CN103736134B - Medical sponge dressing and preparation method thereof - Google Patents
Medical sponge dressing and preparation method thereof Download PDFInfo
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- CN103736134B CN103736134B CN201310743416.8A CN201310743416A CN103736134B CN 103736134 B CN103736134 B CN 103736134B CN 201310743416 A CN201310743416 A CN 201310743416A CN 103736134 B CN103736134 B CN 103736134B
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Abstract
The invention provides medical sponge dressing. The medical sponge dressing comprises polyvinyl alcohol, aloe vera and an antibacterial agent, wherein the polyvinyl alcohol takes the shape of a three-dimensional mesh, the aloe vera and the antibacterial agent are loaded on the surface and in the polyvinyl alcohol, the polyvinyl alcohol, the aloe vera and the antibacterial agent form a composite material with micropores, and the masses of the polyvinyl alcohol, the aloe vera and the antibacterial agent respectively account for 79-94.5%, 5-20% and 0.5-1% in the total mass of the composite material. The invention also provides a preparation method of medical sponge dressing, which comprises: mixing the polyvinyl alcohol, the aloe vera and the antibacterial agent, freezing and unfreezing to prepare the medical sponge dressing. The medical sponge dressing can absorb a large amount of wound exudate, and meanwhile, has the advantages of being antibacterial and anti-inflammatory, moisturizing and relieving pain, absorbing exudate, preventing adhesion and effectively promoting wound healing, and the like.
Description
Technical field
The present invention relates to a kind of medical sponge dressing and preparation method thereof.
Background technology
Medical dressing is the class clinical medical material temporarily covering the wounds such as burn, ulcer and wound, its Main Function be control in wound healing process wound transudate and protection wound pollute from the external source such as antibacterial and grit.Polyvinyl alcohol (PVA) sponge is a kind of non-fiber, has the material of loose structure, there is stable chemical property and good biocompatibility, and there is excellent hydrophilic, imbibition, performance of sucking blood and good antibiont degradation property, with low cost, have broad application prospects in medical dressing field.
But, polyvinyl alcohol medical grade sponge does not possess antibacterial function, for easy infection or the infected wound suitability is poor, in order to obtain the polyvinylalcohol sponge with anti-microbial property, usually polyvinylalcohol sponge is immersed in antibacterials in prior art, by the mode of physical absorption in conjunction with antibacterials, because antibacterials are combined only by physics mode with polyvinylalcohol sponge, medicine is easy to separate from carrier, does not have good antibacterial curative effect; Prior art is also by making powder or liquid by antibacterials, after mixing with polyvinyl alcohol material, foaming agent and cross-linking agent etc. again, carry out the polyvinylalcohol sponge that foaming obtains having anti-microbial property again, due to the impact of the chemicals such as foaming agent and cross-linking agent, the drug effect of antibacterials and the biocompatibility of polyvinylalcohol sponge can be affected.Therefore, the emphasis that the good medical sponge dressing of anti-microbial property becomes research at present how is prepared.
In prior art, Aloe is the herbaceous plant that a kind of medical value is very high, the pharmacological actions such as it has antibacterial, antiinflammatory, immunomodulating, short granulation tissue are formed, moisturizing and analgesia, can be used for antibacterial, detumescence and promoting granulation, repair tissue damage and wound healing etc.Existing research also shows, the wound surface epithelization adopting Aloe comparatively early, effectively can promote wound healing.
Poly-own methylene hydrochloric acid (PHMB) is that one is acknowledged as 21 century broad spectrum antimicrobicide the most safely and efficiently, it is low that it has Mlc, wide spectrum low toxicity, speed of action is fast, effective time is long, and antibacterial can not be made to produce the advantages such as drug resistance, be widely used in the fields such as medical apparatus and instruments, household and food at present.
Chitosan quaternary ammonium salt derivatives has excellent bacteria resistance and moisture absorbability and moisture retentivity, and maintains the performances such as the original good film property of chitosan, biocompatibility and biodegradation.
Medical sponge dressing provided by the invention comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described medical sponge dressing can protect wound well, tridimensional network and microcellular structure can make a large amount of absorbing wound exudate of described medical sponge dressing energy, keep wound surface moisture state, play the effect of " moistening healing ", promote the healing of wound, and the wound that can not bond, avoid causing secondary insult, Aloe has the effect of antiinflammatory and the formation of short granulation tissue, also has promotion repair to impaired epithelial cell simultaneously, promotes wound healing, the bactericidal effect of antibacterial is good, antibacterial can not be made during use to produce drug resistance, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on described tridimensional network, Aloe and antibacterial are closely wrapped in wherein by described tridimensional network, in use difficult drop-off, after described medical sponge dressing contacts with wound surface, can antibacterial and Aloe described in slow release, play the antibacterial effect of persistent high efficiency and promote the effect of wound healing.
Described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the micropore of described composite is positioned at surface and the inside of composite, and the surface apertures of described composite is 1 μm ~ 5 μm, and inner aperture is 20 μm ~ 50 μm.The surface apertures that described medical sponge dressing is less can effectively intercept antibacterial and unwanted particles, can prevent wounded tissue from boning simultaneously, avoid causing secondary insult; The aperture, inside that described medical sponge dressing is larger can make a large amount of absorbing wound exudate of described medical sponge dressing, there is good absorbability and larger absorptive capacity, keep wound surface moisture state simultaneously, play the effect of " moistening healing ", promote the healing of wound.
The quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79% ~ 94.5%, 5% ~ 20% and 0.5% ~ 1% of described composite gross mass.Under mass fraction described in this, the load of Aloe and antibacterial can not block the tridimensional network of polyvinyl alcohol completely, thus the effect of a large amount of absorbing wound exudate of polyvinyl alcohol can not be affected, simultaneously, the tridimensional network of polyvinyl alcohol can adsorb Aloe and antibacterial well, make antibacterial and Aloe difficult drop-off, the antibacterial effect with promoting wound healing of more lasting performance.
Medical sponge dressing of the present invention has the anti-stick and advantage that is effectively wound healing of inhibiting bacteria and diminishing inflammation, moisturizing analgesia, imbibition, can be widely used in treatment infected wound, ulcer in body surface, various burn and scald injure the bio-medical fields such as surgical wound.
Second aspect, the invention provides a kind of preparation method of medical sponge dressing, comprises the following steps:
(1) aloe water solution is obtained after being dissolved by aloe frozen-dried powder;
(2) polyvinyl alcohol water solution is obtained after being dissolved by polyvinyl alcohol material;
(3) described aloe water solution and described polyvinyl alcohol water solution are mixed to get the first mixed solution, in described first mixed solution, add antibacterial, after stirring, obtain the second mixed solution;
(4) described second mixed solution is injected mould, described second mixed solution thickness is in the mold 50 μm ~ 500 μm, 4 ~ 8h is left standstill at 4 DEG C, subsequently at-20 DEG C ~-80 DEG C freezing 4h ~ 24h, again at 20 DEG C ~ 30 DEG C 1h ~ 4h that thaw, repeated freezing and thawing 1 ~ 6 time, obtain gel, by described gel successively lyophilization, after cutting out packaging and sterilizing, obtain described medical sponge dressing, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described polyvinyl alcohol, the quality of Aloe and antibacterial accounts for 79% ~ 94.5% of described composite gross mass respectively, 5% ~ 20% and 0.5% ~ 1%.
The micropore of described composite is positioned at surface and the inside of composite.
Preferably, the micropore size of described composite material surface is 1 μm ~ 5 μm.
Preferably, the micropore size of described composite inner is 20 μm ~ 50 μm.
Preferably, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
More preferably, described chitosan quaternary ammonium salt derivatives is hydroxypropyltrimethyl ammonium chloride chitosan.
Preferably, described in step (1), aloe frozen-dried powder is obtained by purchase.
Preferably, the solvent in aloe water solution described in step (1) is distilled water.
Preferably, in aloe water solution described in step (1), the mass concentration of Aloe is 0.1% ~ 2%.
Preferably, described in step (2), the molecular weight of polyvinyl alcohol material is 60,000 ~ 200,000.
Preferably, described in step (2), the alcoholysis degree of polyvinyl alcohol material is 88% ~ 99.9%.
Preferably, the solvent in polyvinyl alcohol water solution described in step (2) is distilled water.
Preferably, in polyvinyl alcohol water solution described in step (2), the mass concentration of polyvinyl alcohol is 10% ~ 25%.
Preferably, in step (2) by described polyvinyl alcohol material heating for dissolving at 90 DEG C.
Preferably, sterilizing methods described in step (4) is sterilizing or Co 60 sterilizing under High Temperature High Pressure.
Preferably, the described mould in step (4) is Teflon mould.
In prior art, Aloe is the herbaceous plant that a kind of medical value is very high, the pharmacological actions such as it has antibacterial, antiinflammatory, immunomodulating, short granulation tissue are formed, moisturizing and analgesia, can be used for antibacterial, detumescence and promoting granulation, repair tissue damage and wound healing etc.Existing research also shows, the wound surface epithelization adopting Aloe comparatively early, effectively can promote wound healing.
Poly-own methylene hydrochloric acid (PHMB) is that one is acknowledged as 21 century broad spectrum antimicrobicide the most safely and efficiently, it is low that it has Mlc, wide spectrum low toxicity, speed of action is fast, effective time is long, and antibacterial can not be made to produce the advantages such as drug resistance, and oneself is widely used in the fields such as medical apparatus and instruments, household and food at present.
Chitosan quaternary ammonium salt derivatives has excellent bacteria resistance and moisture absorbability and moisture retentivity, and maintains the performances such as the original good film property of chitosan, biocompatibility and biodegradation.
The present invention is by after polyvinyl alcohol, Aloe and antibacterial mixing, carrying out freeze-thaw, polyvinyl alcohol carries out physical crosslinking when freeze-thaw, polyvinyl alcohol molecule interchain is by hydrogen bond and micro-crystal zone formation tridimensional network, described Aloe and antibacterial are carried in described tridimensional network, polyvinyl alcohol can closely wrap up Aloe and antibacterial, and obtained medical sponge dressing pore size is even, and absorbability is strong.
Described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described medical sponge dressing can protect wound well, tridimensional network and microcellular structure can make a large amount of absorbing wound exudate of described medical sponge dressing energy, keep wound surface moisture state, play the effect of " moistening healing ", promote the healing of wound; Aloe and antibacterial are closely wrapped in wherein by the tridimensional network of described polyvinyl alcohol, and Aloe has the effect of antiinflammatory and the formation of short granulation tissue, also has promotion repair to impaired epithelial cell simultaneously; Antibacterial bactericidal effect is good, antibacterial can not be made during use to produce drug resistance, simultaneously, described Aloe and antibacterial are closely wrapped in the network structure of polyvinyl alcohol, in use difficult drop-off, after described medical sponge dressing contacts with wound surface, can antibacterial and Aloe described in slow release, play the antibacterial effect of persistent high efficiency and promote the effect of wound healing.
Described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the micropore of described composite is positioned at surface and the inside of composite, and the surface apertures of described composite is 1 μm ~ 5 μm, and inner aperture is 20 μm ~ 50 μm.The surface apertures that described medical sponge dressing is less can effectively intercept antibacterial and unwanted particles, can prevent wounded tissue from boning simultaneously, avoid causing secondary insult; The aperture, inside that described medical sponge dressing is larger can make a large amount of absorbing wound exudate of described medical sponge dressing, there is good absorbability and larger absorptive capacity, keep wound surface moisture state simultaneously, play the effect of " moistening healing ", promote the healing of wound.
The quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79% ~ 94.5%, 5% ~ 20% and 0.5% ~ 1% of described composite gross mass.Under described mass fraction, the load effect of Aloe and antibacterial can not block the tridimensional network of polyvinyl alcohol completely, thus the effect of a large amount of absorbing wound exudate of polyvinyl alcohol can not be affected, simultaneously, polyvinyl alcohol carries out physical crosslinking when freeze-thaw, the tridimensional network formed can wrap up Aloe and antibacterial well, makes antibacterial and Aloe difficult drop-off, the antibacterial effect with promoting wound healing of more lasting performance.
Medical sponge dressing of the present invention has the anti-stick and advantage that is effectively wound healing of inhibiting bacteria and diminishing inflammation, moisturizing analgesia, imbibition, can be widely used in treatment infected wound, ulcer in body surface, various burn and scald injure the bio-medical fields such as surgical wound.
Polyvinyl alcohol of the present invention forms tridimensional network by physical crosslinking, not and the chemical reagent such as cross-linking agent react, more hydroxyl in polyvinyl alcohol molecule can form hydrogen bond with water thus absorb water better, improves the water absorbing properties of medical sponge dressing.
The present invention is without the need to adding foaming agent and cross-linking agent in preparation process, and can not have an impact to Aloe and the drug effect of antibacterial and the biocompatibility of described medical sponge dressing, environmental protection, preparation method technique is simple, cost is low.
To sum up, beneficial effect of the present invention comprises the following aspects:
(1) medical sponge dressing of the present invention has the anti-stick and advantage that is effectively wound healing of inhibiting bacteria and diminishing inflammation, moisturizing analgesia, imbibition;
(2) the preparation process environmental protection of medical sponge dressing of the present invention, preparation technology is simple, and cost is low.
Summary of the invention
For solving the problem, the invention provides a kind of medical sponge dressing and preparation method thereof, a large amount of absorbing wound exudate of described medical sponge dressing energy, has good antibacterial action simultaneously.
First aspect, the invention provides a kind of medical sponge dressing, described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79% ~ 94.5%, 5% ~ 20% and 0.5% ~ 1% of described composite gross mass respectively.
The micropore of described composite is positioned at surface and the inside of composite.
Preferably, the micropore size of described composite material surface is 1 μm ~ 5 μm.
Preferably, the micropore size of described composite inner is 20 μm ~ 50 μm.
Preferably, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
More preferably, described chitosan quaternary ammonium salt derivatives is hydroxypropyltrimethyl ammonium chloride chitosan.
Accompanying drawing explanation
Fig. 1 is the surface topography map of the medical sponge dressing that embodiment 1 obtains;
Fig. 2 is the cross-sectional morphology figure of the medical sponge dressing that embodiment 1 obtains;
Fig. 3 is that the obtained medical sponge dressing of embodiment 1 is to the fungistatic effect figure of Staphylococcus aureus;
Fig. 4 is that the obtained medical sponge dressing of embodiment 1 is to colibacillary fungistatic effect figure.
Detailed description of the invention
The following stated is the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Embodiment one
(1) aloe frozen-dried powder is dissolved in distilled water to obtain mass concentration be 1% aloe water solution, is placed in 4 DEG C of refrigerators and stores for future use;
(2) be 60,000 by molecular weight, alcoholysis degree be 99.9% polyvinyl alcohol material at 90 DEG C, be dissolved in distilled water obtain the polyvinyl alcohol water solution that mass concentration is 10%;
(3) polyvinyl alcohol water solution that aloe water solution step (1) obtained and step (2) obtain is mixed to get the first mixed solution, adds poly-own methylene hydrochloric acid, obtain the second mixed solution after stirring in the first mixed solution;
(4) the second mixed solution is injected Teflon mould, the thickness of the second mixed solution in Teflon mould is 50 μm, 4h is left standstill at 4 DEG C, subsequently at-80 DEG C of freezing 24h, again at 25 DEG C of 4h that thaw, obtain gel, by gel successively lyophilization, cut out packaging, after autoclave sterilization, obtain medical sponge dressing, polyvinyl alcohol is three-dimensional netted, Aloe and poly-own methylene hydrochloric acid are carried on surface and the inside of polyvinyl alcohol, polyvinyl alcohol, Aloe and poly-own methylene hydrochloric acid form the composite with micropore, polyvinyl alcohol, the quality of Aloe and poly-own methylene hydrochloric acid accounts for 94.5% of composite gross mass, 5% and 0.5%.
Scanning electron microscope is adopted to observe the obtained surface topography map of medical sponge dressing of embodiment 1 and the cross-sectional morphology figure of medical sponge dressing respectively; Result is see Fig. 1 and Fig. 2, as can be seen from Figure 1, obtained medical sponge dressing surface has a large amount of micropores, the micropore size on surface is 1 μm ~ 5 μm, and as can be seen from Figure 2, obtained medical sponge dressing is three-dimensional netted, inner micropore size is 20 μm ~ 50 μm, the surface apertures that this medical sponge dressing is less can effectively intercept antibacterial and unwanted particles, can prevent wounded tissue from boning simultaneously, avoid causing secondary insult; The aperture, inside that this medical sponge dressing is larger can make a large amount of absorbing wound exudate of medical sponge dressing, there is good absorbability and larger absorptive capacity, keep wound surface moisture state simultaneously, play the effect of " moistening healing ", promote the healing of wound.
The present invention determines the Balance Absorption rate of medical sponge dressing in the Acetic acid-sodium acetate buffer of pH=5.5 that the present embodiment under 37 DEG C of conditions obtains, and result shows, the equilibrium water absorption of this medical sponge dressing can reach more than 90%, has stronger absorbent.
The present invention is also tested for this medical sponge dressing to staphylococcus aureus and colibacillary bacteriostatic experiment, Fig. 3 is that this medical sponge dressing is to the bacteriostatic experiment of staphylococcus aureus, Fig. 3 a is blank group (not adding medical sponge dressing), Fig. 3 b is experimental group (adding the medical sponge dressing of the present embodiment), Fig. 4 is that this medical sponge dressing is to colibacillary bacteriostatic experiment, Fig. 4 a is blank group (not adding medical sponge dressing), Fig. 4 b is experimental group (adding the medical sponge dressing of the present embodiment), as can be seen from the figure, the obtained medical sponge dressing of the present embodiment to staphylococcus aureus and colibacillary fungistatic effect all fine, as calculated, the antibacterial effect of this sponge sample to escherichia coli and gold-coloured staphylococci all can reach more than 99%, there is very strong antibacterial effect, be suitable as the dressing of infective wound surface.
Embodiment two
(1) aloe frozen-dried powder is dissolved in distilled water to obtain mass concentration be 2% aloe water solution, is placed in 4 DEG C of refrigerators and stores for future use;
(2) be 200,000 by molecular weight, alcoholysis degree be 88% polyvinyl alcohol material at 90 DEG C, be dissolved in distilled water obtain the polyvinyl alcohol water solution that mass concentration is 25%;
(3) polyvinyl alcohol water solution that aloe water solution step (1) obtained and step (2) obtain is mixed to get the first mixed solution, adds poly-own methylene hydrochloric acid, obtain the second mixed solution after stirring in the first mixed solution;
(4) the second mixed solution is injected Teflon mould, the thickness of the second mixed solution in Teflon mould is 500 μm, 4h is left standstill at 4 DEG C, subsequently at-20 DEG C of freezing 4h, again at 30 DEG C of 1h that thaw, repeated freezing thaws 6 times, obtain gel, by gel successively lyophilization, cut out packaging, after Co 60 sterilizing, obtain medical sponge dressing, polyvinyl alcohol is three-dimensional netted, Aloe and poly-own methylene hydrochloric acid are carried on surface and the inside of polyvinyl alcohol, polyvinyl alcohol, Aloe and poly-own methylene hydrochloric acid form the composite with micropore, polyvinyl alcohol, the quality of Aloe and poly-own methylene hydrochloric acid accounts for 79% of composite gross mass, 20% and 1%.
Embodiment three
(1) aloe frozen-dried powder is dissolved in distilled water to obtain mass concentration be 0.1% aloe water solution, is placed in 4 DEG C of refrigerators and stores for future use;
(2) be 100,000 by molecular weight, alcoholysis degree be 88% polyvinyl alcohol at 90 DEG C, be dissolved in distilled water obtain the polyvinyl alcohol water solution that mass concentration is 15%;
(3) polyvinyl alcohol water solution that aloe water solution step (1) obtained and step (2) obtain is mixed to get the first mixed solution, adds hydroxypropyltrimethyl ammonium chloride chitosan, obtain the second mixed solution after stirring in the first mixed solution;
(4) the second mixed solution is injected Teflon mould, the thickness of the second mixed solution in Teflon mould is 200 μm, 8h is left standstill at 4 DEG C, subsequently at-60 DEG C of freezing 12h, again at 30 DEG C of 2h that thaw, repeated freezing thaws 4 times, obtain gel, by gel successively lyophilization, cut out packaging, after Co 60 sterilizing, obtain medical sponge dressing, polyvinyl alcohol is three-dimensional netted, Aloe and hydroxypropyltrimethyl ammonium chloride chitosan are carried on surface and the inside of polyvinyl alcohol, polyvinyl alcohol, Aloe and hydroxypropyltrimethyl ammonium chloride chitosan form the composite with micropore, polyvinyl alcohol, the quality of Aloe and hydroxypropyltrimethyl ammonium chloride chitosan accounts for 85% of composite gross mass, 14% and 1%.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. a medical sponge dressing, it is characterized in that, described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79% ~ 94.5%, 5% ~ 20% and 0.5% ~ 1% of described composite gross mass respectively; The micropore size of described composite material surface is 1 μm ~ 5 μm, and the micropore size of described composite inner is 20 μm ~ 50 μm.
2. medical sponge dressing as claimed in claim 1, is characterized in that, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
3. a preparation method for medical sponge dressing, is characterized in that, comprises the following steps:
(1) aloe water solution is obtained after being dissolved by aloe frozen-dried powder;
(2) polyvinyl alcohol water solution is obtained after being dissolved by polyvinyl alcohol material;
(3) described aloe water solution and described polyvinyl alcohol water solution are mixed to get the first mixed solution, then in described first mixed solution, add antibacterial, after stirring, obtain the second mixed solution;
(4) described second mixed solution is injected mould, described second mixed solution thickness is in the mold 50 μm ~ 500 μm, 4 ~ 8h is left standstill at 4 DEG C, subsequently at-20 DEG C ~-80 DEG C freezing 4 ~ 24h, again at 20 DEG C ~ 30 DEG C 1 ~ 4h that thaw, repeated freezing and thawing 1 ~ 6 time, obtain gel, by described gel successively lyophilization, after cutting out packaging and sterilizing, obtain described medical sponge dressing, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described polyvinyl alcohol, the quality of Aloe and antibacterial accounts for 79% ~ 94.5% of described composite gross mass respectively, 5% ~ 20% and 0.5% ~ 1%.
4. the preparation method of medical sponge dressing as claimed in claim 3, it is characterized in that, the micropore size of described composite material surface is 1 μm ~ 5 μm.
5. the preparation method of medical sponge dressing as claimed in claim 3, it is characterized in that, the micropore size of described composite inner is 20 μm ~ 50 μm.
6. the preparation method of medical sponge dressing as claimed in claim 3, is characterized in that, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
7. the preparation method of medical sponge dressing as claimed in claim 3, it is characterized in that, in aloe water solution described in step (1), the mass concentration of Aloe is 0.1% ~ 2%.
8. the preparation method of medical sponge dressing as claimed in claim 3, it is characterized in that, in polyvinyl alcohol water solution described in step (2), the mass concentration of polyvinyl alcohol is 10% ~ 25%.
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2537337A (en) * | 2014-10-14 | 2016-10-19 | Hero Healthcare Ltd | Bandage |
| CN105597136A (en) * | 2016-02-01 | 2016-05-25 | 上海昌颌医药科技有限公司 | Moisture-transfer and fast drying wound dressing |
| CN106521697A (en) * | 2016-11-17 | 2017-03-22 | 无锡明盛纺织机械有限公司 | Carboxyethyl chitosan and polyvinyl alcohol composite fiber and preparation method and application thereof |
| CN108310475A (en) * | 2018-01-08 | 2018-07-24 | 广州润虹医药科技股份有限公司 | A kind of anti-clogging sucked type negative pressure drainage device |
| CN108498852B (en) * | 2018-04-24 | 2020-01-14 | 万绵水 | Ag/SiO2Wound dressing of hydrogel composite sponge and preparation method thereof |
| CN109568650A (en) * | 2018-12-19 | 2019-04-05 | 广州润虹医药科技股份有限公司 | A kind of chitosan quaternary ammonium salt antiseptic dressing and preparation method thereof |
| CN111249179A (en) * | 2020-03-18 | 2020-06-09 | 成都斯瑞宁科技有限公司 | Mask with medical function |
| CN112546282A (en) * | 2020-12-17 | 2021-03-26 | 中国人民解放军总医院第四医学中心 | Cationic polymer medical antibacterial dressing and preparation method thereof |
| CN113181422A (en) * | 2021-05-18 | 2021-07-30 | 四川轻化工大学 | Antibacterial nontoxic hydrogel dressing and preparation method thereof |
| CN114106400B (en) * | 2021-12-02 | 2023-02-10 | 江西省科学院应用化学研究所 | Aziridine crosslinked N-halamine type antibacterial PVA sponge as well as preparation method and application thereof |
| CN116574300A (en) * | 2023-05-12 | 2023-08-11 | 华南理工大学 | Long-acting antibacterial polyvinyl acetal sponge and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1527860A (en) * | 2001-05-11 | 2004-09-08 | ������ϵ�о���˾ | Methods for the preparation of cellular hydrogels |
| CN1554705A (en) * | 2003-12-26 | 2004-12-15 | 中国科学院山西煤炭化学研究所 | Polyurethane porous film and its preparing method |
| CN1610724A (en) * | 2001-10-29 | 2005-04-27 | 纳米体系研究公司 | Reinforced, laminated, impregnated and composite-like materials as crosslinked polyvinyl alcohol hydrogel structures |
| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
| CN101954115A (en) * | 2010-10-22 | 2011-01-26 | 佘振定 | Medical antibacterial sponge dressing and preparation method thereof |
| CN102335452A (en) * | 2011-09-22 | 2012-02-01 | 边俊杰 | Formula of functional dressing and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6613347B2 (en) * | 2001-02-21 | 2003-09-02 | Tolland Development Company, Llc | PVA sponge with low durometer skin silicone |
| EP2099503A4 (en) * | 2006-11-28 | 2013-11-13 | Ats Biotech Inc | Burn bandage |
-
2013
- 2013-12-30 CN CN201310743416.8A patent/CN103736134B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1527860A (en) * | 2001-05-11 | 2004-09-08 | ������ϵ�о���˾ | Methods for the preparation of cellular hydrogels |
| CN1610724A (en) * | 2001-10-29 | 2005-04-27 | 纳米体系研究公司 | Reinforced, laminated, impregnated and composite-like materials as crosslinked polyvinyl alcohol hydrogel structures |
| CN1554705A (en) * | 2003-12-26 | 2004-12-15 | 中国科学院山西煤炭化学研究所 | Polyurethane porous film and its preparing method |
| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
| CN101954115A (en) * | 2010-10-22 | 2011-01-26 | 佘振定 | Medical antibacterial sponge dressing and preparation method thereof |
| CN102335452A (en) * | 2011-09-22 | 2012-02-01 | 边俊杰 | Formula of functional dressing and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| Preparation and Properties of Electrospun Poly(vinyl alcohol) Blended Hybrid Polymer with Aloe vera and HPMC as Wound Dressing;Ibrahim Uslu et al.;《HACETTEPE JOURNAL OF BIOLOGY AND CHEMISTRY》;20100415;第38卷(第1期);第19-25页 * |
| 含纳米银壳聚糖/聚乙烯醇抗菌敷料的制备和性能;曾晓峰等;《中国组织工程研究与临床康复》;20110219;第15卷(第8期);第1413-1416页 * |
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