CN103735248A - Near infrared spectroscopy and electrode combined detection device - Google Patents
Near infrared spectroscopy and electrode combined detection device Download PDFInfo
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- CN103735248A CN103735248A CN201310733760.9A CN201310733760A CN103735248A CN 103735248 A CN103735248 A CN 103735248A CN 201310733760 A CN201310733760 A CN 201310733760A CN 103735248 A CN103735248 A CN 103735248A
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Abstract
The invention relates to a near infrared spectroscopy and electrode combined detection device. The near infrared spectroscopy and electrode combined detection device is divided into an elastic inner layer and an inelastic outer layer; the elastic inner layer adapts to different shapes of detected physiological positions; electrodes which are arranged according to the standard positioning are loaded on the elastic inner layer; the inelastic outer layer is provided with near infrared probes, wherein the distances between the near infrared probes are fixed; every near infrared probe is formed by a probe positioner, an optical fiber clamp and a non-metallic elastic pressure cap; the probe positioners are fixed on the inelastic outer layer and used for positioning the probes; the middles of the probe positioners are provided with through holes; the diameter of the through holes is slightly larger than that of the optical fiber clamps and accordingly the optical fiber clamps can slide in the through holes freely; the optical fiber clamps are cylindrical parts; the middles of the optical fiber clamps are provided with through holes which are used for clamping optical fibers; the elastic pressure caps are used for applying the elastic force on the optical fibers. According to the near infrared spectroscopy and electrode combined detection device, the standard positioning requirements of the electrodes and the fixed distance between a near infrared light source and a detector can be met simultaneously, the structure is simple and practical, and the compatibility is achieved under the nuclear magnetism.
Description
Technical field
The present invention relates to biological tissue's functional activity non-destructive detecting device field, particularly relate to a kind of near infrared spectroscopy and electrode joint-detection device.
Background technology
Biological tissue's spectral measurement can be monitored and be followed the tissue optical parameter of physiological activity to change, and bioelectrical signals is measured can monitor the biological electric discharging process of following physiological activity.Biological tissue is carried out to spectrum and electric signal measurement simultaneously and can obtain more comprehensively physiologic information, better cognitive biological tissue functional activity mechanism.
Take brain function monitoring as example, often adopt traditionally the electroencephalogram technology based on neuroelectricity activity.In recent years, the near infrared spectroscopy of measurement hematodinamics response also causes that people more and more pay close attention to.
Brain electricity detects brain function activity by measuring electroneurographic signal.For mankind's EEG research, be mainly divided into two kinds of research meanses of spontaneous brain electricity figure and event-related EEG at present.The advantage of brain power technology is that temporal resolution is high, and still, due to the disperse characteristic of the signal of telecommunication, brain electricity is more difficult for the contrast locating of brain function activity.Near infrared spectroscopy utilizes the characteristic of near infrared band biological organism optical window.While using the rayed human brain of this wave band, part light can enter cerebral tissue, and is scattered out brain.Be scattered the change information that the light of returning is carrying hemodynamic parameter, the detector of service range light source certain distance receives the optical signal from brain outgoing, just can indirectly obtain the functional activity situation of brain.The advantage of near infrared spectroscopy is to carry out other space orientation of Centimeter Level to cerebration.
By brain electricity and near infrared spectroscopy combine use can be in conjunction with two kinds of technology the advantage in time and spatial resolution, and can analyze the electroneurographic signal gathering and the contact between hematodinamics signal simultaneously, better understand the working mechanism of brain.Yet, as the critical component of two kinds of technical tie-ups, the current still important technological problems of Collect jointly device.Xu Baolei etc. [application number 201110216299.0] disclose the device of a kind of brain electricity and near infrared spectroscopy Collect jointly brain signal, at same, cover on the flexible material of scalp and be fixed with electrode for encephalograms and near-infrared probe, wherein near-infrared probe adopts spring design to keep the to pop one's head in abundant contact of fall skin.This design cannot meet the requirement of using brain electrode standard setting and guaranteeing fixing near-infrared light source-detector pitch simultaneously.Use the positioning of electrode of standard, device is wanted to adapt to different head dummys, need device to there is elasticity, can stretch, but so just can cause the distance between near-infrared probe to change, and light source and detector pitch are the key factors that affects near infrared spectroscopy investigation depth, be generally all pre-set fixed value, as 3cm.And elastic device is poor for the fiber support with constant weight, increased the difficulty that device is worn, poor practicability.Guarantee the fixedly requirement of near-infrared light source and detector pitch, device materials need to be non-elastic material, non-stretchable, but like this just can not adapt to different head dummys, cannot guarantee the standard setting of electrode for encephalograms.In this patent, use in addition the near-infrared probe part of metal spring complicated, and incompatible for the research of syncaryon mr imaging technique.
Summary of the invention
Technical problem to be solved by this invention is to propose a kind ofly to meet electrode standard setting and near-infrared light source-detector constant spacing demand simultaneously, simple, practical, compatible near infrared spectroscopy and electrode joint-detection device under nuclear-magnetism.
For solving the problems of the technologies described above, the present invention proposes a kind of near infrared spectroscopy and electrode joint-detection device, device comprises the elastic inner layer that loads electrode and the non-resilient skin that loads near-infrared probe.
Described elastic inner layer adapts to the individual difference of physiological location shape, and is mounted with the electrode of arranging according to standard setting, meets the demand of electrode standard setting.Electrode standard positioning system is selected brain electricity 10-10,10-20,10-20 expanding system or other electrode standard positioning systems.
On described elastic inner layer, there is optical fiber by the first hole, make can touch physiological location from outer field optical fiber.
Described elastic inner layer optical fiber is greater than fibre diameter by the first hole, guarantees when still passing through optic fibre end because of adaptation physiological location shape optical fiber during by the first hole off-centring.
Described elastic inner layer can be by elastic woven material, and gum elastic or other elastomeric materials are made.
Described non-resilient skin can be by plastics, non-resilient rubber, and the non-elastic materials such as thermoplastic material are made.
The fixing near-infrared probe of spacing is installed on described non-resilient skin, luminous source optical fiber or detection optical fiber are installed on near-infrared probe, meet the demand of near-infrared light source-detector constant spacing.
Described non-resilient skin has good enabling capabilities, can support having the fibre-optical probe of constant weight, wears conveniently.Optic fibre end contacts physiological location by the optical fiber on described elastic inner layer by the first hole.
On described non-resilient skin, there is electrode and expose the second hole, the electrode on elastic inner layer is come out, for injecting conductive paste and adjusting electrode.
Electrode on described non-resilient skin exposes the second hole and is greater than electrode diameter, guarantees still can to expose by electrode when adapting to physiological location shape off-centring outside hole is exposed to when electrode.
Straggly the arranging of electrode on described near-infrared probe and elastic inner layer, spreads all over whole physiological location to be detected region, the electrode sign physiological location that near-infrared probe relies on standard setting to arrange.
Described non-resilient skin and described elastic inner layer link together at device edge and the middle elastomeric material that uses, and have certain activity independence and location positioning between assurance device is two-layer
Described near-infrared probe comprises probe positioner, fibre holder, elastic pressing cap three assemblies.
Described probe positioner is fixed on described non-resilient skin, for positioning probe position.
In the middle of described probe positioner, there is through hole, for placing described fibre holder.
Described fibre holder is cylindric part, and centre has through hole and is used for grip optical fiber.
Described fibre holder external diameter is slightly less than described probe positioner through-hole diameter, can in described probe positioner through hole, freely pass through.
The two ends of described elastic pressing cap are fixed on described probe positioner both sides, or are fixed on the described non-resilient skin of described probe positioner both sides.
After the normal elbow optical fiber adopting of described fibre holder clamping near infrared spectroscopy, be placed in described probe positioner through hole, described elastic pressing cap mid portion is pressed in optical fiber elbow.
Three parts of described near-infrared probe are used rubber, and latex or other non-metallic elastic materials are manufactured.Realize under the nuclear magnetic resonance, NMR of popping one's head in compatible.
Good effect of the present invention is, near infrared spectroscopy and electrode integrated apparatus are realized wearing of electrode and near-infrared probe simultaneously, realizing two kinds of technical tie-ups measures, convenient, fast, practicality, has particularly solved the problem that existing near infrared spectroscopy and electrode joint-detection device can not meet electrode standard setting and near-infrared light source-detector constant spacing demand simultaneously.Described fibre holder is free to slide design and has guaranteed fully contacting and comfortable wearing of fiber end face and physiological location to be detected with described elastic pressing cap design in described probe positioner through hole.Described near-infrared probe consists of three parts simple in structure, joins the described non-resilient skin good with supportive, processing ease, and practicality is good, installs simple.The upper technique of described near-infrared probe making is simple in addition, and minimum a kind of technique of need can be produced three parts, is easy to large-scale production.And owing to using nonmetallic materials completely, this installs near infrared spectroscopy, electrode still can be used in the research of three kinds of technical tie-ups of NMR (Nuclear Magnetic Resonance)-imaging.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, technical scheme of the present invention is further described in detail.
Fig. 1 is for forming the probe positioner of near-infrared probe, fibre holder, elastic pressing cap three assembly schematic diagrams.
Fig. 2 is near-infrared probe work front view.
Fig. 3 is near-infrared probe work left view.
The structural representation of Fig. 4 near infrared spectroscopy and electrode joint-detection device.
The specific embodiment
What Fig. 1 showed is the probe positioner 1 that forms near-infrared probe, fibre holder 2, elastic pressing cap 3 three assembly schematic diagrams.The through hole of probe positioner 1 is free to slide for fibre holder 2, and the through hole of fibre holder 2 is for grip optical fiber, and elastic pressing cap 3 is for applying elastic pressure to optical fiber.
What Fig. 2 and Fig. 3 showed is to use three parts in Fig. 1 to add the near-infrared probe work schematic diagram that the conventional elbow optical fiber 5 of non-resilient outer 4 and near infrared spectroscopy of device forms.Probe positioner 1 is fixed on non-resilient outer 4, after fibre holder 2 clamping elbow optical fiber 5, put in probe positioner 1 through hole, again elastic pressing cap 3 is covered to the corner at elbow optical fiber 5, the two ends of elastic pressing cap 3 are fixed on probe positioner 1 both sides, or be fixed on probe positioner 1 both sides non-resilient outer 4 on.Fig. 2 is front view, and Fig. 3 is left view.This design has guaranteed fully contacting and comfortable wearing of fiber end face and physiological location.And it is simple that this probe designs has production technology, the advantages such as NMR (Nuclear Magnetic Resonance)-imaging compatibility are installed simply.
What Fig. 4 showed is the structural representation of near infrared spectroscopy and electrode joint-detection device.Near-infrared probe need to be arranged in the spacing of fixing on non-resilient outer 4 according to measuring, on elastic inner layer 6 according to electrode standard positioning system installing electrodes 7.On elastic inner layer 6, there is optical fiber by the first hole 8, thus make optical fiber 5 termination can with physiological location good contact.The diameter that the diameter of optical fiber by the first hole 8 is greater than optical fiber 5 adapts to the displacement causing because of physiological location change of shape.On non-resilient outer 4, there is electrode and expose the second hole 9, for electrode 7 is injected to conductive paste and adjustment.The diameter that the diameter that electrode exposes the second hole 9 is greater than electrode 7 adapts to the displacement causing because of physiological location change of shape.Thisly comprise elastic inner layer 6 and non-resilient outer 4 apparatus structure both can adapt to physiological location shape individual variation, thereby electrode standard setting need to be met, can guarantee that again near-infrared light source-detector pitch keeps fixing, can not change along with physiological location shape individual variation.
The present invention specifically implements can various ways, and a kind of embodiment of take below describes as example.
Embodiment: take head measurement as example, use the elastic inner layer of elastic woven material producing device, silver/silver chloride sintered electrode is installed on elastic inner layer, brain electrode is located according to international 10-20 system.Use the non-resilient skin of heat-stabilized wood flitch producing device.With the rubber of different hardness, produce the probe positioner of near-infrared probe, fibre holder, three kinds of parts of elastic pressing cap.At probe positioner outer wall, on position, process the locating hole that a circle groove is accomplished fluently in advance for being stuck in non-resilient skin on the lower side.Fibre holder through-hole diameter is slightly less than optical fiber external diameter, by caoutchouc elasticity extruding force, clamps optical fiber.Fibre holder external diameter is slightly less than probe positioner through-hole diameter, and fibre holder is put into probe positioner through hole after having clamped optical fiber.The two ends of elastic pressing cap are used super glue to be bonded on the non-resilient skin of probe positioner both sides, and middle part is covered in optical fiber elbow.According to near-infrared probe and electrode for encephalograms, arrange, on elastic inner layer and non-resilient skin, process respectively optical fiber and expose the second hole by the first hole and electrode.
The stiff outer profile of loading the elastic inner layer of electrode and loading near-infrared probe by change, the present invention equally can be for to shank, and arm and other physiological location are carried out the signal of telecommunication and spectral technique combined measurement.
It should be noted last that, the above specific embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (11)
1. a near infrared spectroscopy and electrode joint-detection device, it is characterized in that, comprise elastic inner layer and non-resilient skin, described elastic inner layer is adapted to detected position shape, and be mounted with the electrode of arranging according to standard positioning system, the near-infrared probe that meets the requirement of near-infrared light source-detector constant spacing is installed on described non-resilient skin, and described near-infrared probe loads luminous source optical fiber or detection optical fiber; Described elastic inner layer is provided with the first hole, described light source or detection optical fiber are by the first hole, described non-resilient skin is provided with the second hole, and described electrode exposes described non-resilient skin by the second hole, described near-infrared probe and described electrode is straggly arranges.
2. near infrared spectroscopy according to claim 1 and electrode joint-detection device, it is characterized in that, described near-infrared probe comprises probe positioner, fibre holder, described probe positioner is fixed on described non-resilient skin by draw-in groove, described fibre holder is arranged in the middle of described probe positioner, has through hole and be used for grip optical fiber in the middle of described fibre holder.
3. near infrared spectroscopy according to claim 1 and electrode joint-detection device, is characterized in that, described the first hole diameter is greater than described light source or detection optical fiber diameter.
4. near infrared spectroscopy according to claim 1 and electrode joint-detection device, is characterized in that, described the second hole diameter is greater than described electrode diameter.
5. near infrared spectroscopy according to claim 2 and electrode joint-detection device, is characterized in that, in the middle of described probe positioner, has than the large through hole of described fibre holder external diameter.
6. near infrared spectroscopy according to claim 2 and electrode joint-detection device, it is characterized in that, described near-infrared probe also comprises elastic pressing cap, and described elastic pressing cap two ends are fixed on described probe positioner both sides, be used for being pressed in optical fiber elbow, optical fiber is applied to elastic pressure.
7. near infrared spectroscopy according to claim 1 and electrode joint-detection device, is characterized in that, electrode standard positioning system is selected brain electricity 10-10,10-20,10-20 expanding system or other electrode standard positioning systems.
8. near infrared spectroscopy according to claim 1 and electrode joint-detection device, is characterized in that, described non-resilient skin and described elastic inner layer link together by elastomeric material.
9. near infrared spectroscopy according to claim 1 and electrode joint-detection device, is characterized in that, described non-resilient skin is by plastics, non-resilient rubber, and thermoplastic material or other non-elastic materials are made.
10. near infrared spectroscopy according to claim 1 and electrode joint-detection device, is characterized in that, described elastic inner layer is by elastic woven material, and gum elastic or other elastomeric materials are made.
11. according to the near infrared spectroscopy described in claim 2 or 6 and electrode joint-detection device, it is characterized in that, and described nearly probe positioner, fibre holder and elastic pressing cap adopt respectively rubber, and latex or other non-metallic elastic material are manufactured.
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| CN201310733760.9A CN103735248B (en) | 2013-12-26 | 2013-12-26 | A kind of near infrared spectroscopy and electrode joint-detection device |
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| CN103445774A (en) * | 2013-07-14 | 2013-12-18 | 北京师范大学 | Photoelectric electrode capable of synchronously collecting EEG signals and blood oxygen signals |
| CN106037667A (en) * | 2016-07-06 | 2016-10-26 | 苏州格林泰克科技有限公司 | Electroencephalograph (EEG) and near-infrared spectroscopy combined collecting device |
| CN106037665A (en) * | 2016-07-06 | 2016-10-26 | 苏州格林泰克科技有限公司 | Near infrared spectrum cerebral function imaging device |
| CN106137135A (en) * | 2016-08-10 | 2016-11-23 | 中国医学科学院生物医学工程研究所 | It is applied to the headgear of the electrical combined collection brain signal of transcranial magnetic stimulation |
| CN106937868A (en) * | 2017-03-03 | 2017-07-11 | 燕山大学 | A kind of brain electricity and near infrared spectrum Collect jointly device applied to rat |
| CN108042131A (en) * | 2017-12-26 | 2018-05-18 | 武汉智普天创科技有限公司 | The Portable cap of brain electricity and near infrared spectrum Collect jointly brain signal |
| CN110618094A (en) * | 2019-08-12 | 2019-12-27 | 山西省平遥牛肉集团有限公司 | Multi-index composite synchronous detection table for fresh beef and use method |
| CN113951901A (en) * | 2021-11-19 | 2022-01-21 | 郑州大学第一附属医院 | Electroencephalograph data acquisition effectiveness automatic analysis system and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103445774A (en) * | 2013-07-14 | 2013-12-18 | 北京师范大学 | Photoelectric electrode capable of synchronously collecting EEG signals and blood oxygen signals |
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| CN113951901A (en) * | 2021-11-19 | 2022-01-21 | 郑州大学第一附属医院 | Electroencephalograph data acquisition effectiveness automatic analysis system and method |
| CN113951901B (en) * | 2021-11-19 | 2024-03-01 | 中国中医科学院西苑医院 | Automatic analysis system and method for data acquisition effectiveness of electroencephalogram |
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