CN103705771B - The medicine of control swine fever and its preparation method - Google Patents
The medicine of control swine fever and its preparation method Download PDFInfo
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Abstract
The present invention discloses a kind of medicine preventing and treating swine fever, its be by the following method step obtain: one, take raw material and take raw material by following proportion by weight: Spine of Chinese Honeylocust 63��77 parts, reed rhizome 63��77 parts, astragalus polysaccharides 38��46 parts, windproof 63��78 parts, cassia twig 64��78 parts, radix bupleuri 63��77 parts, the stem of noble dendrobium 64��78 parts, Membrane of Chicken Gizzard 63��77 parts, pseudo-ginseng 64��79 parts, the red sage root 63��77 parts, rhizome of cyrtomium 102��124 parts, 63��77 parts, shizandra berry, cape jasmine 64��78 parts, Herba Lobeliae Chinensis 63��77 parts; Two, the raw material pulverizing that will claim, mixes, and obtains preventing and treating the medicine of swine fever. For not having, the pig of infected pigs's seasonal febrile diseases uses the medicine of the present invention can improve pig immunity in advance for it, and swine fever has good prophylactic effect; Pig for affected pig seasonal febrile diseases symptom has good therapeutic action.
Description
Technical field
The present invention relates to the medicine of a kind of pig prevailing disease control and its preparation method, particularly a kind of medicine and its preparation method that swine fever is had obvious preventive and therapeutic action.
Background technology
Swine fever is commonly called as " rinderpest ", also known as hog cholera, is that one has hyperinfection epidemic disease, and one, when infecing swine fever disease, will cause serious financial loss to pig farmer, and it one of threatens the main infection of pig industry sick. Swine fever is mainly through direct contact, or falls ill due to the vehicle of contact stain, and digestive tube, nasal membrane and the skin broken are all routes of infection, all can occur throughout the year, taking spring and summer rainy season as many.
Swine fever cause of disease is Pestivirus suis (CSFV), is a kind of picornavirus, belongs to flaviviridae (Flavivirisae) plague virus and belongs to (pestivirus).
During morbidity, swine disease disease is mainly manifested in: acute, and the course of disease is generally 1��15 day, and most (more than 90%) is dead; Main symptom is the change in septic, and organa parenchymatosum is hemorrhage, downright bad and infarct, and it is hemorrhage that whole skin, serous coat, mucous membrane and internal organs have in various degree; Total lymphoid knot swelling, succulence, hyperemia, hemorrhage, appearance present atropurpureus, and tangent plane is such as marble-like, and kidney look light, and cortex has the blutpunkte of needle point to millet shape, and spleen has stalk cold, common with edge, the little purple block in look black, and larynx mucous membrane and tonsilla are hemorrhage; Mucous membrane of urinary bladder has the blutpunkte being dispersed in; Stomach, intestinal mucosa are Catarrhal inflammation; The ileocaecal sphineter place of large intestine forms button shape ulcer. Chronic type, mainly shows as necrotic enteritis, and the course of disease is generally 3��8 weeks, and piglet is 100% death almost, and pig mortality ratio of growing up is more than 60%; Main symptom is: mucous membrane is pale, and eyelid has blutpunkte, and general hemorrhage change is not obvious; There is purple plague purpura in skin, and sick pig extremely becomes thin;Chronic in cellulosic necrotic enteritis, often there are paratyphoid and Bacillus pasteurii disease secondary in the later stage; Due to the upset of alcium and phosphor metabolization, the sick visible rib end of pig of wean and cartilaginous tissue become place of boundary, and the yellow formed because of ossified obstacle is ossify line; The state of an illness time is long.
Diagnosis: on the basis of table disease, available Immunofluorescent Antibody inspection, enzyme labelling tissue antigen localization method, exempts from the test of body Immunogenicity, and serum neutralization test, one of methods such as swine fever monoclonal antibody purifying enzyme linked immunosorbent adsorption test are made a definite diagnosis.
Sick for swine fever at present, people mainly take following measure to tackle:
1. slaughter the sick pig of infection. Swine fever disease slaughters disease pig after confirming immediately, carries out immediately strictly blocking, isolation, sterilization, restriction disease pig move and a series of activities such as meat listing; Morbidity swinery carries out harmless treatment after slaughtering again, and sick pig eats surplus forage or drinking-water, burns or buried. Although this kind for the treatment of process can be stretched to a certain degree controlling swine fever disease, but the processing cost that needs cost a lot of money, and serious financial loss can be caused to pig farmer.
2. immunization. By pig is carried out immunization, it is to increase immune level, reduce popular severity and popular scope. Although immunization can play certain immunization, reduce sickness rate, but vaccine inoculation success ratio is not very high, facts have proved that mortality ratio is still very high, particularly do not have anything to act on the pig fallen ill, the loss of disease pig cannot be retrieved, and vaccine inoculation can cause some untoward reactions to pig: after part pig vaccinate, One's spirits are drooping depressed, appetite stimulator, body temperature slightly raise, affect the normal growth of pig, after indivedual pig vaccinate, there will be acute allergic reaction.
3. medical treatment
Anti-swine fever hyper-immune serum, each 40��60ml of piggy every, middle pig 80��120ml, big pig 120��160ml, add row's epidemic disease peptide (every 50kg body weight Iml, the severe amount of adding), and intramuscular injection, every day 1 time, is used in conjunction 2d; Radix Astragali polysaccharide injection (every kg body weight 0.1��0.2ml) adds Interferon, rabbit (every 40kg body weight Iml, the severe amount of adding) and mixes intramuscular injection, every day 1 time, is used in conjunction 4d; Coordinating intramuscular injection ceftiofur sodium injection etc., every kg body weight 5mg, every day 1 time, is used in conjunction 4d simultaneously.
Sick pig drinks water available electrolysis multidimensional, adds glucose powder, adds Root of Indigowoad powder, add antibacterial peptide, drink 7d.
Although above medical treatment can to a certain degree control mortality ratio, it is to increase pig immunity, but current drug main will to there is curative effect not obvious, facts have proved that mortality ratio is very high, and too expensive etc. not enough.
Summary of the invention
It is an object of the invention to overcome the above-mentioned deficiency of prior art and provide a kind of medicine preventing and treating swine fever, swine fever disease can effectively be prevented and treated by the medicine of the present invention; Special in not having the pig of infected pigs's seasonal febrile diseases to use the medicine of the present invention can improve pig immunity in advance, swine fever is had good prophylactic effect; Pig for affected pig seasonal febrile diseases symptom has good therapeutic action.
It is a further object of the present invention to provide the preparation method of a kind of said medicine, its technique is simple, and its bulk drug is common, cheap.
The technical scheme of the present invention is: a kind of medicine preventing and treating swine fever, and it is made up of the bulk drug of following masses part proportioning: Spine of Chinese Honeylocust 63��77 parts, reed rhizome 63��77 parts, astragalus polysaccharides 38��46 parts, windproof 63��78 parts, cassia twig 64��78 parts, radix bupleuri 63��77 parts, the stem of noble dendrobium 64��78 parts, Membrane of Chicken Gizzard 63��77 parts, pseudo-ginseng 64��79 parts, the red sage root 63��77 parts, rhizome of cyrtomium 102��124 parts, 63��77 parts, shizandra berry, cape jasmine 64��78 parts, Herba Lobeliae Chinensis 63��77 parts.
Its further preferred mass part proportioning is: Spine of Chinese Honeylocust 63��74 parts, reed rhizome 63��74 parts, astragalus polysaccharides 38��44 parts, windproof 63��74 parts, cassia twig 64��74 parts, radix bupleuri 63��74 parts, the stem of noble dendrobium 64��74 parts, Membrane of Chicken Gizzard 63��74 parts, pseudo-ginseng 64��74 parts, the red sage root 63��74 parts, rhizome of cyrtomium 102��118 parts, 63��74 parts, shizandra berry, cape jasmine 64��74 parts, Herba Lobeliae Chinensis 63��74 parts.
Its further preferred mass part proportioning is: Spine of Chinese Honeylocust 67��77 parts, reed rhizome 67��77 parts, astragalus polysaccharides 40��46 parts, windproof 67��78 parts, cassia twig 67��78 parts, radix bupleuri 67��77 parts, the stem of noble dendrobium 67��78 parts, Membrane of Chicken Gizzard 67��77 parts, pseudo-ginseng 67��79 parts, the red sage root 67��77 parts, rhizome of cyrtomium 106��124 parts, 67��77 parts, shizandra berry, cape jasmine 67��78 parts, Herba Lobeliae Chinensis 67��77 parts.
Its further preferred mass part proportioning is: Spine of Chinese Honeylocust 67��74 parts, reed rhizome 67��74 parts, astragalus polysaccharides 40��44 parts, windproof 67��74 parts, cassia twig 67��74 parts, radix bupleuri 67��74 parts, the stem of noble dendrobium 67��74 parts, Membrane of Chicken Gizzard 67��74 parts, pseudo-ginseng 67��74 parts, the red sage root 67��74 parts, rhizome of cyrtomium 106��118 parts, 67��74 parts, shizandra berry, cape jasmine 67��74 parts, Herba Lobeliae Chinensis 67��74 parts.
Its further preferred mass part proportioning is: Spine of Chinese Honeylocust 70 parts, reed rhizome 70 parts, astragalus polysaccharides 42 parts, windproof 70 parts, cassia twig 71 parts, radix bupleuri 70 parts, the stem of noble dendrobium 71 parts, Membrane of Chicken Gizzard 70 parts, pseudo-ginseng 72 parts, the red sage root 70 parts, rhizome of cyrtomium 113 parts, 70 parts, shizandra berry, cape jasmine 71 parts, Herba Lobeliae Chinensis 70 parts.
Another technical scheme of the present invention is: the preparation method of a kind of medicine preventing and treating swine fever, it mainly comprises the steps:
One, raw material is taken
Take raw material by following proportion by weight: Spine of Chinese Honeylocust 63��77 parts, reed rhizome 63��77 parts, astragalus polysaccharides 38��46 parts, windproof 63��78 parts, cassia twig 64��78 parts, radix bupleuri 63��77 parts, the stem of noble dendrobium 64��78 parts, Membrane of Chicken Gizzard 63��77 parts, pseudo-ginseng 64��79 parts, the red sage root 63��77 parts, rhizome of cyrtomium 102��124 parts, 63��77 parts, shizandra berry, cape jasmine 64��78 parts, Herba Lobeliae Chinensis 63��77 parts;
Two, the raw material pulverizing that will claim, mixes, and obtains preventing and treating the medicine of swine fever.
Further another technical scheme of the present invention is: raw material preferred mass part proportioning that step one takes is: Spine of Chinese Honeylocust 67��74 parts, reed rhizome 67��74 parts, astragalus polysaccharides 40��44 parts, windproof 67��74 parts, cassia twig 67��74 parts, radix bupleuri 67��74 parts, the stem of noble dendrobium 67��74 parts, Membrane of Chicken Gizzard 67��74 parts, pseudo-ginseng 67��74 parts, the red sage root 67��74 parts, rhizome of cyrtomium 106��118 parts, 67��74 parts, shizandra berry, cape jasmine 67��74 parts, Herba Lobeliae Chinensis 67��74 parts.
The present invention further another technical scheme be: raw material preferred mass part proportioning that step one takes is: Spine of Chinese Honeylocust 70 parts, reed rhizome 70 parts, astragalus polysaccharides 42 parts, windproof 70 parts, cassia twig 71 parts, radix bupleuri 70 parts, the stem of noble dendrobium 71 parts, Membrane of Chicken Gizzard 70 parts, pseudo-ginseng 72 parts, the red sage root 70 parts, rhizome of cyrtomium 113 parts, 70 parts, shizandra berry, cape jasmine 71 parts, Herba Lobeliae Chinensis 70 parts.
The present invention further another technical scheme be: after step 2 raw material pulverizing, cross 100��300 orders sieve.
The present invention further another technical scheme be: after step 2 raw material pulverizing, cross 120��200 orders sieve.
The primary symbols that the present invention uses and name resolving are as follows:
��: numerical range, such as 1��5 represents 1 to 5.
The main raw material medicine that the present invention uses is described as follows:
Spine of Chinese Honeylocust: be the quil of leguminous plants Chinese honey locust;[another name] Fructus Gleditsia acupuncture, soap thorn, sky fourth, Chinese honey locust pin, soap pin. [return through]: lung channel, Liver Channel. [nature and flavor]: pungent, temperature. [textual criticism]: come from " Amplification on Materia Medica addendum ". [effect classification]: blood circulation promoting medicine, dispel-wind drug. [curing mainly]: swollen ulcer drug, scrofula, sore rash stubborn dermatitis, puerperal hypogalactia, retention of placenta, pestilence wind.
Reed rhizome: another name: reed lalang grass rhizome, reed root, reed head, reed stems root, reed mushroom root, suitable Jiang Long, water, Lu Tong, reed root, reed bud root, sweet stalk. Classification: heat-clearing and fire-purging drug. Ji Yuan: this product is the fresh or dry rhizome of monocotyledons Gramineae reed. Nature and flavor: sweet, cold. Gui Jing: return lung channel, stomach warp. Function: clearing heat and promoting fluid, promotes the production of body fluid to quench thirst, and relieving restlessness is only vomitted, diuresis. Cure mainly: tell purulence, the heat puckery pain of pouring for pyreticosis polydipsia, gastropyretic vomiting, cough due to lung-heat, lung carbuncle. Meridian distribution of property and flavor: sweet, cold. Attach to the lung and stomach meridians.
Astragalus polysaccharides is the dried powder that the dry root of the Radix Astragali becomes through concentration extraction; Color and luster is palm fibre (Huang) brown powder, and taste is micro-sweet, and tool draws wet property; Applicable formulation is drinking agent, spice agent, oral liquid, injection; Can be used as immunopotentiating agent or conditioning agent, there is antiviral, antitumor, anti-ageing, radioprotective, anti-stress, the effect such as anti-oxidant simultaneously.
Windproof, another name copper rue, Hui Yun, return grass, hundred. Gui Jing: bladder warp; Lung channel; The spleen channel; Liver Channel. Effect: dispel the wind induce sweat, removing dampness to relieve pain, spasmolysis, antipruritic. Cure mainly: catch cold; Headache bodily pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella itch; Sore from the beginning of. Nature and flavor: taste is pungent; Sweet; Slightly warm in nature. Medicinal material Ji Yuan: be the root of umbelliferae Saposhnikovia divaricata. Effect is classified: separate medicine administered to bring out the cold, dispel-wind drug.
Radix bupleuri: another name: Asia puecon recklessly, smoke " Shennong Bencaojing ", mountain dish, eat grass " WU Pu Bencao ", faggot " product converge essence want ", the wormwood artemisia that rues (Compendium of Materia Medica). Meridian distribution of property and flavor: cold nature, bitter, pungent, return Liver Channel, gallbladder channel, effect of tool depressed liver-energy dispersing and function of gallbladder promoting, fire strongly fragrant, loose of dredging gas solution. Function: table expels the heat-evil thoroughly, dispersing the stagnated live-QI to relieve the stagnation of QI, rises and lifts yang-energy. Cure mainly: the heating that cures cold, the empty labor heating of fever and chills; Children's's acne rash waste heat, lean and haggard belly expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, and uterus comes off, menoxenia.
Cassia twig, rectification of name: Chinese cassia tree, has another name called beautiful osmanthus, cassia bark etc., belongs to buttercup order, the medium megaphanerophyte of Lauraceae. Its nature and flavor are pungent, sweet, enter liver, kidney, spleen, it is cure mainly medicine in the conventional temperature of interior cold, there is the effect mending Yuanyang, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, the cold arteries and veins of limb are micro-, treat coldness and pain in the epigastrium, arthritis pain in the back with medicine compatibility in other temperature, have the effect of significantly analgesia and anti-cancer and cancer-preventing. The existing various wind oils medicine that drives is if menthocamphorate, rheumatism oil etc. are all containing osmanthus oil component. Cure mainly exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Through closing dysmenorrhoea; Abdominal mass lumps; The obstruction of qi in the chest; Palpitaition; Phlegm and retained fluid; Dysuria.
The stem of noble dendrobium: classification: tonic; Medicinal part: stem. Without smelly, lightly seasoned. Stem of noble dendrobium medicinal history is long, and medicinal ingredients is not only abundant but also balanced, can treat multiple illness, is used for treatment chronic pharyngitis, gastroenteropathy, ophthalmic diseases clinically, the treatment of thrombosis, diabetes, sacroiliitis, cancer or assisting therapy. Meridian distribution of property and flavor: micro-cold;Sweet; Return stomach, kidney channel. Function cures mainly: reinforcing stomach reg fluid, nourishing Yin and clearing heat; Hindering body fluid deficiency for the moon, dry polydipsia, food is few retches, and abnormal heat after being ill, order is secretly failed to understand. Effect: 1, anti-ageing, it is to increase immunizing power; 2, promoting blood circulation and removing blood stasis, it is to increase cardio and vascular function; 3, antitumor; 4, digestive system is treated; 5, ophthalmic diseases is treated. Taboo: pyreticosis is the non-the wounded of the moon in early days, the non-dryness-transformation person of damp-warm diseases, and insufficiency of spleen-YANG person (refers to the very few person of gastric acid secretion), all prohibits clothes.
Membrane of Chicken Gizzard: the gizzard inwall referring to a chicken, [another name] chicken gizzard skin, chicken yellow skin, chicken gizzard, chicken's gizzard, chicken gold. [property hide return through] is sweet, cold. Return spleen, stomach, small intestine, bladder warp. [effect] food digesting stomach fortifying is aid digestion, arresting seminal emission; Can promoting gastric secretion, it is to increase gastric acidity and eupepsy, stomach motor function is obviously strengthened, stomach emptying is accelerated; For diseases such as maldigestion, seminal emission night sweat, excellent.
Pseudo-ginseng, has another name called Radix Notoginseng, pseudo-ginseng, Herba Senecionis Chrysanthemoidis, blood mountain grass, pouring in June, Sedum spectabile Boreau, and ancient times, also known as clear ginseng, blood ginseng, Panax pseudoginseng, Typhonium flagelliforme (Lodd.) Blume, mountain paint, Radix Notoginseng etc., belongs to Araliaceae Panax per nnial herb. The efficacy effect of pseudo-ginseng is very big, and it is warm in nature, and taste is pungent, has scattered silt hemostasis, effect of subduing swelling and relieving pain, can be used for treatment bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, spitting of blood, haematemesis, traumatic hemorrhage, the disease such as chest and abdomen shouting pain. And the flavonoid compound in pseudo-ginseng has the effect, Sitosterol and the daucosterol energy reducing blood-fat that improve blood supply of cardiac muscle, increase blood vessel elasticity, coronary artery dilator. Often eat pseudo-ginseng, coronary heart diseases and angina pectoris is had preventive and therapeutic action. Hemostasis, the loose stasis of blood, detumescence, analgesic therapy. Controlling haematemesis, hemoptysis, bleeding from five sense organs or subcutaneous tissue, have blood in stool, bloody flux, uterine bleeding, abdominal mass, puerperal blood faints, retention of lochia, fall and flutter hemostasis, traumatic hemorrhage, carbuncle swells pain. " detailed outline ": hemostasis, loose blood, analgesic therapy. Gold sword arrow wound, falls and flutters cane sore, and blood goes out more than person, chews rotten painting, or for mixing it in end, namely its blood stop. Also main haematemesis, bleeding from five sense organs or subcutaneous tissue, lower blood, bloody flux, metrorrhagia, more than through water, postpartum extravesated blood not under, blood is transported, blood pain, and Akamu, carbuncle swells, and tiger stings, all diseases of snakebite. " jade seizes medicine solution ": with battalion hemostasis, the row stasis of blood of promoting blood circulation, row hemostasis and hold back new blood. All postpartum, menstrual period, fall beat, carbuncle swell, all hemostasis are all broken; All tell nosebleed, uterine bleeding, knife wound, arrow penetrate, all new blood all stop.
The red sage root: have another name called red ginseng, Radix Salviae Miltiorrhizae, red etc. For dicotyledons Labiatae, dry root and rhizome. Main product in Anhui, Henan, the ground such as Shaanxi. Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, cool blood disappears carbuncle, and clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind. Record according to Compendium of Material Medica: the red sage root, release the red ginseng of name, mountain ginseng, Xi cicada grass, wooden sheep breast, by horse, galloping horse grass; Smell, (root) is bitter, micro-cold, nontoxic.
Rhizome of cyrtomium: another name: pod fern, little rhizome of cyrtomium, Fortune Holly Fern, little Rhizome or herb of Dactyloleaved Brake; Medicine name: Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak; Classification: Dryopteridaceae (Dryopteridaceae), squama Rabdosia eriocalyx (Dryopteris); Source: be the rhizome of Dryopteridaceae plant Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak; Effect: clearing heat and detoxicating, cooling blood for hemostasis, kills worm; Cure mainly: for time evil sense, partial heat person, heating is heavy, aversion to cold is light, have a headache, swallow red, pharynx is swollen, dry and thirsty, red tongue body, white and thin fur, arteries and veins float person; Meridian distribution of property and flavor: pungent is bitter, cold; " Xinhua's book on Chinese herbal medicine outline ": rhizome: have clearing heat and detoxicating effect; For preventing influenza.
Shizandra berry: call profound and, meeting and, five plums, Fructus Zanthoxyli Plansipini, strong taste, the five tastes etc., " Xinxiu Bencao " load " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of shizandra berry.Shizandra berry is fallen leaves woody climbers, except the spire back side is by remaining without hair except pubescence and perula tool echinid; Children's branch sorrel, old branch beige, often plays wrinkle, and sheet is peeled off. Arranging in Shennong Bencaojing top grade the earliest, herbal function is the power of strengthening by means of tonics, and pharmaceutical use is extremely high, and Biphenylylmethylcarbinol, Bicyclol have liver protecting function. Effect: hold back lung, nourshing kidney, promotes the production of body fluid, and receives sweat, puckery essence; Curing mainly: control the deficiency syndrome of the lung and breath with cough, dry is done thirsty, and spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, nocturnal emission involuntary emission, rushes down dysentery of a specified duration for a long time.
Cape jasmine: another name Yellow Fructus Gardeniae, mountain Cape jasmine, white toad, flower of Capa Jasmine are the fruits of madder wort cape jasmine. Genus rubia section, Gardenia Ellis, evergreen shrubs; Root, leaf, fruit all can be used as medicine, and have purging intense heat relieving restlessness, clearing away heat and promoting diuresis, effect of removing pattogenic heat from the blood and toxic material from the body; Effect: removing heat from the lung to relieve cough, cooling blood for hemostasis, purging intense heat, cures mainly cough due to lung-heat, coughs up phlegm, and swollen poison, controls pyreticosis restlessness of asrhenia type and insomnia, jaundice, gonorrhoea, quench one's thirst, hot eyes, pharyngalgia, spits blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, and heat poison sore, sprains and swell and ache. " Chinese medicine voluminous dictionary " is recorded: cape jasmine, different name: wood red (" herbal classic "), fresh (" upper woods is composed "), ancient wine vessel (" Chinese book " Meng Kang notes), more peach (" not Lu "), stand (" Collective Notes to the Canon of Materia medica "), SHANZHIZI (" property of medicine opinion "), branch (" Xinxiu Bencao "), little danger (" book on Chinese herbal medicine is original "), yellow sprout (" east, Fujian book on Chinese herbal medicine "), Yellow Fructus Gardeniae (" Jiangsu medicinal material will "), yellow Cape jasmine, mountain yellow Cape jasmine, mountain Cape jasmine (" Zhejiang medicinal plant will "); For the fruit of Rubiaceae Gardenia Ellis plant cape jasmine.
Herba Lobeliae Chinensis: have another name called for: it is anxious that to separate rope, thin rice grass, Herba Hedyotidis Diffusae, half ray flower, narcissus flowers and plants, sickle young careless etc. Effect is classified: heat-clearing and detoxicating drug; Excreting dampness hydragog(ue). Section belongs to classification: campanulaceae. Another name: anxious separate rope, Hedyotis diffusa Willd, thin rice grass, Herba Hedyotidis Diffusae, fish tail flower, half of chrysanthemum, Semipinnated Brake Herb, milk grass, half ray flower, arrow beans careless, with the wind flag, monolithic bud, little lotus flower grass, continuous beeweed, blow blood grass, Veronicastrum Herb, infantile malnutrition due to digestive disturbances or intestinalparasites grass, white cured grass skating, golden aster grass, golden pheasant tongue, film clips lotus, Pian Lian, the edible kernel of melon seeds are careless, snake pecks grass, snake is careless. Nature and flavor: taste is sweet; Property is put down. Gui Jing: thoughts of returning home warp; Lung channel; Small intestine warp. Function: clearing heat and detoxicating; Inducing diuresis to remove edema. Cure mainly: venomous snake bite; Carbuncle swells furunculosis; Tonsillitis; Temperature rash; Tinea pedis; Wound; Jaundice due to damp-heat; Ecphyaditis; Enteritis; Ephritis; Hepatic ascites and multiple cancer.
" Chinese medicine voluminous dictionary ": " Chinese medicine voluminous dictionary " second edition is write by Nanjing University of Traditional Chinese Medicine, publishes limited-liability company Shanghai century and Shanghai science tech publishing house publishes and distributes.
The efficacy of drugs of the present invention with cure mainly:
1. the medicine of the present invention has clearing heat and detoxicating, cooling blood, expelling wind, removes the swollen poison of sore Huang; Strengthening immunity;
2. the following symptom of pair pig has obvious preventive and therapeutic effect: body temperature is elevated to 40.0 DEG C��40.5 DEG C, has conjunctivitis, sick just constipation;
3. the present inventor is by a large amount of contrast controlling experiment, and swine fever disease is had obvious preventive and therapeutic action by the medicine of the control swine fever of sufficient proof the present invention, can control the mortality ratio of pig well.
4. pure Chinese medicine is made, few side effects.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to the scope of invention.
Embodiment
Embodiment 1
Take Spine of Chinese Honeylocust 700 grams, reed rhizome 700 grams, astragalus polysaccharides 420 grams, windproof 700 grams, cassia twig 710 grams, radix bupleuri 700 grams, the stem of noble dendrobium 710 grams, Membrane of Chicken Gizzard 700 grams, pseudo-ginseng 720 grams, the red sage root 700 grams, rhizome of cyrtomium 1130 grams, 700 grams, shizandra berry, cape jasmine 710 grams, Herba Lobeliae Chinensis 700 grams, these material compositions are the quality after drying, 100��300 orders (being generally 120��200 orders) are pulverized into supper micron mill, mix, then pack with plastic bag sealing, the medicine of obtained control swine fever.
Using method: when every time feeding, according to feed amount, the medicine of the control swine fever that the present embodiment taking 1��1.5% feeding quality obtains (namely each ton of feed takes the medicine of the control swine fever that the present embodiment of 10 to 15 kilograms obtains), again this medicine is exchanged with appropriate water, then add in feed, mix all, feed immediately, every day is sooner or later each fed once, within 4��7 days, is a course for the treatment of, fed a course for the treatment of of this medicine every 40 days.
Contrast control test:
1. symptom standard (for judging the state of an illness) for observing:
Symptom 1: non-evident sympton, CSFV Virus monitory is negative, namely healthy;
Symptom 2: body temperature is elevated to 40.0 DEG C��40.5 DEG C, has conjunctivitis, sick just constipation, CSFV Virus monitory is positive, namely infects;
Symptom 3: body temperature is elevated to 40.5 DEG C��41 DEG C, has purulence conjunctivitis, diarrhoea, there is the red point that differs in size or erythema, refer to that pressure is not faded, CSFV Virus monitory be the positive in the places such as the rare skin of hair is thin after sick pig ear, inside belly, four limbs etc.; Namely serious;
Symptom 4: body temperature about 41 DEG C, changes in septic, skin or subcutaneous have blutpunkte, and organa parenchymatosum is hemorrhage, downright bad and infarct, and it is hemorrhage that whole skin, serous coat, mucous membrane and internal organs have in various degree; Total lymphoid knot swelling, succulence, hyperemia, hemorrhage, appearance present atropurpureus, and larynx mucous membrane and tonsilla are hemorrhage, and sick pig extremely becomes thin, and CSFV Virus monitory be the positive; Namely it is critically ill;
Symptom 5: dead.
2. prevent and treat and it be divided into four-stage (number of days in each stage is all bought from piglet and started at day, instead of starts at from pig date of birth) course for the treatment of:
First stage: the 1st day��the 10th day;
Subordinate phase: the 11st day��the 57th day;
Phase III: the 58th day��the 102nd day;
Fourth stage: the 103rd day��the 150th day.
3. group experiment.
When having swine fever in Hunan in 2011, the present inventor have purchased month big piggy 20, it is divided into two groups, often organize 10, feed in the cultivation of Hengyang one pig, being separated by farming site wire netting between two groups of pigs, the medicine that first group of 10 pig are the control swine fever obtained by the present embodiment carries out controlling experiment group (i.e. embodiment controlling experiment group), and the 2nd group of 10 pigs are for carrying out contrast controlling experiment group (i.e. contrast controlling experiment group) by currently available vaccines, existing vaccines and microbiotic.
4. embodiment controlling experiment group: the medicine of the control swine fever that the present embodiment adding 1��1.5% during first group of 10 pigs morning and evening feeding respectively in feed obtains, use 7 days continuously, during by the 10th day, it is first course for the treatment of (i.e. first stage), namely swine fever disease symptoms 2(infects to have 5 pigs to occur), all 10 pigs are carried out CSFV Virus monitory, and it is positive that result detects out the CSFV of 5 pigs, and it is namely healthy that all the other are symptom 1(); Feeding the feed 7 days of the medicine adding the present embodiment after 40 days again, be the 2nd course for the treatment of (i.e. subordinate phase), namely swine fever disease symptoms 2(infects to have 3 pigs to occur), all the other are symptom 1; Feeding again the feed 4 days of the medicine adding the present embodiment again through 40 days, be the 3rd course for the treatment of (i.e. phase III), namely swine fever disease symptoms 2(infects to have 1 pig to occur), all the other are symptom 1; When delivering for sale to 5 months (fourth stage), be all symptom 1(it is namely all health pig), the mean body weight of 10 pigs increases by 110 kilograms.
5. contrast controlling experiment group:
Inject anti-swine fever hyper-immune serum, add row's epidemic disease peptide, Radix Astragali polysaccharide injection and the control of intramuscular injection ceftiofur sodium injection.
2nd group of 10 pigs all inject the control of anti-swine fever hyper-immune serum, through 10 days, i.e. and the first stage, there are 4 pigs that symptom 2 occurs, having 1 pig symptom 3 occur, all the other are symptom 1, then are treated by pig injection cephalosporin analog antibiotic (ceftiofur sodium) symptom 2,3 occur; During subordinate phase (during by the 57th day), there are 3 pigs that symptom 2 occurs, have 2 pigs that symptom 3 occurs, have 1 pig that symptom 4 occurs, have 4 pigs to be symptom 1, then pig symptom 2, symptom 3, symptom 4 occur is continued injection row's epidemic disease peptide, Radix Astragali polysaccharide injection and cephalosporin analog antibiotic treat; During the phase III (during by the 102nd day), there are 2 pigs that symptom 2 occurs, there are 2 pigs that symptom 3 occurs, there are 2 pigs that symptom 4 occurs, there is 1 pig that symptom 5 (namely dead) occurs, there are 3 pigs to be symptom 1, then pig continuation injection cephalosporin analog antibiotic symptom 2, symptom 3, symptom 4 occur is treated; During fourth stage (during by the 150th day), there are 2 pigs that symptom 2 occurs, have 1 pig that symptom 3 occurs, have 2 pigs that symptom 4 occurs, have again 2 pigs that symptom 5 (namely dead) occurs, have 2 pigs to be symptom 1, remaining 7 pig average weight gains 79 kilograms.
Embodiment 2-19
Embodiment 2-19 is except raw material mass mixture ratio is different from embodiment 1, its raw material type is identical with embodiment 1 with manufacturing process steps, the raw material that embodiment 2-19 uses and quality as shown in Table 1 below, table 1 below illustrates raw material and quality that embodiment 1-19 uses; The present inventor has also done Contrast control test substantially the same manner as Example 1 at the medicine of the different local embodiment 2-19 of employing respectively during 2011 to 2013 years swine fever occur, table 2 below shows the medicine of the control swine fever by embodiment 1-19 and carry out controlling experiment situation data, table 3 shows contrast controlling experiment (by injecting existing swine fever poison vaccine and microbiotic controlling experiment) the situation data simultaneously carried out respectively with embodiment 1-19.
Table 1
Table 2
Table 3
Controlling experiment data are contrasted it may be seen that swine fever disease is had obvious preventive and therapeutic action (when feeding with the medicine of the present invention, it does not have dead pig occur, when delivering for sale, average weight gain is 107.3 kilograms by the medicine of swine fever of the present invention from above table 2, table 3; And adopt the control that traditional vaccine and microbiotic carry out, then dead pig rate reaches 48%, it does not have mean body weight only 69 kilograms when dead pig is delivered for sale).
So the present invention is not limited to the protective agents as swine fever, as long as the composition of raw materials medicine identical or equivalent with the present invention just drops within protection scope of the present invention. Raw material with the protective agents same recipe of the control swine fever of the present invention is made any a kind of Chinese medicine preparation also drop within protection scope of the present invention, as long as the medicine that namely composition of raw materials is identical with the present invention just drops within protection scope of the present invention.
Claims (10)
1. prevent and treat a medicine for swine fever, it is characterized in that: it is made up of the bulk drug of following masses part proportioning: Spine of Chinese Honeylocust 63��77 parts, reed rhizome 63��77 parts, astragalus polysaccharides 38��46 parts, windproof 63��78 parts, cassia twig 64��78 parts, radix bupleuri 63��77 parts, the stem of noble dendrobium 64��78 parts, Membrane of Chicken Gizzard 63��77 parts, pseudo-ginseng 64��79 parts, the red sage root 63��77 parts, rhizome of cyrtomium 102��124 parts, 63��77 parts, shizandra berry, cape jasmine 64��78 parts, Herba Lobeliae Chinensis 63��77 parts.
2. the medicine of control swine fever according to claim 1, is characterized in that: Spine of Chinese Honeylocust 63��74 parts, reed rhizome 63��74 parts, astragalus polysaccharides 38��44 parts, windproof 63��74 parts, cassia twig 64��74 parts, radix bupleuri 63��74 parts, the stem of noble dendrobium 64��74 parts, Membrane of Chicken Gizzard 63��74 parts, pseudo-ginseng 64��74 parts, the red sage root 63��74 parts, rhizome of cyrtomium 102��118 parts, 63��74 parts, shizandra berry, cape jasmine 64��74 parts, Herba Lobeliae Chinensis 63��74 parts.
3. the medicine of control swine fever according to claim 1, is characterized in that: Spine of Chinese Honeylocust 67��77 parts, reed rhizome 67��77 parts, astragalus polysaccharides 40��46 parts, windproof 67��78 parts, cassia twig 67��78 parts, radix bupleuri 67��77 parts, the stem of noble dendrobium 67��78 parts, Membrane of Chicken Gizzard 67��77 parts, pseudo-ginseng 67��79 parts, the red sage root 67��77 parts, rhizome of cyrtomium 106��124 parts, 67��77 parts, shizandra berry, cape jasmine 67��78 parts, Herba Lobeliae Chinensis 67��77 parts.
4. the medicine of control swine fever according to claim 1, is characterized in that: Spine of Chinese Honeylocust 67��74 parts, reed rhizome 67��74 parts, astragalus polysaccharides 40��44 parts, windproof 67��74 parts, cassia twig 67��74 parts, radix bupleuri 67��74 parts, the stem of noble dendrobium 67��74 parts, Membrane of Chicken Gizzard 67��74 parts, pseudo-ginseng 67��74 parts, the red sage root 67��74 parts, rhizome of cyrtomium 106��118 parts, 67��74 parts, shizandra berry, cape jasmine 67��74 parts, Herba Lobeliae Chinensis 67��74 parts.
5. the medicine of control swine fever according to the arbitrary item of claim 1-4, is characterized in that: Spine of Chinese Honeylocust 70 parts, reed rhizome 70 parts, astragalus polysaccharides 42 parts, windproof 70 parts, cassia twig 71 parts, radix bupleuri 70 parts, the stem of noble dendrobium 71 parts, Membrane of Chicken Gizzard 70 parts, pseudo-ginseng 72 parts, the red sage root 70 parts, rhizome of cyrtomium 113 parts, 70 parts, shizandra berry, cape jasmine 71 parts, Herba Lobeliae Chinensis 70 parts.
6. prevent and treat a preparation method for the medicine of swine fever, it is characterized in that: it mainly comprises the steps:
One, raw material is taken
Take raw material by following proportion by weight: Spine of Chinese Honeylocust 63��77 parts, reed rhizome 63��77 parts, astragalus polysaccharides 38��46 parts, windproof 63��78 parts, cassia twig 64��78 parts, radix bupleuri 63��77 parts, the stem of noble dendrobium 64��78 parts, Membrane of Chicken Gizzard 63��77 parts, pseudo-ginseng 64��79 parts, the red sage root 63��77 parts, rhizome of cyrtomium 102��124 parts, 63��77 parts, shizandra berry, cape jasmine 64��78 parts, Herba Lobeliae Chinensis 63��77 parts;
Two, the raw material pulverizing that will claim, mixes, and obtains preventing and treating the medicine of swine fever.
7. the preparation method of the medicine of control swine fever according to claim 6, is characterized in that: raw materials quality part proportioning that step one takes is: Spine of Chinese Honeylocust 67��74 parts, reed rhizome 67��74 parts, astragalus polysaccharides 40��44 parts, windproof 67��74 parts, cassia twig 67��74 parts, radix bupleuri 67��74 parts, the stem of noble dendrobium 67��74 parts, Membrane of Chicken Gizzard 67��74 parts, pseudo-ginseng 67��74 parts, the red sage root 67��74 parts, rhizome of cyrtomium 106��118 parts, 67��74 parts, shizandra berry, cape jasmine 67��74 parts, Herba Lobeliae Chinensis 67��74 parts.
8. the preparation method of the medicine of control swine fever according to claim 6, is characterized in that: raw materials quality part proportioning that step one takes is: Spine of Chinese Honeylocust 70 parts, reed rhizome 70 parts, astragalus polysaccharides 42 parts, windproof 70 parts, cassia twig 71 parts, radix bupleuri 70 parts, the stem of noble dendrobium 71 parts, Membrane of Chicken Gizzard 70 parts, pseudo-ginseng 72 parts, the red sage root 70 parts, rhizome of cyrtomium 113 parts, 70 parts, shizandra berry, cape jasmine 71 parts, Herba Lobeliae Chinensis 70 parts.
9. the preparation method of the medicine of control swine fever according to the arbitrary item of claim 6-8, is characterized in that: after step 2 raw material pulverizing, crosses 100��300 orders sieves.
10. the preparation method of the medicine of control swine fever according to claim 9, is characterized in that: after step 2 raw material pulverizing, crosses 120��200 order sieves.
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| CN101219171A (en) * | 2007-01-12 | 2008-07-16 | 张爱民 | Chinese medicine for preventing and treating virosis of livestock and poultry |
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| CN101219171A (en) * | 2007-01-12 | 2008-07-16 | 张爱民 | Chinese medicine for preventing and treating virosis of livestock and poultry |
| CN101862452A (en) * | 2010-07-22 | 2010-10-20 | 山西芮城亚宝兽药有限公司 | Method for preparing swine multi-valent antiserum compound preparation |
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