CN103800281B - Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation - Google Patents
Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation Download PDFInfo
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- CN103800281B CN103800281B CN201410034286.5A CN201410034286A CN103800281B CN 103800281 B CN103800281 B CN 103800281B CN 201410034286 A CN201410034286 A CN 201410034286A CN 103800281 B CN103800281 B CN 103800281B
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- saikoside
- gel preparation
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- itch stopping
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Abstract
The invention discloses a kind of method utilizing saikoside a to prepare children's's Itch Stopping Gel preparation, comprise the following steps: get saikoside a respectively, Mentholum, thymol, methyl salicylate, Camphora, Oleum Eucalypti, add 50-150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 40-80ml is added while stirring, and continue at stirred at ambient temperature 2-5h, wherein mixing speed is 60-120r/min, under 40-60 DEG C of condition, crosslinked 12-18 hour is placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.The gel preparation being substrate by saikoside a hydrogel has good biocompatibility and biodegradability, low to the zest of biological tissue in addition, and can reduce the absorption in gel surface of protein and cell.
Description
Technical field
The present invention relates to a kind of preparation method of gel preparation, be specifically related to a kind of method utilizing saikoside a to prepare children's's Itch Stopping Gel preparation.
Background technology
Gel is made up of medicine dissolution or be dispersed in gel.Gel can with site of action close adhesion, how by skin, mucosal drug delivery, also can oral performance drug effect.Because the hydrated gel layer of the water-soluble swollen rear formation of gel absorption to have the effect of certain Co ntrolled release to medicine, now be widely used in the slow-released system of medicine, in addition gel preparation itself has that breathability is good, not pollution clothes, persistent, feature easy to use, increasing to the research of gel preparation in recent years.High-molecular gel is the important substrate of gel.Macromolecule hydrogel is the network size of hydrophilic high mol, its swellable keep large quantity of moisture and do not dissolve in water.But the performance of most macromolecule hydrogel in biocompatibility, biodegradable etc. is not fully up to expectations up to now, limit their application at field of medicaments.
Radix Bupleuri is conventional Chinese medicine simply.At present, the saponin component found from this plant reaches hundreds of, following 7 classes are belonged to: ether epoxy (I) from structure type, different ring diene (II), 12-alkene (III), with ring diene (IV), 12-alkene-28-carboxylic acid (V), different ring diene-30-carboxylic acid (VI), 18-ene-type (VII).Wherein, saikoside a belongs to ether epoxy (I) type, and its structure belongs to pentacyclic triterpene saponin constituent, as a kind of natural component, has much good character, as biocompatibility, degradability etc.Wherein, saikoside a and water effect can form the character of hydrogel, have no bibliographical information so far.
Summary of the invention
The object of the present invention is to provide a kind of method utilizing saikoside a to prepare children's's Itch Stopping Gel preparation, the gel preparation utilizing saikoside a to prepare has good biocompatibility and biodegradability, in addition low to the zest of biological tissue, and the absorption in gel surface of protein and cell can be reduced, and the method is simple, cost is low, reaction reagent is nontoxic, reaction medium is water, and environmentally safe is harmless.
The technical scheme that the present invention realizes above-mentioned purpose employing is: utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get 1g saikoside a respectively, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 50-150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 40-80ml is added while stirring, and continue at stirred at ambient temperature 2-5h, wherein mixing speed is 60-120r/min, under 40-60 DEG C of condition, crosslinked 12-18 hour is placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.
It is oxygen atom in a saikoside a molecular structure between 13,28 by hydrone and another one saikoside a molecular structure 16 that saikoside a forms the mechanism of hydrogel
, be connected to each other by hydrogen bond.Saikoside a molecule links as crosslinking points by a large amount of hydrogen bonds, and form significant number of layers laminated structure, and pile up mutually under intermolecular active force, a large amount of hydrones is present in the gap of the lamellar structure of formation, forms saikoside a hydrogel.
beneficial effect of the present invention
It is matrix composition gel preparation that the present invention adopts saikoside a and water to react the biodegradable hydrogel prepared first.Because saikoside a is as the natural component in bupleurum Chinese, belong to pentacyclic triterpene constituents, there is good biocompatibility and biodegradability, thus, the gel preparation being substrate by saikoside a hydrogel has good biocompatibility and biodegradability, in addition low to the zest of biological tissue, and the absorption in gel surface of protein and cell can be reduced.Preparation technology of the present invention is simple, and reaction reagent is nontoxic, and reaction medium is water, and reaction condition is gentle, and be conducive to the activity keeping medicine, production process does not produce environmental pollution.Containing a large amount of, highdensity hydrogen bond in this gel, thus mechanical strength and stability higher.Saikoside a comes from bupleurum Chinese, and therefore the present invention is also for the comprehensive utilization of bupleurum Chinese provides an effective way.
Detailed description of the invention
Below by way of specific embodiment, the present invention will be further described, but the embodiment be to provide can not as the restriction to the method, method provided by the invention can also prepare other gel preparation, or saikoside a prepares gel preparation together with other gel monomers raw materials.
Embodiment 1:
Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get 1g saikoside a respectively, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 50ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 40ml is added while stirring, and continue at stirred at ambient temperature 2h, wherein mixing speed is 60r/min, under 40 DEG C of conditions, crosslinked 12 hours are placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.
Embodiment 2:
Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get 1g saikoside a respectively, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 80ml is added while stirring, and continue at stirred at ambient temperature 5h, wherein mixing speed is 120r/min, under 60 DEG C of conditions, crosslinked 18 hours are placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.
Embodiment 3:
Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get 1g saikoside a respectively, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 100ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 60ml is added while stirring, and continue at stirred at ambient temperature 3.5h, wherein mixing speed is 90r/min, under 50 DEG C of conditions, crosslinked 15 hours are placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.
Embodiment 4:
Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation, comprise the following steps: get 1g saikoside a respectively, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 100ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 60ml is added while stirring, then carrageenan 0.5g is added, and continue at stirred at ambient temperature 3.5h, wherein mixing speed is 90r/min, under 50 DEG C of conditions, crosslinked 15 hours are placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.
Claims (1)
1. utilize saikoside a to prepare the method for children's's Itch Stopping Gel preparation, it is characterized in that: comprise the following steps: get 1g saikoside a respectively, Mentholum 0.3g, thymol 0.75g, methyl salicylate 0.5g, Camphora 0.5g, Oleum Eucalypti 0.7g, add 50-150ml dissolve with ethanol solution complete, the mass concentration of alcoholic solution is not less than 70%, then distilled water 40-80ml is added while stirring, and continue at stirred at ambient temperature 2-5h, wherein mixing speed is 60-120r/min, under 40-60 DEG C of condition, crosslinked 12-18 hour is placed after stirring terminates, place crosslinked end, namely children's's Itch Stopping Gel preparation that saikoside a is gel-type vehicle is able to.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410034286.5A CN103800281B (en) | 2014-01-24 | 2014-01-24 | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410034286.5A CN103800281B (en) | 2014-01-24 | 2014-01-24 | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation |
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| CN103800281A CN103800281A (en) | 2014-05-21 |
| CN103800281B true CN103800281B (en) | 2015-09-30 |
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| CN201410034286.5A Expired - Fee Related CN103800281B (en) | 2014-01-24 | 2014-01-24 | Saikoside a is utilized to prepare the method for children's's Itch Stopping Gel preparation |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101333240A (en) * | 2007-06-25 | 2008-12-31 | 孙蓉 | Process for extracting and separating high-purity saikosaponin A |
| CN103446237A (en) * | 2012-05-28 | 2013-12-18 | 苏州玉森新药开发有限公司 | Rectal gelata of traditional Chinese medicine composition and preparation method thereof |
-
2014
- 2014-01-24 CN CN201410034286.5A patent/CN103800281B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101333240A (en) * | 2007-06-25 | 2008-12-31 | 孙蓉 | Process for extracting and separating high-purity saikosaponin A |
| CN103446237A (en) * | 2012-05-28 | 2013-12-18 | 苏州玉森新药开发有限公司 | Rectal gelata of traditional Chinese medicine composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 柴胡鼻用pH敏感型原位凝胶的制备及退热效果评价;陈恩 等;《中国医药工业杂志》;20081231;第39卷(第9期);666-670页 * |
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| CN103800281A (en) | 2014-05-21 |
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