CN103751277A - Infantile traditional Chinese medicine cooling patch - Google Patents
Infantile traditional Chinese medicine cooling patch Download PDFInfo
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- CN103751277A CN103751277A CN201310742780.2A CN201310742780A CN103751277A CN 103751277 A CN103751277 A CN 103751277A CN 201310742780 A CN201310742780 A CN 201310742780A CN 103751277 A CN103751277 A CN 103751277A
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Abstract
The invention discloses an infantile traditional Chinese medicine cooling patch, belonging to the field of pharmaceutical compositions. The infantile traditional Chinese medicine cooling patch disclosed by the invention comprises ephedra, cassia twig, gypsum, borneol, azone and medical pressure-sensitive adhesive and is prepared by crushing, mixing and stirring to form medicinal rubber emulsion, putting the medicinal rubber emulsion into a spiral type medicinal film coating machine, coating and cutting. Compared with the similar products on the market, in the aspect of compatibility, the infantile traditional Chinese medicine cooling patch disclosed by the invention is simple in medicine and few in medicine variety, however, the pharmaceutical effect is not decreased; the appearance of the infantile traditional Chinese medicine cooling patch is cut, so that two sides form two circular arcs with different radians, namely, the infantile traditional Chinese medicine cooling patch is shaped as crescent moon, and therefore, the infantile traditional Chinese medicine cooling patch accords with the ear structures of human bodies, and heat dissipation efficiency is improved while preventing dropping.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly a kind of Chinese medicine children's antipyretic patch.
Background technology
Fever of children is pathological process common in infant infectious diseases, and not only the child's of impact growth, also may bring other complication.If children's continues high heat, just may affect the growth of brain, so we are when looking after the children's of heating, be exactly first to control body temperature, that can not burn is too high.World Health Organization's suggestion bans use of any medicine of bringing down a fever with interior baby in 2 months.Except medicine, bring down a fever, use some physical cooling methods also can help the child of heating to bring down a fever, wherein the way of simple and fast is carried out Physical temperature-lowering with defervescence plaster used for child exactly.It is a kind of novel Physical temperature-lowering articles for use that children's antipyretic pastes.
Existing children's antipyretic pastes the following problem that exists.First, on drug component, the large prescription of the many employings of a lot of products of the same type, formula greatly, drug kinds is numerous; The second, the subsides employing physics of mostly bringing down a fever is brought down a fever and is aided with Western medicine, and the present invention adopts natural Chinese medicines material component, and side effect is little, and Chinese medicine ingredients can also effectively coordinate physics mode to strengthen the effect of bringing down a fever.
Summary of the invention
The present invention has overcome the shortcoming of prior art, and a kind of Chinese medicine children's antipyretic patch is provided.
A kind of Chinese medicine children's antipyretic patch of the present invention, is characterized in that, comprises by weight: 10 parts, Herba Ephedrae, 10 parts of Ramulus Cinnamomi, 15 parts of Gypsum Fibrosum, 2 parts of Borneolum Syntheticums.
The preparation method of a kind of Chinese medicine children's antipyretic patch of the present invention, comprises the following steps:
1) Herba Ephedrae, Ramulus Cinnamomi, Gypsum Fibrosum, Borneolum Syntheticum are pulverized through pulverizer, added 1 part of azone, mix and stir evenly;
2) in step 1) add 30 parts of medical pressure-sensitive adhesive to stir evenly in the mixture prepared to make medicine latex solution;
3) medicine latex solution entered to spiral type medicinal membrane coating machine coating, be dried and make medicine glued membrane material, be medicine layer, after disinfection by ultraviolet light, at medicine layer surface coverage layer protecting film layer, one deck air-permeable layer is also established in medicine layer below, and air-permeable layer is provided with ventilative micropore.
4) medicine film material is cut machine through film and by standard, is cut material and can obtain 30*25*0.3mm film type paster, and being cut into two limits is two circular arcs that radian is different.
Described protective film is selected release paper, and air-permeable layer is selected non-woven fabrics, absorbent carbasus or PVC mesh film.
Azone, as penetrating agent, can promote the Transdermal absorption of medicine.
A kind of Chinese medicine children's antipyretic patch of the present invention comprises protective film, medicine layer, air-permeable layer, has micropore in air-permeable layer.Not pastille of protective film, has controlled-release function, also has an antipollution effect simultaneously.Medicine layer is thinner, and the infant patch softness that loses money in a business is comfortable, does not harden, and is not clamminess.Air-permeable layer is positioned at outside medicine layer.Air-permeable layer also hommization design for the micropore of skin oxygen uptake, be conducive to like this skin oxygen uptake, reduce anaphylaxis, also have and prevent from polluting the safeguard protection effect of playing.
The present invention reaches cooling-down effect after being affixed on ear, therefore it is two circular arcs that radian is different that profile is cut into two limits, be crescent, meet the structure after human body ear, in the time of slip-off preventing, can improve radiating efficiency, the site of action that pediatrics febricide pastes is less, and the essence of the appearance design that we spy pastes pediatrics febricide is smaller.
The present invention includes Herba Ephedrae, Ramulus Cinnamomi, Gypsum Fibrosum, Borneolum Syntheticum a few herbs.Herba Ephedrae can diaphoresis cold expelling, and effect relaxes, and is suitable for old man, child and empty people's anemofrigid cold.Ramulus Cinnamomi, property and flavor of peppery and warm, has the effect of expelling cold and relieving exterior syndrome, often coordinates Herba Ephedrae to treat lossless anemofrigid cold, helps the effect of Herba Ephedrae relieving the exterior syndrome by diaphoresis.Gypsum Fibrosum has clearing away heat-fire, and relieving restlessness is quenched the thirst, the effect of convergence granulation promoting.The Borneolum Syntheticum refreshment of can having one's ideas straightened out, clearing away heat to alleviate pain.This children's antipyretic pastes that the taste of Chinese medicine number containing is few, and drug level is high, by defervescence plaster used, is attached to after ear, can be fast, stable performance cooling effect, reach cold compress effect.Safety cooling, does not destroy the immunologic function system response in child's body.
The compatibility of children's antipyretic patch of the present invention product medicine of the same type is more on the market simple, and drug kinds is few, but drug effect does not subtract.It is two circular arcs that radian is different that profile is cut into two limits, is crescent, meets the structure after human body ear, in the time of slip-off preventing, can also improve radiating efficiency.The present invention is acupoint adhesive plaster, brings down a fever simple and easy to do, and inner disease outer treat, also also controls and prevent, the hardship that saving has an injection takes medicine, and more traditional Physical temperature-lowering, and cooling rate is faster, and effect is more obvious.Compared with the cooling repeatedly of Western medicine, this product cooling is continual and steady, no longer rise, also can improve infant whole body symptom, can effectively alleviate the malaise symptoms such as heating, headache, nasal obstruction, agitation, can alleviate heating to brain cell detrimental effect, have wide market prospect, meanwhile, this product medicine source is extensive, with low cost, price is easily accepted by patient.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, the present invention is further detailed explanation:
Fig. 1 is the structure chart of a kind of Chinese medicine children's antipyretic of the present invention patch
In Fig. 11, protective film; 2, medicine layer; 3, air-permeable layer; 4, micropore.
The specific embodiment
Embodiment:
Compatibility:
Comprise by weight: 10 parts, Herba Ephedrae, 10 parts of Ramulus Cinnamomi, 15 parts of Gypsum Fibrosum, 2 parts of Borneolum Syntheticums.
Preparation method comprises the following steps:
1) 2 parts, 10 parts, weight portion Herba Ephedrae, 10 parts of Ramulus Cinnamomi, 15 parts of Gypsum Fibrosum, Borneolum Syntheticum pulverized through pulverizer, add 1 part of azone, mix and stir evenly;
2) in step 1) add 30 parts of medical pressure-sensitive adhesive to stir evenly in the mixture prepared to make medicine latex solution;
3) medicine latex solution entered to spiral type medicinal membrane coating machine coating, be dried and make medicine glued membrane material, be medicine layer, after disinfection by ultraviolet light, at medicine layer surface coverage layer protecting film layer, one deck air-permeable layer is also established in medicine layer below, and air-permeable layer is provided with ventilative micropore;
4) medicine film material is cut machine through film and by standard, is cut material and can obtain 30*25*0.3mm film type paster, and being cut into two limits is two circular arcs that radian is different.
In the present embodiment, protective film is selected release paper, and air-permeable layer is selected non-woven fabrics.
Experimental example:
(1) animal experimental observation
1, grouping and administration: choose 12 of 12 hours close rabbit of body weight of fasting, platform scale is weighed, and body weight 1.5～2.5kg is divided into 2 groups at random, is respectively defervescence plaster used group and matched group, 6 every group, picric acid labelling.
2, process and observe: before experiment, first measuring every rabbit anus temperature 2 times, average as normal body temperature.Then two groups of rabbit auricular vein Escherichia Coli Injection endotoxin 1ml/kg respectively, measured an anus temperature every 30 minutes, treated that fervescence is greater than 0.8 ℃, stick children's antipyretic and paste on the ear of defervescence plaster used group of rabbit.0.5h after administration, 1h, 1.5h, 2h measures respectively rabbit anus temperature.
Children's antipyretic pastes the refrigeration function to rabbit endotoxin fever model
Experimental result shows that children's antipyretic subsides can reduce endotoxin-induced fever, and its refrigeration function is sure.Pasting after children's antipyretic subsides 1h～1.5h, there is obvious cooling-down effect.
This experiment points for attention:
1. rabbit should be got health, body weight 1.5～2.5kg, and body temperature is at 38.5～39.5 ℃.
2. each anus Wen Qianying that surveys is coated with a little liquid paraffin to anus temperature meter.
3. before measurement, should first fix animal, while measuring anus temperature, operation should be soft, prevents that in measuring process, animal struggles, to such an extent as to dampen intestinal wall or the clinical thermometer that fractures.
4. can, by the fixing clinical thermometer of experimenter's right hand, after 3 minutes, take out observed reading during anus thermometre thermometric.
5. after experiment finishes, the rag soaking with neutral detergent is cleaned anus temperature meter, after anus temperature meter is dry, puts back in box again and preserves.
(2) clinical observation on the therapeutic effect
Randomly draw fever patient's 120 examples of Affiliated Hospital of Hunan University of Traditional Chinese Medicine outpatient service, male 54 examples, female's 66 examples, child's 62 examples, 0.5～14 years old age, 5.6 years old mean age; 58 examples of being grown up, 16～52 years old age, 28 years old mean age, patient temperature is at 38～40 ℃, and clinical diagnosis major part is the hyperpyrexia causing due to common infectious disease (as: upper respiratory tract infection, tracheitis, bronchitis, pneumonia, suppurative tonsillitis etc.).
1, use and observational technique:
Patch top layer protection sheet is thrown off, be attached to after patient's upper limb inner side or ear.Within after each administration 0.5 hour, start take temperature, each hour measures once later, and the body temperature of observing in five hours changes and the situation repeatedly after 24 hours.
2, efficacy assessment standard:
Recovery from illness: after medication, body temperature is dropped rapidly to normally, and symptom disappears completely.
Effective: after medication, temperature decline is more than 1 ℃, and symptom obviously alleviates.
Effective: 0.5～1 ℃ of temperature decline after medication, symptom alleviates.
Invalid: temperature decline after medication, symptom is without significant change.
3, observed result
With 120 routine hyperpyrexia patients of children's antipyretic patch treatment, recovery from illness 74 examples (62%); Effective 37 examples (31%); Effective 7 examples (6%); Invalid 2 examples (2%), total effective rate 98%.
Claims (3)
1. a Chinese medicine children's antipyretic patch, is characterized in that, comprises by weight: 10 parts, Herba Ephedrae, 10 parts of Ramulus Cinnamomi, 15 parts of Gypsum Fibrosum, 2 parts of Borneolum Syntheticums.
2. a preparation method for Chinese medicine children's antipyretic patch, is characterized in that comprising the following steps:
1) according to the weight portion of claim 1, Herba Ephedrae, Ramulus Cinnamomi, Gypsum Fibrosum, Borneolum Syntheticum are pulverized through pulverizer, added 1 part of azone, mix and stir evenly;
2) in step 1) add 30 parts of medical pressure-sensitive adhesive to stir evenly in the mixture prepared to make medicine latex solution;
3) medicine latex solution entered to spiral type medicinal membrane coating machine coating, be dried and make medicine glued membrane material, be medicine layer, after disinfection by ultraviolet light, at medicine layer surface coverage layer protecting film layer, one deck air-permeable layer is also established in medicine layer below, and air-permeable layer is provided with ventilative micropore;
4) medicine film material is cut machine through film and by standard, is cut material and can obtain 30*25*0.3mm film type paster, and being cut into two limits is two circular arcs that radian is different.
3. a kind of Chinese medicine children's antipyretic patch according to claim 1, is characterized in that: comprise protective film, medicine layer, air-permeable layer, have micropore in air-permeable layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310742780.2A CN103751277A (en) | 2013-12-30 | 2013-12-30 | Infantile traditional Chinese medicine cooling patch |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310742780.2A CN103751277A (en) | 2013-12-30 | 2013-12-30 | Infantile traditional Chinese medicine cooling patch |
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| CN103751277A true CN103751277A (en) | 2014-04-30 |
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| CN201310742780.2A Pending CN103751277A (en) | 2013-12-30 | 2013-12-30 | Infantile traditional Chinese medicine cooling patch |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031479A (en) * | 2015-08-29 | 2015-11-11 | 梁万新 | Traditional Chinese medicine paste for allaying fever by being applied to acupuncture point of children |
| CN105311109A (en) * | 2015-11-13 | 2016-02-10 | 康文杰 | Traditional Chinese medicinal composition for treating fever as well as preparation method and application of traditional Chinese medicinal composition |
| CN105920565A (en) * | 2016-06-24 | 2016-09-07 | 南阳医学高等专科学校第附属医院 | Infantile umbilical paste and preparation method thereof |
Citations (3)
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|---|---|---|---|---|
| CN1144110A (en) * | 1995-08-28 | 1997-03-05 | 刘安西 | Pure traditional Chinese medicine antipyretic plaster for baby and its preparation technology thereof |
| CN1273819A (en) * | 2000-05-16 | 2000-11-22 | 刘安西 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
| CN1279067A (en) * | 1999-07-01 | 2001-01-10 | 李建民 | Defervescent picking for baby |
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2013
- 2013-12-30 CN CN201310742780.2A patent/CN103751277A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144110A (en) * | 1995-08-28 | 1997-03-05 | 刘安西 | Pure traditional Chinese medicine antipyretic plaster for baby and its preparation technology thereof |
| CN1279067A (en) * | 1999-07-01 | 2001-01-10 | 李建民 | Defervescent picking for baby |
| CN1273819A (en) * | 2000-05-16 | 2000-11-22 | 刘安西 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
Non-Patent Citations (2)
| Title |
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| 王秀珍等: "大青龙汤治疗小儿高热88例", 《陕西中医》 * |
| 金福厚等: "石膏配方灌肠治疗小儿外感高热50例", 《中医药信息》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031479A (en) * | 2015-08-29 | 2015-11-11 | 梁万新 | Traditional Chinese medicine paste for allaying fever by being applied to acupuncture point of children |
| CN105031479B (en) * | 2015-08-29 | 2019-02-22 | 梁万新 | A kind of children acupuncture point is brought down a fever Chinese herbs paste |
| CN105311109A (en) * | 2015-11-13 | 2016-02-10 | 康文杰 | Traditional Chinese medicinal composition for treating fever as well as preparation method and application of traditional Chinese medicinal composition |
| CN105920565A (en) * | 2016-06-24 | 2016-09-07 | 南阳医学高等专科学校第附属医院 | Infantile umbilical paste and preparation method thereof |
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Application publication date: 20140430 |