CN103829933A - Method for detecting vessel stenosis based on double interventional pressure sensors - Google Patents

Method for detecting vessel stenosis based on double interventional pressure sensors Download PDF

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Publication number
CN103829933A
CN103829933A CN201210470083.1A CN201210470083A CN103829933A CN 103829933 A CN103829933 A CN 103829933A CN 201210470083 A CN201210470083 A CN 201210470083A CN 103829933 A CN103829933 A CN 103829933A
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pressure transducer
pressure
narrow
lumen
circuit board
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任勇
于洋
赵培森
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Abstract

The invention relates to a method for detecting vessel stenosis based on double interventional pressure sensors. According to the method for detecting the vessel stenosis based on double interventional pressure sensors, the two pressure sensors are guided into a blood vessel (mainly the artery blood vessel) in an interventional mode, and whether stenosis happens to the blood vessel between the two pressure sensors can be judged by measuring the numerical values of the two pressure sensors through calculation.

Description

The two pressure sensing lumen of vessels stenosis detection methods of insertion type
Technical field
The present invention relates to one in medical field, detect the narrow method of lumen of vessels.
Background technology
At present, China's cardiovascular patient has 2.3 hundred million at least, hyperpietic 200,000,000, in numerous kinds of cardiovascular disease, the M & M of coronary heart disease is high, increases comparatively fast, between 1998 to 2008, China's males with coronary disease sickness rate will increase by 26.1% the same period more in the past, and women will increase by 19.0%.Coronary heart disease Etiological is to pile up and form white speckle at some lipid materials of endarterium, causes lumen of artery narrow, and blood flow is obstructed, and causes heart ischemia, produces angina pectoris.Generally, patients with coronary heart disease carries out cardiac stent intervene operation more, and 2011, China's cardiac stent intervene operation 40.8 ten thousand examples, and with annual 35% speed increment.
Coronary heart disease mainly causes by lumen of artery is narrow, therefore it is detected very important.The detection method of coronary heart disease, has the methods such as thermal imaging, radionuclide, excusing from death kinetocardiogram, coronarography at present.These methods, without exception, all need a larger instrument and equipment to carry out auxiliary detection, and can only carry out in hospital, can not be carried at patient and detect in real time with it.Patent of the present invention aims to provide a kind of lumen of vessels stenosis detection method getting involved in body, and volume is little, can carry, and can detect in real time patient.
Summary of the invention
The object of this invention is to provide the two pressure sensing lumen of vessels stenosis detection methods of insertion type.
The step of this method is:
Step 1: get involved two pressure transducers in human body section blood vessel: pressure transducer 1 (1001) and pressure transducer 2 (1002), as shown in fig. 1;
Step 2: read pressure transducer 1 (1001) and the measured numerical value P of pressure transducer 2 (1002) 1and P 2;
Step 3: according to P 1and P 2pressure differential, judge between pressure transducer 1 (1001) and pressure transducer 2 (1002) whether occur angiostenosis.If
Figure BSA00000808048400011
be less than certain threshold k, think do not occur narrow; If
Figure BSA00000808048400012
be greater than certain threshold k, think that appearance is narrow.Or by P 1and P 2as parameter index, offer doctor and carry out reference.
The specification specified of said method:
In step 1, the fixing means of two pressure transducers: general two pressure transducers are fixed on a strip flexible PCB, have some components and parts on circuit board, is responsible for the functions such as power supply, communication, read sensor numerical value.Flexible PCB can compatible shell parcel with biology.
In step 1, the interventional method of two pressure transducers: (as shank large artery trunks) opening in human vas somewhere, utilize tubule that above-mentioned strip circuit board is imported in blood vessel, and go deep into diseased region, detect.
In step 2, pressure sensor data reading manner: the value of pressure transducer, by the chip on circuit board, is launched with communication, passes to body external connector.
In step 2, the power supply mode of circuit board: can carry minicell on circuit board, also can utilize wireless power technology.
In step 3, judge narrow principle: due to the iris action of angiostenosis part, cause blood vessel to intercept rear portion areal pressure and diminish, then become again large, as shown in Figure 2.Therefore, the pressure of sensor 2 (1002) is less than sensor 1 (1001).
Figure BSA00000808048400013
be less than certain threshold k, think do not occur narrow; If be greater than certain threshold k, think that appearance is narrow.Through verification experimental verification, draw empirical data, can setting threshold K ∈ (0.05,0.3).
Advantage of the present invention is: small volume, whether occur in can Real-Time Monitoring section blood vessel narrowly, and send in time early warning information, patient was treated timely and effectively in the optimal treatment phase.
Accompanying drawing explanation
The two pressure sensing lumen of vessels stenosis detection method schematic diagrams of Fig. 1 insertion type
The each interfacial pressure scattergram of blood vessel when Fig. 2 lumen of vessels is narrow
The specific embodiment
The present invention is intended to propose a kind of method, and in this method, need to use the hardware device that some do not have on the market, in order to prove the feasibility of this method, in case study on implementation, the preparation scheme of the needed hardware device of this method is proposed in the lump.
The preparation scheme of detection module in body: in body, detection module is shaped as strip, its internal circuit comprises two pressure transducers (being distributed in module two ends), radio communication radiating circuit, wireless charging receiving circuit, electric energy temporary storage cell (as electric capacity), and this module is wrapped up by biological compatibility shell.Wherein, miniature pressure transducer, radio communication radiating circuit, radio communication receiving circuit, electric energy temporary storage cell are mature technology, therefore do not repeat them here.In this module, contain inflated type fixed support, this support contains balloon, in the time that this module arrives detected position, balloon inflation, support is opened, and is supported in blood vessel wall, make detection module be fixed on detected position, the similar existing cardiac stent of this supporting structure.This module also can directly be fixed on cardiac stent, and cardiac stent is used in conjunction with.
External module core component comprises: radio communication receiving circuit, wireless charging radiating circuit, processor, display, memorizer, some buttons.
Step 1: at human body thigh tremulous pulse place opening, above-mentioned detection module is fixed on conduit to (this catheter is like cardiac stent intervene operation conduit), detection module is imported to position to be detected with conduit.Opening fixed support fixes.
Step 2: external module utilizes wireless charging radiating circuit to charge to body inner module, body inner module by power storage at electric energy temporary storage cell, now, body inner module is transferred to external module by the data of pressure transducer by radio communication radiating circuit, and external module receives the data of two pressure transducers.
Step 3: external module receives after the data of two pressure transducers, and processor resolves, if
Figure BSA00000808048400022
be less than certain threshold k, think do not occur narrow; If
Figure BSA00000808048400023
be greater than certain threshold k, think that appearance is narrow.Through verification experimental verification, draw empirical data, can setting threshold K ∈ (0.05,0.3).Or by P 1and P 2as parameter index, offer doctor and carry out reference, diagnosed by doctor.Processor shows result by display, and can deposit in memorizer, facilitates doctor to check data enquiry of historical data.
The implementation case is the one of the method implementation method, and details part may disagree, but not from this method scope.As detection module in body adopts micro cell power supply, and do not adopt wireless power mode, such situation, all within the scope of the invention.

Claims (8)

1. the narrow detection method of lumen of vessels, is characterized in that: adopt insertion type scheme, two pressure sensings (pressure transducer 1 and pressure transducer 2) are got involved in human vas, measure respectively the numerical value P of two pressure transducers 1and P 2, according to P 1and P 2pressure differential, judge between these two pressure transducers whether occur angiostenosis.If
Figure FSA00000808048300011
be less than certain threshold k, think do not occur narrow; If be greater than certain threshold k, think that appearance is narrow; Or P 1and P 2as with reference to value, offer doctor and carry out reference, diagnosed by doctor.Wherein, along blood flow direction, pressure transducer 1 is front, and pressure transducer 2 is rear.
2. the narrow detection method of a kind of lumen of vessels according to claim 1, is characterized in that: through verification experimental verification, draw empirical data, and can setting threshold K ∈ (0.05,0.3).
3. the narrow detection method of a kind of lumen of vessels according to claim 1, is characterized in that: pressure transducer 1 and pressure transducer 2 are fixed on same strip flexible PCB.
4. the narrow detection method of a kind of lumen of vessels according to claim 1, is characterized in that: in human body somewhere arteriotomy, utilize conduit that two fixing circuit boards of pressure transducer are imported to detected position.
5. circuit board according to claim 2, is characterized in that: it adopts biology to wrap up by compatible shell.
6. circuit board according to claim 2, is characterized in that: integrated wireless communication element on it, can send to external receiving equipment by wireless signal by the data of two sensors.
7. circuit board according to claim 2, is characterized in that: it adopts minicell power supply.
8. circuit board according to claim 2, is characterized in that: it adopts wireless power mode to power.
CN201210470083.1A 2012-11-20 2012-11-20 Method for detecting vessel stenosis based on double interventional pressure sensors Pending CN103829933A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104382676A (en) * 2014-11-21 2015-03-04 清华大学深圳研究生院 In-vivo wireless communication device based on vascular stent and wireless communication system
DE112016005603T5 (en) 2015-12-08 2018-10-25 Pulse Medical Imaging Technology (Shanghai) Co., Ltd METHOD AND SYSTEM FOR CALCULATING A BLOOD VESSEL PRESSURE DIFFERENCE AND THE FRACTIONAL RIVER RESERVE
CN110464311A (en) * 2019-09-02 2019-11-19 西安交通大学医学院第一附属医院 A kind of velocity of blood flow monitoring device and its method based on carotid stents
WO2021134868A1 (en) * 2019-12-31 2021-07-08 深圳北芯生命科技有限公司 Intravascular pressure measurement system

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104382676A (en) * 2014-11-21 2015-03-04 清华大学深圳研究生院 In-vivo wireless communication device based on vascular stent and wireless communication system
DE112016005603T5 (en) 2015-12-08 2018-10-25 Pulse Medical Imaging Technology (Shanghai) Co., Ltd METHOD AND SYSTEM FOR CALCULATING A BLOOD VESSEL PRESSURE DIFFERENCE AND THE FRACTIONAL RIVER RESERVE
DE112016005603B4 (en) 2015-12-08 2021-07-15 Pulse Medical Imaging Technology (Shanghai) Co. Ltd. METHOD AND SYSTEM FOR CALCULATING A BLOOD VESSEL PRESSURE DIFFERENCE AND THE FRACTIONAL FLOW RESERVE
US11064897B2 (en) 2015-12-08 2021-07-20 Pulse Medical Imaging Technology (Shanghai) Co., Ltd Method and system for calculating blood vessel pressure difference and fractional flow reserve
CN110464311A (en) * 2019-09-02 2019-11-19 西安交通大学医学院第一附属医院 A kind of velocity of blood flow monitoring device and its method based on carotid stents
WO2021134868A1 (en) * 2019-12-31 2021-07-08 深圳北芯生命科技有限公司 Intravascular pressure measurement system

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Application publication date: 20140604

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