CN103751692A - Seal penis special tonifying capsule and preparation method thereof - Google Patents
Seal penis special tonifying capsule and preparation method thereof Download PDFInfo
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- CN103751692A CN103751692A CN201410048798.7A CN201410048798A CN103751692A CN 103751692 A CN103751692 A CN 103751692A CN 201410048798 A CN201410048798 A CN 201410048798A CN 103751692 A CN103751692 A CN 103751692A
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Abstract
The invention relates to a capsule made of traditional Chinese medicinal materials such as seal penis and herba epimedii, and a preparation method of the capsule. The capsule comprises the following raw materials: 1-7 parts of seal penis, 50-120 parts of herba epimedii, 10-70 parts of ginseng, 15-60 parts of fructus amomi, 10-110 parts of carthamus tinctorius, 10-110 parts of Chinese date, 50-120 parts of poria cocos, 50-120 parts of Chinese yam, 50-120 parts of fructus lycii, 10-70 parts of cassia bark, 20-70 parts of eucommia, 10-60 parts of schisandra chinensis and 20-60 parts of herba cistanches. The preparation method adopts different treatment methods according to different characteristics of raw medicinal materials, makes full use of active substances, and is practical. The product has effects of warming and invigorating kidney yang, nourishing yin, tonifying a kidney, resisting fatigue and delaying senescence, and has better opsonic actions on weakness of a whole body, dizziness, sexual debility and the like.
Description
Technical field
The present invention relates to health product and manufacturing technology field thereof, be specifically related to special invigorating capsule of a kind of Testis et penis callorhini and preparation method thereof.
Background technology
There is the symptoms such as kidney is short of power, overtired, senilism in the increasing people of China, body constitution declines, and well-known, and kidney is our human body vitals, regulates water, electrolyte balance; Environment acid-base balance in regulating; Discharge metabolic waste; Secretion feritin, promotes blood pressure; Secretion erythropoietin, prevents anemia etc.
Testis et penis callorhini, Chinese medicine name: Testis et penis callorhini (different name: the penis and tester of an ursine seal), all on the books in < < Bencao Tujing > >, < < Haiyao Bencao, Oversea Materia Medica > > and < < Compendium of Materia Medica > >.Testis et penis callorhini is flat, gentleness is not dry, takes and does not get angry, and is rich in kidney power active factors, 18 seed amino acids of multiple peptide matters, needed by human; Have the effective ingredient such as multiple unsaturated fatty acid (EPA, DPA, DHA) and nucleic acid, nucleotide.Testis et penis callorhini belongs to the in love product of flesh and blood, and its contained effective ingredient is combination form, and being easy to absorption of human body can tonifying YANG YIN nourishing, kidney tonifying nourishing the liver, bone and muscle strengthening, endocrine regulation blood yiqi, is applicable to the weak patient of blood deficiency gas.Skin care skin Caring.There is slow down aging, keep the effect of skin elasticity and moisture.
Current disclosed kidney-tonifying heath nutriment is a lot, and also having some to adopt Testis et penis callorhini is raw material.For example publication number is CN 1378845A, within open day, be that the Chinese patent on November 13rd, 2002 discloses a kind of Ursine seal penis capsule, but its composition is only Testis et penis callorhini, and component is single, and effect is single; Notification number is CN 101182449B, and the Chinese patent in May 25 2011 day for announcing discloses a kind of tortoise penis kidney-tonifying wine, contains the raw materials such as Testis et penis callorhini, and this scheme is just by simply alcohol-pickled, low to utilization rate of active components in medicine.Sum up existing the kidney invigorating product, there are the following problems: the effect of the kidney invigorating haves much room for improvement on the one hand; In the kidney invigorating, can bring side effect to human body on the other hand, threaten health, these are determined by its formula.In addition, in traditional health product production process, also exist technological deficiency as: utilization rate of active components is low; Introduce harmful chemical reagent; While taking, the efficacy of a drug easily loses; Gastrointestinal tract is easily caused to damage etc.
Summary of the invention
The object of the invention is: provide a kind of and have good warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, resisting fatigue, slow down aging effect, the capsule little to human body side effect, and a kind of utilization rate of active components is high, the preparation method of the health-caring capsule of green safety.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 1-7 part, Herba Epimedii 50-120g, Radix Ginseng 10-70 part, Fructus Amomi 15-60 part, Flos Carthami 10-110 part, Fructus Jujubae 10-110 part, Poria 50-120 part, Rhizoma Dioscoreae 50-120 part, Fructus Lycii 50-120 part, Cortex Cinnamomi 10-70 part, Cortex Eucommiae 20-70 part, Fructus Schisandrae Chinensis 10-60 part, Herba Cistanches 20-60 part.
The special invigorating capsule of described Testis et penis callorhini, the raw material composition of its effective ingredient is preferably: Testis et penis callorhini 2-6 part, Herba Epimedii 55-110 part, Radix Ginseng 15-60 part, Fructus Amomi 20-55 part, Flos Carthami 15-100 part, Fructus Jujubae 15-100 part, Poria 55-120 part, Rhizoma Dioscoreae 55-120 part, Fructus Lycii 55-120 part, Cortex Cinnamomi 15-65 part, Cortex Eucommiae 25-65 part, Fructus Schisandrae Chinensis 15-57 part, Herba Cistanches 25-55 part.
In the special invigorating capsule formula of above-mentioned Testis et penis callorhini, the medical material adopting is all to adopt first-class medical material, and the effective ingredient in medicine is more obvious than the effect of other medical materials, when active constituent content is not high, can produce adverse influence to drug effect.
Testis et penis callorhini has another name called Testis et penis callorhini.Effect: tonifying YANG YIN nourishing, kidney-supplementing liver-boosting, blood yiqi, skin care skin Caring, bone and muscle strengthening.Cure mainly: impotence in male, woman's deficiency and coldness leucorrhea, fails to be impregnated for a long time.
Herba Epimedii has another name called Herba Epimedii.Effect: reinforcing the kidney and supporting YANG.Wind-damp dispelling.Cure mainly: impotence due to deficiency of the kidney, arthralgia due to cold-dampnes or numb limbs and tense tendons etc.
Cortex Cinnamomi effect: warming middle-JIAO YANG invigorating, dispersing cold for relieving pain.Cure mainly: deficiency of spleen-YANG and kidneyYANG, anosis weak, arthralgia due to cold lumbago etc.
Radix Ginseng effect: strongly invigorating primordial QI, tonifying the lung strengthening the spleen.Promote the production of body fluid, calm the nerves.Cure mainly: deficiency of vital energy wish is de-.Deficiency of the lung asthma, weakness of the spleen and stomach.Chronic diarrhea proctoptosis, quenches one's thirst, malaise etc.
Fructus Amomi effect: removing dampness is amusing, antiabortive.Cure mainly: stagnation of QI in spleen and stomach, stomachache is had loose bowels, frequent fetal movement etc.
Flos Carthami effect: activating blood circulation to dissipate blood stasis, improves body microcirculation.Cure mainly: the stasis of blood is only had a pain, joint aches, blood stops amenorrhea etc.
Fructus Jujubae effect: tonifying the spleen and stomach, nutrition is calmed the nerves, and relaxes the property of medicine.Cure mainly: weakness of the spleen and stomach, deficiency of vital energy deficiency, lassitude etc.
Poria effect: diuretic dampness removing, spleen invigorating and in, mind tranquilizing and the heart calming.Cure mainly: dysuria, edema, lack of appetite gastral cavity is vexed, loose stool, palpitation and insomnia etc.
Rhizoma Dioscoreae effect: tonifying the spleen and stomach, lung benefiting kidney.Cure mainly: weakness of the spleen and stomach.Lack of appetite body is tired, chronic cough of deficiency lung, frequent micturition etc.
Fructus Lycii effect: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Cure mainly: deficiency of the liver and kindey, seminal emission, has a dizzy spell etc.
Radix Astragali effect: the raw sun of QI invigorating, strengthening superficial resistance to stop perspiration, holder skin ulcer granulation promoting, diuresis detumescent.Cure mainly: the deficiency of vital energy is weak, lassitude, skin infection is burst and is not held back for a long time, edema etc.
Cortex Eucommiae effect: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Cure mainly: deficiency of the liver and kindey, sexual impotence, frequent micturition, anemia of pregnant woman's body void, liability to abortion etc.
Fructus Schisandrae Chinensis effect: the nourishing kidney of astringing the lung, spermatogenesis arresting sweating.Cure mainly: chronic cough asthma, the empty hyperhidrosis of body, essence is sliding not solid, frequent micturition, incessant chronic diarrhea etc.
Herba Cistanches effect: nourishing kidney gas, replenishing vital essence and blood, for the agent temperature compensation of flat benefit not dry not hot.Cure mainly: some symptoms that cause because suffering from a deficiency of the kidney.
Why the special invigorating capsule of Testis et penis callorhini of the present invention adopts above-mentioned formula, the main medical material with warming and recuperating the kidney-YANG such as superfine product Testis et penis callorhini, Herba Epimedii, Cortex Cinnamomis in the tonic of kind nourishing YIN the yang aspect of yang is principal agent, be aided with Radix Ginseng strongly invigorating primordial QI, invigorating the spleen to benefit the lung, Flos Carthami blood circulation promoting and blood stasis dispelling, Poria, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Amomi invigorating the spleen and regulating the stomach, Fructus Lycii nourishing kidney yin.After composition of prescription, can make negative and positive with mending, Liver and kidney, with benefit, QI and blood complementation, reaches the effect of warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, resisting fatigue, slow down aging.
The mechanism of effect:
(1) negative and positive are with mending: in Testis et penis callorhini, contain a large amount of property power active factorses, can improve people's energy, muscle power and mental, supplement the property power active factors losing in human body and carry out enhancing human body immunity power, reinforcing the kidney and supporting YANG, take into account nourishing kidney yin, across-the-board regulation human body yin-yang balancing, thus reach the object of diseases prevention health care.
(2) Liver and kidney is with mending: The liver and the kidney have a common source, blood stored in the liver, and kidney storing essence, the change life of blood depends on the gasification of essence in kidney, the filling Sheng and also depend on the nourishing of blood of essence in kidney.Renal essence generating blood, blood generating essence, the effect that Liver and kidney plays with complementary energy.
(3) activating blood circulation to dissipate blood stasis: this product is take Testis et penis callorhini as main material, is equipped with again the medical material of activating blood circulation to dissipate blood stasis in side, can kidney tonifying gas, and warm waist knee joint, promoting blood circulation, promoting the circulation of QI to relieve pain.
The manufacture method of the special invigorating capsule of above-mentioned Testis et penis callorhini, comprises the steps:
(1) take by weight medical material, standby;
(2) Testis et penis callorhini is pulverized after vacuum drying at 30-60 ℃, sieved, make fine powder standby;
(3) after Radix Ginseng, Flos Carthami, Fructus Amomi are mixed, pulverize, sieve, make fine powder standby;
(4) after other residue medical materials such as Herba Epimedii are mixed, add water boil, after boiling, 2h filters, and obtains filtrate for the first time; Above-mentioned medical material is repeated to add water boil, and after boiling, 2h filters, and obtains filtrate for the second time; Merge filtrate twice, by filtrate concentrating under reduced pressure, obtain concentrated solution I;
(5) in concentrated solution I, add 95% ethanol, limit edged stirs, and the standing 24h of cold preservation at 0～5 ℃, gets supernatant; The supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, concentrate and become concentrated solution II, at 40-70 ℃, vacuum drying is dry cream, pulverizes and sieves, and obtains fine powder standby;
(6), by filled capsules after the fine powder mix homogeneously obtaining in step (2), step (3) and step (5), be the special invigorating capsule of Testis et penis callorhini.
Use in the present invention multiple medical material, according to the characteristic of different medical materials, process, guarantee the maximum utilization of effective ingredient in each medical material.
Testis et penis callorhini has stronger toughness as animality medical material, need to first be dried processing, and adopt 30-60 ℃ of vacuum drying, be because hot environment can be destroyed the nutritional labeling in Testis et penis callorhini, temperature is too low can extend again the vacuum drying time, dry standard is for controlling water content in 5% left and right, after drying and crushing, sieve, obtain fine powder.
In order to prevent the loss of effective ingredient, improve the utilization rate of effective ingredient in medicine, Radix Ginseng is is directly pulverized and sieved to powder process, and Flos Carthami, Fructus Amomi contain a large amount of volatile oil (effective ingredient) for avoiding it to lose, and also take the mode of direct powder process.
For main component, be water miscible medical material, adopt in step of the present invention (5) decoction and alcohol sedimentation technique to extract effective ingredient wherein, according to the different choice of medical material used the suitable amount that adds ethanol, reached best extraction effect.The mixed extract that obtains the medical materials such as Herba Epimedii after water extract-alcohol precipitation extracts, is dried, pulverizes and sieves, and obtains fine powder.
For keeping being loaded into the even particle size in capsule, the operation of sieving adopts 80-100 object sieve, and the powder particle after sieving is even, and good fluidity is suitable for filled capsules, and loading amount is also stable.For the ease of taking and having good therapeutic effect, capsule specification, it is 0.45 gram/.The present invention adopts conventional method to fill capsule.
In the water extract-alcohol precipitation operation of described step (5), the object that adds alcohol is to remove a part of impurity, in order to reach desirable impurity-eliminating effect, add alcohol quality be concentrated solution I quality 1-4 doubly.
In water extract-alcohol precipitation operation, concentration operation is the addition in order to reduce alcohol, if but medicinal liquid overrich, effective ingredient is easily wrapped in precipitation, so concentrate for twice in step (4) and (5), the density of concentrated solution is controlled at respectively: concentrated solution I:1.12～1.14g/cm
3; Concentrated solution II:1.36～1.40g/cm
3.
Why the special invigorating capsule of this Testis et penis callorhini adopts the encapsulated form of medicated powder, rather than adopting other dosage forms as forms such as tablet, powder, pills, its final purpose is exactly in order to guarantee giving full play to of pharmaceutical efficacy, uses other dosage forms, the efficacy of a drug is is easily scattered and disappeared, and is just difficult to play the effect of expection.And this dosage form of the present invention had both made medicine can fully act on human body, again owing to there being the protection of capsule, be unlikely to the intestines and stomach of human body to cause damage, thereby reach the optimum efficiency of formula.Utilize formula of the present invention take other dosage forms be not cannot, but the medicament of every other form is all be not as remarkably productive as capsule of the present invention.
The present invention has the effect of enhancing kidney power, resisting fatigue, slow down aging, has simultaneously and mends and not dry, and negative and positive are with mending, and Liver and kidney, with benefit, QI and blood complementation, reaches warming and recuperating the kidney-YANG, enriching yin and nourishing kidney, the feature of blood circulation promoting and blood stasis dispelling.In practice to physical fatigue, energy is weak, the whole body is weak, the head is dim-sighted, sexual disorder etc. has good effect, and this formula for a product adopts natural Chinese medicines formula,, containing chemical reagent, can not bring side effect, is easy to absorption of human body.Preparation method of the present invention is practical, can utilize fully the effective ingredient in medicine, reduces dose; adopt the form preparation of capsule; can when drug administration, keep for a long time its drug effect, due to the protection of capsule, can also protect human body the intestines and stomach injury-free.
The specific embodiment
Embodiment 1
The medical material of using in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 1g, Herba Epimedii 50g, Radix Ginseng 10g, Fructus Amomi 15g, Flos Carthami 10g, Fructus Jujubae 10g, Poria 50g, Rhizoma Dioscoreae 50g, Fructus Lycii 50g, Cortex Cinnamomi 10g, Cortex Eucommiae 20g, Fructus Schisandrae Chinensis 10g, Herba Cistanches 20g.
Its preparation process is:
(1) by above-mentioned quality, take medical material, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 30 ℃, crossed 80 mesh sieves, make fine powder standby;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicines are pulverized, crossed 80 mesh sieves, make fine powder standby;
(4) other medical materials of the residues such as Herba Epimedii are added to 2.2L water boil, 2h after boiling, filters, and obtains filtrate for the first time, again medical material is added 1.6L water to repeat to boil, 2h after boiling, filters, and obtains filtrate for the second time, merge filtrate twice, filtrate is carried out to conventional concentrating under reduced pressure operation, obtain concentrated solution I, density is 1.14g/cm
3.
(5) concentrated solution I is placed in to Alcohol-settling tank, add inside 95% ethanol, addition is 1 times of amount of concentrated solution I quality, limit edged stirs, then the standing 24h of cold preservation at 0～5 ℃, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, supernatant is extracted out with self priming pump, because of the in-built float-ball type drain apparatus of tank, with supernatant liquid level, decline gradually, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, concentrate and become concentrated solution II, density is 1.36g/cm
3, at 40 ℃, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, and obtains fine powder standby;
(6), by filled capsules after the fine powder mix homogeneously obtaining in step (2), step (3) and step (5), be the special invigorating capsule of Testis et penis callorhini.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 2
The medical material of using in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 2g, Herba Epimedii 55g, Radix Ginseng 15g, Fructus Amomi 20g, Flos Carthami 15g, Fructus Jujubae 15g, Poria 55g, Rhizoma Dioscoreae 55g, Fructus Lycii 55g, Cortex Cinnamomi 15g, Cortex Eucommiae 25g, Fructus Schisandrae Chinensis 15g, Herba Cistanches 25g.
Its preparation process is:
(1) by above-mentioned quality, take medical material, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 40 ℃, crossed 80 mesh sieves, make fine powder standby;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicines are pulverized, crossed 80 mesh sieves, make fine powder standby;
(4) other medical materials of the residues such as Herba Epimedii are added to 2.5L water boil, 2h after boiling, filters, and obtains filtrate for the first time, again medical material is added 1.9L water to repeat to boil, 2h after boiling, filters, and obtains filtrate for the second time, merge filtrate twice, filtrate is carried out to conventional concentrating under reduced pressure operation, obtain concentrated solution I, density is 1.13g/cm
3;
(5) concentrated solution I is placed in to Alcohol-settling tank, add inside 95% ethanol, addition is 2 times of amounts of concentrated solution I quality, limit edged stirs, then the standing 24h of cold preservation at 5 ℃, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, supernatant is extracted out with self priming pump, because of the in-built float-ball type drain apparatus of tank, with supernatant liquid level, decline gradually, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, concentrate and become concentrated solution II, density is 1.37g/cm
3, at 50 ℃, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, and obtains fine powder standby;
(6), by filled capsules after the fine powder mix homogeneously obtaining in step 2, step 3 and step 5, be the special invigorating capsule of Testis et penis callorhini.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 3
The medical material of using in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 4g, Herba Epimedii 85g, Radix Ginseng 40g, Fructus Amomi 40g, Flos Carthami 60g, Fructus Jujubae 60g, Poria 80g, Rhizoma Dioscoreae 80g, Fructus Lycii 80g, Cortex Cinnamomi 40g, Cortex Eucommiae 50g, Fructus Schisandrae Chinensis 40g, Herba Cistanches 40g.
Its preparation process is:
(1) by above-mentioned quality, take medical material, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 50 ℃, crossed 100 mesh sieves, make fine powder standby;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicines are pulverized, crossed 100 mesh sieves, make fine powder standby;
(4) other medical materials of the residues such as Herba Epimedii are added to 4.4L water boil, 2h after boiling, filters, and obtains filtrate for the first time, again medical material is added 3.3L water to repeat to boil, 2h after boiling, filters, and obtains filtrate for the second time, merge filtrate twice, filtrate is carried out to conventional concentrating under reduced pressure operation, obtain concentrated solution I, density is 1.13g/cm
3;
(5) concentrated solution I is placed in to Alcohol-settling tank, add inside 95% ethanol, addition is 3 times of amounts of concentrated solution I quality, limit edged stirs, then the standing 24h of cold preservation at 0～5 ℃, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, supernatant is extracted out with self priming pump, because of the in-built float-ball type drain apparatus of tank, with supernatant liquid level, decline gradually, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, concentrate and become concentrated solution II, density is 1.36g/cm
3, at 60 ℃, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, and obtains fine powder standby;
(6), by filled capsules after the fine powder mix homogeneously obtaining in step 2, step 3 and step 5, be the special invigorating capsule of Testis et penis callorhini.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 4
The medical material of using in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 6g, Herba Epimedii 110g, Radix Ginseng 60g, Fructus Amomi 55g, Flos Carthami 100g, Fructus Jujubae 100g, Poria 100g, Rhizoma Dioscoreae 100g, Fructus Lycii 100g, Cortex Cinnamomi 65g, Cortex Eucommiae 65g, Fructus Schisandrae Chinensis 57g, Herba Cistanches 55g.
Its preparation process is:
(1) by above-mentioned quality, take medical material, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 60 ℃, crossed 100 mesh sieves, make fine powder standby;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicines are pulverized, crossed 100 mesh sieves, make fine powder standby;
(4) other medical materials of the residues such as Herba Epimedii are added to 6.0L water boil, 2h after boiling, filters, and obtains filtrate for the first time, again medical material is added 4.5L water to repeat to boil, 2h after boiling, filters, and obtains filtrate for the second time, merge filtrate twice, filtrate is carried out to conventional concentrating under reduced pressure operation, obtain concentrated solution I, density is 1.12g/cm
3;
(5) concentrated solution I is placed in to Alcohol-settling tank, add inside 95% ethanol, addition is 3 times of amounts of concentrated solution I quality, limit edged stirs, then the standing 24h of cold preservation at 0 ℃, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, supernatant is extracted out with self priming pump, because of the in-built float-ball type drain apparatus of tank, with supernatant liquid level, decline gradually, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.The supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, be condensed into concentrated solution II, density is 1.40g/cm
3, at 70 ℃, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, and obtains fine powder standby;
(6) by filled capsules after the fine powder mix homogeneously obtaining in step 2, step 3 and step 5.
All the other operating procedures all adopt prior art, repeat no more.
Embodiment 5
The medical material of using in the present embodiment all adopts first-class medical material, and wherein Testis et penis callorhini is Canadian import Testis et penis callorhini.
The special invigorating capsule of a kind of Testis et penis callorhini, the raw material of its effective ingredient consists of: Testis et penis callorhini 7g, Herba Epimedii 120g, Radix Ginseng 70g, Fructus Amomi 60g, Flos Carthami 110g, Fructus Jujubae 110g, Poria 120g, Rhizoma Dioscoreae 120g, Fructus Lycii 120g, Cortex Cinnamomi 70g, Cortex Eucommiae 70g, Fructus Schisandrae Chinensis 60g, Herba Cistanches 60g.
Its preparation process is:
(1) by above-mentioned quality, take medical material, get the raw materials ready;
(2) Testis et penis callorhini is pulverized after vacuum drying at 60 ℃, crossed 100 mesh sieves, make fine powder standby;
(3) Radix Ginseng, Flos Carthami, Fructus Amomi three taste medicines are pulverized, crossed 100 mesh sieves, make fine powder standby;
(4) other medical materials of the residues such as Herba Epimedii are added to 6.8L water boil, 2h after boiling, filters, and obtains filtrate for the first time, again medical material is added 5.1L water to repeat to boil, 2h after boiling, filters, and obtains filtrate for the second time, merge filtrate twice, filtrate is carried out to general concentrating under reduced pressure operation, obtain concentrated solution I, density is 1.13g/cm3.
(5) concentrated solution I is placed in to Alcohol-settling tank, add inside ethanol, addition is 4 times of amounts of concentrated solution I quality, limit edged stirs, then the standing 24h of cold preservation at 2 ℃, after precipitation is complete, open the supernatant outlet valve of Alcohol-settling tank, supernatant is extracted out with self priming pump, because of the in-built float-ball type drain apparatus of tank, with supernatant liquid level, decline gradually, ball float also declines with liquid level, treats that supernatant exhausts, because turbid liquid-tight degree is much larger than supernatant, ball float floats over precipitate surface and no longer declines, and drain apparatus stops fluid automatically.Now can open slag notch, precipitate is discharged.Different according to the different deposits of material, can first open bottom butterfly valve solvent or diluent is emitted.Get supernatant, the supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, concentrate and become concentrated solution II, density is 1.39g/cm3, and at 70 ℃, vacuum drying is dry cream (water content is less than 5%), pulverizes and sieves, and obtains fine powder standby;
(6) by filled capsules after the fine powder mix homogeneously obtaining in step 2, step 3 and step 5.
All the other operating procedures all adopt prior art, repeat no more.
Experimental example 1
Zoopery, tests the slow down aging effect of this product.
1. experiment material: Drosophila melanogaster: draw from Shanghai The 2nd Army Medical College environmental mutagenesis research department; The special invigorating capsule of Testis et penis callorhini that uses embodiment 3 to prepare.
2. experimental technique: by fly blow at 25 ℃, 65% regulation of relative humidity incubator is hatched, the adult sprouting wings in 10 hours is anaesthetized with ether steam, under anatomical lens, distinguish male and female, select 1600 to be in charge of cultivation, then be divided at random 4 groups, every group 400, male and female half and half, wherein blank group is cultivated and is fed with basis, other three groups is experimental group, in basal medium, add respectively 0.2wt%, 1wt%, the special invigorating capsule powder of 5wt% Testis et penis callorhini, more renew culture medium every day, observe fruit bat, male 52 days, female 60 days survival rates, and calculate average life and maximum life span.Result: refer to table 2.
Table 2 drosophila survival experiment
*with relatively P<0.05 of matched group
*with relatively P<0.01 of matched group
Epidemiological Analysis by statistics, 0.2% experimental group and matched group comparison, P<0.05 has notable difference, and 1% has significant differences with 5% experimental group P<0.01 compared with matched group.Show that the special invigorating capsule of Testis et penis callorhini has the effect of obvious slow down aging.
Experimental example 2
Zoopery: use the special invigorating capsule of Testis et penis callorhini of preparation in embodiment 1, the resisting fatigue effect of this product is tested.
Mice pole-climbing experiment:
1. laboratory animal: Kunming kind white mice, draw the animal center from Shandong Province.
2. experimental technique:
(1) acute anti-fatigue test: 50 of Kunming mouses (22-25g), male and female half and half, be divided at random 5 groups, wherein blank group gavage every day normal saline 1.0ml/ only, positive controls only gives Radix Ginseng aqueous solution 1.0ml/, another three groups are suspended from 150cm by mice by only climbing with large, medium and small three dosage samples (0.5g/kg, 0.1g/kg, 0.01g/kg) gavage after 2 hours respectively, on diameter 0.75cm glass rod, record the time that mice drops down from glass rod, after mice falls, get immediately eye socket blood and survey urea nitrogen content.
(2) subacute anti-fatigue test: mice group method is the same, the continuous gavage of mice 15 days, in last gavage after 2 hours, by only carrying out pole-climbing experiment (bar is same as above), record the time that mice falls from glass rod, after mice falls, get immediately eye socket blood, adopt conventional diacetyl monoxime method to survey urea nitrogen content.Experimental result: refer to table 3, table 4.
Table 3 chmice acute resisting fatigue (pole-climbing) test
| Group | Number of animals | Climb the outstanding time | Urea nitrogen content (mg/L) |
| Blank | 10 | 362±16 | 17.75±0.41 |
| Radix Ginseng group | 10 | 371±24 | 16.76±0.42 |
| Heavy dose of group | 10 | 382±26 * | 16.97±0.39 * |
| Middle dosage group | 10 | 371±28 | 17.25±0.39 |
| Small dose group | 10 | 359±25 | 17.47±0.41 |
*with relatively P<0.05 and relatively P>0.05 of Radix Ginseng group of blank group
The subacute resisting fatigue of table 4 mice (pole-climbing) test
| Group | Number of animals | Swimming time | Urea nitrogen content (mg/L) |
| Blank | 10 | 371±21 | 17.81±0.41 |
| Radix Ginseng group | 10 | 425±26 | 15.33±0.41 |
| Heavy dose of group | 10 | 497±28 | 15.16±0.38 * |
| Middle dosage group | 10 | 411±26 | 15.41±0.40 * |
| Small dose group | 10 | 383±27 | 16.61±0.39 |
*with relatively P<0.01 and relatively P>0.01 of Radix Ginseng group of blank group
As can be seen from Table 3, taking the special invigorating capsule powder of Testis et penis callorhini has antifatigue effect to a certain degree at short notice, and in body, blood urea nitrogen accumulation has minimizing trend.As can be seen from Table 4, take after special invigorating capsule a period of time of Testis et penis callorhini, mice pole-climbing is climbed the outstanding time and is obviously extended, and in body, blood urea nitrogen accumulation obviously reduces, and shows that the special tonic wine of Testis et penis callorhini has obvious antifatigue effect.
Experimental example 3
The special invigorating capsule usage and dosage of Testis et penis callorhini of the present invention: oral, 2 of adult every days.
Take 100, suffer from the symptoms such as insomnia and dreamful sleep, physical fatigue and lassitude of spirit, neurasthenia, physical weakness, alopecia senilism as subjects, adopt and take for each person every day 2, take 30 days, after the oral health-caring capsule of the present invention of experimenter, 15% takes effect obviously or cures, 75% patient shows improvement, 10% patient's DeGrain.
Above disclosed is only preferred embodiment of the present invention, certainly can not limit with this interest field of the present invention, and any modification of therefore being done with the claims in the present invention, equivalent variations, improvement etc., all should be included in the scope that the present invention is contained.
Claims (6)
1. the special invigorating capsule of Testis et penis callorhini, is characterized in that: the raw material of its effective ingredient consists of: Testis et penis callorhini 1-7 part, Herba Epimedii 50-120 part, Radix Ginseng 10-70 part, Fructus Amomi 15-60 part, Flos Carthami 10-110 part, Fructus Jujubae 10-110 part, Poria 50-120 part, Rhizoma Dioscoreae 50-120 part, Fructus Lycii 50-120 part, Cortex Cinnamomi 10-70 part, Cortex Eucommiae 20-70 part, Fructus Schisandrae Chinensis 10-60 part, Herba Cistanches 20-60 part.
2. the special invigorating capsule of Testis et penis callorhini according to claim 1, is characterized in that: the raw material of its effective ingredient consists of: Testis et penis callorhini 2-6 part, Herba Epimedii 55-110 part, Radix Ginseng 15-60 part, Fructus Amomi 20-55 part, Flos Carthami 15-100 part, Fructus Jujubae 15-100 part, Poria 55-120 part, Rhizoma Dioscoreae 55-120 part, Fructus Lycii 55-120 part, Cortex Cinnamomi 15-65 part, Cortex Eucommiae 25-65 part, Fructus Schisandrae Chinensis 15-57 part, Herba Cistanches 25-55 part.
3. the method for the special invigorating capsule of preparation Testis et penis callorhini claimed in claim 1, is characterized in that: comprise the steps:
(1) take by weight medical material, standby;
(2) Testis et penis callorhini is pulverized after vacuum drying at 30-60 ℃, sieved, make fine powder standby;
(3) after Radix Ginseng, Flos Carthami, Fructus Amomi are mixed, pulverize, sieve, make fine powder standby;
(4) after other residue medical materials such as Herba Epimedii are mixed, add water boil, after boiling, 2h filters, and obtains filtrate for the first time; Above-mentioned medical material is repeated to add water boil, and after boiling, 2h filters, and obtains filtrate for the second time; Merge filtrate twice, by filtrate concentrating under reduced pressure, obtain concentrated solution I;
(5) in concentrated solution I, add 95% ethanol, limit edged stirs, and the standing 24h of cold preservation at 0～5 ℃, gets supernatant; The supernatant of taking-up is carried out to concentrating under reduced pressure for the second time, concentrate and become concentrated solution II, at 40-70 ℃, vacuum drying is dry cream, pulverizes and sieves, and obtains fine powder standby;
(6), by filled capsules after the fine powder mix homogeneously obtaining in step (2), step (3) and step (5), be the special invigorating capsule of Testis et penis callorhini.
4. the preparation method of the special invigorating capsule of Testis et penis callorhini according to claim 3, is characterized in that: described in sieve the order number of sieve used in operation between 80-100 order.
5. the preparation method of the special invigorating capsule of Testis et penis callorhini according to claim 3, is characterized in that: in described step (5) 95% ethanol add quality be concentrated solution I quality 1-4 doubly.
6. the preparation method of the special invigorating capsule of Testis et penis callorhini according to claim 3, is characterized in that: the density of described concentrated solution I is 1.12-1.14g/cm
3; The density of concentrated solution II is 1.36-1.40g/cm
3.
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| CN108938939A (en) * | 2017-05-20 | 2018-12-07 | 沈金山 | A kind of Vitality Source health care product for male sexual function health care |
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|---|---|---|---|---|
| CN101381668A (en) * | 2008-09-18 | 2009-03-11 | 何官平 | Method for preparing health-care medicinal liquor |
| CN102212446A (en) * | 2011-05-09 | 2011-10-12 | 成中方 | Physical strength strengthening health-care medicinal liquor capable of tonifying kidney, strengthening yang and enhancing immunity and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101381668A (en) * | 2008-09-18 | 2009-03-11 | 何官平 | Method for preparing health-care medicinal liquor |
| CN102212446A (en) * | 2011-05-09 | 2011-10-12 | 成中方 | Physical strength strengthening health-care medicinal liquor capable of tonifying kidney, strengthening yang and enhancing immunity and preparation method thereof |
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| Title |
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| 栾同芳等: "《家庭医学宝典》", 30 June 2002 * |
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| CN108938939A (en) * | 2017-05-20 | 2018-12-07 | 沈金山 | A kind of Vitality Source health care product for male sexual function health care |
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