CN103849653B - A kind of preparation method of the Hongqu powder (red colouring agent) of no citrinin High color values - Google Patents
A kind of preparation method of the Hongqu powder (red colouring agent) of no citrinin High color values Download PDFInfo
- Publication number
- CN103849653B CN103849653B CN201410118527.4A CN201410118527A CN103849653B CN 103849653 B CN103849653 B CN 103849653B CN 201410118527 A CN201410118527 A CN 201410118527A CN 103849653 B CN103849653 B CN 103849653B
- Authority
- CN
- China
- Prior art keywords
- citrinin
- liquid
- culture medium
- colouring agent
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CQIUKKVOEOPUDV-IYSWYEEDSA-N antimycin Chemical compound OC1=C(C(O)=O)C(=O)C(C)=C2[C@H](C)[C@@H](C)OC=C21 CQIUKKVOEOPUDV-IYSWYEEDSA-N 0.000 title claims abstract description 51
- CQIUKKVOEOPUDV-UHFFFAOYSA-N citrinine Natural products OC1=C(C(O)=O)C(=O)C(C)=C2C(C)C(C)OC=C21 CQIUKKVOEOPUDV-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 239000000843 powder Substances 0.000 title claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 26
- 238000004040 coloring Methods 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 49
- 238000000855 fermentation Methods 0.000 claims abstract description 40
- 230000004151 fermentation Effects 0.000 claims abstract description 40
- 239000001963 growth medium Substances 0.000 claims abstract description 34
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 15
- 230000001580 bacterial effect Effects 0.000 claims abstract description 14
- -1 carbon ketone Chemical class 0.000 claims abstract description 12
- 229920002261 Corn starch Polymers 0.000 claims abstract description 7
- 239000008120 corn starch Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 7
- 210000000582 semen Anatomy 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000011218 seed culture Methods 0.000 claims description 10
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Inorganic materials [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 10
- 241000031003 Monascus ruber Species 0.000 claims description 9
- 239000007836 KH2PO4 Substances 0.000 claims description 7
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 7
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 7
- 238000003556 assay Methods 0.000 claims description 6
- 230000033228 biological regulation Effects 0.000 claims description 6
- 239000003547 immunosorbent Substances 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 5
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 5
- 239000012531 culture fluid Substances 0.000 claims description 4
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- 239000011686 zinc sulphate Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 239000001888 Peptone Substances 0.000 claims description 3
- 108010080698 Peptones Proteins 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 3
- 229910052564 epsomite Inorganic materials 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 238000011177 media preparation Methods 0.000 claims description 3
- 235000019319 peptone Nutrition 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 3
- 240000007594 Oryza sativa Species 0.000 abstract description 3
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract description 3
- 235000009566 rice Nutrition 0.000 abstract description 3
- 244000113306 Monascus purpureus Species 0.000 description 11
- 235000002322 Monascus purpureus Nutrition 0.000 description 11
- 229940057059 monascus purpureus Drugs 0.000 description 11
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 10
- 239000000047 product Substances 0.000 description 6
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 239000001054 red pigment Substances 0.000 description 2
- 235000010344 sodium nitrate Nutrition 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 231100000678 Mycotoxin Toxicity 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000002824 peroxisome Anatomy 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000020795 whole food diet Nutrition 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410118527.4A CN103849653B (en) | 2014-03-27 | 2014-03-27 | A kind of preparation method of the Hongqu powder (red colouring agent) of no citrinin High color values |
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CN201410118527.4A CN103849653B (en) | 2014-03-27 | 2014-03-27 | A kind of preparation method of the Hongqu powder (red colouring agent) of no citrinin High color values |
Publications (2)
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CN103849653A CN103849653A (en) | 2014-06-11 |
CN103849653B true CN103849653B (en) | 2016-07-27 |
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CN201410118527.4A Active CN103849653B (en) | 2014-03-27 | 2014-03-27 | A kind of preparation method of the Hongqu powder (red colouring agent) of no citrinin High color values |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104694400B (en) * | 2015-03-30 | 2018-05-08 | 福建农林大学 | A kind of method that solid state fermentation prepares High color values monascus product |
CN111394404A (en) * | 2019-05-14 | 2020-07-10 | 江苏臻大天园健康科技有限公司 | Method for producing coenzyme Q10 by using red yeast rice |
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CN102702780A (en) * | 2012-01-18 | 2012-10-03 | 天津天康源生物技术有限公司 | Method for preventing fading of monascus red pigment and application thereof |
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2014
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CN103849653A (en) | 2014-06-11 |
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TR01 | Transfer of patent right |
Effective date of registration: 20191021 Address after: 236820 No. 1298, Ziyuan Road, Qiaocheng Economic Development Zone, Bozhou City, Anhui Province Patentee after: Bozhou Kanghe traditional Chinese Medicine Technology Co.,Ltd. Address before: 510663 Guangzhou high tech Industrial Development Zone, Guangdong Province, No. 3 spectrum East Road, A410 Patentee before: GUANGZHOU DAZHENG ADVANCED MATERIAL TECHNOLOGY Co.,Ltd. |
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TR01 | Transfer of patent right | ||
CP03 | Change of name, title or address |
Address after: No. 1298, Ziyuan Road, Qiaocheng Economic Development Zone, Bozhou City, Anhui Province, 236800 Patentee after: Anhui Kanghe traditional Chinese Medicine Technology Co.,Ltd. Address before: No. 1298, Ziyuan Road, Qiaocheng Economic Development Zone, Bozhou City, Anhui Province, 236820 Patentee before: Bozhou Kanghe traditional Chinese Medicine Technology Co.,Ltd. |
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CP03 | Change of name, title or address | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of high color value red yeast powder without citrinin Effective date of registration: 20231212 Granted publication date: 20160727 Pledgee: Bozhou Yaodu Rural Commercial Bank Co.,Ltd. Pledgor: Anhui Kanghe traditional Chinese Medicine Technology Co.,Ltd. Registration number: Y2023980070851 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |