CN103705552B - A kind of have the externally-applied liniment improving irritated function - Google Patents
A kind of have the externally-applied liniment improving irritated function Download PDFInfo
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- CN103705552B CN103705552B CN201310729836.0A CN201310729836A CN103705552B CN 103705552 B CN103705552 B CN 103705552B CN 201310729836 A CN201310729836 A CN 201310729836A CN 103705552 B CN103705552 B CN 103705552B
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Abstract
The invention discloses and a kind ofly have the externally-applied liniment improving irritated function, its component and mass percent thereof are: blackcurrant seed oil 65 ~ 74%; Gamma-Linolenic acid 8 ~ 12%, Ribes nigrum L. extracting solution 8 ~ 12%, anthocyanidin 2 ~ 4%; Vitamin C 1 ~ 3%, zinc compound 0.5 ~ 0.8%, yellow beeswax 1 ~ 3%, lecithin 1 ~ 4%, Borneolum Syntheticum 0.2 ~ 0.5%, the mass percent sum of each component is 100%.Made externally-applied liniment folk prescription use or coordinate take Fructus Forsythiae 20 ~ 30 parts, Radix Cynanchi Paniculati 10 ~ 18 parts, Herba Menthae 6 ~ 8 parts and 2 ~ 4 parts, Radix Glycyrrhizae decoction liquor for improving skin allergy.The present invention has blood circulation promoting according to the gamma-Linolenic acid be rich in blackcurrant seed and peel and anthocyanidin, regulate body prostaglandin balance, improve immune function, utilize the residual seed in the Ribes nigrum L. course of processing and marc to prepare externally-applied liniment, thus play the therapeutic effect improving allergic symptom.
Description
Technical field
The invention belongs to tcm field, be specifically related to a kind of to there is the externally-applied liniment improving irritated function.
Background technology
Allergy is a kind of allergy of body, is a kind of abnormal response of human body to koinomatter (i.e. anaphylactogen), and under specific condition, the crowd of allergic constitution touches anaphylactogen and just allergy can occur.It is generally acknowledged, the inflammatory reaction that allergy causes is owing to producing a large amount of histamine in body after human body and allergen exposure, symptoms such as causing red swelling of the skin, generate heat, itch.Therefore, most antiallergic agent mainly by suppressing histamine release, reach the object alleviating allergic symptom, but antihistaminic has larger side effect.
Much research is verified, when identical anaphylactogen enters body again, after being combined with the mastocyte of sensitization and the antibody specificity of basophil cellular surface, in the biologically active medium of cell release, except histamine, also comprise the medium such as prostaglandin, leukotriene, prostaglandin can promote local vascular dilation, capillary permeability increases, and brings out inflammatory reaction.Therefore, in body, the unbalance of prostaglandin is also cause one of anaphylactoid principal element.In addition, have scientist to think, the generation of allergic dermatitis may be owing to lacking zinc in body, and therefore, suitable zinc supplement contributes to alleviating scytitis.
Ribes nigrum L., i.e. black currant (RibesnigrumL.), have another name called black currant, purple enzyme, and Saxifragales Grossulariaceae currant belongs to perennial machaka, extensively plants in the Northeast of China.Existing known, Ribes nigrum L. contains the mineral such as abundant vitamin C, anthocyanidin, aldehydes matter and calcium, magnesium, zinc.Wherein, the anthocyanidin that Ribes nigrum L. fruit is rich in can effective blood circulation promoting, and has extremely strong antioxidation; Blackcurrant seed can be used for refining Ribes nigrum L. oil, and is rich in gamma-Linolenic acid in Ribes nigrum L. oil, and gamma-Linolenic acid is the unsaturated fatty acid of needed by human, also be the precursor of synthesis of prostaglandins, thus effectively can maintain body inner cholesterol level, regulate prostaglandin, improve function of immune system.The nutritional labeling that the present invention is rich according to Ribes nigrum L., develops the externally-applied liniment having and improve irritated function.
Summary of the invention
The object of the present invention is to provide and a kind of there is the externally-applied liniment improving irritated function, according to the gamma-Linolenic acid be rich in blackcurrant seed and peel and anthocyanidin, there is blood circulation promoting, regulate body prostaglandin balance, improve immune function, utilize the residual seed in the Ribes nigrum L. course of processing and marc to prepare externally-applied liniment, thus play the therapeutic effect improving allergic symptom.
For achieving the above object, the present invention adopts following technical scheme:
There is the externally-applied liniment improving irritated function, its recipe ingredient and each constituent mass percent as follows:
Blackcurrant seed oil 65 ~ 74%;
Gamma-Linolenic acid 8 ~ 12%;
Ribes nigrum L. extracting solution 8 ~ 12%;
Anthocyanidin 2 ~ 4%;
Vitamin C 1 ~ 3%;
Zinc compound 0.5 ~ 0.8%;
Yellow beeswax 1 ~ 3%;
Lecithin 1 ~ 4%;
Borneolum Syntheticum 0.2 ~ 0.5%;
The mass percent sum of above-mentioned each component is 100%.
There is the externally-applied liniment improving irritated function, its recipe ingredient and preferred each constituent mass percent as follows:
Blackcurrant seed oil 70%;
Gamma-Linolenic acid 10%;
Ribes nigrum L. extracting solution 10%;
Anthocyanidin 3%;
Catergen %;
Zinc compound 0.8%;
Yellow beeswax 2%;
Lecithin 2%;
Borneolum Syntheticum 0.2%.
Described blackcurrant seed oil is the residual seed after being processed by black currant berry is the ethanol wash of 75% with 60 ~ 70 DEG C of mass fractions, and after removing contained skin, slag and pectin, room temperature dries, the cold pressing of employing oil press, and after filtration, sterilizing obtains blackcurrant seed oil;
Described residual seed after ethanol wash, content≤2% of contained skin, slag and pectin.
Described Ribes nigrum L. extracting solution is that the marc after processing of being squeezed the juice by black currant berry adds the ethanol of the mass fraction 75% of its quality 6 ~ 8 times amount, regulates solution ph to be 2,45 ~ 55 DEG C of supersound extraction 30 ~ 50min, filters, sterilizing obtains Ribes nigrum L. extracting solution.
Described zinc compound comprises zinc gluconate, zinc citrate or zinc lactate.
Described lecithin is soybean lecithin or Ovum Gallus domesticus Flavus lecithin.
The preparation method of described externally-applied liniment comprises the following steps:
1) Ribes nigrum L. extracting solution, gamma-Linolenic acid, anthocyanidin, vitamin C and zinc are mixed, stir and obtain A phase;
2) yellow beeswax is added lecithin and Borneolum Syntheticum after 60 ~ 70 DEG C of fusings, stir evenly rear stopping heating, add blackcurrant seed oil while hot, mixing obtains B phase;
3) when B phase is cooled to room temperature, A is added to mixing in B phase, obtains described externally-applied liniment.
There is a using method for the externally-applied liniment improving irritated function, be that externally-applied liniment folk prescription is used, or coordinate the decoction liquor taking Fructus Forsythiae 20 ~ 30 parts, Radix Cynanchi Paniculati 10 ~ 18 parts, Herba Menthae 6 ~ 8 parts and 2 ~ 4 parts, Radix Glycyrrhizae.
remarkable advantage of the present invention is:
(1) Ribes nigrum L. is applied to field of medicaments, makes full use of the abundant nutrition material contained by Ribes nigrum L., during for improving allergy skin generate heat, the symptom such as to itch; Ribes nigrum L. is as the edible fruit of one simultaneously, and safety non-toxic, the externally-applied liniment therefore prepared is applicable to various allergic constitution crowd.
(2) the residual seed after Ribes nigrum L. fruit juice production, marc still have the higher gamma-Linolenic acid of content, anthocyanidin and other nutritional labelings, but often abandoned by as waste material, the present invention utilizes the residual seed of Ribes nigrum L., marc prepares externally-applied liniment, both expanded the range of application of Ribes nigrum L., and can Business Economic Benefit have been improved again.
Detailed description of the invention
Embodiment 1
There is the externally-applied liniment improving irritated function, its recipe ingredient and each constituent mass percent as follows:
Blackcurrant seed oil 70%;
Gamma-Linolenic acid 10%;
Ribes nigrum L. extracting solution 10%;
Anthocyanidin 3%;
Catergen %;
Zinc gluconate 0.8%;
Yellow beeswax 2%;
Ovum Gallus domesticus Flavus lecithin 2%;
Borneolum Syntheticum 0.2%.
Its concrete preparation method is as follows:
1) the residual seed after being processed by black currant berry is the ethanol wash of 75% with 60 DEG C of mass fractions, and after removing contained skin, slag and pectin, room temperature dries, the cold pressing of employing oil press, and after filtration, sterilizing obtains blackcurrant seed oil; Residual seed after ethanol wash, content≤2% of contained skin, slag and pectin;
2) marc after processing of being squeezed the juice by black currant berry adds the ethanol of the mass fraction 75% of its quality 6 times amount, and regulate solution ph to be 2,45 DEG C of supersound extraction 50min, filtration, sterilizing obtain Ribes nigrum L. extracting solution;
3) Ribes nigrum L. extracting solution, gamma-Linolenic acid, anthocyanidin, vitamin C and zinc gluconate are mixed, stir and obtain A phase;
4) yellow beeswax is added Ovum Gallus domesticus Flavus lecithin and Borneolum Syntheticum after 60 ~ 70 DEG C of fusings, stir evenly rear stopping heating, add blackcurrant seed oil while hot, mixing obtains B phase;
5) when B phase is cooled to room temperature, A is added to mixing in B phase, obtains described externally-applied liniment.
Certain female, 25 years old, during treatment there is erythema in patient skin, and with hotness, after the externally-applied liniment obliterating of embodiment 1, patient obviously feels that hotness alleviates, continuous obliterating 5 days, and erythema disappears, and skin allergy symptom disappears.
Embodiment 2
There is the externally-applied liniment improving irritated function, its recipe ingredient and each constituent mass percent as follows:
Blackcurrant seed oil 65%;
Gamma-Linolenic acid 8%;
Ribes nigrum L. extracting solution 12%;
Anthocyanidin 4%;
Vitamin C 3%;
Zinc citrate 0.5%;
Yellow beeswax 3%;
Ovum Gallus domesticus Flavus lecithin 4%;
Borneolum Syntheticum 0.6%.
Its concrete preparation method is as follows:
1) the residual seed after being processed by black currant berry is the ethanol wash of 75% with 65 DEG C of mass fractions, and after removing contained skin, slag and pectin, room temperature dries, the cold pressing of employing oil press, and after filtration, sterilizing obtains blackcurrant seed oil; Residual seed after ethanol wash, content≤2% of contained skin, slag and pectin;
2) marc after processing of being squeezed the juice by black currant berry adds the ethanol of the mass fraction 75% of its quality 7 times amount, and regulate solution ph to be 2,50 DEG C of supersound extraction 40min, filtration, sterilizing obtain Ribes nigrum L. extracting solution;
3) Ribes nigrum L. extracting solution, gamma-Linolenic acid, anthocyanidin, vitamin C and zinc citrate are mixed, stir and obtain A phase;
4) yellow beeswax is added Ovum Gallus domesticus Flavus lecithin and Borneolum Syntheticum after 60 ~ 70 DEG C of fusings, stir evenly rear stopping heating, add blackcurrant seed oil while hot, mixing obtains B phase;
5) when B phase is cooled to room temperature, A is added to mixing in B phase, obtains described externally-applied liniment.
Certain man, 34 years old, during treatment, before patient chest there is erythema in skin, and with hotness, scratchy, scratching causes skin injury, after the externally-applied liniment obliterating of embodiment 2, patient obviously feels nice and cool, and prodding and itching feeling alleviates, continuous obliterating 2 days with Fructus Forsythiae 20 parts, Radix Cynanchi Paniculati 10 parts, Herba Menthae 6 parts with 2 parts, Radix Glycyrrhizae is to boil water takes, erythema disappears, and skin allergy symptom disappears.
Embodiment 3
There is the externally-applied liniment improving irritated function, its recipe ingredient and each constituent mass percent as follows:
Blackcurrant seed oil 74%;
Gamma-Linolenic acid 12%;
Ribes nigrum L. extracting solution 8%;
Anthocyanidin 2%;
Vitamin C 1%;
Zinc lactate 0.6%;
Yellow beeswax 1%;
Soybean lecithin 1%;
Borneolum Syntheticum 0.4%.
Its concrete preparation method is as follows:
1) the residual seed after being processed by black currant berry is the ethanol wash of 75% with 70 DEG C of mass fractions, and after removing contained skin, slag and pectin, room temperature dries, the cold pressing of employing oil press, and after filtration, sterilizing obtains blackcurrant seed oil; Residual seed after ethanol wash, content≤2% of contained skin, slag and pectin;
2) marc after processing of being squeezed the juice by black currant berry adds the ethanol of the mass fraction 75% of its quality 8 times amount, and regulate solution ph to be 2,55 DEG C of supersound extraction 30min, filtration, sterilizing obtain Ribes nigrum L. extracting solution;
3) Ribes nigrum L. extracting solution, gamma-Linolenic acid, anthocyanidin, vitamin C and zinc lactate are mixed, stir and obtain A phase;
4) yellow beeswax is added soybean lecithin and Borneolum Syntheticum after 60 ~ 70 DEG C of fusings, stir evenly rear stopping heating, add blackcurrant seed oil while hot, mixing obtains B phase;
5) when B phase is cooled to room temperature, A is added to mixing in B phase, obtains described externally-applied liniment.
Certain female, 35 years old, due to collar friction cervical region, during treatment there is erythema, scratchy in patient's skin of neck, scratching causes skin injury, breakage is hemorrhage, and after the externally-applied liniment obliterating of embodiment 3, patient obviously feels nice and cool, prodding and itching feeling alleviates, continuous obliterating 5 days with Fructus Forsythiae 30 parts, Radix Cynanchi Paniculati 18 parts, Herba Menthae 8 parts with 4 parts, Radix Glycyrrhizae is to boil water takes, erythema disappears, and skin allergy symptom disappears.
The present invention through 50 routine case observations, obvious effective rate more than 98%, cure rate more than 80%.After patient uses externally-applied liniment wiping, heating paresthesia weakens immediately, and prodding and itching feeling alleviates, and uses the allergic symptom of more than 3 days all patients all effectively alleviated or fully recover; Be equipped with Fructus Forsythiae, Radix Cynanchi Paniculati, Herba Menthae during serious symptom, Radix Glycyrrhizae is to boil water takes, within 2 ~ 5 days, allergic symptom can effectively be alleviated or be fully recovered.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (1)
1. there is the externally-applied liniment improving irritated function, it is characterized in that: recipe ingredient and each constituent mass percent of described externally-applied liniment are as follows:
Blackcurrant seed oil 65 ~ 74%;
Gamma-Linolenic acid 8 ~ 12%;
Ribes nigrum L. extracting solution 8 ~ 12%;
Anthocyanidin 2 ~ 4%;
Vitamin C 1 ~ 3%;
Zinc compound 0.5 ~ 0.8%;
Yellow beeswax 1 ~ 3%;
Lecithin 1 ~ 4%;
Borneolum Syntheticum 0.2 ~ 0.5%;
The mass percent sum of above-mentioned each component is 100%;
Described blackcurrant seed oil is the residual seed after being processed by black currant berry is the ethanol wash of 75% with 60 ~ 70 DEG C of mass fractions, and after removing contained skin, slag and pectin, room temperature dries, the cold pressing of employing oil press, and after filtration, sterilizing obtains blackcurrant seed oil;
Described residual seed after ethanol wash, content≤2% of contained skin, slag and pectin;
Described Ribes nigrum L. extracting solution is that the marc after processing of being squeezed the juice by black currant berry adds the ethanol of the mass fraction 75% of its quality 6 ~ 8 times amount, regulates solution ph to be 2,45 ~ 55 DEG C of supersound extraction 30 ~ 50min, filters, sterilizing obtains Ribes nigrum L. extracting solution;
Described zinc compound comprises zinc gluconate, zinc citrate or zinc lactate;
Described lecithin is soybean lecithin or Ovum Gallus domesticus Flavus lecithin;
The preparation method of described externally-applied liniment comprises the following steps:
1) Ribes nigrum L. extracting solution, gamma-Linolenic acid, anthocyanidin, vitamin C and zinc are mixed, stir and obtain A phase;
2) yellow beeswax is added lecithin and Borneolum Syntheticum after 60 ~ 70 DEG C of fusings, stir evenly rear stopping heating, add blackcurrant seed oil while hot, mixing obtains B phase;
When B phase is cooled to room temperature, A is added to mixing in B phase, obtains described externally-applied liniment.
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| CN201310729836.0A CN103705552B (en) | 2013-12-26 | 2013-12-26 | A kind of have the externally-applied liniment improving irritated function |
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| CN201310729836.0A CN103705552B (en) | 2013-12-26 | 2013-12-26 | A kind of have the externally-applied liniment improving irritated function |
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| CN103705552A CN103705552A (en) | 2014-04-09 |
| CN103705552B true CN103705552B (en) | 2016-03-16 |
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| CN106389170B (en) * | 2016-11-30 | 2019-06-11 | 广州赛莱拉干细胞科技股份有限公司 | A kind of Chinese herbaceous peony Anti-allergic cosmetic composition |
| CN106620069A (en) * | 2017-03-10 | 2017-05-10 | 申翰昭 | Medicinal composition for treating skin allergy caused by insect bites and stings and preparation method of medicinal composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178673A (en) * | 1997-10-30 | 1998-04-15 | 王更红 | External use liniment for curing dermatosis |
| CN101129522A (en) * | 2007-08-27 | 2008-02-27 | 滕大浪 | Exterior-applied medicine for treating dermatopathy |
| CN102824513A (en) * | 2012-09-14 | 2012-12-19 | 贺新辉 | External liniment and preparation method thereof |
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2013
- 2013-12-26 CN CN201310729836.0A patent/CN103705552B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178673A (en) * | 1997-10-30 | 1998-04-15 | 王更红 | External use liniment for curing dermatosis |
| CN101129522A (en) * | 2007-08-27 | 2008-02-27 | 滕大浪 | Exterior-applied medicine for treating dermatopathy |
| CN102824513A (en) * | 2012-09-14 | 2012-12-19 | 贺新辉 | External liniment and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 中药外搽剂治疗皮肤病;潘琪龙;《北京中医杂志》;19911231(第1期);32 * |
| 抗敏止痒乳膏的制备与临床应用;盛国荣等;《中国药师》;19991231;第2卷(第6期);306-309 * |
| 抗敏止痒乳膏研制与质量控制;盛国荣;《时珍国医国药》;19991231;第10卷(第6期);435-436 * |
| 蒺藜在皮肤科的应用;李光宗等;《北京中医药》;20080131;第27卷(第1期);48-50 * |
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