizonepetae, 10%-24% of notopterygium incisum, 5%-15% of heracleum hemsleyanum, 5%-15% of carthamus tinctorius, 5%-15% of xanthium sibiricum, 2%-6% of pyrola calliantha, 3%-5% of raw ginger, 6%-12% of haw tree root, and the mass percentage of the above compositions is 100%. The invention also discloses a preparation method of the above traditional Chinese medicine composition, the composition is prepared by crushing all weighed raw materials and fully mixing the raw materials. The traditional Chinese medicine composition for treating rheumatism is good in treatment effect, fast in effectiveness and free of toxic and side effects.

Description

Treat rheumatoid Chinese medicine composition and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, relate to one and treat rheumatoid Chinese medicine composition, the invention still further relates to the preparation method of this Chinese medicine composition.

Background technology

Rheumatoid is a kind of common inflammation, and atrophic diseases is that general reference affects bone, joint and surrounding soft tissue thereof as one group of disease of tendon, synovial membrane, fascia etc., taking joint, the pain such as muscle, soft tissue, nerve is as cardinal symptom.Often show as slight heating or middle heat, pathological changes part presents the symptoms such as redness, scorching hot, severe pain, distending pain.Rheumatoid arthritis is that the evil human body of invading of wind, cold, wet causes, multiple abscess meridians, due to QI-blood circulation is lost freely.Rheumatoid disease is not because of also very clear and definite, the little arthralgia of normal appearance, increase, when serious, can invade large joint and heart, brain, lung, blood vessel etc., treatment rheumatoid mainly adopts the Western medicine of plaster and anti-inflammatory class at present, but only cure the symptoms, not the disease, easily repeatedly, and Western medicine has side effect, and long-term prescription can bring the degeneration of physical function.

Summary of the invention

The object of this invention is to provide one and treat rheumatoid Chinese medicine composition, good effect, instant effect, has no side effect.

Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.

The technical solution adopted in the present invention is, treats rheumatoid Chinese medicine composition, according to mass percent, is made up of following raw material:

Radix Saposhnikoviae 22% ~ 32%, Herba Schizonepetae 10% ~ 23%, Rhizoma Et Radix Notopterygii 10% ~ 24%, Radix Angelicae Pubescentis 5% ~ 15%, Flos Carthami 5% ~ 15%, Herba Xanthii 5% ~ 15%, Pyrola rotundifolia ssp.chinensis 2% ~ 6%, Rhizoma Zingiberis Recens 3%-5%, tree root of Fructus Crataegi Pinnatifidae 6-12%, the mass percent summation of above component is 100%.

Another technical scheme of the present invention is, a kind of preparation method for the treatment of rheumatoid Chinese medicine composition is specifically implemented according to following steps:

Step 1

According to mass percent, take respectively Radix Saposhnikoviae 22% ~ 32%, Herba Schizonepetae 10% ~ 23%, Rhizoma Et Radix Notopterygii 10% ~ 24%, Radix Angelicae Pubescentis 5% ~ 15%, Flos Carthami 5% ~ 15%, Herba Xanthii 5% ~ 15%, Pyrola rotundifolia ssp.chinensis 2% ~ 6%, Rhizoma Zingiberis Recens 3%-5%, tree root of Fructus Crataegi Pinnatifidae 6-12%, the mass percent summation of above component is 100%;

Step 2

After each raw material pulverizing that step 1 is taken, abundant mixing, make.

The rheumatoid Chinese medicine composition for the treatment of of the present invention, can make rheumatoid fumigant, two kinds of preparations of rheumatism reparation spray, good effect, and instant effect, has no side effect.Two kinds of preparations can configure separately, use separately.Rheumatoid fumigant is mainly used in rheumatism, gout etc. and uses in gassing machine; Solve rheumatism, gout etc. and cause that arthroncus crosses reparation and the rehabilitative action of arthralgia, and pain-relieving rheumatism-dispelling heat rapidly, control activeness rheumatoid and rheumatism, reach part or hydrosarca and alleviate until disappear.From the immune disorder of external adjusting human body and deficiency, shorten and treat rheumatism, rheumatoid time and the course for the treatment of, compare with chemicals than traditional oral drugs, this composition of medicine need not be oral, do not injure human body, thereby regulate blood circulation and the immune system of human body to reach therapeutic purposes.Rheumatoid is repaired spray and is mainly used in rheumatoid, rheumatism, gout, scapulohumeral periarthritis, intervertebral disk hernia or bulging, cervical vertebra pain, sprain, carry out at magnet therapeutic apparatus or infrared therapy apparatus that ion is got involved and soak penetrates diseased region topical therapeutic, through thermion, photoion or magnetic wave enter blood circulation by effective ingredient Transdermal absorption and arrive each tissue, higher in diseased region concentration, the metabolite harmful to pathological tissues decomposes, kill the rheumatoid factor in blood, the osteoclast of pathological changes joint part, abnormal proliferation cell, allergy cell, decompose destroyed histiocyte and immune complex, get rid of externally through blood circulation, recover the microcirculqtory system of diseased region, set up normal blood circulation passage, allow the automatic and passive reparation pathological tissues of human body, thereby reach therapeutic purposes.Can solve infrared ray and magnet therapeutic apparatus does not have the defect of soak and hot compress, promotes local lesion's rehabilitation Shorten the Treatment Process.According to clinical trial, rheumatoid fumigant can be controlled rheumatic fever that activeness rheumatoid causes and rheumatalgia, migratory rheumatism pain for 3-4 days, light disease rheumatic arthritis can be cured for 7 days substantially, recovery from illness in 25 days, rheumatoid fumigant and rheumatoid are repaired spray and are used 10 days can control violent arthralgia simultaneously, within 3 months to 6 months, rheumatoid returns to one's perfect health and reaches 97%, and common knee joint rheumatic arthritis returns to one's perfect health 78% in 25 days.

Detailed description of the invention

Below by detailed description of the invention, the present invention is described in detail.

The rheumatoid Chinese medicine composition for the treatment of of the present invention, is made up of following raw material according to mass percent:

Radix Saposhnikoviae 22% ~ 32%, Herba Schizonepetae 10% ~ 23%, Rhizoma Et Radix Notopterygii 10% ~ 24%, Radix Angelicae Pubescentis 5% ~ 15%, Flos Carthami 5% ~ 15%, Herba Xanthii 5% ~ 15%, Pyrola rotundifolia ssp.chinensis 2% ~ 6%, Rhizoma Zingiberis Recens 3%-5%, tree root of Fructus Crataegi Pinnatifidae 6-12%, the mass percent summation of above component is 100%.

In the present invention, Radix Saposhnikoviae acrid-sweet flavor is warm in nature nontoxic, thus pungent walk the logical knot for the treatment of all pathogenic wind of agent of lung, the trouble of pain person's wind.

Herba Schizonepetae acrid in the mouth bitterness tepor, nontoxic enter the promoting the circulation of blood of lung liver treat all wind of wind diaphoresis peeling hair.Herba Schizonepetae in vitro tests has weak anticancer effect.Herba Schizonepetae decoct has the effect of obvious inhibition mice auricle swelling, and the inflammation that Dichlorodiphenyl Acetate causes also has obvious antiinflammatory action.

Rhizoma Et Radix Notopterygii sweet in the mouth slightly warm in nature enters lung kidney two through curing mainly new and old all rheumatism numbness, enters the few cloudy kidney of lunar lung to manage floating wind.Rhizoma Et Radix Notopterygii volatile oil has antiinflammatory and anti-allergic effects.After gastric infusion, xylol dropsy of ear, carrageenin and dextran foot swelling have inhibitory action.To DNFB, caused delayed hypersensitivity has certain inhibitory action, and can make Vitamin C content in adrenal gland have reduction trend. and its antiinflammatory action may be relevant with Pituitary Adrenal cortex system.

Radix Angelicae Pubescentis bitter but sweet flavor slightly warm in nature nontoxic enter small intestinal urinary bladder channel spill into table ailment said due to cold or exposure, sharp Zhousheng arthralgia, except the disease of new and old rheumatism enters sun small intestinal, bladder meridian with the mutual the exterior and the interior of reason urticaria.Book on Chinese herbal medicine converges to be sayed: Radix Angelicae Pubescentis, and benefaction blood system, the medicine of the wet cold expelling of row that dispels the wind is also.The card of all sick wind, can not pitching as head term, and waist knee joint can not bend and stretch, or arthralgia pain is difficult to walk, numbness need not, all wind with cold due to, summer-heat is hindered also with wet institute; Must be by the toil of Radix Angelicae Pubescentis and temperature, activity QI and blood, the cold expelling heresy of dispelling, the beriberi therefore " book on Chinese herbal medicine " speech can fall apart, changes renal mass, treatment hernia abdominal mass, subduing inflammation, controls harmful wind hundred joints to attack bitterly, surely lacks the strongly fragrant headache of YIN-cold, is intended to this.

Flos Carthami acrid in the mouth warm in nature nontoxic enter conscience two warps, treat the swelling of traumatic injury sore.Carthamus yellow has calmness, analgesia and anti-frightened effect.Hot plate method in mice and acetic acid twisting experimental results show that: Carthamus yellow has analgesic activity, and can strengthen the central inhibitory action of barbital and chloral hydrate, reduce response rate and mortality rate that nikethamide is fainted from fear.Extract can suppress the caused foot swelling of carrageenin, points out it to have antiinflammatory action.Safflor yellow also has immunosuppressive action, can reduce the leukocytic phagocytic function of serum lysozyme content, peritoneal macrophage and whole blood.

The Herba Xanthii grass acrid-sweet flavor slightly poisonous anemofrigid-damp arthralgia that cures mainly warm in nature." herbal classic ": Herba Xanthii grass " spasm of the limbs pain, dislikes the dead mark of meat for the cold pain of main air head, rheumatism general arthralgia " is for rheumatic arthralgia.This product expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, uses dispelling the wind and dampness pathogens arthromyodynia, and spasm of the limbs can be alone.

Pyrola rotundifolia ssp.chinensis sweet in the mouth is warm in nature, slightly poisonous, removing blood stasis, externally used detumescence pain relieving, blood circulation promoting and blood stasis dispelling, the nameless gall that disappears, rheumatalgia.

Rhizoma Zingiberis Recens, pungent, tepor.

Tree root of Fructus Crataegi Pinnatifidae, has the effect of relaxing muscles and tendons and activating QI and blood in the collateral.Treatment rheumatoid arthromyodynia.

In the middle of the present invention, Radix Saposhnikoviae is that monarch drug goes first of all wind, and Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis are that the auxiliary Radix Saposhnikoviae of minister removes anemofrigid-damp arthralgia, the power reducing swelling and alleviating pain that Flos Carthami, Herba Xanthii grass, Pyrola rotundifolia ssp.chinensis are assistant the monarch and his subjects, and Herba Schizonepetae leads all medicines to disperse whole body to treat anemofrigid-damp arthralgia reducing swelling and alleviating pain for making.

The preparation method of the rheumatoid Chinese medicine composition for the treatment of of the present invention, specifically implement according to following steps:

Step 1

According to mass percent, take respectively Radix Saposhnikoviae 22% ~ 32%, Herba Schizonepetae 10% ~ 23%, Rhizoma Et Radix Notopterygii 10% ~ 24%, Radix Angelicae Pubescentis 5% ~ 15%, Flos Carthami 5% ~ 15%, Herba Xanthii 5% ~ 15%, Pyrola rotundifolia ssp.chinensis 2% ~ 6%, Rhizoma Zingiberis Recens 3%-5%, tree root of Fructus Crataegi Pinnatifidae 6-12%, the mass percent summation of above component is 100%;

Step 2

Each raw material pulverizer that step 1 is taken makes after pulverizing, fully mixing.

The rheumatoid Chinese medicine composition for the treatment of making by said method can be made fumigant with ventilative non-toxic material package.Using method is: fumigant is put into gassing machine and fumigate, temperature is controlled between 39-60 degree Celsius, is advisable with Human Tolerance, between time 30-40 minute, can not exceed 40 minutes.

The rheumatoid Chinese medicine composition for the treatment of making by said method can also add water, add the ratio of 2000ml water to mix according to every 53 grams of Chinese medicine compositions, heat 20 minutes to 95-100 degree Celsius, extract effective liquid by high pressure extract method and make rheumatism repair liquid spray, during for infrared ray and magnet therapeutic apparatus treatment, nebulizer is sprayed at lesion.

The rheumatoid Chinese medicine composition for the treatment of of the present invention, allergic constitution forbidding, serious symptom heart patient avoids use.

The present invention treats fumigant that rheumatoid Chinese medicine composition makes and rheumatoid repair liquid spray and can jointly arrange in pairs or groups and use treatment rheumatism.

Pharmacodynamic experiment:

Rheumatoid Chinese medicine composition analgesic activity:

1, the impact on the mice threshold of pain:

Adopt hot plate method to measure the threshold of pain, its condition is that hot plate temperature is 55 ± 0.5 DEG C.Get body weight 18g-20g female mice, after the response latency, select 20 of the mices that its response latency is no more than 30 hours, divide equally two groups, smear affected part with water decoction for one group; Another group is for matched group, to medicine.First group is applied in affected part with rheumatism, rheumatoid Chinese medicine composition water decoction (Chinese medicine composition 40g/kg of the present invention and 40ml water mix), measure the administration front and back mice response latency, 60 hours and 90 hours after the taking medicine response latency of result rheumatism, rheumatoid Chinese medicine composition group mice all obviously extended, and had proved that rheumatism, rheumatoid Chinese medicine composition have good analgesic effect.

2, electricity irritation Mus tail method:

Electricity irritation Mus tail method is measured analgesic effect, and its condition is that the unidirectional current used time 1-2 of 180v wounds mouse tail second, surveys the pain reaction number of times of mice, gets 10 of the mices of 16 grams of-20 grams of body weight, is divided into two groups, 5 every group, is divided into matched group and reference group.White mice and spray are that every kg body weight white mice 20g treats rheumatism, rheumatoid Chinese medicine composition according to weight ratio, and every kg body weight is treated rheumatism, rheumatoid Chinese medicine composition with 42g, add the ratio of 2000ml water to mix according to every 53 grams of Chinese medicine compositions again Chinese medicine composition and make rheumatism, rheumatoid repair liquid spray, being sprayed on white mice affected part observes, after administration, 10 minutes analgesia rates are respectively 71% and 86%, analgesia rate after 60 minutes distinguishes 89% and 97%, can find out and all have certain analgesic activity.

Anxious poison experiment:

Giving 20 Healthy Peoples with rheumatism doubly of 2-3, fumigant that rheumatoid Chinese medicine composition makes fumigates, do not find toxic reaction, continue and be sprayed on joint part to rheumatism, rheumatoid repair liquid spray 200ml, irradiate with infrared ray and magnet therapeutic apparatus simultaneously, observe 1-48 hour without toxic reaction, local without red and swollen, without anaphylaxis.

Embodiment 1

According to mass percent, take respectively 26% Radix Saposhnikoviae, 23% Herba Schizonepetae, 24% Rhizoma Et Radix Notopterygii, 6% Radix Angelicae Pubescentis, 5% Flos Carthami, 5% Herba Xanthii, 2% Pyrola rotundifolia ssp.chinensis, Rhizoma Zingiberis Recens 3%, tree root of Fructus Crataegi Pinnatifidae 6%, after the each raw material pulverizer taking is pulverized, fully mixed, make.

Embodiment 2

According to mass percent, take respectively 22% Radix Saposhnikoviae, 21% Herba Schizonepetae, 24% Rhizoma Et Radix Notopterygii, 6% Radix Angelicae Pubescentis, 5% Flos Carthami, 5% Herba Xanthii, 2% Pyrola rotundifolia ssp.chinensis, Rhizoma Zingiberis Recens 5%, tree root of Fructus Crataegi Pinnatifidae 10%, after the each raw material pulverizer taking is pulverized, fully mixed, make.

Embodiment 3

According to mass percent, take respectively 20% Radix Saposhnikoviae, 21% Herba Schizonepetae, 24% Rhizoma Et Radix Notopterygii, 6% Radix Angelicae Pubescentis, 5% Flos Carthami, 5% Herba Xanthii, 2% Pyrola rotundifolia ssp.chinensis, Rhizoma Zingiberis Recens 5%, tree root of Fructus Crataegi Pinnatifidae 12%, after the each raw material pulverizer taking is pulverized, fully mixed, make.

Claims (2)

1. the rheumatoid Chinese medicine composition for the treatment of, is characterized in that, according to mass percent, is made up of following raw material:

Radix Saposhnikoviae 22% ~ 32%, Herba Schizonepetae 10% ~ 23%, Rhizoma Et Radix Notopterygii 10% ~ 24%, Radix Angelicae Pubescentis 5% ~ 15%, Flos Carthami 5% ~ 15%, Herba Xanthii 5% ~ 15%, Pyrola rotundifolia ssp.chinensis 2% ~ 6%, Rhizoma Zingiberis Recens 3%-5%, tree root of Fructus Crataegi Pinnatifidae 6-12%, the mass percent summation of above component is 100%.

2. a preparation method for the treatment of rheumatoid Chinese medicine composition, is characterized in that, specifically implements according to following steps:

Step 1

According to mass percent, take respectively Radix Saposhnikoviae 22% ~ 32%, Herba Schizonepetae 10% ~ 23%, Rhizoma Et Radix Notopterygii 10% ~ 24%, Radix Angelicae Pubescentis 5% ~ 15%, Flos Carthami 5% ~ 15%, Herba Xanthii 5% ~ 15%, Pyrola rotundifolia ssp.chinensis 2% ~ 6%, Rhizoma Zingiberis Recens 3%-5%, tree root of Fructus Crataegi Pinnatifidae 6-12%, the mass percent summation of above component is 100%;

Step 2

After each raw material pulverizing that step 1 is taken, abundant mixing, make.