CN103734545B - High-calcium nutritional lick block for treating antenatal and postnatal paresis of milk cows and preparation method of high-calcium nutritional lick block - Google Patents
High-calcium nutritional lick block for treating antenatal and postnatal paresis of milk cows and preparation method of high-calcium nutritional lick block Download PDFInfo
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Abstract
The invention discloses a high-calcium nutritional lick block for treating antenatal and postnatal paresis of milk cows and a preparation method of the high-calcium nutritional lick block. The high-calcium nutritional lick block comprises the following components in parts by weight: 600-900 parts of table salt, 40-100 parts of rock flour, 20-60 parts of light calcium carbonate of which the mass ratio of calcium is 39.2%, 3-10 parts of copper sulfate of which the mass ratio of copper is 25%, 3-8 parts of zinc sulfate of which the mass ratio of zinc is 34.5%, 6-18 parts of ferrous sulfate of which the mass ratio of iron is 30%, 2-8 parts of manganese sulfate of which the mass ratio of manganese is 31.8%, 0.5-2 parts of potassium iodide of which the mass ratio of iodine is 74.9%, 0.1-0.8 part of sodium selenite of which the mass ratio of selenium is 44.7% and 0.2-1.5 parts of cobalt chloride of which the mass ratio of cobalt is 39.1%. The high-calcium nutritional lick block for treating antenatal and postnatal paresis of milk cows has the beneficial effects that a clinical effect is remarkable, the addition of surplus elements is avoided, the cost for adding microelements can be reduced, the pollution caused by the unbridled and excessive addition to the environment can be prevented, and meanwhile, the content ratio of mineral elements in the bodies of the milk cows can be well adjusted, so that the production properties of animals are maximized.
Description
Technical field
The present invention relates to one and lick brick formula.
Background technology
The antenatal postpartum paralysis of milk cow is a kind of serious alcium and phosphor metabolization obstacle disease occurred suddenly before and after cow birth.With serious hypocalcemia, poor appetite, hypesthesia or disappearance, quadriplegia, sleeping ground does not rise, spirit is depressed, ruminate stoppings, gastrointestinal peristalsis weakens, twitches, drain suppression, lie on one's side, even death etc. be main Clinical symptoms.It is the main cause that the antenatal postpartum paralysis of milk cow occurs that gestation, childbirth and blood calcium caused by lactation are lost in a large number, and calcium homeostasis regulation mechanism does not play one's part to the full, and to affect body to the absorption of calcium and mobilization be another reason.Calcium another factor that supply falls short of demand is that dry matter intakes is not enough simultaneously, causes the calcium run off in blood not supplemented rapidly, causes dairy cow acute calcium metabolism disorder.The morbidity of milk cow antenatal postpartum paralysis has certain regularity, from spring to winter, this sick incidence of disease increases gradually, and main cause is, temperature reduced gradually in autumn and winter season, milk cow is in order to maintain body temperature, energy matter requirement increase, if raise improper, nutriment undersupply, especially microelement deficiencies, easily cause paralysis.In addition, the antenatal postpartum paralysis of milk cow can also secondary or the retention of afterbirth that occurs together, gastroenteritis, ketoacidosis, postpartum uterine infection and the disease such as mammitis.The antenatal postpartum paralysis incidence of disease 13.2% of China milk cow, sometimes up to more than 30%, sick ox mortality about 65%, in the majority with high, middle milking cow morbidity.Therefore, the metabolic disease-antenatal postpartum paralysis having a strong impact on milk cattle cultivating benefit causes the great attention of milk cow production.And the mode that feeding micro-element nutrition licks brick to supplement the trace element that milk cow lacks be one of effective nutritional supplementation method.High-calcium nutrient licks brick effectively can prevent and treat the diseases such as the antenatal postpartum paralysis that milk cow alcium and phosphor metabolization obstacle induces.
China herding worker carries out, in a large number about milk cow mine trace element licks the test of brick, achieving certain achievement.But have not been reported about the nutrition lap brick of the antenatal postpartum paralysis of control milk cow, only have medicine or the nutritious supplementary pharmaceutical of control.As Chinese patent 201210091855.0 discloses a kind of Chinese medicine composition for the treatment of milk cow postpartum paralysis, it is made up of the Chinese medicine material of following weight parts, parasitic loranthus 120, the fruit of Chinese wolfberry 150, mulberry fruit 150, rhizoma cibotii 90, keel 120, oyster 120, turtle shell 80, the fruit of glossy privet 120, mother-of-pearl 150, raw hawthorn 180, rice sprout 130, the banksia rose 80.It is fast that the medicine of this patent has curative effect, and cure rate is high, has no side effect, and not easily recurs, and without poisoning, the advantage such as at the bottom of cost, treats that milk cow postpartum paralysis is efficient reaches 100%, cure rate about 96%.Chinese patent 201310296239.3 discloses a kind of new milking cow and to gavage nutritious supplementary pharmaceutical and the application in the nutritious supplementary pharmaceutical for the treatment of milk cow hypocalcemia in postpartum, abomasum displacement or ketoacidosis disease thereof postpartum.This nutritious supplementary pharmaceutical comprises the raw material of following parts by weight: calcium propionate 15-25, solid propane diols 20-25, calcium chloride 10-15, potassium chloride 5-9, magnesium sulfate 10-15, sodium bicarbonate 2-5, sodium chloride 1-4, yeast culture 15-25.Adopt the nutritious supplementary pharmaceutical of this patent, effectively can maintain blood calcium, blood magnesium, glucose level, reduce the level of NEFA and beta-hydroxybutyric acid, effectively reduce the generation of the metabolic diseases such as new milking cow postpartum paralysis, ketosis, abomasum displacement.Cow is regained one's strength postpartum fast, recovers feed intake, improve health status, improve the output of milk, good economic benefit can be obtained.
Above prior art is the medicine or nutritious supplementary pharmaceutical developed for the antenatal postpartum paralysis of milk cow, and medicine plays therapeutic action, but there is unfavorable factors such as curing the symptoms, not the disease, therapeutic process is inconvenient; Though nutritious supplementary pharmaceutical has certain effect, but there is the problems such as palatability.In current China milk cattle cultivating process, there is the problems such as essential mineral trace element imbalance, abuse of antibiotics.
Summary of the invention
The technical problem to be solved in the present invention overcomes existing defect, provides a kind of high-calcium nutrient effectively supplementing the antenatal postpartum paralysis of control milk cow of the trace element required for milk cow and lick brick.
Object of the present invention carrys out specific implementation by the following technical programs:
The high-calcium nutrient preventing and treating the antenatal postpartum paralysis of milk cow licks a brick, comprises following component:
By weight, the precipitated calcium carbonate 20 ~ 60 parts of salt 600 ~ 900 parts, stone flour 40 ~ 100 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 3 ~ 10 parts, copper sulphate, containing 6 ~ 18 parts, the ferrous sulfate of 3 ~ 8 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 2 ~ 8 parts of manganese mass ratio 31.8%, containing the KI 0.5 ~ 2 part of iodine quality than 74.9%, containing the sodium selenite 0.1 ~ 0.8 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 0.2 ~ 1.5 part.
Preferably, the high-calcium nutrient of the above-mentioned antenatal postpartum paralysis of control milk cow licks brick, comprises following component:
By weight, the precipitated calcium carbonate 40 parts of salt 850 parts, stone flour 62.5 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 5.5 parts, copper sulphate, containing 11 parts, the ferrous sulfate of 7 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 6 parts of manganese mass ratio 31.8%, containing the KI 1.5 part of iodine quality than 74.9%, containing the sodium selenite 0.3 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 1.2 parts.
The high-calcium nutrient of the above-mentioned antenatal postpartum paralysis of control milk cow licks the preparation method of brick, and after each component is mixed mixing by weight, the round pie being suppressed into five kilogram weights licks brick.
high-calcium nutrient licks the contrast test of brick on the impact of the milk cow Major Nutrient metabolic disease incidence of disease:
1 materials and methods
1.1 lick brick for examination milk cow high-calcium nutrient
This is tested milk cow high-calcium nutrient used and licks brick and developed by Lanzhou Livestock and Animal Drug Inst., Chinese Academy of Agricultural Science, and Chinese Veterinarian Inst., Chinese Academy of Sciences pharmaceutical factory produces.Concrete component by weight, the precipitated calcium carbonate 40 parts of salt 850 parts, stone flour 62.5 parts, calcic mass ratio 39.2%, 5.5 parts, the copper sulphate of cupric mass ratio 25%, containing 11 parts, the ferrous sulfate of 7 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 6 parts of manganese mass ratio 31.8%, containing the KI 1.5 part of iodine quality than 74.9%, containing the sodium selenite 0.3 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 1.2 parts.It is cylindric for licking brick, and the heavy 5kg of every block, containing microelements of calcium, copper, zinc, manganese, iron, iodine, selenium and other trace elements.
1.2 test sites and confession examination cows
China holstein cows is selected in test, is provided by occasion cattle farm, Dingxi, Gansu sky.Test adopts single-factor design, selects low yield perinatal period, middle product and high yield cow totally 60, and age-based, parity etc. is divided into test group and control group at random, often organizes 30, and age of two groups of milk cows, parity, body weight and health status are close.In table 1.
Table 1 is for examination cows basic condition
。
1.3 test method
In test Niu Caiyong totally-enclosed drylot feeding, jube location is raised, control group fed basal diet, and test group is fed basal diet, and supplementary feeding high-calcium nutrient licks brick, and every 2 oxen 1 piece lick arbitrarily; Fine fodder (mainly comprising corn, Cottonseed Meal, dregs of beans etc.) every 2kg every day feeds by head, and ensilage is rule of thumb supplied, every every day Silage Corn Straw 15kg, brewex's grains 6kg, cortex of Rhizoma Dioscoreae 3kg, straw 3kg, sheep's hay 2kg free choice feeding, by head metering, freely drink water, day feeding 3 times.The incidence of disease of statistics milk cow Major Nutrient metabolic disease before and after experiment.
1.4 data processing
SPSS17.0 is adopted to carry out statistical disposition to all data.
2 results and analysis
Result of the test is in table 2.As can be seen from Table 2,
high-calcium nutrient licks the incidence of disease that brick significantly can reduce milk cow main metabolic sick retention of afterbirth, allotriophagy, antenatal postpartum paralysis and endometritis, wherein prevents and treats antenatal postpartum paralysis effect significantly (p<0.01).
Table 2 high-calcium nutrient licks the impact of brick on milk cow main metabolic disease
。
* represents and to compare difference with control group extremely significantly (p<0.01), and * represents significant difference (p<0.05)
3 conclusions and discussion
This result of the test shows, the high-calcium nutrient of the antenatal postpartum paralysis of control milk cow licks the incidence of disease that brick significantly can reduce milk cow Major Nutrient metabolic disease, wherein the incidence of disease of postpartum paralysis extremely significantly reduces, and reduces milk cattle cultivating risk, improves the economic benefit of dairy cow farm.Think that licking brick to milk cow supplementary feeding high-calcium nutrient effectively can prevent and treat antenatal postpartum paralysis caused by calcium deficiency.
the present invention licks the safety evaluatio test of brick:
Acute toxicity test: for the high-calcium nutrient evaluating control milk cow postpartum paralysis licks the security of brick, 70 cleaning grade kunming mouses (22.0 ± 1.0g) are divided into 7 groups (male and female half and half) at random, 1 control group, 6 dose drug groups.Above-mentioned high-calcium nutrient is licked brick to pulverize, cross 120 mesh sieves, press the dosage gavage of 5g/kg, 10g/kg, 20g/kg, 40g/kg, 60g/kg, 80g/kg respectively, observe 7 days, record dead mouse number, tries to achieve LD
50for 52.75g/kg, the credibility interval of 95% is 36.66 ~ 80.87 g/kg.
Long term toxicity test: the mouse of above-mentioned equal conditions 70, often organizes 10, respectively with LD
501/9,1/8,1/7,1/6,1/5,1/4 dosage be added in mouse daily ration, and establish a control group, feed 3 months.Result: (1), in 10 d, small white mouse weightening finish is negative correlation with addition; (2) liver and blood sample medium trace element content are all proportionate with additive capacity; (3) when test 90 d, control group and test group mouse are all without obviously visible pathological change; Basis of microscopic observation: 1/4 LD
50dosage group mouse hepatic hilar region meronecrosis, core concentrates, the vacuolar degeneration of lobuli hepatis popularity, and liver cell is muddy, downright bad, and endochylema bursts apart, karyolysis.Glomerular epithelium cell cloudy swelling, coagulation necrosis, luminal stenosis or blocking.
Conclusion: the high-calcium nutrient of the antenatal postpartum paralysis of control milk cow licks the incidence of disease that brick significantly can reduce antenatal postpartum paralysis; The high-calcium nutrient of suitable dosage licks the grown facilitation of brick to small white mouse, and the high-calcium nutrient of high dose is licked brick and then affected it and grow, and can cause histocyte damage in various degree.
Mouse toxicity test shows, when the dosage that high-calcium nutrient licks brick is 10.55g/kg, in 90 d, mouse tissue structure does not find obvious pathological change; LD
50for 52.75g/kg, the credibility interval of 95% is 36.66 ~ 80.87 g/kg.
From above test, the high-calcium nutrient of the antenatal postpartum paralysis of control milk cow of the present invention licks the incidence of disease that brick effectively can reduce milk cow Major Nutrient metabolic disease, and wherein antenatal postpartum paralysis effect is the most remarkable.
Beneficial effect of the present invention:
The cause of disease of the antenatal postpartum paralysis of the milk cow of the present invention caused by calcium deficiency, takes into full account the physiology of China milk cow, industry characteristics, then through clinical feeding experiment, constantly finally determines after adjustment formula rate.The contrast test of brick on the impact of the milk cow Major Nutrient metabolic disease incidence of disease is licked as can be seen from high-calcium nutrient, it is remarkable that the high-calcium nutrient that the present invention prevents and treats the antenatal postpartum paralysis of milk cow licks brick control milk cow antenatal postpartum paralysis clinical effectiveness, avoid the interpolation of unnecessary element, not only can reduce trace element interpolation cost but also can prevent because blindly excessive interpolation causes the pollution to environment, the Mineral Concentrations ratio in Contents in Cows can be regulated simultaneously better, make the production performance of animal obtain maximum performance.
Detailed description of the invention
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein is only for instruction and explanation of the present invention, is not intended to limit the present invention.
embodiment 1:
The high-calcium nutrient preventing and treating the antenatal postpartum paralysis of milk cow licks a brick, comprises following component:
By weight, the precipitated calcium carbonate 40 parts of salt 850 parts, stone flour 62.5 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 5.5 parts, copper sulphate, containing 11 parts, the ferrous sulfate of 7 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 6 parts of manganese mass ratio 31.8%, containing the KI 1.5 part of iodine quality than 74.9%, containing the sodium selenite 0.3 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 1.2 parts.
Its preparation method is: after each component is mixed mixing by weight, the round pie being suppressed into five kilogram weights licks brick.
embodiment 2:
The high-calcium nutrient preventing and treating the antenatal postpartum paralysis of milk cow licks a brick, comprises following component:
By weight, the precipitated calcium carbonate 20 parts of salt 600 parts, stone flour 100 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 10 parts, copper sulphate, containing 18 parts, the ferrous sulfate of 3 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 2 parts of manganese mass ratio 31.8%, containing the KI 2 part of iodine quality than 74.9%, containing the sodium selenite 0.1 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 1.5 parts.
Its preparation method is: after each component is mixed mixing by weight, the round pie being suppressed into five kilogram weights licks brick.
embodiment 3:
The high-calcium nutrient preventing and treating the antenatal postpartum paralysis of milk cow licks a brick, comprises following component:
By weight, the precipitated calcium carbonate 60 parts of salt 900 parts, stone flour 40 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 3 parts, copper sulphate, containing 6 parts, the ferrous sulfate of 8 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 8 parts of manganese mass ratio 31.8%, containing the KI 0.5 part of iodine quality than 74.9%, containing the sodium selenite 0.8 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 0.2 part.
Its preparation method is: after each component is mixed mixing by weight, the round pie being suppressed into five kilogram weights licks brick.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. the high-calcium nutrient preventing and treating the antenatal postpartum paralysis of milk cow licks a brick, it is characterized in that: be made up of following component:
By weight, the precipitated calcium carbonate 20 ~ 60 parts of salt 600 ~ 900 parts, stone flour 40 ~ 100 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 3 ~ 10 parts, copper sulphate, containing 6 ~ 18 parts, the ferrous sulfate of 3 ~ 8 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 2 ~ 8 parts of manganese mass ratio 31.8%, containing the KI 0.5 ~ 2 part of iodine quality than 74.9%, containing the sodium selenite 0.1 ~ 0.8 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 0.2 ~ 1.5 part.
2. the high-calcium nutrient of the antenatal postpartum paralysis of control milk cow according to claim 1 licks brick, it is characterized in that: be made up of following component:
By weight, the precipitated calcium carbonate 40 parts of salt 850 parts, stone flour 62.5 parts, calcic mass ratio 39.2%, cupric mass ratio 25% 5.5 parts, copper sulphate, containing 11 parts, the ferrous sulfate of 7 parts, the zinc sulfate of zinc mass ratio 34.5%, iron content mass ratio 30%, containing the manganese sulfate 6 parts of manganese mass ratio 31.8%, containing the KI 1.5 part of iodine quality than 74.9%, containing the sodium selenite 0.3 part of selenium mass ratio 44.7%, containing cobalt mass ratio 39.1% cobalt chloride 1.2 parts.
3. the high-calcium nutrient of the antenatal postpartum paralysis of control milk cow according to claim 1 and 2 licks brick, it is characterized in that: after each component is mixed mixing by weight, the round pie being suppressed into five kilogram weights licks brick.
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| CN104938790A (en) * | 2015-06-09 | 2015-09-30 | 甘肃天利达生物科技有限责任公司 | Mineral trace element nutrition lick block for cattle and sheep |
| CN105028987A (en) * | 2015-06-15 | 2015-11-11 | 中国农业科学院兰州畜牧与兽药研究所 | Compound-polysacchariderace-enriched trace element licking block special for dairy cattle and preparation method for compound-polysacchariderace-enriched trace element licking block |
| CN107333984A (en) * | 2017-06-19 | 2017-11-10 | 广汉隆达饲料有限公司 | Diseases of Cow specific complex premixed feed licks brick |
| CN108719604A (en) * | 2018-05-18 | 2018-11-02 | 王可 | A kind of nutrition reinforced type for perinatal period ewe licks brick and preparation method thereof |
| CN108719605A (en) * | 2018-06-06 | 2018-11-02 | 甘肃省家畜繁育改良管理站 | It is a kind of prevention cow in perinatal period paralysis anion salt lick brick and method for production |
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| CN103355508A (en) * | 2012-03-27 | 2013-10-23 | 中国农业科学院兰州畜牧与兽药研究所 | Special nutrient block for dairy cows in Qinghai-Xizang region and preparation method thereof |
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| CN103355508A (en) * | 2012-03-27 | 2013-10-23 | 中国农业科学院兰州畜牧与兽药研究所 | Special nutrient block for dairy cows in Qinghai-Xizang region and preparation method thereof |
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Effective date of registration: 20160617 Address after: 734000 Ganzhou City, Zhangye Province Zhang Su Road, road, 27 kilometers away from the Department of Patentee after: Zhangye beautkey Neville Biotechnology Co. Ltd. Address before: 730000 Gansu city of Lanzhou province West Lake Qilihe district along the 335 base Patentee before: Lanzhou Inst. of Animal Husbandary & Veterinary Medicine, Chinese Academy of Agr |