CN103751568A - Traditional Chinese medicine composition for treating pruritus and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating pruritus and a preparation method thereof, belonging to the field of pharmacy technologies of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw medicines or extractives: polygonum multiflorum, Chinese parsnip root, caltrop, gastrodia elata, flax, leonurus, fructus viticis, fructus aurantii, rhizoma atractylodis, xanthium strumarium, radix sophorae flavescentis, stiff silkworm, astragalus membranaceus, uncaria, liquorice, semen plantaginis, schizonepeta, Chinese angelica, radix paeoniae alba, golden cypress, coptis chinensis, root of common peony, lithospermum, fructus forsythia, lily, dandelion, bunge corydalis herb, honeysuckle and fructus forsythia. The traditional Chinese medicine composition is combined scientifically according to the Chinese medicine dialectical therapy; the traditional Chinese medicine composition has effects of dispelling wind and eliminating dampness, warming the channels, relieving pain, relieving rheumatism rheumatism pain, clearing heat, removing toxicity, relieving numbness of limb, relieving joint pain, clearing heat, arresting convulsion, treating weak spleen and lungs; the traditional Chinese medicine composition is high in cure rate, short in therapy course, low in recurrence rate and few in side effects; the traditional Chinese medicine composition is good in effect of treating pruritus; the traditional Chinese medicine composition is popularized and used in clinic.

Description

A kind of Chinese medicine composition for the treatment of pruritus and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of pruritus and preparation method thereof, belong to technical field of traditional Chinese medicine pharmacy.

Background technology

Pruritus is a kind ofly to have skin pruritus and without the dermatosis of former skin lesion, the cause of disease has internal diseases, neural factors, and medicine or food anaphylaxis, climate change, xerosis cutis or atrophy, soap or anti-inflammation drugs stimulate, part massage or humidity.Mainly comprise dermatitis, prurigo, is apt to occur in extremity and stretches side, and secondly, for bending side, severe one spreads whole body, and conscious play is itched, and the course of disease is chronic and obstinate.

Skin pruritus refers to without primary cutaneous infringement, and the dermatosis of paresthesia of skin take pruritus as cardinal symptom.Be characterized in skin paroxysmal pruritus, after scratching, often occur the secondary lesions such as scratch, blood crusts, pigmentation and lichenification.The position of pruritus is apt to occur in the easily position of friction of limbs, neck portion, and fossa cubitalis ， month popliteal nest, forearm, waist, caudal vertebra, shanks etc. are located, and regional pruritus is apt to occur in female vulva, males scrotum etc. and locates, and whole body pruritus is apt to occur in old people.Often there is strip scratch at pruritus place.If do not treated, there is sepage at scratch place, and with the passing of time pigmentation can appear that eczema sample becomes, in incrustation or blood crusts equivalent damage.There are clinically two kinds of limitation, general property.Around pruritus is the most common with pudendum, anus for limitation person, and a general property person can general whole body.Skin pruritus belongs to the traditional Chinese medical science " pruritus caused by wind pathogen ", " pruritus " category.It is not resistance to that pathogenesis mainly contains natural endowment, blood hot air wind producing; Deficiency of qi and blood, wind syndrome due to blood-deficiency; Eating and drinking without temperance, wet hot air wind producing.Clinical syndrome differentiation opinion is controlled and is often divided into wind heat heat in blood, retention of damp-heat in the interior, 3 of blood-deficiency leading to hyperactivity of the liver and levies type.

Pruritus person is without suitable treatment, and pruritus can occur at whole skin, and constantly increase, causes skin damage.Secondly, pruritus severe patient skin scratch causes local skin to infect, and easily causes total white blood cells to raise, and that outbreak position occurs is red, swollen, heating and seriously having difficulty in going to sleep, now any touching and all can make the aggravation of itching slightly.

For the straightforward procedure for the treatment of pruritus, first be to note on diet, dieting, bringing out the food of pruritus outbreak resolutely refuses to eat, the food of dieting can and have medicine food anaphylaxis according to individual physique, secondly, PIYANPING and some contain hormone has a medicine outward, can be in acute attack stage external, relieving itch in can the short time, but side effect is very large, do not advise long-term external, in addition, long-term treatment needs food vegetable-fruit regulation, side effect is little, picture Fructus Musae, Herba Apii graveolentis, Fructus Cucumidis sativi etc., wherein contain trace element and can reduce allergic constitution, drink water again more, can increase the excretion of uric acid, reach the object of toxin expelling dietetic therapy, if things go on like this, pruritus symptom alleviates gradually.

To some pruritus severe patient, often use clinically antihistamine drug and calming soporific medicine, external adrenocortical hormone cream, PIYANNING DING etc., but these medicines all contain some hormones or chemicals, and health is produced to certain hazardness, also there is the symptom that is not suitable with such as irritated simultaneously, more importantly these chemicalses are difficult to play the effect for the treatment of both the principal and secondary aspects of a disease, and a lot of medicines are just cured the symptoms, not the disease, instant effect but be difficult to lasting.Therefore, choice for use Chinese medicine composition can play the effect for the treatment of both the principal and secondary aspects of a disease, the many side effect that can avoid again chemicals to produce human body simultaneously.

Summary of the invention

For existing treatment pruritus medicine, there is many side effect and the problem such as drug effect is unstable, one of object of the present invention is to provide a kind of Chinese medicine composition for the treatment of pruritus, according to clinical need to the practice of experimentation, said composition can be made to corresponding preparations.

Another object of the present invention is to provide a kind of method of preparing above-mentioned Chinese medicine composition or preparation.

Another object of the present invention is to provide the purposes of a kind of above-mentioned Chinese medicine composition in the medicine for the preparation of pruritus antipruritic.

On the one hand, the invention provides a kind of Chinese medicine composition of pruritus antipruritic, comprise following former spice or its extract: Radix Polygoni Multiflori, Radix Saposhnikoviae, Fructus Tribuli, Rhizoma Gastrodiae, linum, Herba Leonuri, Fructus Viticis, Fructus Aurantii, Rhizoma Atractylodis, Herba Xanthii, Radix Sophorae Flavescentis, Bombyx Batryticatus, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Semen Plantaginis, Herba Schizonepetae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Phellodendri, Rhizoma Coptidis, Radix Paeoniae Rubra, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Lilii, Herba Taraxaci, Herba Corydalis Bungeanae, Flos Lonicerae, Fructus Forsythiae.

Be preferably as follows former spice or its extract of weight portion: Radix Polygoni Multiflori 10-35, Radix Saposhnikoviae 10-30, Fructus Tribuli 5-20, Rhizoma Gastrodiae 10-30, linum 5-25, Herba Leonuri 10-40, Fructus Viticis 5-25, Fructus Aurantii 5-20, Rhizoma Atractylodis 5-15, Herba Xanthii 5-15, Radix Sophorae Flavescentis 10-40, Bombyx Batryticatus 5-15, Radix Astragali 10-30, Ramulus Uncariae Cum Uncis 5-15, Radix Glycyrrhizae 5-25, Semen Plantaginis 5-25, Herba Schizonepetae 5-15, Radix Angelicae Sinensis 15-40, Radix Paeoniae Alba 5-25, Cortex Phellodendri 10-30, Rhizoma Coptidis 5-15, Radix Paeoniae Rubra 5-15, Radix Arnebiae (Radix Lithospermi) 5-20, Fructus Forsythiae 5-20, Bulbus Lilii 10-40, Herba Taraxaci 5-20, Herba Corydalis Bungeanae 5-20, Flos Lonicerae 5-25, Fructus Forsythiae 5-15.

Preferably, comprise former spice or its extract of following weight portion: Radix Polygoni Multiflori 20, Radix Saposhnikoviae 15, Fructus Tribuli 15, Rhizoma Gastrodiae 20, linum 15, Herba Leonuri 20, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 10, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 10, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 10, Radix Glycyrrhizae 15, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 20, Rhizoma Coptidis 5, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 10, Bulbus Lilii 25, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 15, Fructus Forsythiae 10.

Extract of the present invention is water extract or alcohol extract.

On the other hand, the invention provides a kind of method of preparing described Chinese medicine composition, described former spice is added to the water 5000-7000 of following weight portion, at a simmer to 200-400 part, filter, obtain filtrate.

Preferably, described former spice is added to the water 6000 of following weight portion, at a simmer to 400 parts, filter, obtain filtrate.

At the alternative aspect aspect this, the invention provides a kind of method of preparing described Chinese medicine composition and be

1. pretreatment: Radix Saposhnikoviae, Fructus Tribuli, Bombyx Batryticatus, Cortex Phellodendri, Radix Paeoniae Rubra are pulverized, obtained medicine soup and medicinal residues for decocting in water 2-3 hour at 60-90 ℃;

2. water extraction: by Radix Sophorae Flavescentis, Herba Taraxaci, the Radix Paeoniae Alba, with 2-3 hour extraction volatile oil of steam distillation;

3. alcohol extraction: by described medicine soup and medicinal residues, Radix Polygoni Multiflori, Rhizoma Gastrodiae, linum, Herba Leonuri, Fructus Viticis, Fructus Aurantii, Rhizoma Atractylodis, Herba Xanthii, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Semen Plantaginis, Herba Schizonepetae, Radix Angelicae Sinensis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Lilii, Herba Corydalis Bungeanae, Flos Lonicerae, Fructus Forsythiae, soak with ethanol 30min, microwave power 300-500W, merge extractive liquid,, filters, by filtrate recycling ethanol, concentrate to obtain thick paste, add described volatile oil, mix.

On the one hand, the invention provides the purposes of described Chinese medicine composition in the medicine for the preparation of gout pain relieving again.

Radix Polygoni Multiflori, has another name called Caulis Polygoni Multiflori, Folium Polygoni multiflori, and its root is elongated, and end becomes loose tuber, and appearance bronzing is to crineous.Chinese medicine Radix Polygoni Multiflori has dividing of Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata: Radix Polygoni Multiflori function removing toxic substances (carrying malaria), loosening bowel to relieve constipation, eliminating carbuncle; Radix Polygoni Multiflori Preparata function enrich and benefit essence and blood, black beard and hair, bone and muscle strengthening, invigorating the liver and kidney.Radix Polygoni Multiflori cures mainly scrofula infections carbuncle sore, rubella pruritus, dryness of the intestine constipation.

Radix Saposhnikoviae, has another name called Herba Epimeredis Indicae, air draft grass, native Radix agastaches, Spuropimpinella brachycarpa (Kom.) Kitag., the clothing of failing, dirty grass, is the dry root of Umbelliferae plant Radix Saposhnikoviae.Acrid in the mouth, sweet, warm in nature.Expelling wind and cold pathogens, removing dampness to relieve pain.

Fructus Tribuli, nature and flavor hardship, pungent, flat, enter Liver Channel.Function effect: suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.For dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.

Rhizoma Gastrodiae, it is a kind of important medical material for the treatment of dizziness, sweet in the mouth is flat, enter Liver Channel, main function is suppressing the hyperactive liver to relieve the wind syndrome, having a dizzy spell due to all excessive rising of liver-YANG, complexion is aglow, top-heavy, or the hyperpyrexia and infantile convulsion that causes of liver-wind stirring up internally, infantile convulsion tic, opisthotonus etc., with his medicine of Rhizoma Gastrodiae compatibility, take, often have good effect.

Linum, contains abundant unsaturated acids in siritch, they are to improve human body intelligent, suppress the essential nutrient substance of cardiovascular and cerebrovascular disease.In siritch, a-linolenic acid content reaches 40～52%, is that in oil and fatty plant, content is the highest.Its alimentary health-care function can compare favourably with bathypelagic fish oil, but cheap.

Herba Leonuri, acrid in the mouth tepor.Main improving eyesight benefit essence, except aqueous vapor.Clothes are made light of one's life by commiting suicide for a long time, and the raw urticaria of stem is itched, and can bathe soup.

Fructus Viticis, the mature fruit hyoscine of section's plant Vitex rotundifolia or wild pepper.There is loose wind heat, refresh oneself's effect.Control headache, dizziness, two order distending pains, supraorbital neuralgia, myoneuralgia.

Fructus Aurantii is dicotyledon medicine rutaceae Citrus aurantium Linn. and the near dry immature fruit of variety thereof.For conventional Chinese medicine, cold nature, bitter in the mouth, pungent, acid.Generally need after clean system, cutting, be used as medicine.There is the pharmacological action that acts on cardiovascular system, gastrointestinal, uterus etc.

Rhizoma Atractylodis, nature and flavor are pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Effect: the wet tired transporting imbalance causing, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.

Herba Xanthii is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii.Nature and flavor: toil, cold, poisonous.Containing strumaroside (xanthostrumarin).Leaf is containing xanthanol (xanthanol), isoxanthanol (jsoxanthanol), xanthumin (xanthumin) etc.Staphylococcus aureus, group B streptococcus, Diplococcus pneumoniae are had to certain inhibitory action, and have antifungic action.

Radix Sophorae Flavescentis, Radix Sophorae Flavescentis is the plant that pulse family Radix Sophorae Flavescentis belongs to.There is heat clearing and damp drying, parasite killing, the effect of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.

Bombyx Batryticatus, another name flying worm, Rhizoma Zingiberis Recens silkworm.It is a kind of more special product, it has another name called Bombyx Batryticatus, that silkworm larva infects muscardine and the lethal dry sclerosis polypide that falls ill in the cause of weaving silk, due to the densely covered white hypha of its body surface and conidium, likeness in form one deck tunica albuginea, therefore named, be mainly used in convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes inflammation, facial paralysis, the diseases such as skin pruritus.Bombyx Batryticatus is conventional Chinese medicine simply, acrid in the mouth, salty, and property is flat, has expelling wind to relieve convulsion, dissipating phlegm and resolving masses, the effect of heat-clearing and toxic substances removing dampness, is clinically used for controlling heat syndrome cough, and phlegm dyspnea, spits blood, and collapses, band, traumatic injury, rheumatalgia, sore etc., Bombyx Batryticatus in daily use scope and field in continuous expansion.

The Radix Astragali, the Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely

Ramulus Uncariae Cum Uncis, another name hangs rattan, Ramulus Uncariae Cum Uncis hook, fishhook rattan, Oriolus chinensis diffusus pawl wind, tender hook hook, golden Ramulus Uncariae Cum Uncis, hook rattan, Ramulus Uncariae Cum Uncis, Ramulus Uncariae Cum Uncis, lifting lug, Ramulus Uncariae macrophyllae, Wang Gambirplant Branchlet, reversal of the natural order of things is perverse.Function: heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.

Radix Glycyrrhizae, another name Glycyrrhizae, close sweet (honey sweet), close grass, state are old, Radix Glycyrrhizae, Herba Hedyotis cantonensis, sweet root, rod grass.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Semen Plantaginis, nature and flavor are sweet, light, cold nature.Effect: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm; Dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.

Herba Schizonepetae, the false Soviet Union of Herba Schizonepetae original name, popular name Rhizoma Zingiberis Recens mustard, this medicine is the dry aerial parts of labiate Herba Schizonepetae.Enter medicinal its dry stem and leaf and spica.Taste is flat, and warm in nature, nontoxic, faint scent is dense.Herba Schizonepetae is diaphoresis, and antipyretic is one of conventional medical herbs of China.Energy town expectorant, timid wind, removing heat from blood.Control influenza

Radix Angelicae Sinensis, nature and flavor are sweet, pungent, bitter, warm in nature.Effect: all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

The Radix Paeoniae Alba, also claims Paeonia sterniana Fletcher in Journ., is Ranunculaceae Paeonia plant.That paeoniflorin has is antibacterial, antipyretic, antiinflammatory, increase coronary flow, improve the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.

Cortex Phellodendri, nature and flavor hardship, cold.Return kidney, bladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.

Rhizoma Coptidis, another name: Rhizoma Coptidis, Jiang Lian, Rhizoma Coptidis, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, RHIZOMA COPTIDIS from Sichuan of China.Effect: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, heart-fire is high.External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.

Radix Paeoniae Rubra, clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.

Radix Arnebiae (Radix Lithospermi), nature and flavor: cold in nature, sweet in the mouth, salty.Gui Jing: GUIXIN, Liver Channel.Function cures mainly removing heat from blood, invigorates blood circulation, and removing toxic substances rash.For heat in blood poison contain, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.

Fructus Forsythiae, has another name called that Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, fall to sticking up, Huang Qidan etc.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, pyretic stranguria urine retention.

Bulbus Lilii has the effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and especially fresh Bulbus Lilii is more sweet delicious.The people that Bulbus Lilii is particularly suitable for foster lung, nourishing the stomach eats, such as chronic cough, pulmonary tuberculosis, aphtha of the mouth and tongue.

Herba Taraxaci herb is containing taraxasterol, choline, inulin and pectin etc.Function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Herba Corydalis Bungeanae is the herb of bloodroot corydalis bungeana.Function cures mainly: heat-clearing and toxic substances removing.Control furuncle carbuncle, jaundice interior-heat, children's's nose bleeding, appendicitis, venom.

Flos Lonicerae effect is mainly heat-clearing and toxic substances removing, cures mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle furunculosis etc.Modern study proves, Flos Lonicerae contains the pharmacological components such as chlorogenic acid, luteolin glycosides, the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc. are had to stronger restraint, in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application is very extensive, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.

Fructus Forsythiae, has another name called that Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, fall to sticking up, Huang Qidan etc.Having antibacterial, heart tonifying, diuresis, town the pharmacological action such as to tell, is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of symptom, its bacteriostasis and Flos Lonicerae broadly similars such as, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus

The present invention utilizes the penetrance of microwave, penetrates the inner endogenous pyrogen that forms of substrate, utilizes the selectivity of its heating, makes that each organelle in cell boosts, cell wall rupture, makes effective ingredient from cell, discharge and be dissolved in solvent.With conventional solvent extraction process, compare, it has the advantages such as extraction rate is fast, extract quality is high, impurity is few.

Chinese medicine composition of the present invention is according to the abstract science compatibility of tcm treatment according to syndrome differentiation, there is expelling wind and removing dampness, the effect of antalgic, rheumatic arthralgia, heat-clearing and toxic substances removing, numb limbs and tense tendons, arthralgia, heat clearing away arresting convulsion, deficiency of the spleen and lung, its cure rate is high, short treating period, relapse rate is low, toxic and side effects is few, treatment pruritus and antipruritic are had to better effects, be worth carrying out clinically promotion and application.

The specific embodiment

Following non-limiting example can make the present invention of those of ordinary skill in the art's comprehend, but does not limit the present invention in any way.

One, prepare Chinese medicine composition

Embodiment 1

By following grams, take each former spice: Radix Polygoni Multiflori 23, Radix Saposhnikoviae 18, Fructus Tribuli 15, Rhizoma Gastrodiae 25, linum 22, Herba Leonuri 30, Fructus Viticis 20, Fructus Aurantii 25, Rhizoma Atractylodis 10, Herba Xanthii 15, Radix Sophorae Flavescentis 20, Bombyx Batryticatus 12, the Radix Astragali 24, Ramulus Uncariae Cum Uncis 10, Radix Glycyrrhizae 8, Semen Plantaginis 15, Herba Schizonepetae 17, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 25, Rhizoma Coptidis 7, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 18, Fructus Forsythiae 10, Bulbus Lilii 20, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 10, Fructus Forsythiae 5, remove after impurity, add the water of 5000-7000 milliliter, with at a simmer to 200-400 milliliter, medicine temperature drop is to 38-40 ℃ of left and right, filter with gauze, obtain 3 dosage medicinal liquids.

Embodiment 2

Radix Polygoni Multiflori 30, Radix Saposhnikoviae 15, Fructus Tribuli 15, Rhizoma Gastrodiae 20, linum 20, Herba Leonuri 15, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 15, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 10, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 10, Radix Glycyrrhizae 15, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 33, the Radix Paeoniae Alba 18, Cortex Phellodendri 25, Rhizoma Coptidis 8, Radix Paeoniae Rubra 10, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 15, Bulbus Lilii 20, Herba Taraxaci 10, Herba Corydalis Bungeanae 6, Flos Lonicerae 13, Fructus Forsythiae 7.By above grams, take each former spice: remove after impurity, add the water of 6000 milliliters, to 400 milliliters, medicine temperature drop, to 38-40 ℃ of left and right, with gauze filtration, obtains 3 dosage medicinal liquids with at a simmer.

Embodiment 3

By following grams, take each former spice: Radix Polygoni Multiflori 28, Radix Saposhnikoviae 17, Fructus Tribuli 20, Rhizoma Gastrodiae 20, linum 22, Herba Leonuri 30, Fructus Viticis 25, Fructus Aurantii 20, Rhizoma Atractylodis 13, Herba Xanthii 12, Radix Sophorae Flavescentis 35, Bombyx Batryticatus 13, the Radix Astragali 24, Ramulus Uncariae Cum Uncis 12, Radix Glycyrrhizae 9, Semen Plantaginis 18, Herba Schizonepetae 12, Radix Angelicae Sinensis 35, the Radix Paeoniae Alba 20, Cortex Phellodendri 25, Rhizoma Coptidis 8, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 13, Fructus Forsythiae 7, Bulbus Lilii 17, Herba Taraxaci 20, Herba Corydalis Bungeanae 8, Flos Lonicerae 13, Fructus Forsythiae 7.

Radix Saposhnikoviae, Fructus Tribuli, Bombyx Batryticatus, Cortex Phellodendri, Radix Paeoniae Rubra are pulverized, within decocting in water 2-3 hour at 60-90 ℃, obtained medicine soup and medicinal residues; By Radix Sophorae Flavescentis, Herba Taraxaci, the Radix Paeoniae Alba, with 2-3 hour extraction volatile oil of steam distillation; By described medicine soup and medicinal residues, Radix Polygoni Multiflori, Rhizoma Gastrodiae, linum, Herba Leonuri, Fructus Viticis, Fructus Aurantii, Rhizoma Atractylodis, Herba Xanthii, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Semen Plantaginis, Herba Schizonepetae, Radix Angelicae Sinensis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Lilii, Herba Corydalis Bungeanae, Flos Lonicerae, 5-8 times of 70%-80% ethanol for Fructus Forsythiae, microwave extraction 3-5min at 20-30 ℃, microwave power 300-500W, merge extractive liquid,, filters, by filtrate recycling ethanol, so concentrated that to measure extractum, add described volatile oil, mix, obtain 3 dosage ointment.

Two, clinical therapeutic efficacy

1, the pungent XX of patient, 37 years old, male, whole body pruritus, ill 5 years, integrative therapy is without being clearly better, by following grams, take each former spice: Radix Polygoni Multiflori 20, Radix Saposhnikoviae 15, Fructus Tribuli 15, Rhizoma Gastrodiae 20, linum 20, Herba Leonuri 15, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 15, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 6, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 6, Radix Glycyrrhizae 6, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 25, Rhizoma Coptidis 5, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 10, Bulbus Lilii 20, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 10, Fructus Forsythiae 5, remove after impurity, add the water of 5000-7000 milliliter, with at a simmer to 200-400 milliliter, medicine temperature drop is to 38-40 ℃ of left and right, filter with gauze, obtain 3 dosage medicinal liquids.1 dose of every day, to take 15 days, pruritus is obviously alleviated.

2, patient Liu X, 56 years old, women, suffer from diabetes, with skin pruritus, ill 11 years, use Western medicine and oral medicinal herb to treat throughout the year, cure the symptoms, not the disease, effect is undesirable, by following grams, take each former spice: Radix Polygoni Multiflori 20, Radix Saposhnikoviae 15, Fructus Tribuli 15, Rhizoma Gastrodiae 20, linum 20, Herba Leonuri 15, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 15, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 6, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 6, Radix Glycyrrhizae 6, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 25, Rhizoma Coptidis 5, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 10, Bulbus Lilii 20, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 10, Fructus Forsythiae 5, remove after impurity, add the water of 6000 milliliters, with at a simmer to 400 milliliters, medicine temperature drop is to 38-40 ℃ of left and right, filter with gauze, obtain 3 dosage medicinal liquids.Take 2 doses every day, take 10 days, symptom is obviously alleviated, and can depart from Western medicine such as using ointment, and through taking continuously after 60 days, pruritus symptom all disappears, and after 2 years, has no recurrence.

3,9 of patients, wherein 6 of male, 3 of women, age 27-64 year not etc., does not all suffer from refractory pruritus disease, and not etc., though through repeatedly Chinese and western medicine out-patient treatment, curative effect is all not obvious for sick time 3-12.By following grams, take each former spice: Radix Polygoni Multiflori 20, Radix Saposhnikoviae 15, Fructus Atriplicis Sibiricae 15, Rhizoma Gastrodiae 20, linum 20, Herba Leonuri 15, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 15, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 6, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 6, Radix Glycyrrhizae 6, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 25, Rhizoma Coptidis 5, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 10, Bulbus Lilii 20, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 10, Fructus Forsythiae 5, obtains medicine soup and medicinal residues for decocting in water 2-3 hour at 60-90 ℃ by Radix Saposhnikoviae, Fructus Tribuli, Bombyx Batryticatus, Cortex Phellodendri, Radix Paeoniae Rubra; By Radix Sophorae Flavescentis, Herba Taraxaci, the Radix Paeoniae Alba, with 2-3 hour extraction volatile oil of steam distillation; By described medicine soup and medicinal residues, Radix Polygoni Multiflori, Rhizoma Gastrodiae, linum, Herba Leonuri, Fructus Viticis, Fructus Aurantii, Rhizoma Atractylodis, Herba Xanthii, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Semen Plantaginis, Herba Schizonepetae, Radix Angelicae Sinensis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Lilii, Herba Corydalis Bungeanae, Flos Lonicerae, Fructus Forsythiae, with 5-8 times of 70%-80% ethanol, microwave extraction 3-5min at 20-30 ℃, microwave power 300-500W, merge extractive liquid,, filters, by filtrate recycling ethanol, so concentrated that to measure extractum, add described volatile oil, mix, obtain 3 dosage ointment.Take 1 dose every day, take continuously 15 days, pruritus symptom all be improved significantly, take after 30 days, have 6 patients' pruritus symptom to disappear completely, other 3 patients are taking respectively after 17 days, 30 days, 45 days continuously, all patient's pruritus symptoms all disappear, all not recurrences in a year.

Three, toxicological experiment research

The present invention has carried out the emergency toxicology experimentation of the Chinese medicine composition for the treatment of pruritus simultaneously, method: Chinese medicine composition preparation: Radix Polygoni Multiflori 20, Radix Saposhnikoviae 15, Fructus Tribuli 15, Rhizoma Gastrodiae 20, linum 20, Herba Leonuri 15, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 15, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 6, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 6, Radix Glycyrrhizae 6, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 25, Rhizoma Coptidis 5, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 10, Bulbus Lilii 20, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 10, Fructus Forsythiae 5, remove after impurity, add 6000 ml waters, with at a simmer to 400 milliliters, filter with gauze, treat that medicine temperature drop is to 38-40 ℃ of left and right, bottle standby.The acute disease experimental technique of science of mice: 20 of ICR mices, male and female half and half, body weight 18g, 2g, clean level, Dalian Medical Univ provides, and is divided at random 2 groups, feeding carried out Chinese medicine and gavaged after 1 hour noon every day, evening, and each mice gavages 5 milliliters at every turn, observes 7 days effects.The acute disease pharmacological research result of mice: observe mice Continuous Observation 7 days, result: animal well-grown in 7 days after administration, outward appearance, behavior, activity, hair color, defecation no abnormality seen.7 rear execution mices are also dissected, and the major organs outward appearance such as the heart, liver, spleen, lung, kidney shows no obvious abnormalities change by the naked eye, the more each organs and tissues of clip makes pathological examination, and each internal organs show no obvious abnormalities.The acute and chronic toxicological experiment result of the Chinese medicine composition of gout pain relieving shows: Chinese medicine composition of the present invention is without obvious toxic-side effects.

Claims (8)

1. treat a Chinese medicine composition for pruritus, comprise following former spice or its extract: Radix Polygoni Multiflori, Radix Saposhnikoviae, Fructus Tribuli, Rhizoma Gastrodiae, linum, Herba Leonuri, Fructus Viticis, Fructus Aurantii, Rhizoma Atractylodis, Herba Xanthii, Radix Sophorae Flavescentis, Bombyx Batryticatus, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Semen Plantaginis, Herba Schizonepetae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Phellodendri, Rhizoma Coptidis, Radix Paeoniae Rubra, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Lilii, Herba Taraxaci, Herba Corydalis Bungeanae, Flos Lonicerae, Fructus Forsythiae.

2. Chinese medicine composition according to claim 1, it is characterized in that comprising former spice or its extract of following weight portion: Radix Polygoni Multiflori 10-35, Radix Saposhnikoviae 10-30, Fructus Tribuli 5-20, Rhizoma Gastrodiae 10-30, linum 5-25, Herba Leonuri 10-40, Fructus Viticis 5-25, Fructus Aurantii 5-20, Rhizoma Atractylodis 5-15, Herba Xanthii 5-15, Radix Sophorae Flavescentis 10-40, Bombyx Batryticatus 5-15, Radix Astragali 10-30, Ramulus Uncariae Cum Uncis 5-15, Radix Glycyrrhizae 5-25, Semen Plantaginis 5-25, Herba Schizonepetae 5-15, Radix Angelicae Sinensis 15-40, Radix Paeoniae Alba 5-25, Cortex Phellodendri 10-30, Rhizoma Coptidis 5-15, Radix Paeoniae Rubra 5-15, Radix Arnebiae (Radix Lithospermi) 5-20, Fructus Forsythiae 5-20, Bulbus Lilii 10-40, Herba Taraxaci 5-20, Herba Corydalis Bungeanae 5-20, Flos Lonicerae 5-25, Fructus Forsythiae 5-15.

3. Chinese medicine composition according to claim 1, is characterized in that comprising former spice or its extract of following weight portion: Radix Polygoni Multiflori 20, Radix Saposhnikoviae 15, Fructus Tribuli 15, Rhizoma Gastrodiae 20, linum 15, Herba Leonuri 20, Fructus Viticis 15, Fructus Aurantii 10, Rhizoma Atractylodis 10, Herba Xanthii 10, Radix Sophorae Flavescentis 25, Bombyx Batryticatus 10, the Radix Astragali 15, Ramulus Uncariae Cum Uncis 10, Radix Glycyrrhizae 15, Semen Plantaginis 15, Herba Schizonepetae 10, Radix Angelicae Sinensis 25, the Radix Paeoniae Alba 20, Cortex Phellodendri 20, Rhizoma Coptidis 5, Radix Paeoniae Rubra 5, Radix Arnebiae (Radix Lithospermi) 10, Fructus Forsythiae 10, Bulbus Lilii 25, Herba Taraxaci 15, Herba Corydalis Bungeanae 5, Flos Lonicerae 15, Fructus Forsythiae 10.

4. according to the Chinese medicine composition described in claim 1-3 any one, it is characterized in that described extract is water extract or alcohol extract.

5. prepare a method for Chinese medicine composition described in claim 1-4 any one, it is characterized in that described former spice to add the water 5000-7000 of following weight portion, at a simmer to 200-400 part, filter, obtain filtrate.

6. the method for Chinese medicine composition according to claim 5, is characterized in that described former spice to add the water 6000 of following weight portion, at a simmer to 400 parts, filters, and obtains filtrate.

7. a method of preparing Chinese medicine composition described in claim 1-4 any one, is characterized in that

1. pretreatment: Radix Saposhnikoviae, Fructus Tribuli, Bombyx Batryticatus, Cortex Phellodendri, Radix Paeoniae Rubra are pulverized, obtained medicine soup and medicinal residues for decocting in water 2-3 hour at 60-90 ℃;

2. water extraction: by Radix Sophorae Flavescentis, Herba Taraxaci, the Radix Paeoniae Alba, with 2-3 hour extraction volatile oil of steam distillation;

3. alcohol extraction: by described medicine soup and medicinal residues, Radix Polygoni Multiflori, Rhizoma Gastrodiae, linum, Herba Leonuri, Fructus Viticis, Fructus Aurantii, Rhizoma Atractylodis, Herba Xanthii, the Radix Astragali, Ramulus Uncariae Cum Uncis, Radix Glycyrrhizae, Semen Plantaginis, Herba Schizonepetae, Radix Angelicae Sinensis, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Lilii, Herba Corydalis Bungeanae, Flos Lonicerae, Fructus Forsythiae, soak with ethanol 30min, microwave power 300-500W, merge extractive liquid,, filters, by filtrate recycling ethanol, concentrate to obtain thick paste, add described volatile oil, mix.

8. the purposes of Chinese medicine composition in the medicine for the preparation of pruritus described in claim 1-4 any one.