CN103751627A - Traditional Chinese medicine preparation for treating neurasthenia and preparation method - Google Patents
Traditional Chinese medicine preparation for treating neurasthenia and preparation method Download PDFInfo
- Publication number
- CN103751627A CN103751627A CN201410056360.3A CN201410056360A CN103751627A CN 103751627 A CN103751627 A CN 103751627A CN 201410056360 A CN201410056360 A CN 201410056360A CN 103751627 A CN103751627 A CN 103751627A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- chinese medicine
- portions
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 56
- 206010003549 asthenia Diseases 0.000 title abstract description 18
- 208000007443 Neurasthenia Diseases 0.000 title abstract description 16
- 241000222336 Ganoderma Species 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 241000206469 Pulsatilla Species 0.000 claims abstract description 9
- 239000004615 ingredient Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 10
- 239000009806 pulsatillae Substances 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 241001071795 Gentiana Species 0.000 claims description 8
- 241000208966 Polygala Species 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- -1 boil 2~3 hours Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 24
- 210000004369 blood Anatomy 0.000 abstract description 16
- 239000008280 blood Substances 0.000 abstract description 16
- 208000024891 symptom Diseases 0.000 abstract description 14
- 210000004185 liver Anatomy 0.000 abstract description 12
- 230000007812 deficiency Effects 0.000 abstract description 10
- 210000003734 kidney Anatomy 0.000 abstract description 8
- 208000031971 Yin Deficiency Diseases 0.000 abstract description 6
- 230000002929 anti-fatigue Effects 0.000 abstract description 3
- 230000001914 calming effect Effects 0.000 abstract description 3
- 210000005036 nerve Anatomy 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 241000411851 herbal medicine Species 0.000 abstract description 2
- 241001412627 Adenophora liliifolia Species 0.000 abstract 1
- 235000016811 Biondella Nutrition 0.000 abstract 1
- 240000003483 Leersia hexandra Species 0.000 abstract 1
- 241000219071 Malvaceae Species 0.000 abstract 1
- 241000378467 Melaleuca Species 0.000 abstract 1
- 235000017784 Mespilus germanica Nutrition 0.000 abstract 1
- 244000182216 Mimusops elengi Species 0.000 abstract 1
- 235000000560 Mimusops elengi Nutrition 0.000 abstract 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 abstract 1
- 235000011613 Pinus brutia Nutrition 0.000 abstract 1
- 241000018646 Pinus brutia Species 0.000 abstract 1
- 241001080798 Polygala tenuifolia Species 0.000 abstract 1
- 240000008301 Rhynchosia minima Species 0.000 abstract 1
- 235000014116 Spondias axillaris Nutrition 0.000 abstract 1
- 244000218979 Spondias axillaris Species 0.000 abstract 1
- 241001530209 Swertia Species 0.000 abstract 1
- 235000007837 Vangueria infausta Nutrition 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 201000010099 disease Diseases 0.000 description 13
- 208000002193 Pain Diseases 0.000 description 12
- 230000036407 pain Effects 0.000 description 11
- 206010019233 Headaches Diseases 0.000 description 9
- 231100000869 headache Toxicity 0.000 description 9
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 8
- 206010022437 insomnia Diseases 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 208000002173 dizziness Diseases 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 230000001717 pathogenic effect Effects 0.000 description 7
- 231100000614 poison Toxicity 0.000 description 6
- 238000012790 confirmation Methods 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 230000003340 mental effect Effects 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 206010000087 Abdominal pain upper Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 206010016256 fatigue Diseases 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 206010029216 Nervousness Diseases 0.000 description 3
- 206010033557 Palpitations Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 230000008451 emotion Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002440 hepatic effect Effects 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 201000004792 malaria Diseases 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 208000004371 toothache Diseases 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- 206010010144 Completed suicide Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 238000001467 acupuncture Methods 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 230000000242 pagocytic effect Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 238000001671 psychotherapy Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000589155 Agrobacterium tumefaciens Species 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000224489 Amoeba Species 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010006100 Bradykinesia Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 235000002673 Dioscorea communis Nutrition 0.000 description 1
- 241000544230 Dioscorea communis Species 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010014020 Ear pain Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000002740 Muscle Rigidity Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 241000893976 Nannizzia gypsea Species 0.000 description 1
- 206010029412 Nightmare Diseases 0.000 description 1
- 241000187654 Nocardia Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000035753 Periorbital contusion Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000037114 Symptom Flare Up Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 1
- 229960000836 amitriptyline Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001775 anti-pathogenic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 208000007176 earache Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 210000001202 rhombencephalon Anatomy 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical group 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 208000023409 throat pain Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for treating neurasthenia and a preparation method, and belongs to the field of traditional Chinese medicine. The effective components of the traditional Chinese medicine preparation comprise the raw materials of pine leaves, melaleuca bark, polygala tenuifolia, herb of clubhead cutgrass, radix polygonati officinalis, the roots of Chinese pulsatilla, medlar, the roots of straight ladybell, choerospondias axillaris, melangolo, roots of common bombax, radix zanthoxyli, lucid ganoderma, felwort, rhynchosia volubilis and semen boitae. The traditional Chinese medicine preparation provided by the invention selects and adopts a high-quality Chinese herbal medicine formula, has the effects of calming mind and soothing nerves, being nursed back of Qi and blood and nourishing yin to lessen fire, has a significant treatment effect on the neurasthenia caused by fire excess from yin deficiency and liver and kidney deficiency and has an excellent anti-fatigue effect, and as for various symptoms caused by the neurasthenia, the traditional Chinese medicine preparation has a significant curative effect and no side effects, is short in course of treatment, quick in operation and safe, and can be clinically and widely popularized and applied.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of neurasthenic Chinese medicine preparation and preparation method for the treatment of.
Background technology
Neurasthenia refers to that brain is due to long-term nervous and stress, thereby produces weakening of ergasia ability, and its principal character is easily excitement and mental fatiguability of spirit, sleep disorder, and hypomnesis, headaches etc., with symptoms such as various body discomforts.The delay of the primary disease course of disease, heavy when light during symptom, state of an illness fluctuation is normal relevant with socio-psychological factors.Most of cases are fallen ill between 16-40 year, both sexes morbidity number no significant difference.The person of being engaged in mental work occupies the majority.Even primary disease can be delayed and reach several years many decades as dealt with improperly.As new Nervous and Mental Factors or the deficiency of having a rest, symptom can be reappeared or aggravate.But through psychiatric department or Psychology Dept. doctor actively, treatment in time, patient directions is eliminated the cause of disease, adopts a correct attitude towards disease, primary disease can reach alleviates or cures, prognosis is generally good.
For neurasthenic treatment, at present as long as take psychotherapy as main, and be aided with Drug therapy, physics or other therapies and treat.Psychotherapy be take and explain to be supported treatment as main, and will establish the good relationship with patient, eliminates patient's hypochondriacal idea, allow patient understand to produce neurasthenic process and with the relation of psychological event; Medicine plays tranquilizing effect, helps to adjust the physiologic derangement of body; In addition, also can suitably merge acupuncture, ear acupuncture static or alternating current ion arrives as physical therapys such as importings.
Above-mentioned therapy all has certain effect for treatment neurasthenia, but medical expense is comparatively huge, to patient, has brought certain financial burden, and severe patient even increases the weight of the state of an illness.
Chinese medicine is as China's traditional medicine, for the treatment of disease, has its unique therapeutic effect, if therefrom develop a kind of medicine for neurasthenic treatment through thering is important medical significance.
Summary of the invention
The invention provides a kind of neurasthenic Chinese medicine preparation and preparation method for the treatment of; Chinese medicine preparation of the present invention is selected high-quality Chinese crude drug formula, there is anchoring mind, take good care of QI and blood, the effect of nourishing YIN to lower pathogenic fire, for the neurasthenia due to hyperactivity of fire caused by deficiency of YIN, the hepatic and renal YIN deficiency, there is significant therapeutic effect, and there is good antifatigue effect, if the various symptoms that cause for neurasthenia have significant curative effect, short treating period, instant effect, safety has no side effect, clinically wide popularization and application.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a neurasthenic Chinese medicine preparation, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
42～66 parts of 43～67 parts of Herba leerisae hexandrae of 44～71 parts of Radix Polygalaes of 50～74 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
31～54 parts of 35～59 parts of Radix Adenophorae (Radix Glehniae) of 37～61 portions of Fructus Lyciis of 40～64 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
14～38 parts of 16～40 portions of Radix Zanthoxylis of 20～44 parts of Radix Gossampinis of 25～49 parts of bigarabes of Fructus Choerospondiatis
3～22 parts of 7～27 parts of Semen Platycladi of 12～31 parts of Herba rhynchosiae volubilis of 12～32 portions of Radix Gentianaes of Ganoderma.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
46～62 parts of 47～63 parts of Herba leerisae hexandrae of 48～67 parts of Radix Polygalaes of 54～70 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
35～50 parts of 39～55 parts of Radix Adenophorae (Radix Glehniae) of 41～57 portions of Fructus Lyciis of 44～60 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
18～34 parts of 20～36 portions of Radix Zanthoxylis of 24～40 parts of Radix Gossampinis of 29～45 parts of bigarabes of Fructus Choerospondiatis
6～19 parts of 10～24 parts of Semen Platycladi of 15～28 parts of Herba rhynchosiae volubilis of 15～29 portions of Radix Gentianaes of Ganoderma.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
50～58 parts of 51～59 parts of Herba leerisae hexandrae of 53～63 parts of Radix Polygalaes of 58～66 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
39～47 parts of 43～51 parts of Radix Adenophorae (Radix Glehniae) of 45～53 portions of Fructus Lyciis of 48～56 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
22～30 parts of 24～32 portions of Radix Zanthoxylis of 28～36 parts of Radix Gossampinis of 33～41 parts of bigarabes of Fructus Choerospondiatis
9～16 parts of 13～21 parts of Semen Platycladi of 18～25 parts of Herba rhynchosiae volubilis of 18～26 portions of Radix Gentianaes of Ganoderma.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
54 parts of 55 parts of Herba leerisae hexandrae of 58 parts of Radix Polygalaes of 62 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
43 parts of 47 parts of Radix Adenophorae (Radix Glehniae) of 49 portions of Fructus Lyciis of 52 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
26 parts of 28 portions of Radix Zanthoxylis of 32 parts of Radix Gossampinis of 37 parts of bigarabes of Fructus Choerospondiatis
13 parts of 17 parts of Semen Platycladi of 22 parts of Herba rhynchosiae volubilis of 22 portions of Radix Gentianaes of Ganoderma.
Treat a preparation method for neurasthenic Chinese medicine preparation, comprise following processing step:
(1) Folium Pini is put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, standby;
(2) Cortex Melaleucae leucadendrae skin, Radix Polygalae, Herba leerisae hexandrae, Rhizoma Polygonati Odorati, the Radix Pulsatillae, Radix Adenophorae (Radix Glehniae), Fructus Choerospondiatis, Radix Gossampini, Radix Zanthoxyli, Radix Gentianae, Herba rhynchosiae volubilis and Semen Platycladi are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.13, standby;
(3) Fructus Lycii and Ganoderma are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 4 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 65 ℃ of simmer down tos, relative density is 1.11～1.15, standby;
(4) bigarabe is cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make capsule, obtain the neurasthenic Chinese medicine preparation for the treatment of of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Folium Pini: bitter in the mouth, warm in nature; GUIXIN, spleen channel.Dispeiling pathogenic wind and removing dampness, killing parasites for relieving itching, blood-promoting and mind-easing.Cure mainly rheumatism flaccidity syndrome and arthralgia syndrome, beriberi, eczema, tinea, rubella pruritus, traumatic injury, neurasthenia, chronic nephritis, hypertension; Can be used for preventing encephalitis, influenza.
Cortex Melaleucae leucadendrae skin: lightly seasoned, property is flat.The calmness of calming the nerves.Modern medicine study confirmation, Cortex Melaleucae leucadendrae skin can alleviate neuralgia, headache, toothache, otalgia, gout, rheumatism, muscle rigidity and dysmenorrhoea.
Radix Polygalae: bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian.The Fructus Alpiniae Oxyphyllae of calming the nerves, eliminating phlegm for diminishing swelling.The insomnia and dreamful sleep, the forgetful palpitation with fear that for disarmony between the heart and kidney, cause, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.< < Mingyi Bielu > > carries: " centering gas, spasmolytic is throbbed with fear, and benefit essence goes heat in heart intake of food in the morning and vomitting in the evening gas, skin, appearance yellow.”
Herba leerisae hexandrae: taste is flat, and property is pungent.Dispelling wind to relieve the exterior syndrome, dampness removing, removing obstruction in the collateral to relieve pain.Cure mainly flu, headache body pain, malaria, leucorrhea, lower limbs edema, dysuria, arthralgia pain is numb.< < Traditional Chinese Medicine in Sichuan will > > carries: " energy expelling cold and relieving exterior syndrome, the meridian dredging.Treating malaria disease, flu head-body-pain.”
Rhizoma Polygonati Odorati: sweet in the mouth, be slightly cold, property is flat; Attach to the lung and stomach meridians.Nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst.Cure mainly cough caused by dryness, chronic cough, the dry throat and mouth of the cloudy liquid consumption of calentura wound, interior-heat is quenched one's thirst, and deficiency of YIN diseases caused by exogenous pathogenic factor are dizzy dizzy, muscle arteries and veins spasm and pain.< < herbal classic > > carries: " main apoplexy sudden high fever, can not shake, and falls muscle knot meat, various symptoms and signs of deficiency.Clothes go dark complexion wild for a long time, and good color is moist, makes light of one's life by commiting suicide not old." modern medicine study confirmation, these product have the laboratory animal of promotion antibody and generate, and improve phagocytic percentage and the phagocytic index of macrophage; promote interferon to synthesize; to suppress growth of bacillus tubercle, blood sugar lowering, blood fat reducing; alleviate atherosclerotic plaque and form; make peripheral blood vessel and coronary dilation, extend hypoxia endurance time, heart tonifying; antioxidation, the anti-ageing effect of waiting for a long time.
The Radix Pulsatillae: bitter in the mouth, cold in nature; Enter stomach, large intestine channel.Removing heat from blood, heat clearing away, removing toxic substances.Cure mainly toxic-heat and blood stasis, pyrexial malaria, blood nosebleed, the diseases such as bleeding hemorrhoids.Modern medicine study confirmation, Radix Pulsatillae decoct can suppress the growth of ameba grass, and effective ingredient is Saponin, Herba Potentillae Chinensis, and amoeba trophozoite is had to killing action, in addition, also has the effect of antifungal and antibacterium (to bacillus pyocyaneus, staphylococcus aureus).
Fructus Lycii: sweet in the mouth, property are put down, tonifying liver, kidney tonifying.Be commonly used to treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission.< < Compendium of Materia Medica > > carries: " take for a long time hard muscles and bones, make light of one's life by commiting suicide not old, cold-resistant summer-heat." modern pharmacology studies confirm that; Fructus Lycii scalable body's immunity, effectively inhibition tumor cell growth and cell mutation, there is the effect of the aspects such as slow down aging, anti-fatty liver, adjusting blood fat and blood glucose, promotion hemopoietic function, and be applied to clinical.
Radix Adenophorae (Radix Glehniae): sweet in the mouth, cool in nature; Attach to the lung and stomach meridians.The light gas of body and, rise and edge down, removing heat from the lung and dissipating phlegm, nourishing YIN to relieve dryness, reinforcing stomach reg fluid.Cure mainly fever due to yin deficiency, dryness of the lung dry cough, consumptive lung disease consumptive disease is coughed, sputum mixed with blood, sore throat pharyngalgia, Tianjin wound is thirsty.
Fructus Choerospondiatis: sweet in the mouth, acid, property is flat; Return spleen, Liver Channel.Promoting flow of QI and blood, tranquilizing by nourishing the heart, removing food stagnancy removing toxic substances.Cure mainly qi depression to blood stasis, chest pain, shortness of breath and palpitation, neurasthenia, insomnia, bronchitis, dyspepsia abdominal distention, diarrhoea, hernia, burn and scald.< < Guangxi Chinese herbal medicine > > carries: " fresh fruit, eliminating indigested food are controlled dyspepsia stomachache.Pit, heat clearing away poison, parasite killing convergence.Control burn.”
Bigarabe: can prevent that skin inflammation is red and swollen by anti-inflammation and sterilization; Balance skin fat secretion, strengthens cellular metabolism function, promotes cell regeneration, and the skin corium that maintenance is impaired helps hole, cicatrix hole to recover as early as possible normally, the effect that desalination pox prints.
Radix Gossampini: acrid in the mouth, sweet, property is flat.Removing dampness for regulating stomach, the resolving depression of regulating the flow of vital energy.Cure mainly taste turbid damp and do not change, eat less gastral cavity vexed, diarrhoea or dysentery stomachache.Modern medicine study confirmation, Radix Gossampini has the effect of liver heat removing and eyesight improving, makes people's life lengthening, physical and mental health.
Radix Zanthoxyli: bitter in the mouth, pungent, property is flat, slightly poisonous; Return liver, stomach warp.Promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral.The traumatic injury, rheumatic arthralgia, stomachache, the toothache that for qi depression to blood stasis, cause, venom, the burning hot wound of external treatment soup.Modern medicine study confirms, Radix Zanthoxyli is made powder, at topical therapeutic ulcer eliminate pain, promote the each side such as healing and Shorten the Treatment Process all to receive satisfied effect, and there is antiinflammatory, analgesia, antitumor, antifungal, regulate the effect of the aspects such as cardiovascular system, also there is the pharmacological actions such as heart tonifying, blood pressure lowering.
Ganoderma: sweet in the mouth, property is flat; GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Pharmacology shows experiment, and Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, effects such as in addition, also having hepatoprotective, improve immunologic function, be antibacterial.
Radix Gentianae: bitter in the mouth, cold in nature; Return liver, gallbladder meridian.Heat clearing and damp drying, eliminating pathogen in the liver arresting convulsion.Cure mainly jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear is swollen, hypochondriac pain bitter taste, calentura convulsion with spasms.< < detailed outline > > carries: " treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.But in large bitter Great Cold, cross probably the injure one's stomach gas of middle hair growth promoting of clothes, the anti-pathogenic fire that helps, also takes Rhizoma Coptidis for a long time instead from the justice of cremate." modern medicine study confirmation, Radix Gentianae is to root nodule bacteria, and escherichia coli, bacillus subtilis, Agrobacterium tumefaciens etc. have effect; Radix Gentianae water logging agent has inhibitory action in various degree to dermatophytess such as trichophyton gypseum star nocardias in vitro.
Herba rhynchosiae volubilis: bitter in the mouth, pungent, property is flat.Removing food stagnancy eliminating stagnation, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.For infantile malnutrition, toothache, nervous headache, lymphoid tuberculosis, rheumatic arthritis, lumbar muscle strain; Carbuncle furuncle and phyma poison, venom are controlled in external.Jiangxi < < medical herbs handbook > > carries: " eliminate the phlegm, removing toxic substances, parasite killing, wind-damp dispelling, and vim and vigour, control acute appendicitis, scrofula, headache, ophthalmalgia, stomachache.”
Semen Platycladi: sweet in the mouth, property is flat; GUIXIN, kidney, large intestine channel.Tranquilizing by nourishing the heart, hidroschesis intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.< < detailed outline > > carries: " gas that nourishes heart, profit kidney is dry, and Fructus Alpiniae Oxyphyllae is allayed excitement; Burn drop and control scabies.”
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention is selected high-quality Chinese crude drug formula, there is anchoring mind, take good care of QI and blood, the effect of nourishing YIN to lower pathogenic fire, for the neurasthenia due to hyperactivity of fire caused by deficiency of YIN, the hepatic and renal YIN deficiency, there is significant therapeutic effect, and there is good antifatigue effect, if the various symptoms that cause for neurasthenia have significant curative effect, short treating period, instant effect, safety has no side effect, clinically wide popularization and application.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Folium Pini 70g Cortex Melaleucae leucadendrae skin 67g Radix Polygalae 63g Herba leerisae hexandrae 62g
Rhizoma Polygonati Odorati 60g Radix Pulsatillae 57g Fructus Lycii 55g Radix Adenophorae (Radix Glehniae) 50g
Fructus Choerospondiatis 45g bigarabe 40g Radix Gossampini 36g Radix Zanthoxyli 34g
Ganoderma 29g Radix Gentianae 28g Herba rhynchosiae volubilis 24g Semen Platycladi 19g.
Treat a preparation method for neurasthenic Chinese medicine preparation, comprise following processing step:
(1) Folium Pini is put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, standby;
(2) Cortex Melaleucae leucadendrae skin, Radix Polygalae, Herba leerisae hexandrae, Rhizoma Polygonati Odorati, the Radix Pulsatillae, Radix Adenophorae (Radix Glehniae), Fructus Choerospondiatis, Radix Gossampini, Radix Zanthoxyli, Radix Gentianae, Herba rhynchosiae volubilis and Semen Platycladi are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.13, standby;
(3) Fructus Lycii and Ganoderma are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 4 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 65 ℃ of simmer down tos, relative density is 1.11～1.15, standby;
(4) bigarabe is cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make capsule, obtain the neurasthenic Chinese medicine preparation for the treatment of of the present invention.
Usage and dosage: oral, every day 3 times, morning, noon and afternoon each 1 time, each 2 (every 0.5g), after meal warm water delivery services; Within 15 days, be 1 course for the treatment of, can fully recover 2～3 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Folium Pini 66g Cortex Melaleucae leucadendrae skin 63g Radix Polygalae 59g Herba leerisae hexandrae 58g
Rhizoma Polygonati Odorati 56g Radix Pulsatillae 53g Fructus Lycii 51g Radix Adenophorae (Radix Glehniae) 47g
Fructus Choerospondiatis 41g bigarabe 36g Radix Gossampini 32g Radix Zanthoxyli 30g
Ganoderma 26g Radix Gentianae 25g Herba rhynchosiae volubilis 21g Semen Platycladi 16g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Folium Pini 62g Cortex Melaleucae leucadendrae skin 58g Radix Polygalae 55g Herba leerisae hexandrae 54g
Rhizoma Polygonati Odorati 52g Radix Pulsatillae 49g Fructus Lycii 47g Radix Adenophorae (Radix Glehniae) 43g
Fructus Choerospondiatis 37g bigarabe 32g Radix Gossampini 28g Radix Zanthoxyli 26g
Ganoderma 22g Radix Gentianae 22g Herba rhynchosiae volubilis 17g Semen Platycladi 13g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Folium Pini 58g Cortex Melaleucae leucadendrae skin 53g Radix Polygalae 51g Herba leerisae hexandrae 50g
Rhizoma Polygonati Odorati 48g Radix Pulsatillae 45g Fructus Lycii 43g Radix Adenophorae (Radix Glehniae) 39g
Fructus Choerospondiatis 33g bigarabe 28g Radix Gossampini 24g Radix Zanthoxyli 22g
Ganoderma 18g Radix Gentianae 18g Herba rhynchosiae volubilis 13g Semen Platycladi 9g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Folium Pini 54g Cortex Melaleucae leucadendrae skin 48g Radix Polygalae 47g Herba leerisae hexandrae 46g
Rhizoma Polygonati Odorati 44g Radix Pulsatillae 41g Fructus Lycii 39g Radix Adenophorae (Radix Glehniae) 35g
Fructus Choerospondiatis 29g bigarabe 24g Radix Gossampini 20g Radix Zanthoxyli 18g
Ganoderma 15g Radix Gentianae 15g Herba rhynchosiae volubilis 10g Semen Platycladi 6g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the neurasthenic Chinese medicine preparation for the treatment of, select the routine clinical observation of neurastheniac 138 make a definite diagnosis, patient to be divided at random two groups for the treatment of group and matched groups, treatment group 69 examples, male's 33 examples wherein, women's 36 examples, 16～40 years old age, 28 years old mean age, the course of disease 1～20 year; Matched group 69 examples, wherein male 34
Example, women's 35 examples, 17～41 years old age, 37.5 years old mean age, the course of disease 1～18 year; The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken Chinese medicine preparation of the present invention, oral, every day 3 times, morning, noon and afternoon each 1 time, each 2 (every 0.5g), after meal warm water delivery services; Within 15 days, be 1 course for the treatment of, can fully recover 2～3 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Matched group is taken amitriptyline sheet, oral, adult's usual amounts; Start one time 25mg, every day 2～4 times, then according to the state of an illness and tolerance situation, increase to gradually 150-300mg every day.
3, efficacy determination:
(1) cure: be emotionally stable, symptom disappears completely.
(2) effective: the physiological functions such as sleep are recovered substantially, and emotion slightly fluctuates.
(3) effective: the physiological functions such as sleep are recovered to some extent, and emotion slightly fluctuates.
(4) invalid: psychology and physiological signs are unchanged.
4, result:
| Number of cases is cured effective enabledisable cure rate total effective rate |
| Treatment group 69 36 15 16 2 52.2% 94.3% |
| Matched group 69 12 11 13 33 17.4% 52.2% |
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, leaf, female, 32 years old, certain well-known relationship supervisor of foreign enterprise, Zhejiang Hangzhou people.Patient is from often occurring feel not sleep well in evening the year before, and the symptoms such as insomnia, dreaminess, lean on vitimin supplement to improve spirit every day, by cosmetic, cover up black eye and tired out.After half a year, because customer requirement is changeable, follow-up intensity increases, and overtime work in late into the night several months continuously causes that the symptom of deficiency of heart-QI is deepened.Health is especially easily tired, obviously sensation brain is not enough, and anxious state of mind is large, easily flighty and impetuous, after admission examination, doctor advised patient does " DNBR leads sleep detection system " more and detects, although did before CT examination, because CT examination can only detect the morphological change of brain, but the brain of most of patients does not have the change of obvious morphology aspect, it is inaccurate that this just causes detecting the cause of disease, and treatment lacks specific aim, unsatisfactory curative effect.Through detecting in detail, diagnosis Mrs Ye has suffered from moderate neurasthenia.Doctor says, patient just occurred symptom before 1 year, did not draw attention, and due to continuous overtime work, operating pressure was large afterwards, caused symptom to increase the weight of, although accepted treatment, because treatment lacks specific aim, causes the state of an illness to delay again and again, final aggravation.Rear doctor recommends patient to take Chinese medicine preparation of the present invention, takes medicine after 2 courses for the treatment of, and the conscious Sufficient Sleeping of patient, energetic, mental restoration normality.
2, Lee, man, 26 years old, postgraduate, people from Changzhi, Shanxi.Patient is depressed for a long time, headache, and head is not felt bad especially, and with general malaise, often easily frightened, be ictal.Through the traditional Chinese medical science, feel the pulse and be diagnosed as neurasthenia, suffer from a deficiency of the kidney, weakness of the spleen and stomach, hyperactivity of fire caused by deficiency of YIN.In many ways seek medical advice and take medicine, all to no effect, the conscious blindness of patient, does not know how to treat.Rear patient is through friend recommendation, to our hospital, and it takes Chinese medicine preparation of the present invention doctor advised, takes medicine after 3 courses for the treatment of, and patient is conscious, and things are as usual, the check of being admitted to hospital, and it is normal that physiological status is recovered,
3, field, man, 18 years old, student, Jinan, Shandong Province people.Patient is owing to facing college entrance examination, and long-term intermittent insomnia, is difficult to fall asleep, also with dreaminess (not night dream is many, but the number of times that dream occurs in one-period is ordinary than usual), and majority is to have a dream in the morning, the rear left of waking up hindbrain has headache sense, also occurs the symptoms such as alopecia.Patient father and mother are with it to our hospital, be diagnosed as neurasthenia, through doctor, recommend to bring into use medicine of the present invention to treat, take medicine after 1 course for the treatment of, patient feels that health is spry and light, sleep recovers, continue to take 1 course for the treatment of, it is normal that patient health recovers, and sleep mental restoration is normal, energetic, very confident putting into prepared for war in college entrance examination.
4, Zhang, male, 33 years old, grade teacher, people from Datong.Patient is because of insomnia, and spirit is poor, and fatiguability comes institute medical.Through patient, tell about, patient over 5 years due to work strain, task weight, pressure is large, engenders insomnia, shows as difficulty falling asleep, needs just to fall asleep for two or three hours, easily wakes up with a start dreaminess after sleeping.Daytime is drowsy, and spirit is poor, fatiguability, and upper class hour is absent minded, and memory and the learning efficiency decline, and occur dizzy headache, and emotion is fidgety.Patient previously body is strong, denies serious organic disease and infectious disease, and diagnosis is for god is by weak.Take 2 courses for the treatment of of Chinese medicine preparation of the present invention, above-mentioned symptom disappears, and continues to take medicine 1
Consolidate the individual course for the treatment of, and all recoveries of rear patient are as usual.
5, hole, female, 38 years old, civil servant, people from Tangshan.Patient for many years susceptible is tired, bradykinesia, hypomnesis.Recently how tired thing is, and symptom increases the weight of, inappetence, evening many nightmares.To our hospital, start to take after 2 courses for the treatment of of the present invention afterwards, sleep stable night, the disappearance of feeling dizzy, appetite is bestirred oneself, and works full of vitality.
6, bent certain, female, 42 years old, engineer, jiangsu wuxi people.Patient speculate in shares, hypomnesis listless with having a sleepless night, feel dizzy, going to work after failure, tired asthenia, spiritual atrophy, often lose control of with people and dispute because of minor matter, regrets again endlessly afterwards; At nightfall, toss about, be difficult to fall asleep.Admission examination, diagnosis is neurasthenia, takes Chinese medicine preparation of the present invention after 3 courses for the treatment of, all recover normal patient, and follow up a case by regular visits to the state of an illness without recurrence.
Claims (5)
1. treat a neurasthenic Chinese medicine preparation, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
42～66 parts of 43～67 parts of Herba leerisae hexandrae of 44～71 parts of Radix Polygalaes of 50～74 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
31～54 parts of 35～59 parts of Radix Adenophorae (Radix Glehniae) of 37～61 portions of Fructus Lyciis of 40～64 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
14～38 parts of 16～40 portions of Radix Zanthoxylis of 20～44 parts of Radix Gossampinis of 25～49 parts of bigarabes of Fructus Choerospondiatis
3～22 parts of 7～27 parts of Semen Platycladi of 12～31 parts of Herba rhynchosiae volubilis of 12～32 portions of Radix Gentianaes of Ganoderma.
2. a kind of neurasthenic Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
46～62 parts of 47～63 parts of Herba leerisae hexandrae of 48～67 parts of Radix Polygalaes of 54～70 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
35～50 parts of 39～55 parts of Radix Adenophorae (Radix Glehniae) of 41～57 portions of Fructus Lyciis of 44～60 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
18～34 parts of 20～36 portions of Radix Zanthoxylis of 24～40 parts of Radix Gossampinis of 29～45 parts of bigarabes of Fructus Choerospondiatis
6～19 parts of 10～24 parts of Semen Platycladi of 15～28 parts of Herba rhynchosiae volubilis of 15～29 portions of Radix Gentianaes of Ganoderma.
3. a kind of neurasthenic Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
50～58 parts of 51～59 parts of Herba leerisae hexandrae of 53～63 parts of Radix Polygalaes of 58～66 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
39～47 parts of 43～51 parts of Radix Adenophorae (Radix Glehniae) of 45～53 portions of Fructus Lyciis of 48～56 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
22～30 parts of 24～32 portions of Radix Zanthoxylis of 28～36 parts of Radix Gossampinis of 33～41 parts of bigarabes of Fructus Choerospondiatis
9～16 parts of 13～21 parts of Semen Platycladi of 18～25 parts of Herba rhynchosiae volubilis of 18～26 portions of Radix Gentianaes of Ganoderma.
4. a kind of neurasthenic Chinese medicine preparation for the treatment of according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
54 parts of 55 parts of Herba leerisae hexandrae of 58 parts of Radix Polygalaes of 62 parts of Cortex Melaleucae leucadendrae skins of Folium Pini
43 parts of 47 parts of Radix Adenophorae (Radix Glehniae) of 49 portions of Fructus Lyciis of 52 portions of Radix Pulsatillaes of Rhizoma Polygonati Odorati
26 parts of 28 portions of Radix Zanthoxylis of 32 parts of Radix Gossampinis of 37 parts of bigarabes of Fructus Choerospondiatis
13 parts of 17 parts of Semen Platycladi of 22 parts of Herba rhynchosiae volubilis of 22 portions of Radix Gentianaes of Ganoderma.
5. as described in claim 1～4 any one, treat a preparation method for neurasthenic Chinese medicine preparation, it is characterized in that: comprise following processing step:
(1) Folium Pini is put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, standby;
(2) Cortex Melaleucae leucadendrae skin, Radix Polygalae, Herba leerisae hexandrae, Rhizoma Polygonati Odorati, the Radix Pulsatillae, Radix Adenophorae (Radix Glehniae), Fructus Choerospondiatis, Radix Gossampini, Radix Zanthoxyli, Radix Gentianae, Herba rhynchosiae volubilis and Semen Platycladi are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.13, standby;
(3) Fructus Lycii and Ganoderma are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 4 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 65 ℃ of simmer down tos, relative density is 1.11～1.15, standby;
(4) bigarabe is cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice standby;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make capsule, obtain the neurasthenic Chinese medicine preparation for the treatment of of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410056360.3A CN103751627B (en) | 2014-02-19 | 2014-02-19 | One treats neurasthenic Chinese medicine preparation and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410056360.3A CN103751627B (en) | 2014-02-19 | 2014-02-19 | One treats neurasthenic Chinese medicine preparation and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103751627A true CN103751627A (en) | 2014-04-30 |
| CN103751627B CN103751627B (en) | 2016-03-30 |
Family
ID=50519054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410056360.3A Expired - Fee Related CN103751627B (en) | 2014-02-19 | 2014-02-19 | One treats neurasthenic Chinese medicine preparation and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103751627B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173767A (en) * | 2014-08-19 | 2014-12-03 | 金先琦 | Traditional Chinese medicine capsule for treating neurasthenia |
| CN111494597A (en) * | 2020-05-26 | 2020-08-07 | 陈琪 | Traditional Chinese medicine composition for conditioning neurasthenia constitution and related diseases |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711850A (en) * | 2009-10-26 | 2010-05-26 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating symptoms of myocardial ischemia, palpitation and severe palpitation and preparation method |
| CN101874891A (en) * | 2010-04-26 | 2010-11-03 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating heart-throb and preparation method thereof |
-
2014
- 2014-02-19 CN CN201410056360.3A patent/CN103751627B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711850A (en) * | 2009-10-26 | 2010-05-26 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating symptoms of myocardial ischemia, palpitation and severe palpitation and preparation method |
| CN101874891A (en) * | 2010-04-26 | 2010-11-03 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating heart-throb and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 吴静芳: "治疗神经衰弱症候群的体会", 《中医杂志》, 31 December 1986 (1986-12-31), pages 38 - 39 * |
| 程蕴: "神经官能症的证治体会", 《新中医》, 31 May 1978 (1978-05-31), pages 24 - 27 * |
| 黄顺东: "松针临床应用及药理研究概况", 《实用中医药杂志》, vol. 21, no. 8, 31 August 2005 (2005-08-31), pages 514 - 515 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173767A (en) * | 2014-08-19 | 2014-12-03 | 金先琦 | Traditional Chinese medicine capsule for treating neurasthenia |
| CN111494597A (en) * | 2020-05-26 | 2020-08-07 | 陈琪 | Traditional Chinese medicine composition for conditioning neurasthenia constitution and related diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103751627B (en) | 2016-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104435775A (en) | Chinese medicinal health-care spirit and preparation method thereof | |
| CN103432475B (en) | Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof | |
| CN104642654A (en) | Health tea for controlling body weight, reducing uric acid and reducing hypertension, hyperglycemia and hyperlipemia | |
| CN103860941A (en) | Traditional Chinese medicine for treating schizophrenia and preparation method thereof | |
| CN103736072B (en) | Medicine of a kind for the treatment of of allergic rhinitis and preparation method thereof | |
| CN104306678A (en) | Traditional Chinese medicine preparation for treating postpartum depression and preparation method of traditional Chinese medicine preparation | |
| CN103751627B (en) | One treats neurasthenic Chinese medicine preparation and preparation method | |
| CN106511705A (en) | Traditional Chinese medicine preparation for treating and regulating blood fat and reducing blood pressure and blood sugar and preparation method | |
| CN104547598A (en) | Traditional Chinese medicine preparation for treating neurasthenia and preparation method thereof | |
| CN104606469A (en) | Traditional Chinese medicine composition for treating insomnia | |
| CN104474342A (en) | Tea cream for drinking of people with high blood pressure, high blood sugar and hyperlipidemia and preparation method of tea cream | |
| CN105012732B (en) | Traditional Chinese medicine pill for treating sleep disorder syndrome and preparation method thereof | |
| CN104435865B (en) | Traditional Chinese medicine for treating arrhythmia and preparation method thereof | |
| CN103341054B (en) | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN108524861A (en) | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating insomnia | |
| CN103520644B (en) | Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition | |
| CN104706942A (en) | Medicine composition for treating cerebrocardiac syndrome and preparation method of medicine composition | |
| CN105456929A (en) | Traditional Chinese medicinal pill for treating hypoglycemia and preparation method of traditional Chinese medicinal pill | |
| CN104825846A (en) | Traditional Chinese medicinal composition for treating facial neuritis | |
| CN104547695B (en) | It is a kind of for treating the pharmaceutical composition and its application of trigeminal neuralgia | |
| CN105194241A (en) | Traditional Chinese medicine preparation for treating neurasthenia and preparation method | |
| CN105125653A (en) | Drug for treating myasthenia gravis and preparation method thereof | |
| CN103845626A (en) | Medicine for treating schizophrenia and preparation method thereof | |
| CN103893598A (en) | Traditional Chinese medicine for treating insomnia | |
| CN103356984B (en) | Traditional Chinese medicine composition for preventing and treating female iron deficiency anemia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Yonggang Inventor before: Qiu Hua Inventor before: Li Renzhen Inventor before: Zhao Haimei Inventor before: Wang Yongxue Inventor before: Li Hongyan |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160302 Address after: 271500 Gaomi City Hospital of traditional Chinese medicine, 588 Fenghuang street, Weifang, Shandong, Gaomi City Applicant after: Li Yonggang Address before: 276600 Junan County People's Hospital, Tianqiao Road, Linyi, Shandong, Junan, China Applicant before: Qiu Hua |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zuo Yaoxian Inventor before: Li Yonggang |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170829 Address after: 065000, No. 1, unit 401, family building, CCB, Yongan Road, Dachang County, Dachang Hui Autonomous County, Hebei, Langfang Patentee after: Zuo Yaoxian Address before: 271500 Gaomi City Hospital of traditional Chinese medicine, 588 Fenghuang street, Weifang, Shandong, Gaomi City Patentee before: Li Yonggang |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160330 Termination date: 20180219 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |