CN103828804A - Complexly-formulated quaternary ammonium salt disinfectant - Google Patents
Complexly-formulated quaternary ammonium salt disinfectant Download PDFInfo
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- CN103828804A CN103828804A CN201410072549.1A CN201410072549A CN103828804A CN 103828804 A CN103828804 A CN 103828804A CN 201410072549 A CN201410072549 A CN 201410072549A CN 103828804 A CN103828804 A CN 103828804A
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- quaternary ammonium
- ammonium salt
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Abstract
The invention relates to a complexly-formulated quaternary ammonium salt disinfectant. The complexly-formulated quaternary ammonium salt disinfectant is prepared from the following ingredients: N,N-bis(3-amino propyl) dodecylamine used as a main ingredient of the antibacterial agent, didecyldimethylammonium chloride (DDDMAC) with strong antibacterial effect, a synergist, a stabilizing agent, a pH regulator, an antioxidant and a cosolvent; the complexly-formulated quaternary ammonium salt disinfectant is mainly characterized in that novel, stable and high-efficiency quaternary ammonium salt is adopted for achieving disinfectant and antibacterial effects; the complexly-formulated quaternary ammonium salt disinfectant can rapidly kill fungus, saccharomycetes, colon bacillus, pseudomonas aeruginosa, Staphylococcus aureus, Tritirachium album, virus and other microorganisms in a highly-efficiency broad-spectrum manner; the complexly-formulated quaternary ammonium salt disinfectant has the advantages of having wide application range, good disinfection effect, no toxic action, no carcinogenic effect, no sensitization, no mutagenesis, no pesticide resistance formation, no irritation, no corrosivity, no foreign smell and no flammability, having capability of effectively killing harmful microorganisms such as bacteria, viruses and fungus, which are harm to higher organisms in all life stages (including a reproduction period and a juvenile stage), having capability of natural degradation in soil, no secondary pollution, having stable performance, having less possibility of losing efficacy due to light, heat and the like, and having economical and practical effects, can achieve rapid high-efficiency broad-spectrum disinfection effect compared with similar products, and has low price.
Description
Technical field
The present invention relates to a kind of compound prescription quaternary ammonium salt disinfectant of a kind of disinfectant, particularly environment-friendly high-efficiency.
Background technology
At present, in market, common disinfectant major part is chloride (iodine) class, Peracetic acid class, hydroperoxide kind, formalin class, penta and traditional disinfectants such as aldehydes, chlorohexidene class, phenols, mercury class, bases, acids are mainly used in: government utility sterilization, daily life sterilization, health care sterilization, food and drink and the sterilization of medicine industry, livestock breeding industry sterilization, Water Disinfection.But be widely used traditional disinfectant and show gradually the shortcomings that is difficult to elimination: on the one hand, tradition disinfectant needs relatively high valid density just can reach Disinfection Effect, and mostly there is penetrating odor, the article that are sterilized are had to corrosivity, even produce noxious material harm human and livestock health.On the other hand: traditional disinfectant is difficult for degraded, flow in water system and soil and can cause secondary environmental pollution.Moreover the complicate fabrication process of some disinfectant, is difficult for storing and transport, indirectly causes high cost.Therefore, these defects of traditional disinfectant have limited their ranges of application in modern society greatly, are abandoned just matter of time by fast-developing society.
In the face of the active demand of social each field to novel environment friendly high-efficiency sterile products, researchers have developed various types of new products.Wherein quaternary ammonium disinfectant is exactly one of disinfectant being sent to very big hope.The sterilization mechanism of generally acknowledging at present quaternary ammonium salt disinfectant liquid is: quaternary ammonium salt carries positive charge in the aqueous solution, can be adsorbed on electronegative microorganism surface and form micelle, and progressively infiltrate cytoplasmic lipoid layer and protein layer.This ability of quaternary ammonium salt can change after birth permeability, and cellular content is exosmosed, and finally causes microbial death.Quaternary ammonium salt solidifies again the intracellular protein of energy simultaneously, makes enzyme (as the enzyme of dehydrogenase oxidoreductase enzyme and decomposition glucose succinate acetonate) and structural proteins sex change, and the metabolism of destroy microorganisms, thoroughly kills microorganism.In addition, in two long chain quaternary structures, with 1 hydrophilic radical and 2 hydrophobic groupings, there is the capillary ability of reasonable water-soluble and good reduction, also there is the adverse effect of opposing anion active agent, hard water, albumen organic matter etc.In addition quaternary ammonium salt solution is not only water-soluble fabulous but also be subject to water quality impact less, and its foam is also little.
In addition, the film that QAS polymer forms can wrap up microorganism closely, and then suppresses it and copy the reproductive behaviors such as division, so quaternary ammonium salt disinfectant has sterilization fungistatic effect.Sterilization process that it should be noted that this bactericide produces rapidly and not any harmful substance, does not affect other any irrelevant compositions in sterilization environment, is therefore sterilized dose of safety non-toxic.And the sharpest edges of relative other the general disinfectants of quaternary ammonium salt disinfectant are form and kinds that its sterilization mechanism does not rely on microorganism, in other words, the mutation of microorganism and variation do not affect the performance of quaternary ammonium salt bactericide effect, it can not make microorganisms pesticide resistance, even if therefore continue long-term use, drug effect also at all can not reduce.
Since Jocobs in 1915, synthetic concurrent current season, ammonium salt had Action of Surfactant first, and after having certain Disinfection Effect, quaternary ammonium disinfectant has been obtained significant progress.Now common quaternary ammonium disinfectant remain problem be: 1. bactericidal effect is subject to organic substance influence larger; 2. incompatibility is more; 3. price is more expensive; 4. poor to part microorganism effect, particularly for some fungi and virus.
Technical method of the present invention is by literature survey and experimental study, finds that specific strand quaternary ammonium salt and double-chain quaternary ammonium salt, by adopting unique proportioning combination, have powerful sterilization effect.Simultaneously by adding the auxiliary element of specific proportions, can improve effect and the penetration power of quaternary ammonium salt active ingredient in conjunction with cell membrane, and then widen disinfection and compose, improve fungicidal effectiveness, shorten disinfecting time, and do not produce biomolecule resistant, therefore Disinfection Effect obviously improves than current quaternary ammonium salt disinfectant of the same type.This disinfectant can be killed 99% staphylococcus aureus, hay bacillus and Pseudomonas aeruginosa for 30 seconds.Meanwhile, this technology adopts the more active ingredient of low toxic and environment-friendly, less to eco-environmental impact, do not produce secondary environmental pollution, and price is cheaper.In addition, this technical method, by optimizing additive formulations, has improved stability and the dissolubility of disinfectant active ingredient, is not subject to extraneous unfavorable factor as the impact such as organic matter, PH, has also reduced some incompatibility of quaternary ammonium salt disinfectant simultaneously.This technology has improved the concentration of mother liquor by suitable compound method, facilitated preparation to use, and indirectly reduced cost of transportation.
Summary of the invention
Main purpose of the present invention is to solve that existing quaternary ammonium salt disinfectant Disinfection Effect is undesirable, and active ingredient is unstable, is subject to the defects such as such environmental effects, provides a kind of effective and safe more stable quaternary ammonium salt disinfectant compound method.
The technical characterictic that the invention provides the stable disinfectant of a kind of more highly effective and safe is: a kind of compound prescription quaternary ammonium salt thimerosal, it is characterized in that its component and the w/v N that is 10-30%, N-bis-(3-aminopropyl) lauryl amine, the didecyl Dimethy ammonium chloride (DDDMAC) of 5-20%, the additive of 5-15% (comprises synergist, stabilizing agent, pH adjusting agent, antioxidant and cosolvent), all the other are all purified water.Described additive is one or more metal salt compounds and organic high molecular compound.
The feature of the disinfectant of manufacture of the present invention is:
1. " double-chain quaternary ammonium salt " active factors bacteriocidal concentration is low, generally uses 0.01-0.1%;
2. sterilization speed is fast, can kill 99% pathogenic microorganism within 30 seconds.Bactericidal effect, along with the raising of sterilization component concentration and sterilizing time extend and strengthen, is killed logarithm value >=5.00 simultaneously;
3. through acute oral toxicity test and irritation test and acute ocular thorn property result of the test: skin irritation index≤0.5, proves that this compound prescription disinfectant has nontoxic, non-stimulated;
4. LD
50>5000mg/kg body weight, proves that this compound prescription disinfectant is nontoxic
5. through carbon steel, copper, the corrosion test of stainless steel and aluminium, result is corrosion rate R(mm/a) <0.0100, show no corrosion effect;
6. easy to use, stable performance, is difficult for decomposing, fast light, heat-resisting, resistance to storage, and effectively the sterilization duration is long;
7. the structure of main sterilization component is that saturated fatty acid connects, and biological degradability is good, to environment (waters) non-secondary pollution.
To sum up, this invention has overcome that the Disinfection Effect of existing quaternary ammonium salt disinfectant is not good, incompatibility is more, stable effective ingredients is poor and be subject to the deficiencies such as such environmental effects, and therefore this compound prescription quaternary ammonium salt disinfectant can be widely used in the sterilization of industry, agricultural, hospital, family, forestry, oil field, various water circulation system and public environment health.
compound method and step:
Prepare the method for above-mentioned compound prescription quaternary ammonium salt disinfectant, comprise the following steps: progressively add appropriate additive and dissolve according to formula, by proportionally middle dissolving of effective disinfection composition quaternary ammonium salt, then add appropriate pure water constant volume, stir, be the slightly liquid of thickness of clear, packaging is dispatched from the factory.
Can observe with the following Examples implementation procedure of the present invention, these embodiment are only illustrative, can not be construed as limiting the present invention.
Embodiment mono-:
Formula:
| N, N-bis-(3-aminopropyl) lauryl amine | 20ml |
| Didecyl Dimethy ammonium chloride | 10ml |
| Na 2CO 3 | 0.25g |
| Guanidine carbonate | 7g |
| EDTA | 5g |
| Pure water | Add to 100ml |
Step:
1. get purified water 50ml, progressively add Na
2cO
3, guanidine carbonate and EDTA, to be dissolved rear for subsequent use;
2. add N, N-bis-(3-aminopropyl) lauryl amine, is stirred to whole dissolvings;
3. add didecyl Dimethy ammonium chloride, be stirred to whole dissolvings;
4. measure pH value
5. add appropriate amount of purified water to be settled to 100ml.
Embodiment bis-:
Formula:
| N, N-bis-(3-aminopropyl) lauryl amine | 18ml |
| Didecyl Dimethy ammonium chloride | 9ml |
| Na 2CO 3 | 0.25g |
| Guanidine carbonate | 7g |
| EDTA | 5g |
| Pure water | Add to 100ml |
Step:
1. get purified water 50ml, progressively add Na
2cO
3, guanidine carbonate and EDTA, to be dissolved rear for subsequent use;
2. add N, N-bis-(3-aminopropyl) lauryl amine, is stirred to whole dissolvings;
3. add didecyl Dimethy ammonium chloride, be stirred to whole dissolvings;
4. measure pH value
5. add appropriate amount of purified water to be settled to 100ml.
Claims (5)
1. a compound prescription quaternary ammonium salt thimerosal, it is characterized in that its component and the w/v N that is 10-30%, N-bis-(3-aminopropyl) lauryl amine, the didecyl Dimethy ammonium chloride (DDDMAC) of 5-20%, the additive of 5-15% (comprises synergist, stabilizing agent, pH adjusting agent, antioxidant and cosolvent), all the other are distilled water.
2. a compound prescription quaternary ammonium salt thimerosal, is characterized in that additive is metal salt compound or organic high molecular compound.
3. a kind of quaternary ammonium salt thimerosal according to claim 1, is characterized in that: the N that w/v is 10-30%, N-bis-(3-aminopropyl) lauryl amine.
4. a kind of quaternary ammonium salt thimerosal according to claim 1, is characterized in that: the didecyl Dimethy ammonium chloride (DDDMAC) that w/v is 5-20%.
5. according to a kind of quaternary ammonium salt thimerosal described in claim 1 and 2, described slaine is mainly silicate, carbonate and metallo-chelate.
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| CN201410072549.1A CN103828804A (en) | 2014-03-03 | 2014-03-03 | Complexly-formulated quaternary ammonium salt disinfectant |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104488862A (en) * | 2015-01-13 | 2015-04-08 | 北京中海诚达科贸有限公司 | Anion-cation surface-active agent compounded disinfectant technology |
| CN106567278A (en) * | 2016-11-09 | 2017-04-19 | 青岛如相化工科技有限公司 | Onsite & online preparation and synthesis of bactericide |
| CN108566947A (en) * | 2017-03-10 | 2018-09-25 | 洛阳惠中兽药有限公司 | A kind of foam disinfectant auxiliary agent, preparation method and foamaseptic prepared therefrom |
| CN110113943A (en) * | 2016-12-22 | 2019-08-09 | 陶氏环球技术有限责任公司 | The synergistic combination of double-(3- aminopropyl) dodecyl amine and sorbic acid |
| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
| CN112655704A (en) * | 2020-12-23 | 2021-04-16 | 合肥天一生物技术研究所有限责任公司 | Quaternary ammonium salt composite disinfectant |
| CN112970752A (en) * | 2021-03-01 | 2021-06-18 | 中国日用化学研究院有限公司 | Environment-friendly efficient surface disinfectant and preparation method thereof |
| CN114369049A (en) * | 2022-01-12 | 2022-04-19 | 威海东巽生物科技有限公司 | Preparation method of quaternized astaxanthin and antioxidant biological agent |
| CN114532352A (en) * | 2022-01-26 | 2022-05-27 | 苏州百灵威超精细材料有限公司 | Compound quaternary ammonium salt long-acting disinfectant and preparation method and application thereof |
| CN114767560A (en) * | 2022-05-20 | 2022-07-22 | 常州瑞昊环保科技有限公司 | Antibacterial composition and application thereof |
| CN115152758A (en) * | 2022-08-02 | 2022-10-11 | 北京洛娃日化有限公司 | Disinfectant for shoes and socks and preparation method thereof |
| CN116200179A (en) * | 2023-02-17 | 2023-06-02 | 广东海洋大学 | Surfactant preparation for reducing corrosion of sulfate reducing bacteria in petroleum exploitation and pipeline transportation and preparation method thereof |
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| US20070197422A1 (en) * | 2006-02-13 | 2007-08-23 | Andreas Dettmann | Alkaline disinfecting and cleaning compositions having improved cleaning efficiency |
| DE102006051559A1 (en) * | 2006-11-02 | 2008-05-08 | Merz Pharma Gmbh & Co. Kgaa | Cleaning- and disinfectant- concentrate, useful in hygienic surfaces and medical area, preferably medical instruments and composite materials, comprises water, cationic biocidal active agents, amines and heterocyclic components |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE19526481A1 (en) * | 1995-07-20 | 1997-01-23 | Merz & Co Gmbh & Co | Tuberculocidal powdered disinfectant compsn. for instruments |
| US20070197422A1 (en) * | 2006-02-13 | 2007-08-23 | Andreas Dettmann | Alkaline disinfecting and cleaning compositions having improved cleaning efficiency |
| DE102006051559A1 (en) * | 2006-11-02 | 2008-05-08 | Merz Pharma Gmbh & Co. Kgaa | Cleaning- and disinfectant- concentrate, useful in hygienic surfaces and medical area, preferably medical instruments and composite materials, comprises water, cationic biocidal active agents, amines and heterocyclic components |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104488862A (en) * | 2015-01-13 | 2015-04-08 | 北京中海诚达科贸有限公司 | Anion-cation surface-active agent compounded disinfectant technology |
| CN106567278A (en) * | 2016-11-09 | 2017-04-19 | 青岛如相化工科技有限公司 | Onsite & online preparation and synthesis of bactericide |
| CN110113943B (en) * | 2016-12-22 | 2023-05-05 | Mc 3 (美国)有限责任公司 | Synergistic combination of bis- (3-aminopropyl) dodecylamine and sorbic acid |
| CN110113943A (en) * | 2016-12-22 | 2019-08-09 | 陶氏环球技术有限责任公司 | The synergistic combination of double-(3- aminopropyl) dodecyl amine and sorbic acid |
| CN108566947A (en) * | 2017-03-10 | 2018-09-25 | 洛阳惠中兽药有限公司 | A kind of foam disinfectant auxiliary agent, preparation method and foamaseptic prepared therefrom |
| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
| CN112655704A (en) * | 2020-12-23 | 2021-04-16 | 合肥天一生物技术研究所有限责任公司 | Quaternary ammonium salt composite disinfectant |
| CN112970752A (en) * | 2021-03-01 | 2021-06-18 | 中国日用化学研究院有限公司 | Environment-friendly efficient surface disinfectant and preparation method thereof |
| CN114369049A (en) * | 2022-01-12 | 2022-04-19 | 威海东巽生物科技有限公司 | Preparation method of quaternized astaxanthin and antioxidant biological agent |
| CN114369049B (en) * | 2022-01-12 | 2023-10-03 | 威海东巽生物科技有限公司 | Preparation method of quaternized astaxanthin and antioxidation biological agent |
| CN114532352A (en) * | 2022-01-26 | 2022-05-27 | 苏州百灵威超精细材料有限公司 | Compound quaternary ammonium salt long-acting disinfectant and preparation method and application thereof |
| CN114532352B (en) * | 2022-01-26 | 2023-11-21 | 苏州百灵威超精细材料有限公司 | Composite quaternary ammonium salt long-acting disinfectant and preparation method and application thereof |
| CN114767560A (en) * | 2022-05-20 | 2022-07-22 | 常州瑞昊环保科技有限公司 | Antibacterial composition and application thereof |
| CN114767560B (en) * | 2022-05-20 | 2024-02-02 | 常州瑞昊环保科技有限公司 | Antibacterial composition and application thereof |
| CN115152758A (en) * | 2022-08-02 | 2022-10-11 | 北京洛娃日化有限公司 | Disinfectant for shoes and socks and preparation method thereof |
| CN116200179A (en) * | 2023-02-17 | 2023-06-02 | 广东海洋大学 | Surfactant preparation for reducing corrosion of sulfate reducing bacteria in petroleum exploitation and pipeline transportation and preparation method thereof |
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Application publication date: 20140604 |