CN103830675B - A kind of pharmaceutical composition for the treatment of hyperlipemia - Google Patents
A kind of pharmaceutical composition for the treatment of hyperlipemia Download PDFInfo
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- CN103830675B CN103830675B CN201410080484.5A CN201410080484A CN103830675B CN 103830675 B CN103830675 B CN 103830675B CN 201410080484 A CN201410080484 A CN 201410080484A CN 103830675 B CN103830675 B CN 103830675B
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Abstract
The present invention relates to a kind of Chinese medicine composition for the treatment of hyperlipidemia, it is characterized in that being made up of the Chinese crude drug of following weight portion: Rhizoma Sparganii 12-24, Radix Rhapontici 6-12, Herb Gynostemmae Pentaphylli 4-8, Cortex Eucommiae 40-60, Radix Polygoni Multiflori 30-60, Herba Potentillae Discoloris 20-40, Rhizoma Curcumae Longae 40-60, Fructus Arctii 20-60, Herba Centellae 12-24, Radix Glycyrrhizae 12-18.The present invention has evident in efficacy, and side effect is little, effective percentage advantages of higher.
Description
Technical field
The present invention relates to medical art, be specifically related to a kind of pharmaceutical composition being used for the treatment of hyperlipemia.
Background technology
Hyperlipemia is commonly encountered diseases and the frequently-occurring disease of person in middle and old age, and along with the raising of people's living standard and the change of living habit, the sickness rate of this disease obviously increases, and the age of morbidity also shifts to an earlier date to some extent.Atherosclerosis caused by hyperlipemia causes the main cause of coronary heart disease, hypertension and cerebrovascular disease.So the treatment of hyperlipemia is extremely important, this has caused showing great attention to of the whole mankind.The final purpose for the treatment of hyperlipemia suppresses arterioscleroticly to further develop, thus prevent the death that caused by cardio-cerebrovascular diseases.
Mainly adopt Western medicine to be main to the treatment of hyperlipemia at present, main cause is that Western medicine is rapid-action, and stable curative effect, be subject to everybody favor, but Western medicine there is toxic and side effects in various degree, easily produces drug dependence.And Chinese medicine is in treatment hyperlipemia, prevent the aspects such as cardiovascular and cerebrovascular disease generation from having unique advantage, its curative effect certainly, lasting, side effect is little, is that Western medicine institute is incomparable.Particularly in differentiation of symptoms and signs for classification of syndrome, embody the flexible prescription of the traditional Chinese medical science, the therapeutic features of giving treatment in accordance with the patient’s individuality.But this wherein, some prescriptions are excessive, and curative effect is indefinite, and what have causes price quite high owing to employing rare medicinal herbs in side, can obtain the medicine phoenix feathers and unicorn horns especially of listing smoothly.
Summary of the invention
Main purpose of the present invention has carried out lot of experiments on the basis of secret prescription handed down in the family from generation to generation, determine medical material prescription and the drug dose of medicine of the present invention, provide between a kind of each medical material and can work in coordination with compatibility, clinical efficacy is good, is used for the treatment of the Chinese medicine composition of hyperlipemia.
The technical scheme that the present invention takes is:
The Chinese medicine composition being used for the treatment of hyperlipemia of the present invention is made up of the Chinese crude drug of following weight portion:
Rhizoma Sparganii 12-24, Radix Rhapontici 6-12, Herb Gynostemmae Pentaphylli 4-8, Cortex Eucommiae 40-60, Radix Polygoni Multiflori 30-60, Herba Potentillae Discoloris 20-40, Rhizoma Curcumae Longae 40-60, Fructus Arctii 20-60, Herba Centellae 12-24, Radix Glycyrrhizae 12-18.
As one of preferred technical scheme, the Chinese medicine composition being used for the treatment of hyperlipemia of the present invention is made up of the Chinese crude drug of following weight portion:
Rhizoma Sparganii 24, Radix Rhapontici 12, Herb Gynostemmae Pentaphylli 6, the Cortex Eucommiae 48, Radix Polygoni Multiflori 36, Herba Potentillae Discoloris 36, Rhizoma Curcumae Longae 48, Fructus Arctii 24, Herba Centellae 18, Radix Glycyrrhizae 16.
As preferred technical scheme two, the Chinese medicine composition being used for the treatment of hyperlipemia of the present invention is made up of the Chinese crude drug of following weight portion:
Rhizoma Sparganii 18, Radix Rhapontici 6, Herb Gynostemmae Pentaphylli 4, the Cortex Eucommiae 40, Radix Polygoni Multiflori 30, Herba Potentillae Discoloris 24, Rhizoma Curcumae Longae 40, Fructus Arctii 30, Herba Centellae 12, Radix Glycyrrhizae 12.
Fang Xie:
Rhizoma Sparganii: be the dry tuber of Sparganiaceae plant rhizoma scirpi SparganiumstoloniferumBuch.-Ham..Nature and flavor are pungent, bitter, flat.Return liver, spleen channel.Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Skin ulcer swells hard.
Radix Rhapontici: be feverfew centaurea monanthos Georgi Rhaponticumuniflorum(L.) dry root of DC..Nature and flavor: bitter, cold.Return stomach warp.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, and relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.
Herb Gynostemmae Pentaphylli: be cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemmapentaphyllum(Thunb.) herb of Mak..Nature and flavor: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.For chronic bronchitis, infectious hepatitis, nephritis is scorching, gastroenteritis.
The Cortex Eucommiae: be the dry bark of Eucommiaceae plant Cortex Eucommiae EucommiaulmoidesOliv..Nature and flavor: sweet, temperature.
Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix Polygoni Multiflori: be the dried root of polygonum multiflorum thunb PolygonummultiflorumThunb., nature and flavor: bitter, sweet, puckery, temperature.Gui Jing: return liver, the heart, kidney channel.Function cures mainly: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Herba Potentillae Discoloris: Rosaceae potentilla plants Herba Potentillae Discoloris PotentilladiscolorBunge, is used as medicine with herb or root.Xia Qiu gathers, and cleans and dries.Nature and flavor: sweet, micro-hardship are flat.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For enteritis, bacillary dysentery, amebic dysentery, spit blood, epistaxis, has blood in stool, leucorrhea; Wound is controlled in external, carbuncle furuncle and phyma poison.
Rhizoma Curcumae Longae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae CurcumalongaL..Nature and flavor: pungent, bitter, temperature.Return spleen, Liver Channel.Function cures mainly: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.
Fructus Arctii: be the dry mature fruit of feverfew Fructus Arctii ArctiumlappaL..Nature and flavor: pungent, bitter, cold.
Attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Herba Centellae: be samphire Herba Centellae Centellaasiatica(L.) the dry herb of Urb..Nature and flavor bitter, acrid, cold.Return liver,spleen,kidney warp.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
Radix Glycyrrhizae: sweet in the mouth, property is put down, nontoxic.Cure mainly vital organs of the human body cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.
Drug combination preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms include but not limited to: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill.Be preferably capsule, can according to the preparation technology of routine, direct crushed filling No. 0 capsule uses.
The pharmaceutical composition that the invention provides a kind for the treatment of hyperlipidemia has the following advantages:
1. pharmaceutical composition of the present invention is worked in coordination with mutually, mutually promotes, and in a short time blood fat can be dropped to normal level, and to the various diseases caused because of hyperlipemia as coronary atherosclerosis, heart infarction, cerebral arteriosclerosis, cerebral thrombosis etc. have treatment and preventive effect.
2. Chinese medicine composition of the present invention can without extraction, and direct crushed filling capsule uses.
3. Chinese medicine composition dosage of the present invention is economized, cheap for manufacturing cost.
4. clinical experiment confirms, Chinese medicine composition good effect of the present invention, and side effect is little, and to the cure rate of hyperlipidemia more than 68%, total effective rate is greater than 90%.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but range of application of the present invention is not limited to the following example, some modification and equivalent variations are apparent for those of ordinary skill in the art and comprise within the scope of the invention.
Example of formulations 1
Accurately take Rhizoma Sparganii 240g, Radix Rhapontici 120g, Herb Gynostemmae Pentaphylli 60g, Cortex Eucommiae 480g, Radix Polygoni Multiflori 360g, Herba Potentillae Discoloris 360g, Rhizoma Curcumae Longae 480g, Fructus Arctii 240g, Herba Centellae 180g, Radix Glycyrrhizae 160g, dry, pulverize, cross 200 mesh sieves, sterilizing, fills No. 0 capsule.
Example of formulations 2
Accurately take Rhizoma Sparganii 180g, Radix Rhapontici 60g, Herb Gynostemmae Pentaphylli 40g, Cortex Eucommiae 400g, Radix Polygoni Multiflori 300g, Herba Potentillae Discoloris 240g, Rhizoma Curcumae Longae 400g, Fructus Arctii 300g, Herba Centellae 120g, Radix Glycyrrhizae 120g, dry, pulverize, cross 200 mesh sieves, sterilizing, fills No. 0 capsule.
Embodiment 3, animal acute toxicity test of the present invention
Medicine: the embodiment of the present invention 3 prescription.
Experimental animal: regular grade NIH mice 12, body weight 18g ± 2g, male and female half and half.
Method and result:
1) Pharmaceutical formulations: the prescription of Example 1, is assigned to 200g/L suspension with the normal saline containing 2% Radix Acaciae senegalis:
2) experiment adopts gastric infusion mode.Once daily, volume 2ml/100g body weight, close observation 8h also notes down, and continues to observe 7d;
3) 7d small mouse is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirty, and without fainting from fear addicted to saliva, eye, mouth, nose, ear and crissum secretions without exception, without the rotten toe of docking.Select 5 execution, finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes, and shows the oral safety of this medicine.
Embodiment 4 long-term toxicity test for animals of the present invention
Medicine: the embodiment of the present invention 1 prescription.
Animal: regular grade SD rat 24, body weight 200g ± 10g, male and female half and half, are divided into 3 groups at random.
Method and result:
1) Pharmaceutical formulations: point high, medium and low three dosage groups, are respectively 300,150,75 times of clinical application amount, mixes with the normal saline 1:1 containing 2% Radix Acaciae senegalis;
2) experiment adopts gastric infusion mode, successive administration 45d, namely more than 3 clinical cycles, observe animal general toxic reaction and the order of severity, each position is checked by rule of operation after execution, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach;
3) long-term oral administration, there is not toxic reaction in high, medium and low three dosage treated animals.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, to think through proved by pathology to animal without poisoning manifestations.
Embodiment 5 clinical experiment
One, clinical data: adopt the present invention to treat hyperlipemia 100 example, wherein man 58 example, female 42 example, the oldest 80 years old, minimum 38 years old of age.
Two, clinical symptoms: dizziness, neurolysis, face yellow wart, cramp, hypomnesis, sensation of oppression over the chest with shortness of breath, visual deterioration etc.; Serum cholesterol more than 230 grams/100 milliliters, triglyceride more than 140 milligrams/100 milliliters, beta lipoprotein more than 390 milligrams/100 milliliters.
Three, Therapeutic Method: patient every day early, evening, respectively the capsule 3-4 grain prepared of the oral embodiment of the present invention 1 weight proportion on an empty stomach; It within 15 days, is a course for the treatment of.
Four, the standard of curative effect evaluation:
Cure: transference cure, experimental check is normal;
Take a turn for the better: symptom is obviously improved, and lab testing is improved;
Do not heal: symptom is not improved or deterioration person, lab testing is without improvement.
Five, model case:
1, together certain, man, 62 years old, suffer from hyperlipidemia 5 years, Symptoms be dizziness, headache, hypomnesis etc., and inspection data show that blood fat is high, high with blood pressure, blood glucose; Take capsule of the present invention two the symptom course for the treatment of obviously to improve, take four recoveries from illness courses for the treatment of, blood fat recovers normal; Follow up a case by regular visits to 1 year, do not recur.
2, bent certain, man, 58 years old, suffers from hyperlipidemia 10 years, and Symptoms be dizzy, forgetful, visual deterioration etc., and inspection data show that blood fat is high, high with blood pressure, blood glucose; Take capsule of the present invention two the symptom course for the treatment of obviously to improve, take four recoveries from illness courses for the treatment of, blood fat recovers normal; Follow up a case by regular visits to 1 year, do not recur.
3, Wang, female, 46 years old, dizziness, neurolysis, sensation of oppression over the chest with shortness of breath, looked into as hyperlipidemia through hospital, takes two courses for the treatment of of capsule of the present invention, substantially cure.Check indices cholesterol, triglyceride, high density lipoprotein, the indices such as low density lipoprotein, LDL, all within normal range, are followed up a case by regular visits to 2 years, are not recurred.
Six, therapeutic outcome:
Adopt the present invention to treat hyperlipemia 100 example, through the treatment of 2-6 the course for the treatment of, wherein cure 68 examples, cure rate is 68%, and take a turn for the better 28%, total effective rate is 96%; Result shows, traditional Chinese medicine composition for treating hyperlipidemia of the present invention is evident in efficacy, can promote the use of.
Claims (3)
1. treat the Chinese medicine composition of hyperlipidemia for one kind, it is characterized in that, be made up of the Chinese crude drug of following weight portion: Rhizoma Sparganii 12-24, Radix Rhapontici 6-12, Herb Gynostemmae Pentaphylli 4-8, Cortex Eucommiae 40-60, Radix Polygoni Multiflori 30-60, Herba Potentillae Discoloris 20-40, Rhizoma Curcumae Longae 40-60, Fructus Arctii 20-60, Herba Centellae 12-24, Radix Glycyrrhizae 12-18.
2. a kind of Chinese medicine composition for the treatment of hyperlipidemia as claimed in claim 1, is characterized in that, be made up of the Chinese crude drug of following weight portion:
Rhizoma Sparganii 24, Radix Rhapontici 12, Herb Gynostemmae Pentaphylli 6, the Cortex Eucommiae 48, Radix Polygoni Multiflori 36, Herba Potentillae Discoloris 36, Rhizoma Curcumae Longae 48, Fructus Arctii 24, Herba Centellae 18, Radix Glycyrrhizae 16.
3. a kind of Chinese medicine composition for the treatment of hyperlipidemia as claimed in claim 1, is characterized in that, be made up of the Chinese crude drug of following weight portion:
Rhizoma Sparganii 18, Radix Rhapontici 6, Herb Gynostemmae Pentaphylli 4, the Cortex Eucommiae 40, Radix Polygoni Multiflori 30, Herba Potentillae Discoloris 24, Rhizoma Curcumae Longae 40, Fructus Arctii 30, Herba Centellae 12, Radix Glycyrrhizae 12.
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| 中药降血脂作用研究进展;庄瑞丰;《河北医药》;20090531;第31卷(第9期);1119-1120页 * |
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Inventor after: Wang Bo Inventor after: Song Weinan Inventor after: Zhang Peijuan Inventor before: Liu Yu |
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Effective date of registration: 20160316 Address after: Qingdao City, Shandong province 266042 four Road No. 127 Applicant after: QINGDAO TUMOUR HOSPITAL Address before: 266109, 1, 700 the Great Wall Road, Chengyang District, Shandong, Qingdao Applicant before: Zhuang Yan |
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