CN103728444B - A kind of accurate attemperating unit of high flux liquid sample of quick response and method - Google Patents
A kind of accurate attemperating unit of high flux liquid sample of quick response and method Download PDFInfo
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- CN103728444B CN103728444B CN201310738518.0A CN201310738518A CN103728444B CN 103728444 B CN103728444 B CN 103728444B CN 201310738518 A CN201310738518 A CN 201310738518A CN 103728444 B CN103728444 B CN 103728444B
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Abstract
The invention provides a kind of accurate attemperating unit of high flux liquid sample and method of quick response, this device comprises hot well, described hot well is primarily of heat-conducting plate and multiple heat conducting sleeve composition, described heat-conducting plate offers the counterbore array matched with multiple heat conducting sleeve, one end of described heat conducting sleeve to be inserted in the counterbore on heat-conducting plate and by being welded and fixed.The present invention also provides a kind of high flux liquid sample of quick response accurate Temp. control method.The present invention can avoid the error of high flux sampling receptacle own, hot well processing and manufacturing error and mechanical processing technique on the impact of hot well thermal behavior, improves hot well thermal behavior, reduces manufacturing cost and the requirement to production equipment.
Description
Technical field
The present invention relates to chemical analysis, biological analysis and medical detection technology, the accurate attemperating unit of high flux liquid sample of specifically a kind of quick response and method.
Background technology
The accurate temperature controller that can respond fast is biochemical analysis and the indispensable instrument of medical detection field.The response speed of temperature control and control accuracy are usually the keys of biochemical analysis experiment success.Particularly in the application of high flux sample, heating and cooling can be carried out equably to all samples and control to be one of very crucial technical requirement.
The core parts of accurate temperature controller are also known as hot well.Hot well plays the effect of fixing high flux sampling receptacle, is also the passage of heat conduction simultaneously.Therefore, the heat conductivility of hot well, thermal capacitance and heat diffusion properties directly can have influence on the homogeneity of the precision of temperature control, the speed of heating and cooling and Temperature Distribution.Hot well design common is at present generally all on the metal of high thermal conductivity, directly process the structure can fixing high flux sampling receptacle.In actual applications because mismachining tolerance and processing technology are to the requirement of hot well structural strength, the thermal behavior of hot well is generally not easy to accomplish optimization, because machining exists error, between each passage of high flux sampling receptacle in addition, there is certain shape and the deviation of position.Ensure that each passage of high flux sampling receptacle can fit tightly with the corresponding fixed sturcture of hot well, and ensure that sampling receptacle can conveniently pick and place again, so in design, just certain interval must be left between high flux sampling receptacle and the corresponding fit structure of hot well, gap generally between 0.5 ~ 1mm, to ensure that high flux sampling receptacle can normally pick and place.Clearance small between sampling receptacle and hot well is very large on heat conduction impact, because air can not produce convection current in small slit, and the coefficient of heat conductivity of air is very low, small air slots defines a very important thermal resistance between hot well and sampling receptacle.In addition, the fit structure of processed sample container on hot well, processing technology requires that hot well will have higher physical strength, and therefore, the wall thickness of hot well is inevitable thicker, causes thermal capacitance higher.Due to above reason, the mode of machining will make the thermal response speed of temperature controller be difficult to promote.
Summary of the invention
The object of the present invention is to provide the accurate attemperating unit of a kind of high flux liquid sample of quick response and method, to avoid the error of high flux sampling receptacle own, hot well processing and manufacturing error and mechanical processing technique on the impact of hot well thermal behavior, improve hot well thermal behavior, reduce manufacturing cost and the requirement to production equipment.
Technical scheme of the present invention is:
A kind of accurate attemperating unit of high flux liquid sample of quick response, comprise hot well, described hot well is primarily of heat-conducting plate and multiple heat conducting sleeve composition, described heat-conducting plate offers the counterbore array matched with multiple heat conducting sleeve, one end of described heat conducting sleeve to be inserted in the counterbore on heat-conducting plate and by being welded and fixed.
The accurate attemperating unit of high flux liquid sample of described quick response, described hot well also comprises stay-warm case, and described stay-warm case is coated on the periphery of heat-conducting plate and heat conducting sleeve.
The accurate attemperating unit of high flux liquid sample of described quick response, the wall thickness of described heat conducting sleeve is less than or equal to 0.8 millimeter.
The accurate attemperating unit of high flux liquid sample of described quick response, the lower end inner wall of described heat conducting sleeve is that circular cone is poroid.
The accurate attemperating unit of high flux liquid sample of described quick response, the thickness of described heat-conducting plate is 2 millimeters, and the degree of depth of described counterbore is 0.5 millimeter.
The accurate Temp. control method of high flux liquid sample of quick response, comprises the following steps:
(1) multiple heat conducting sleeve is inserted successively be filled with in the heat-conducting plate counterbore array of solder;
(2) high flux sampling receptacle is put into the heat conducting sleeve being inserted in heat-conducting plate counterbore, the position of adjustment heat conducting sleeve, makes high flux sampling receptacle reach the state freely picked and placeed;
(3) heat heat-conducting plate, make to be placed on the solder fusing in heat-conducting plate counterbore in advance, heat conducting sleeve and heat-conducting plate are welded together.
The accurate Temp. control method of high flux liquid sample of described quick response, described high flux sampling receptacle comprises 32 conventional orifice plates, 96 orifice plates and 192 orifice plates.
The present invention changes hot well design the composite design of heat conducting sleeve and heat-conducting plate into, and owing to being split design, heat conducting sleeve adopts the mode of turnery processing, and its wall thickness can control within 0.8 millimeter; Heat-conducting plate can use the sheet material of 2 millimeters thick, greatly reduces the thermal capacitance of hot well self like this; The inner wall shape of heat conducting sleeve can according to the coordinating demand of high flux sampling receptacle and designing, between such heat conducting sleeve and high flux sampling receptacle, radial reserved gap can be reduced within 0.1 millimeter.High flux sampling receptacle comprises the sampling receptacle of 32 conventional orifice plates, 96 orifice plates, 192 orifice plates and other unconventional port number.
Before heat conducting sleeve is welded on heat-conducting plate, first arranged on heat-conducting plate by heat conducting sleeve, then high flux sampling receptacle is put into the heat conducting sleeve arranged, because not yet fixing, heat conducting sleeve can adapt to the scale error of high flux sampling receptacle automatically; Under the state that high flux sampling receptacle can freely pick and place, heat heat-conducting plate, make the solder fusing be placed in advance between heat conducting sleeve and heat-conducting plate; After solder cools, the heat conducting sleeve of having had good positioning just has been weldingly fixed on heat-conducting plate.Can avoid in the design for adaptation high flux sampling receptacle its own tolerances and hot well machining tolerance reserve larger gap with this adaptive Position Design, it also avoid the quality for carrying out the hot well that machining must increase simultaneously, while raising hot well thermal behavior, reducing manufacturing cost and the requirement to production equipment.
Accompanying drawing explanation
Fig. 1 is the structural representation of the specific embodiment of the invention;
Fig. 2 is the diagrammatic cross-section of the specific embodiment of the invention;
Fig. 3 is the heat conducting sleeve of the specific embodiment of the invention and the assembling schematic diagram of heat-conducting plate.
Embodiment
The present invention is further illustrated below in conjunction with the drawings and specific embodiments.
As shown in Figure 1 and Figure 2, a kind of accurate attemperating unit of high flux liquid sample of quick response, comprise hot well, hot well forms primarily of heat-conducting plate 1 and multiple heat conducting sleeve 2, heat-conducting plate 1 offers the counterbore array matched with multiple heat conducting sleeve 2, one end of heat conducting sleeve 2 to be inserted in the counterbore 11 on heat-conducting plate 1 and to be fixed by soldering.Heat conducting sleeve 2 is the column construction of hollow, upper end wall thickness 0.8 millimeter, and inside, lower end is designed to taper hole to reduce the clearance between heat conducting sleeve 2 and 96 orifice plate.Heat-conducting plate 1 and heat conducting sleeve 2 are by the C10000 system copper production of high thermal conductivity.Be coated with stay-warm case 3 in the periphery of heat-conducting plate 1 and heat conducting sleeve 2, stay-warm case 3 is formed by thermal insulation material, and isolated external environment is on the impact of hot well.
Hot well is designed to the unitized construction of heat-conducting plate 1 and heat conducting sleeve 2 by the present invention, as shown in Figure 3.Heat-conducting plate 1 can select the sheet material of 2 millimeters thick, and heat-conducting plate 1 devises the counterbore array of 0.5 millimeters deep.During installation, in the counterbore 11 of heat-conducting plate 1, add high temperature soldering solder, then heat conducting sleeve 2 is inserted in counterbore 11 successively, make heat conducting sleeve 2 be arranged on heat-conducting plate 1; Again will
96 orifice plates insert in heat conducting sleeve 2, and now heat conducting sleeve 2 is not also fixed, and adjustment heat conducting sleeve 2 position, makes 96 orifice plates pick and place smoothly; Heating heat-conducting plate 1, solder fusing, heat conducting sleeve 2 has welded with heat-conducting plate 1.Adopt above-mentioned Design and manufacture technique, locate, heat conducting sleeve 2 and heat-conducting plate 1 are welded together after having located again with 96 orifice plates of standard to all heat conducting sleeves 2, therefore, the gap between heat conducting sleeve 2 and 96 orifice plate can be reduced within 0.1 millimeter.
Adopt hot well of the present invention to test: 96 orifice plates filling liquid are put into hot well, thermal source is installed bottom hot well heat-conducting plate homogeneous heating is carried out to hot well; The initial temperature of hot well, 96 orifice plates and liquid is 75 degrees Celsius; Heat source temperature from 75 degrees Celsius of sudden changes to 95 degrees Celsius, and records the temperature-responsive of each point for measuring temperature.Test figure shows, and after starting to heat 50 seconds, in 96 orifice plates, the homogeneous temperature of liquid is elevated to 95 degrees Celsius; Start to heat in 4 seconds, heat-conducting plate temperature is elevated to 95 degrees Celsius from 75 degrees Celsius; The intensification of hot well per second can reach 5 degrees Celsius.
The above embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determine.
Claims (2)
1. the accurate Temp. control method of the high flux liquid sample of response fast, is characterized in that, comprise the following steps:
(1) multiple heat conducting sleeve is inserted successively be filled with in the heat-conducting plate counterbore array of solder;
(2) high flux sampling receptacle is put into the heat conducting sleeve being inserted in heat-conducting plate counterbore, the position of adjustment heat conducting sleeve, makes high flux sampling receptacle reach the state freely picked and placeed;
(3) heat heat-conducting plate, make to be placed on the solder fusing in heat-conducting plate counterbore in advance, heat conducting sleeve and heat-conducting plate are welded together.
2. the accurate Temp. control method of the high flux liquid sample of quick response according to claim 1, it is characterized in that, described high flux sampling receptacle comprises 32 conventional orifice plates, 96 orifice plates and 192 orifice plates.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310738518.0A CN103728444B (en) | 2013-12-30 | 2013-12-30 | A kind of accurate attemperating unit of high flux liquid sample of quick response and method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310738518.0A CN103728444B (en) | 2013-12-30 | 2013-12-30 | A kind of accurate attemperating unit of high flux liquid sample of quick response and method |
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| CN103728444A CN103728444A (en) | 2014-04-16 |
| CN103728444B true CN103728444B (en) | 2015-08-05 |
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| CN108856368B (en) * | 2018-05-30 | 2024-04-19 | 东莞华晶粉末冶金有限公司 | Electronic product middle frame shaping equipment and shaping method |
| CN114669341A (en) * | 2020-12-24 | 2022-06-28 | 厦门致善生物科技股份有限公司 | Reaction device and medical equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE4037955A1 (en) * | 1989-12-05 | 1991-06-06 | Bernd Seidl | Sample container holder - having several holding vessels on hot plate pref. made of high thermal conductivity, low heat capacity material e.g. silver |
| CN201514377U (en) * | 2009-11-02 | 2010-06-23 | 河北科技大学 | Incubation module of chemiluminescent measurement instrument |
| CN102095628B (en) * | 2010-12-02 | 2013-04-17 | 北京普立泰科仪器有限公司 | Sample digestion processing device |
| CN202700539U (en) * | 2012-07-17 | 2013-01-30 | 常州市常顺精细化学品有限公司 | Constant temperature well type dry bath device |
| CN203643451U (en) * | 2013-12-30 | 2014-06-11 | 合肥知常光电科技有限公司 | Quick-response high-throughput liquid sample precision temperature control device |
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