CN103800711A - Preparation method of preparation for clearing away summer-heat and eliminating toxin - Google Patents
Preparation method of preparation for clearing away summer-heat and eliminating toxin Download PDFInfo
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Abstract
The invention discloses a preparation method of a preparation for clearing away summer-heat and eliminating toxin. The preparation for clearing away summer-heat and eliminating toxin is mainly prepared from Reed Rhizome, mint, honeysuckle flower, licorice, lophatherum gracile, talcum powder and self-heal. The preparation method can more effectively extract effective components in drugs, enhance the extraction rate, and perform the function of enhancing the curative effect of the drugs.
Description
Technical field
The present invention relates to a kind of preparation method of summer heat clearing toxin resolving preparation, belong to the field of medicine technology.
Technical background
Miliaria, furuncle, heatstroke are high temperature commonly encountered diseases in summer time, and the traditional Chinese medical science often adopts summer heat clearing toxin resolving, and the means of promoting the production of body fluid to quench thirst are treated it.Summer heat clearing toxin resolving preparation is traditional Chinese medical science summer heat clearing toxin resolving, promoting the production of body fluid to quench thirst common medicine Rhizoma Phragmitis, Herba Menthae, Flos Lonicerae, Radix Glycyrrhizae, Herba Lophatheri, Pulvis Talci, Spica Prunellae composition.In side, Rhizoma Phragmitis sweet in the mouth, cold nature, attach to the lung and stomach meridians, and has effect of clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis; Herba Menthae nature and flavor are pungent, cool, enter liver, lung meridian, have dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, effect of soothing the liver circulation of qi promoting; Flos Lonicerae is cold in nature, sweet in the mouth, micro-hardship, pungent, returns lung, stomach, the heart, large intestine channel, has heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome, effect of the relieving restlessness of relieving summer heat; Radix Glycyrrhizae property is flat, and sweet in the mouth, returns spleen, stomach, lung meridian, has eliminating fire and detoxication; The effects such as coordinating the actions of various ingredients in a prescription; Herba Lophatheri nature and flavor are sweet, cold, GUIXIN, kidney channel, have the profit of oozing and fall clearly effect, the descending and inducing diuresis for treating stranguria syndrome of kind fire of leading the heart and small intestinal; Pulvis Talci is cold in nature, lightly seasoned, sweet, returns bladder, lung, stomach warp, has inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore; Spica Prunellae nature and flavor bitter, acrid, cold.Return liver, gallbladder meridian.There is the effects such as the improving eyesight of relieving inflammation or internal heat, clearing away liver-fire, blood pressure lowering, mass dissipating and swelling eliminating.Modern pharmacological research proves, summer heat clearing toxin resolving preparation has the effects such as heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, eliminating damp-heat, dispelling wind to relieve the exterior syndrome.There is definite curative effect for diseases such as treatment heatstroke in summer, miliaria, furuncles.The method of existing production summer heat clearing toxin resolving preparation is generally to adopt the upper method of recording of ministry standard (WS3-B-1641-93), the extracting method that above-mentioned standard is recorded is decocting cooking method, fairly simple, cause containing a large amount of invalid components and impurity in product, make the clinical efficacy of summer heat clearing toxin resolving preparation not ideal enough.
Summary of the invention:
The object of this invention is to provide a kind of preparation method of summer heat clearing toxin resolving preparation.The method can reduce invalid components and the impurity in product, improves the clinical efficacy of summer heat clearing toxin resolving preparation.
For solving the problems of the technologies described above, the present invention realizes by the following technical solutions:
A kind of summer heat clearing toxin resolving preparation, calculates according to components by weight percent, is prepared from by 100 parts of Rhizoma Phragmitiss, 30 parts of Herba Menthaes, 100 parts of Flos Loniceraes, 40 parts, Radix Glycyrrhizae, 100 parts of Herba Lophatheris, 100 parts of Pulvis Talci, 60 parts of Spica Prunellaes and adjuvant.
The preparation method of above-mentioned summer heat clearing toxin resolving preparation is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray with above-mentioned volatile oil, then add conventional adjuvant can make different oral formulations according to conventional method.
Described oral formulations is capsule, granule or tablet.
The preparation method of described capsule is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray, with above-mentioned volatile oil, adds the magnesium stearate of the amount of making 3%, mixes, and incapsulates, and to obtain final product.
The preparation method of described granule is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray, with above-mentioned volatile oil, adds the starch of the amount of making 45%, granulate, and obtain granule.
The preparation method of described tablet is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray with above-mentioned volatile oil, then add the magnesium stearate of dry grain amount 1%, mix, and tabletting, sugar coating or film-coat, obtain tablet.
Summer heat clearing toxin resolving preparation of the present invention is mainly prepared from by Rhizoma Phragmitis, Herba Menthae, Flos Lonicerae, Radix Glycyrrhizae, Herba Lophatheri, Pulvis Talci, Spica Prunellae; Wherein: Rhizoma Phragmitis has clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, effect of diuresis, its main effective ingredient is polysaccharide composition, has the pharmacological action such as formation and antioxidation that suppresses hepatic fibrosis; Herba Menthae has dispelling wind and heat pathogens, the clear sharp head, and sore-throat relieving rash, the effects such as soothing the liver circulation of qi promoting, main effective ingredient is volatile oil and flavones ingredient, has antiviral, analgesia, antipruritic, sterilization, the pharmacological actions such as function of gallbladder promoting; Flos Lonicerae has effect of heat-clearing and toxic substances removing, cool breeze heat radiation, antiviral, hepatic cholagogic, and its main active ingredient chlorogenic acid has the multiple efficacies such as the free radical of removing, anti-inflammation, antiviral, blood sugar lowering, blood fat reducing, hepatic cholagogic; Radix Glycyrrhizae has heat-clearing and toxic substances removing, nourishing the lung to arrest cough, the effects such as coordinating the actions of various ingredients in a prescription; its main effective ingredient glycyrrhizic acid, liquirtin; there is protection gastric mucosa, the effect of adrenocortical hormone sample, removing toxic substances; regulate the pharmacological actions such as immunity of organism; Herba Lophatheri has oozes effect that profit is fallen clearly, and its main effective ingredient is flavones ingredient, has antipyretic; diuresis, pharmacological action such as antibacterial grade.Spica Prunellae has the improving eyesight of relieving inflammation or internal heat, clearing away liver-fire blood pressure lowering, and the effects such as dispersing swelling and dissipating binds, main effective ingredient triterpenes components, has blood pressure lowering, and resisting pathogenic microbes regulates the pharmacological actions such as immunity.Pulvis Talci has inducing diuresis for treating stranguria syndrome, clearing away summer-heat, and effect of damp eliminating sore, main component is magnesium silicate, has protection inflammation gastrointestinal mucosa, pharmacological action such as antibacterial grade.Above-mentioned medical material prior art is generally that direct water decocts, but inventor is through experimental studies have found that, Rhizoma Phragmitis, Herba Menthae, Herba Lophatheri, Radix Glycyrrhizae, Flos Lonicerae, all taste medicines of Spica Prunellae alcohol extraction effective ingredient extraction rate are all higher than water extraction.
Applicant has carried out following experiment, and provable the present invention has effective effect;
Experimental example 1: Rhizoma Phragmitis, Herba Menthae, Herba Lophatheri, Radix Glycyrrhizae, Flos Lonicerae, Spica Prunellae Study on extraction
Preparation process of the present invention: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter, merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes, 6 times of water gagings of filtering residue and Pulvis Talci decoct twice, each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes.
Former preparation process: Flos Lonicerae, Herba Menthae are extracted volatile oil, and the five tastes such as medicinal residues and all the other Rhizoma Phragmitiss decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, merging filtrate, filtered, and filtrate is concentrated into thick paste.
Detect respectively the wherein content (the main effective ingredient from Flos Lonicerae) of Rhizoma Phragmitis polysaccharide yield (Rhizoma Phragmitis polysaccharide quality/Rhizoma Phragmitis quality * 100%), total flavones (mainly from the main effective ingredient such as Herba Lophatheri, Herba Menthae, Spica Prunellae), chlorogenic acid, result is:
Table 1
Above experimental result shows, Rhizoma Phragmitis polysaccharide yield in preparation process extract of the present invention, total flavones, chlorogenic acid amount are higher, are better than former preparation process.
Experimental example 2: pharmacodynamic study
Applicant has carried out Pharmacodynamics research to the present invention, by experiment data declaration beneficial effect of the present invention.
1, heat-clearing and toxic substances removing test
1.1 experimental animals and grouping
80 of healthy SD rats, male and female half and half, weight (250 ± 30) g.Standard particle forage feed.Be divided at random 4 groups: Normal group (20), model group (20), former preparation process group (20), preparation process group of the present invention (20).
1.2 sample preparation
Former technique extract: make extract according to the technique of the 5th (WS3-B-1641-93) record of the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation, make the medicinal liquid of 10% concentration (g/ml) by purified water;
Extract of the present invention: make extract according to the method for the invention, make the medicinal liquid of 10% concentration (g/ml) by purified water;
1.3 model preparation and medications
Test front 12h fasting, can't help water, 10% chloral hydrate intraperitoneal injection of anesthesia.Open abdomen, separate caecum, sentencing No. 1 silk thread ligation apart from its end 2cm, then boring a hole at cap end with No. 18 syringe needles, successively close abdomen after caecum is put back to abdominal cavity.Continuous Observation 72 h.Each administration group is in preoperative 1 d administration, successive administration 3 d, and 1 time/d gavage, dosage is 24 μ gkg
-1crude drug.Matched group and model group are equivalent normal saline gavage.
1.4 statistical procedures
Measurement data represents with means standard deviation (x ± sd), and data acquisition carries out variance analysis with SPSS 11.5 statistical packages, adopts LSD method row to compare between two, and P < 0.05 has statistical significance.
1.5 result
1.5.1 0～72 h respectively organizes none death of rats death rate rats in normal control group; Model group, after modeling 3 d, mortality rate is 60%, and patent group mortality rate of the present invention is 40%, and former preparation group mortality rate is 50%, and XUEBIJING matched group mortality rate is 50%.Refer to table 2.As can be seen here, with regard to improving the survival rate of rat model, patent group of the present invention has good curative effect.
The comparison of the each group of table 2 rats death rate
Note: technique of the present invention and former technique is * P < 0.05 relatively
1.5.2 the expression of platelet surface PROTEIN C D62P is compared with normal group, the positive expression rate of sepsis model group platelet surface granule CD62P has obvious rising, and administration group of the present invention can reduce the positive hematoblastic percentage rate of CD62P after 3 d of administration, this effect is better than former technique administration group.
The comparison of the each group of table 3 rat CD62P positive blood platelet percentage rate rate
Note: technique of the present invention and former technique is * P < 0.05 relatively
1.6 conclusion
Above experimental studies results shows, preparation of the present invention has obvious antipyretic and antidote functions, and effect is better than former technique.
2, separate heat test
70 of the refrigeration function healthy SD rats of rat fever due to 2.1 pairs of dry yeast, male and female half and half.With the normal anus temperature of body temperature instrumentation rat, every day 2 times, 3d continuously.Before experiment, water 16h is can't help in fasting, and experiment day is measured in the same method every Mus anus temperature 2～3 times.Choose 48 of the rats that body temperature fluctuation is no more than 0.3 ℃ and be divided at random 4 groups: blank group, model control group, the present invention extract administration group, former extraction scheme preparation administration group, 12 every group.Test the same day, except blank group, respectively organize the equal back of rat subcutaneous injection dry yeast distilled water suspension (200gkg
-1) modeling.After modeling 4 h, survey anus temperature as basic value, two kinds of corresponding extract solution 15 mLkg of extraction scheme group gavage
-1, blank, model group gavage normal saline, the body temperature of record after administration 4,5,6,7,8h respectively organizing rat.Compared with before administration, after calculating injection yeast, different time rat temperature changes △ ℃ (the front body temperature of body temperature-administration after △ ℃=administration)
2.2 pairs of 2,4-DNPs cause the refrigeration function of rat fever
Choose continuous 3d anus temperature and measure 48 of the rats that body temperature fluctuation is no more than 0.3 ℃, divide at random 4 groups: blank group, model control group, former extraction scheme preparation group, the present invention extract administration group, 12 every group.Two kinds of corresponding extract solution 15 mLkg of extraction scheme group gavage
-1, blank, model group gavage normal saline 15 mLkg
-1.After administration except blank group in back subcutaneous injection 2,4-DNP 15 mgkg
-1, surveying anus temperature 1 time every 30min, METHOD FOR CONTINUOUS DETERMINATION 2.5h, after record injection 2,4-DNP 30,60,120, the variation of 150min rat temperature.
2.3 experimental result
2.3.1 the refrigeration function of different extracts to rat fever due to dry yeast, the results are shown in Table 4.With model group comparison, clearing away summer-heat fever allaying prepn is in the refrigeration function of rat fever due to dry yeast, with the strongest (P < 0.01) of extract effect of the present invention.There is extremely significantly refrigeration function (P < 0.01) in extract of the present invention, former extraction process administration group has remarkable refrigeration function (P < 0.05) in the time of 5h and 6 h after 4 h.
2.3.2 the refrigeration function of different extracts to 2,4-DNP pyrogenicity, the results are shown in Table 5.With model group comparison, summer heat clearing toxin resolving preparation all has refrigeration function to rat fever due to 2,4-DNP, wherein with the strongest (P < 0.01) of extract effect of the present invention.
The impact of table 4 clearing away summer-heat fever allaying prepn on rat fever due to dry yeast
The refrigeration function of table 5 clearing away summer-heat fever allaying prepn to 2,4-DNP pyrogenicity
2.4 statistical procedures
Measurement data represents with means standard deviation (x ± sd), and data acquisition carries out variance analysis with SPSS 11.5 statistical packages, adopts LSD method row to compare between two, and P < 0.05 has statistical significance.
2.5 conclusion
Above experimental studies results shows, preparation of the present invention has obvious antipyretic and antidote functions, and effect is better than former technique.
Compared with prior art, technique of the present invention can more effectively extract the effective ingredient in medicine, improves its extraction ratio, and has played the effect that improves curative effect of medication, has reached goal of the invention.
The specific embodiment:
Embodiment 1:
Prescription: Rhizoma Phragmitis 100g, Herba Menthae 30g, Flos Lonicerae 100g, Radix Glycyrrhizae 40g, Herba Lophatheri 100g, Pulvis Talci 100g, Spica Prunellae 60g.
Technique: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray, with above-mentioned volatile oil, adds the starch of the amount of making 45%, granulate, and obtain granule.
Usage and consumption: boiled water is taken after mixing it with water or buccal, a 25g, 4～5 times on the one.
Claims (5)
1. the preparation method of a summer heat clearing toxin resolving preparation, it is characterized in that: described summer heat clearing toxin resolving preparation calculates according to components by weight percent, by 100 parts of Rhizoma Phragmitiss, 30 parts of Herba Menthaes, 100 parts of Flos Loniceraes, 40 parts, Radix Glycyrrhizae, 100 parts of Herba Lophatheris, 100 parts of Pulvis Talci, 60 parts of Spica Prunellaes and adjuvant are prepared from by the following method: Flos Lonicerae, Herba Menthae is extracted volatile oil, medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, twice of 70% ethanol extraction for Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter, merge extractive liquid, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes, filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes, above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray with above-mentioned volatile oil, then add conventional adjuvant can make different oral formulations according to conventional method.
2. the preparation method of summer heat clearing toxin resolving preparation as claimed in claim 1, is characterized in that: described oral formulations is capsule, granule or tablet.
3. the preparation method of summer heat clearing toxin resolving preparation as claimed in claim 2, it is characterized in that: the preparation method of described capsule is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter, merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray, with above-mentioned volatile oil, adds the magnesium stearate of the amount of making 3%, mixes, and incapsulates, and to obtain final product.
4. the preparation method of summer heat clearing toxin resolving preparation as claimed in claim 2, it is characterized in that: the preparation method of described granule is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter, merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray, with above-mentioned volatile oil, adds the starch of the amount of making 45%, granulate, and obtain granule.
5. the preparation method of summer heat clearing toxin resolving preparation as claimed in claim 2, it is characterized in that: the preparation method of described tablet is: Flos Lonicerae, Herba Menthae are extracted volatile oil, twice of 70% ethanol extraction for medicinal residues and Rhizoma Phragmitis, Radix Glycyrrhizae, Herba Lophatheri, Spica Prunellae, add for the first time 10 times of amount 70% ethanol, add for the second time 8 times of amount 70% ethanol, each 2 hours, filter, merge extractive liquid,, 80 ℃ of decompression recycling ethanols, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Filtering residue and Pulvis Talci add 6 times of water gagings to decoct twice, and each 1 hour, filter, merge extractive liquid,, being condensed into when relative density is 80 ℃ is 1.10 ~ 1.15 thick pastes; Above-mentioned fine powder and thick paste mix, and 60 ℃ dry, pulverize, and spray with above-mentioned volatile oil, then add the magnesium stearate of dry grain amount 1%, mix, and tabletting, sugar coating or film-coat, obtain tablet.
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| CN104189616A (en) * | 2014-09-25 | 2014-12-10 | 洛阳华以生物工程有限公司 | Food therapy formula for pulmonitis |
| CN104324255A (en) * | 2014-10-21 | 2015-02-04 | 郑州后羿制药有限公司 | Traditional Chinese medicine for treating heat stress of chicken and preparation method of traditional Chinese medicine |
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| CN1686450A (en) * | 2005-05-13 | 2005-10-26 | 张佳翼 | Summer heat clearing toxin resolving granules and its preparation method |
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| CN104189616A (en) * | 2014-09-25 | 2014-12-10 | 洛阳华以生物工程有限公司 | Food therapy formula for pulmonitis |
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Application publication date: 20140521 |