CN103860787A - 含有花蛤有效成分的治疗痤疮的外用中药 - Google Patents
含有花蛤有效成分的治疗痤疮的外用中药 Download PDFInfo
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Abstract
本发明公开了一种含有花蛤有效成分的治疗痤疮的外用中药，将芫荽子、广枣、颠茄草、水河剑、狗肝菜、落地生根、马蔺子、苘麻子放入煎药器具内，加入符合生活饮用水标准的洁净水，加水量以超过药面2-3cm为度，浸泡半小时；用武火煮沸后再改用文火煎煮半小时；将花蛤肉清洗干净捣碎后加入煎药器具内继续文火煎煮半小时，除去药渣，取汤剂即成。本发明与现有技术相比，疗效好、疗程短、副作用小、使用方便、成本低，本发明是通过长期探索，结合民间经验，研制出从天然动植物组合物中提取的活性成分，对痤疮、粉刺、青春痘有很好的祛除效果，使用安全可靠，方便卫生。
Description
技术领域
本发明属于中药领域，特别涉及含有花蛤有效成分的治疗痤疮的外用中药。
背景技术
近年来痤疮的流行病学调查发现，11-25 岁的青少年发病率达80 %以上，25-35的青年人发病率达15%以上，如不及时治疗或防治不当，可遗留终生难愈的瘫痕，而影响容貌，令众多青年患者十分苦恼。
痤疮俗称“粉刺”、“青春痘”，中医学称为：“肺风粉刺”、“面疤”，是一种多发于青少年的慢性皮肤炎症，由于肺胃热盛、流感风邪所致。本病好发于面部、前胸、肩背部及皮脂腺多的部位，有的像针头、芝麻大小毛孔性丘疹，丘疹周围红晕，顶部有黑色小点，也称“黑头粉刺”，挤压时有白色糊状物排出，可继续发展形成脓包痤疮，炎症严重者可发展成硬粉性或囊肿性痤疮。
西医治疗中，目前大多采用红霉素、氯霉素、安体舒通、甲硝哇、美满霉素等抗菌消炎为主药物或维A 酸类药物进行治疗，疗效并不显著、易复发，但有些抗菌消炎药物含有四环霉素，长期服用会加重肝、肾的负担，易造成毒副作用和过敏反应。中药治疗，常用药物有复方珍珠暗疮片、连翘败毒丸等，但在治愈率、治疗效果方面难以到达满意程度，另外，外用的膏霜虽然可以控制炎症，但会使毛囊、腺管更加堵塞，造成恶性循环，故而疗效欠佳。
发明内容
为了弥补现有技术的不足，本发明提供了一种疗效好、疗程短、副作用小、 使用方便、成本低的治疗痤疮的外用中药擦剂。具体是通过如下技术方案实现的：
含有花蛤有效成分的治疗痤疮的外用中药，制备方法为：称取花蛤肉50~100重量份、芫荽子5~30重量份、广枣5~30重量份、颠茄草5~30重量份、水河剑5~30重量份、狗肝菜5~30重量份、落地生根5~30重量份、马蔺子5~30重量份、苘麻子5~30重量份；将上述芫荽子、广枣、颠茄草、水河剑、狗肝菜、落地生根、马蔺子、苘麻子放入煎药器具内，加入符合生活饮用水标准的洁净水，加水量以超过药面2-3cm为度，浸泡半小时；用武火煮沸后再改用文火煎煮半小时；将花蛤肉清洗干净捣碎后加入煎药器具内继续文火煎煮半小时，除去药渣，取汤剂即成。
治疗方法：外用，每日1剂分3次擦洗，每次5分钟；连续治疗30天。
本发明的药物机理：
花蛤：肉味鲜美、营养丰富，蛋白质含量高，氨基酸的种类组成及配比合理； 脂肪含量低，不饱和脂肪酸较高，易被人体消化吸收，还有各种维生素和药用成分。含钙、镁、铁、锌等多种人体必需的微量元素，可作为人类的营养、绿色食品，深受消费者的青睐。蛤肉以及贝类软体动物中，含一种具有降低血清胆固醇作用的代尔太7—胆固醇和24—亚甲基胆固醇，它们兼有抑制胆固醇在肝脏合成和加速***胆固醇的独特作用，从而使体内胆固醇下降。它们的功效比常用的降胆固醇的药物谷固醇更强。人们在食用蛤肉和贝类食物后，常有一种清爽宜人的感觉，这对解除一些烦恼症状无疑是有益的。中医认为，蛤肉有滋阴明目、软坚、化痰之功效，有的贝类还有益精润脏的作用。
芫荽子：【别名】胡荽、香菜、香荽、胡荽子。【来源】伞形科植物芫荽的种子。【性味归经】性平，味辛。归肺经、胃经。【功效与作用】发表透疹、健胃。属解表药下属分类的辛温解表药。【临床应用】用量10~15克，煎汤;鲜用30~60克。用治麻疹不透、感冒无汗;消化不良、食欲不振。
广枣：【别名】五眼果、山枣、人面子。【来源】漆树科植物南酸枣的成熟果实。【性味归经】性平,味甘、酸。归经暂无。【功效与作用】行气活血、养心、安神。属安神药下分类的养心安神药。【临床应用】用量1.5~ 2.5克，煎服。用治气滞血瘀、胸痹作痛、心悸气短、心神不安。
颠茄草：【别名】美女草、别拉多娜草。【来源】茄科植物颠茄的全草。【性味归经】味微苦、辛，气微。【功效与作用】解痉止痛，抑制分泌。能解除平滑肌痉挛和抑制腺体分泌。【临床应用】用作抗胆碱药。临床用于胃及十二指肠溃疡，胃肠道、肾及胆绞痛等。颠茄草多用在制药工业上，供制备颠茄酊、颠茄流浸膏和颠茄浸膏等用。
水河剑：【别名】金星草、飞刀剑。【来源】蹄盖蕨科植物单叶双盖蕨的全草。【性味归经】性寒，味微苦、涩。归经暂缺。【功效与作用】凉血、止血、利尿通淋。属止血药下属分类的凉血止血药。【临床应用】用量9~15克，煎服。用治目赤肿痛、***、热淋尿血。
狗肝菜：【别名】青蛇仔、金龙棒、野辣椒。【来源】爵床科植物狗肝菜的全草。【性味归经】味甘、微苦，性凉。归心经、肝经、肺经。【功效与作用】清热凉血、利尿解毒。属清热药下分类的清热解毒药。【临床应用】用量50~100克，煎服。外用：捣敷或熬膏贴。用治感冒发热、肺热咳嗽、咽喉肿痛、风热目赤及小儿高热惊风；血热所致的斑疹及吐血、衄血、尿血等出血症；湿热痢疾、小便不利、妇女白带;外敷痈疖肿毒、带状疱疹、毒蛇咬伤。现亦用治流行性乙型脑炎及肝炎等疾病。
落地生根：【别名】打不死、脚目草、土三七。【来源】景天科植物落地生根的全草。【性味归经】性寒，味微酸、涩。归肺经、肾经。【功效与作用】解毒消肿、活血止痛、拔毒生肌。属止血药下分类的凉血止血药。【临床应用】用量15~30克。用治咽喉肿痛、热性胃痛、热泻热痢、咳血、吐血、火眼、中耳炎、痈肿疔毒、乳痈、水火烫伤、外伤出血等。
马蔺子：【别名】荔实、马楝子、马莲子。【来源】鸢尾科植物马蔺的成熟种子。【性味归经】性平，味甘。归肝经、胃经、脾经、肺经。【功效与作用】清热利湿、消肿解毒、止血。属止血药下分类的凉血止血药。【临床应用】用量5~ 10克，内服煎汤治疗黄疸型肝炎、痢疾、吐血、衄血、血崩、白带、咽炎、痈肿、疝痛。外用适量捣敷。治疗骨结核：马蔺子置铁锅内炒干研粉，内服，每日3次，每次5。7克，小儿酌减。
苘麻子：【别名】苘实、空麻子、磨盘树子、冬葵子。【来源】锦葵科植物苘麻的成熟种子。【性味归经】性凉，味苦。归大肠经、小肠经。【功效与作用】清热解毒、利水消肿、通乳、退翳。属利水渗湿药下分类的利水消肿药。【临床应用】用于赤白痢疾、水肿尿少、热淋小便涩痛、产后乳汁不通、***胀痛及痈肿、目翳等症。内服：煎汤，用量5~ 10克，或入丸散。
本发明的治疗痤疮的外用中药有益效果是：疗效好、疗程短、副作用小、使用方便、成本低，本发明是通过长期探索，结合民间经验，研制出从天然动植物组合物中提取的活性成分，对痤疮、粉刺、青春痘有很好的祛除效果，使用安全可靠，方便卫生。
具体实施方式
实施例1：
称取花蛤肉50g、芫荽子30g、广枣5g、颠茄草30g、水河剑5g、狗肝菜30g、落地生根5g、马蔺子30g、苘麻子5g；将上述芫荽子、广枣、颠茄草、水河剑、狗肝菜、落地生根、马蔺子、苘麻子放入煎药器具内，加入符合生活饮用水标准的洁净水，加水量以超过药面2-3cm为度，浸泡半小时；用武火煮沸后再改用文火煎煮半小时；将花蛤肉清洗干净捣碎后加入煎药器具内继续文火煎煮半小时，除去药渣，取汤剂即得治疗痤疮的外用中药。
实施例2：
称取花蛤肉100g、芫荽子5g、广枣30g、颠茄草5g、水河剑30g、狗肝菜5g、落地生根30g、马蔺子5g、苘麻子30g；将上述芫荽子、广枣、颠茄草、水河剑、狗肝菜、落地生根、马蔺子、苘麻子放入煎药器具内，加入符合生活饮用水标准的洁净水，加水量以超过药面2-3cm为度，浸泡半小时；用武火煮沸后再改用文火煎煮半小时；将花蛤肉清洗干净捣碎后加入煎药器具内继续文火煎煮半小时，除去药渣，取汤剂即得治疗痤疮的外用中药。
实施例3：
称取花蛤肉75g、芫荽子16g、广枣16g、颠茄草17g、水河剑17g、狗肝菜18g、落地生根16g、马蔺子18g、苘麻子17g；将上述芫荽子、广枣、颠茄草、水河剑、狗肝菜、落地生根、马蔺子、苘麻子放入煎药器具内，加入符合生活饮用水标准的洁净水，加水量以超过药面2-3cm为度，浸泡半小时；用武火煮沸后再改用文火煎煮半小时；将花蛤肉清洗干净捣碎后加入煎药器具内继续文火煎煮半小时，除去药渣，取汤剂即得治疗痤疮的外用中药。
临床资料：
对安徽300例痤疮患者进行临床观察治疗，其中男性195例，女性105例，年龄19至65岁，平均年龄45岁。随即分成3个治疗组，每组100人，治疗组1采用实施例1的中药治疗；治疗组2采用实施例2的中药治疗；治疗组3采用实施例3的中药治疗。
(1) 治疗方法 ：
外用，每日1剂分3次擦洗，每次5分钟；连续治疗30天。
(2) 疗效评定标准：
痊愈：皮损消退率≥ 95％，或仅遗留少许色素沉着，症状消失；
显效：皮损大部分消退，消退率70％~95％，症状明显减轻；
有效：皮损部分消退，消退率50％~70％，症状改善；
无效：皮损消退不明显或者加重，消退率＜50％，症状未见变化。
(3)治疗效果：
治疗组1：痊愈90例，占90％；显效10例，占10％；有效0例；无效0例；总有效率100％；
治疗组2：痊愈65例，占65％；显效35例，占35％；有效0例；无效0例；总有效率100％；
治疗组3：痊愈70例，占70％；显效30例，占30％；有效0例；无效0例；总有效率100％。
典型病例：
1、郑某，男，28岁，皮肤油脂分泌旺盛，面颊部密集多个丘疹脓包，前额、下颌也有少许小结节，舌质红，苔薄黄，脉浮滑数，伴有便秘等症状。用本发明实施例1的中药60天，症状明显减轻，继续服用2个疗程，痊愈，半年后随访无复发。
2、朱某，女，24岁，面部油腻，毛孔粗大，面部除鼻及眼外，均可见红色或淡红色丘疹，可挤出白粉色油状物，大结节挤压有稀薄脓性及血性分泌物。用本发明实施例2的中药60天，症状明显好转，继续使用30天，痊愈，一年后随访无复发。
3、黄某，男，21岁，患有痤疮已有多年，面颊部痤疮融合成片，色红，尖部有脓包。用本发明实施例3的中药60天，症状明显好转，继续使用30天，痊愈，一年后随访无复发。
以上所述，仅为本发明的较佳实施例，并非用于限定本发明的保护范围。本领域技术人员应当理解的是，本发明的保护范围以所附的权利要求书为准。
Claims (1)
1. 含有花蛤有效成分的治疗痤疮的外用中药，其特征在于制备方法为：称取花蛤肉50~100重量份、芫荽子5~30重量份、广枣5~30重量份、颠茄草5~30重量份、水河剑5~30重量份、狗肝菜5~30重量份、落地生根5~30重量份、马蔺子5~30重量份、苘麻子5~30重量份；将上述芫荽子、广枣、颠茄草、水河剑、狗肝菜、落地生根、马蔺子、苘麻子放入煎药器具内，加入符合生活饮用水标准的洁净水，加水量以超过药面2-3cm为度，浸泡半小时；用武火煮沸后再改用文火煎煮半小时；将花蛤肉清洗干净捣碎后加入煎药器具内继续文火煎煮半小时，除去药渣，取汤剂即成。
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