CN103816484A - Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof Download PDF

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CN103816484A
CN103816484A CN201410082416.2A CN201410082416A CN103816484A CN 103816484 A CN103816484 A CN 103816484A CN 201410082416 A CN201410082416 A CN 201410082416A CN 103816484 A CN103816484 A CN 103816484A
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chinese medicine
medicine composition
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preparation
olibanum
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CN103816484B (en
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杨洪霞
沃金善
韩淑红
韩淑燕
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Abstract

The invention belongs to the field of medicine, and relates to a medicinal preparation for treating stomach cancer, in particular to a traditional Chinese medicine composition for treating stomach cancer and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 30-50 parts of radix aucklandiae, 30-60 parts of oldenlandia diffusa, 25-40 parts of andrographis paniculata, 20-40 parts of frankincense, 15-30 parts of pseudo-ginseng, 15-30 parts of tribulus terrestris, 10-20 parts of curcuma zedoaria, 5-15 parts of fructus xanthii, and 5-15 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition has obvious effect on the treatment of stomach cancer, and has no toxic or side effects, the possibility of relapse after cure is low, the effective rate is 94%, the cure rate is 70%, and a hopeful road for treating stomach cancer is discovered for the prior art.

Description

A kind of Chinese medicine composition for the treatment of gastric cancer and preparation method thereof
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine preparation for the treatment of gastric cancer.
Background technology
Gastric cancer (Gastric cancer) is the most common malignant tumor of digestive tract of harm humans health, originates from epithelium, and the sickness rate of gastric cancer is widely different in country variant different regions.China belongs to high incidence area of gastric cancer, the first place that occupies all kinds of tumors at its sickness rate of China, approximately has 170,000 people to die from gastric cancer every year, almost approaches 1/4 of whole mortality of malignant tumors numbers, and also have every year more than 20,000 new Patients with Gastric Cancer to generate, serious threat people's health.
The pathogenic factor of gastric cancer is not clear, may with many factors, as relevant in living habit, dietetic variety, environmental factors, heredodiathesis, Nervous and Mental Factors etc., also with chronic gastritis, polyp of stomach, gastric mucosa special-shaped hyperplasia and intestinal epithelial metaplasia, operation after residual stomach, and long-term helicobacter pylori (HP) infects etc. and to have certain relation.To the treatment of gastric cancer, operation, chemotherapy are still the main method of current treatment gastric cancer.But operation can damage internal organs organ, causes wound hemorrhage; Chemotherapy lacks selectivity, and toxic and side effects is larger, occurs many untoward reaction such as anorexia, pain, the reduction of blood item index, and body's immunity is had damage, and can not well improve the life quality of Patients with Gastric Cancer.If cancer is not yet utterly destroyed, alleviate even if reach for the moment, still can recur rapidly or shift.Chinese medicine is the exclusive medical advantage of China, and Chinese medicine, in treatment gastric cancer, not only can promote physical recovery, strengthens immunologic function, and can bring into play antitumaous effect, prevents recurrence and shifts, and improves survival rate.Therefore, develop and develop effective Chinese medicine preparation and treat gastric cancer, the hygiene medical treatment cause tool of China is of great significance.
The traditional Chinese medical science thinks that primary disease is that chronic dietary does not save, feelings will is unsuccessful, overstrain internal injury or being invaded by exogenous pathogen, causes the liver failing to maintain the normal flow of QI, stomach-QI being unable to descend normally, or prolonged illness taste are impaired, and raw in phlegm-damp, qi depression to blood stasis, is condensed in stomach and forms.Say as " General Treatise on the Cause and Symptoms of Diseases ": " disorder of YIN and YANG, three warmers are isolated, and three warmers are isolated, and body fluid is unfavorable, therefore make vent plug uncomfortable, is into and chokes.Due to this is angerd by melancholy, melancholy is angerd depressed, does not depressedly declare stream, and makes the dysphagia also obstructed "." special effect good recipe regurgitation of food from the stomach door " meaning: " husband regurgitation person, this stomach.How to select and to satisfy because of gastric qi, the wound of drinking, or long-pending wind and cold, or because of the sad calamity of being worried, or because holding anger depression, dyspepsia addiction, gathers cold phlegm, moves and disturbs taste, can not wear down paddy food a little less than stomach, then becomes this disease ".The traditional Chinese medical science is often with heat-clearing and toxic substances removing, and strengthening vital QI to eliminate pathogenic factors, invigorating the spleen and regulating the stomach, benefiting vital QI and blood are method, reach the object for the treatment of.The present invention gropes by a large amount of experiments, has found a kind of Chinese medicine composition for the treatment of gastric cancer, and pharmacodynamic experiment effect is very remarkable, and we have made the dosage forms such as granule, tablet, hard capsule, soft capsule, drop pill, oral liquid by corresponding technique.
Summary of the invention
The present invention is from the rule for the treatment of of Chinese traditional treatment gastric cancer, through development test, by the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae nine taste medicines, through suitable processing, the process of preparing Chinese medicine, extraction, make a kind of effective Chinese medicine preparation for the treatment of gastric cancer.
On the one hand, the invention provides a kind of Chinese medicine composition for the treatment of gastric cancer, formed by the Chinese drug preparation of following weight portion: Radix Aucklandiae 30-50, Herba Hedyotidis Diffusae 30-60, Herba Andrographis 25-40, Olibanum 20-40, Radix Notoginseng 15-30, Fructus Tribuli 15-30, Rhizoma Curcumae 10-20, Fructus Xanthii 5-15, Pericarpium Citri Reticulatae 5-15.
In a preferred embodiment, described Chinese medicine composition is preferably formed by the Chinese drug preparation of following weight portion: the Radix Aucklandiae 40, Herba Hedyotidis Diffusae 45, Herba Andrographis 35, Olibanum 30, Radix Notoginseng 25, Fructus Tribuli 25, Rhizoma Curcumae 15, Fructus Xanthii 10, Pericarpium Citri Reticulatae 10.
On the other hand, the invention provides the preparation method of described Chinese medicine composition, concrete steps are as follows: take the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae nine taste Chinese medicines according to proportioning, the water that adds wherein 6-12 doubly to measure, decoct three times, each 1-3 hour, collecting decoction, filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.25 (80 ℃), add ethanol to containing alcohol amount 60-80% (v/v), stir, leave standstill 12-24 hour, filter, decompression filtrate recycling ethanol, to obtain final product.
In a preferred embodiment, can be according to the preparation method of this area routine, by adding appropriate adjuvant, by preparations such as the agent of present composition granulation, tablet or capsule, soft extract, pill, medicinal tea, powder, drop pill.
Described adjuvant comprises conventional adjuvant, sugar-free sweetener, antiseptic of various medical standard universals etc., and conventional sweeting agent comprises sucrose etc.Sugar-free sweetener comprises the sweeting agent such as stevioside and protein sugar, xylitol, high fructose and cyclamate, and antiseptic comprises sodium benzoate, benzoic acid, Nipagin ester etc.
On the one hand, the present invention also provides the medical usage of described Chinese medicine composition again, and traditional Chinese medicine composition for treating gastric cancer successful of the present invention, has no side effect, and is difficult for more afterwards recurrence, effective percentage 94%, cure rate 70%.Generally the patient of morbidity is taken medicine in 1-5 the course for the treatment of and can reach the object of healing, and be difficult for more afterwards recurring.For prior art has been opened up the road for the treatment of the hope of gastric cancer.
 
The situation of the relevant meridian distribution of property and flavor of Chinese medicine of the present invention, effect is as follows:
This preparation has effect of QI invigorating spleen reinforcing, blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, spleen invigorating removing food stagnancy, can be used for the treatment of gastric cancer.The Radix Aucklandiae: acrid in the mouth, mildly bitter flavor, warm in nature, gas fragrance, enters spleen, stomach, large intestine, gallbladder meridian, has the merit of promoting the circulation of QI to relieve pain.Herba Hedyotidis Diffusae bitter in the mouth, light, cold in nature.Main effect is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Herba Andrographis, bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel, have heat-clearing and toxic substances removing, removing heat from blood, detumescence, effect of dampness.Olibanum is arduous, warm, enters the heart, liver, spleen channel, regulating qi and activating blood, and analgesic therapy, chases after poison.Radix Notoginseng, warm in nature, acrid in the mouth, has scattered silt hemostasis, effect of subduing swelling and relieving pain.Fructus Tribuli toil, temperature, enters liver, lung meridian, has loose wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, effect of promoting the circulation of blood.Rhizoma Curcumae bitter in the mouth is pungent, temperature, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Fructus Xanthii bitter in the mouth; Sweet; Pungent; Warm in nature, enter lung, Liver Channel, dispersing wind and cold; Clearing the nasal passage; Wind-damp dispelling; Antipruritic.Pericarpium Citri Reticulatae is warm in nature, and acrid in the mouth, bitter in the mouth enter spleen channel, stomach warp, lung meridian, have regulating qi-flowing for strengthening spleen, in tune, and dampness, the merit of reducing phlegm.
All medicines share above, play altogether the merit of invigorating the spleen and benefiting QI, blood circulation promoting nourishing kidney, blood circulation promoting and blood stasis dispelling, spleen invigorating removing food stagnancy, for the treatment of gastric cancer.In addition, Chinese medicine composition preparation technology of the present invention is simple, substantially has no side effect, and patient compliance is higher, has good development and application prospect.
 
The specific embodiment
Further describe technical scheme of the present invention by following embodiment.It is pointed out that following explanation is only illustrating of the technical scheme claimed to the present invention, the not any restriction to these technical schemes.The content that protection scope of the present invention is recorded with appended claims is as the criterion.
 
embodiment 1
Composition: Radix Aucklandiae 30g Herba Hedyotidis Diffusae 45g Herba Andrographis 25g
Olibanum 40g Radix Notoginseng 15g Fructus Tribuli 30g
Rhizoma Curcumae 10g Fructus Xanthii 10g Pericarpium Citri Reticulatae 15g
Method for making: take the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae by formula ratio and get the raw materials ready, add 8 times of water, decoct three times, each 2 hours, collecting decoction, filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 60% (v/v), stir, leave standstill 24 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
embodiment 2
Composition: Radix Aucklandiae 50g Herba Hedyotidis Diffusae 30g Herba Andrographis 40
Olibanum 20g Radix Notoginseng 30g Fructus Tribuli 20g
Rhizoma Curcumae 20g Fructus Xanthii 15g Pericarpium Citri Reticulatae 10g.
Method for making: take the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae by formula ratio and get the raw materials ready, add the water of 12 times, decoct three times, each 1 hour, collecting decoction, filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.12 (80 ℃), add ethanol to containing alcohol amount 70% (v/v), stir, leave standstill 12 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
 
embodiment 3
Radix Aucklandiae 40g Herba Hedyotidis Diffusae 45g Herba Andrographis 35g
Olibanum 30g Radix Notoginseng 25g Fructus Tribuli 25g
Rhizoma Curcumae 15g Fructus Xanthii 10g Pericarpium Citri Reticulatae 10g.
Method for making: take the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae by formula ratio and get the raw materials ready, add the water of 10 times, decoct three times, each 1.5 hours, collecting decoction, filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 60% (v/v), stir, leave standstill 18 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
 
embodiment 4
Radix Aucklandiae 50g Herba Hedyotidis Diffusae 60g Herba Andrographis 30g
Olibanum 40g Radix Notoginseng 15g Fructus Tribuli 25g
Rhizoma Curcumae 15g Fructus Xanthii 10g Pericarpium Citri Reticulatae 15g.
Method for making: take the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae by formula ratio and get the raw materials ready, add the water of 8 times, decoct three times, each 1 hour, collecting decoction, filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol amount 80% (v/v), stir, leave standstill 24 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
 
the Clinical observation of embodiment 5 Chinese medicine compositions of the present invention
Instructions of taking: day takes 2 times, sooner or later after meal respectively once.
Treat the course for the treatment of: within 30 days, be 1 course for the treatment of, the lighter 2-3 can cure a course for the treatment of, and can cure severe one 3-6 the course for the treatment of, after curing, be difficult for recurrence.
Medication effect of the present invention: treatment gastric cancer successful, have no side effect, be difficult for more afterwards recurrence, effective percentage 94%, cure rate 70%.
Medicine of the present invention cures mainly gastric cancer, and disease is seen: stomach can touch enclosed mass, abdominal distention, and feed is few, and stomach occurs scorching hot, constipation due to dry stool, have blood in stool greatly, after breastbone, hidden pain, uncomfortable in chest, and food difficulty is swallowed, distension and fullness in the abdomen, belch, thirst with desire to drink, yellow urine, the pallor of breathing hard, puffiness of the face and dropsy of the feet, becomes thin etc.
 
The clinical observation of Drug therapy gastric cancer of the present invention:
1, treatment data
Get treatment patient 50 examples, wherein male 30 examples, female's 20 examples, the age is in 40-60 year.Above patient is all advanced gastric carcinoma by CT and check pathological section.
2, diagnostic criteria
Stomach sharp ache, can touch and see that bag is fast, nausea and vomiting, abdominal distention, feed is few, stomach occurs scorching hot, and constipation due to dry stool, has blood in stool greatly, and food difficulty is swallowed, distension and fullness in the abdomen, belch, or pharynx thing is unfavorable, time have a retrosternal pain, uncomfortable in chest, or spue after food, thirst with desire to drink; yellow urine, the pallor of breathing hard, puffiness of the face and dropsy of the feet; become thin, weak, spirit is poor.
3, Therapeutic Method
Take medicine prepared by the embodiment of the present invention 3, day take 2 times, early, after supper respectively once.
4, treat the course for the treatment of
Within 30 days, be 1 course for the treatment of, the lighter 2-3 can cure a course for the treatment of, and can cure severe one 3-6 the course for the treatment of, after curing, is difficult for recurrence.
5, efficacy assessment standard
Effective: pain relief, appetite increases, and spirit is recovered to some extent, and tumor is dwindled or is not made progress, and the state of an illness can be stablized.
Take a turn for the better: pain disappears, and tumor is obviously dwindled, and appetite is normal, spirit takes a turn for the better, and time has repeatedly, still needs treatment.
Recovery from illness: tumor body disappears, pain disappears, and appetite is normal, energetic, recovers work or physical labor normally.
Invalid: symptom art alleviates, the state of an illness continues to worsen.
6, therapeutic outcome
The above-mentioned patients with gastric cancer of Drug therapy through preparing by the embodiment of the present invention 3, through treating 3 courses for the treatment of, 35 examples of wherein fully recovering, 10 examples that take a turn for the better, effective 2 examples, invalid 3 examples, effective percentage 94%, cure rate 70%, inefficiency 6%.
 
Model case
1, relative, man, 49 years old, people from Anshan, be gastric cancer by hospital diagnosis in November, 2008, invalid through taking western medicines in treatment, withdraw after other drug, according to instructions of taking of the present invention, day takes 2 times, early, after supper respectively once, take medicine prepared by the embodiment of the present invention 3 after 10 days, patient's stomach pain, stomach occurs scorching hot, constipation due to dry stool, distension and fullness in the abdomen, belch, the pallor of breathing hard, the symptoms such as puffiness of the face and dropsy of the feet alleviate gradually.Take continuously 3 courses for the treatment of by above-mentioned instructions of taking, symptom all disappears, and tumor does not exist, and physical recovery is normal, so far not recurrence.
2, bavin, female, 55 years old, people from Hebei, be gastric cancer by hospital diagnosis in October, 2007, according to instructions of taking of the present invention, day take 2 times, early, after supper respectively once, take medicine prepared by the embodiment of the present invention 3 after 15 days, epigastric distending pain, vomiting band blood, has blood in stool, the symptoms such as puffiness of the face and dropsy of the feet have taken a turn for the better, take continuously 4 courses for the treatment of by above-mentioned instructions of taking, and above-mentioned symptom all disappears, CT shows that tumor does not exist, and physical recovery is normal, so far not recurrence.
3, Lee so-and-so, man, 65 years old, be gastric cancer by hospital diagnosis in July, 2009, press immediately instructions of taking, day take 2 times, early, after supper respectively once, take medicine prepared by the embodiment of the present invention 3 after 7 days, patient's stomach pain, heartburn, have blood in stool, distension and fullness in the abdomen, breathes hard, the symptoms such as puffiness of the face and dropsy of the feet take a turn for the better to some extent, take continuously 5 courses for the treatment of by above-mentioned instructions of taking, and above-mentioned symptom all disappears, CT shows that tumor does not exist, and physical recovery is normal, so far not recurrence.
 
Content of the present invention only for example understands some claimed specific embodiments; the technical characterictic of recording in one of them or more technical scheme can be with one or more technical schemes be combined arbitrarily; these technical schemes that obtain through combination are also in the application's protection domain, just as these technical schemes that obtain through combination have specifically been recorded in the disclosure of invention.

Claims (7)

1. treat the Chinese medicine composition of gastric cancer for one kind, it is characterized in that, its Chinese crude drug by following weight portion is prepared from: Radix Aucklandiae 30-50, Herba Hedyotidis Diffusae 30-60, Herba Andrographis 25-40, Olibanum 20-40, Radix Notoginseng 15-30, Fructus Tribuli 15-30, Rhizoma Curcumae 10-20, Fructus Xanthii 5-15, Pericarpium Citri Reticulatae 5-15.
2. Chinese medicine composition according to claim 1, it is preferably prepared from by the Chinese crude drug of following weight portion: the Radix Aucklandiae 40, Herba Hedyotidis Diffusae 45, Herba Andrographis 35, Olibanum 30, Radix Notoginseng 25, Fructus Tribuli 25, Rhizoma Curcumae 15, Fructus Xanthii 10, Pericarpium Citri Reticulatae 10.
3. the preparation method of the Chinese medicine composition described in a claim 1-2, it is characterized in that, concrete steps are as follows: take the Radix Aucklandiae by formula ratio, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae nine taste Chinese medicines, the water that adds wherein 6-12 doubly to measure, decoct three times, each 1-3 hour, collecting decoction, filter, filtrate is condensed into the clear paste that relative density is 1.10-1.25 (80 ℃), add ethanol to containing alcohol amount 60-80% (v/v), stir, leave standstill 12-24 hour, filter, decompression filtrate recycling ethanol, obtain.
4. the preparation method of Chinese medicine composition according to claim 3, it is characterized in that, concrete steps are as follows: take the Radix Aucklandiae, Herba Hedyotidis Diffusae, Herba Andrographis, Olibanum, Radix Notoginseng, Fructus Tribuli, Rhizoma Curcumae, Fructus Xanthii, Pericarpium Citri Reticulatae by formula ratio and get the raw materials ready, add wherein the water of 10 times of amounts, decoct three times, each 1.5 hours, collecting decoction, filters, and filtrate is condensed into the clear paste that relative density is 1.10-1.15 (80 ℃), add ethanol to containing alcohol 60% (v/v), stir, leave standstill 18 hours, filter, decompression filtrate recycling ethanol, to obtain final product.
5. a pharmaceutical preparation that contains Chinese medicine composition claimed in claim 1, it is characterized in that, described Chinese medicine composition and pharmaceutically acceptable adjuvant are prepared into suitable pharmaceutical preparation, such as tablet, granule, capsule, soft extract, pill, medicinal tea, powder, drop pill etc.
6. pharmaceutical preparation according to claim 4, is characterized in that, described pharmaceutical preparation is preferably tablet or granule.
7. the application of the Chinese medicine composition described in claim 1-2 in the medicine of preparation treatment gastric cancer.
CN201410082416.2A 2014-03-07 2014-03-07 A kind of Chinese medicine composition treating cancer of the stomach and preparation method thereof Expired - Fee Related CN103816484B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104398704A (en) * 2014-12-19 2015-03-11 刘武 Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof

Citations (1)

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Publication number Priority date Publication date Assignee Title
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Patent Citations (1)

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CN1238985A (en) * 1999-07-09 1999-12-22 张振海 Exterior-applied medicine for treating cold symptoms type gastroenteropathy and its preparing process

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Title
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104398704A (en) * 2014-12-19 2015-03-11 刘武 Traditional Chinese medicine composition for treating stomach cancer and preparation method thereof

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