CN103690803A - Traditional Chinese medicine preparation for treating anaphylactoid purpura - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating anaphylactoid purpura. The preparation is processed from rhizoma imperatae, madder root, alkanet, fruit of Gardenia jasminoides Ellis, radix geutianae, garden burnet, phellodendron bark, semen plantaginis, Xanthium sibiricum, safflower, raw sophora flower, Radix scutellariae, forsythia fruit, mulberry bark, Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Codonopsis, rehmanniae radix, radix paeoniae rubra and licorice though a scientific technology. The formula contains pure traditional Chinese medicines, which have main effects of clearing heat, cooling blood, dispersing blood stasis and eliminating speckles, and also can regulate immunity, support right and secure the root, so as to gain good effects. The preparation has exact curative effect in the treatment of anaphylactoid purpura, and does not show obvious side effect in the treatment.

Description

A kind of Chinese medicine preparation for the treatment of anaphylactoid purpura

Technical field

The present invention discloses a kind of Chinese medicine preparation for the treatment of anaphylactoid purpura, belongs to Chinese medicine technical field.

Background technology

Anaphylactoid purpura is a kind of blood capillary and thin arteriolar allergic angiitis of invading skin and other organs.Be characterized in that aubergine patch appears in skin, often with joint symptom, or have stomachache, or have kidney to change.The different reasons of polyphyly cause blood not circulate, and overflow grandson's network, and the skin that stagnates is sent out as purpura.Primary disease is early than there being the record of similar symptom in < < General Treatise on the Cause and Symptoms of Diseases > >, in its " suffer from speckle viral disease wait ", have that " disease of speckle poison; be that steam enters stomach; and the main muscle of stomach; its pyretic toxicity accumulates and amasss in stomach, and poison evaporates in muscle, shape is nibbled as mosquito flea; red speckle rises, and is circle time body." in many documents, also there is thereafter the description being much dispersed in, be called " hemorrhagic disease with purpura ".Clinical characters, except skin purpura, often has erythra and vasodilation, joint swelling and pain, stomachache and renal albuminuria etc.Be more common in child and teenager.The generation of anaphylactoid purpura is except the allergic constitution of self, and the impact of outside paathogenic factor is that indispensable essential condition occurs disease.Immune complex deposit in tunica intima, damage little blood vessel, blood capillary and arteriolitis, even necrotizing arteriolitis widely occur.Vascular Permeability and fragility increase, and perivascular infiltration and blood plasma sample ooze out.The treatment of primary disease, clinically except eliminating the cause of disease, often applies Claritin, reduces the treatments such as vascular permeability medicine, anticoagulant medicine, adrenocortical hormone, immunosuppressant.In application hormone therapy process, due to factor impacts such as body constitution and environmental changes, often there will be bounce-back or aggravation phenomenon.

Summary of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of anaphylactoid purpura, the Chinese medicine preparation of the treatment anaphylactoid purpura that does not rebound, has no side effect.

A kind of Chinese medicine preparation for the treatment of anaphylactoid purpura disclosed by the invention is to be made by the crude drug of following weight portion:

Rhizoma Imperatae 10～15, Radix Rubiae 10～15, Radix Arnebiae (Radix Lithospermi) 10～15, Fructus Gardeniae 10～15, Radix Gentianae 10～15, Radix Sanguisorbae 8～10, Cortex Phellodendri 10～15, Semen Plantaginis 10～15, Herba Xanthii grass 10～15, Flos Carthami 5～10, Flos Sophorae 10～15, Radix Scutellariae 12～15, Fructus Forsythiae 12～15, Cortex Mori 12～15, Rhizoma Coptidis 8～10, Radix Sophorae Flavescentis 8～10, Radix Codonopsis 10～15, the Radix Rehmanniae 10～15, Radix Paeoniae Rubra 8～10, Radix Glycyrrhizae 10～15.

The Chinese medicine preparation for the treatment of anaphylactoid purpura of the present invention, optimum ratio is as follows:

Rhizoma Imperatae 15, Radix Rubiae 15, Radix Arnebiae (Radix Lithospermi) 15, Fructus Gardeniae 10, Radix Gentianae 10, Radix Sanguisorbae 10, Cortex Phellodendri 10, Semen Plantaginis 10, Herba Xanthii grass 10, Flos Carthami 10, Flos Sophorae 10, Radix Scutellariae 12, Fructus Forsythiae 12, Cortex Mori 12, Rhizoma Coptidis 8, Radix Sophorae Flavescentis 8, Radix Codonopsis 10, the Radix Rehmanniae 10, Radix Paeoniae Rubra 8, Radix Glycyrrhizae 10.

The Chinese medicine preparation preparation method for the treatment of anaphylactoid purpura of the present invention, is characterized in that:

Take in proportion said medicine, remove impurity, being decocted in water for oral dose of 3 ~ 5 times of doses, fried 3 times, each 60 ~ 120 minutes fried completing, collecting decoction and get final product.

Usage and dosage: every day 2 times, 1 dose of every day, each 1 time sooner or later, each serving about 100ml, serveing on 7 days is 1 course for the treatment of.After general two courses for the treatment of, can fully recover.

China's theory of Chinese medical science thinks that anaphylactoid purpura belongs to the traditional Chinese medical science " blood disorder " " purpura " " hematohidrosis " " hemorrhagic disease with purpura " category, how because pathogenic heat injure blood network, the absurd row of forcing blood or the deficiency of vital energy, can not have under one's command due to blood.Anaphylactoid purpura is clinical the most common with the absurd passerby of pathogenic heat forcing blood.Therefore clinical treatment is primary treatment principle mainly with clearing away heat and cooling blood.On the basis of this rule for the treatment of, according to this sick pathological characteristic, capillary permeability, fragility strengthen.The present invention, in conjunction with Chinese medicine, prescription modern pharmacology and clinical research, drafts out this formula.

side of the present invention separates:

Poison in side in Rhizoma Imperatae, Fructus Gardeniae, Radix Gentianae, Herba Xanthii grass heat clearing away solution blood and removing heat from blood; Radix Rubiae, Radix Arnebiae (Radix Lithospermi), Semen Plantaginis removing heat from blood and promoting blood circulation, eliminating blood stasis and removing ecchymoses; Fructus Forsythiae, Flos Sophorae, Cortex Phellodendri, Radix Scutellariae, Cortex Mori reduce capillary permeability, increase blood capillary density.Flos Carthami, Radix Codonopsis, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling, have enhancing blood flow, improves microcirculation, regulates immunologic function, and resist radical damage, alleviates allergy.To preventing that purpura recurrence from having good preventive effect.Radix Sophorae Flavescentis, Rhizoma Coptidis suppress mastocyte and discharge histamine; Radix Sanguisorbae is bitter to be slightly cold, and property is heavy and enter the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, because of " heat is except blood is more than, heat both clearly blood from pacifying ", Radix Sanguisorbae can fall clearly, again can be astringent or styptic treatment for spontaneous sweating, let out clearly and not, puckery and not stagnant, be the key medicine of cooling blood for hemostasis.Radix Rehmanniae replenishing YIN and removing heat, cooling blood for hemostasis, coronary artery dilator; Radix Glycyrrhizae suppresses egg albumen, horse serum sensitization, and collaborative all medicines regulate body's immunity simultaneously; Radix Arnebiae (Radix Lithospermi) energy removing heat from blood and promoting blood circulation, removing heat from blood and not stagnant, invigorates blood circulation and loose, again can invigorating the spleen and replenishing QI, for the deficiency and excess card of purpura class disease, all can apply.The collaborative compatibility of all medicines is played the merit for the treatment of altogether above.

by showing medical effect of the present invention to suffering from the clinical treatment of anaphylactoid purpura Disease:

(1) patient's data: be First episode patient, male 40 examples, female's 20 examples, 10～15 years old 35 example, 18～30 years old 25 example.

(2) therapeutic modality: patient takes the medicine in embodiment 1, treating 7 days was 1 course for the treatment of, after 2 courses for the treatment of, judged curative effect.

(3) criterion of therapeutical effect: clinical symptoms and sign disappear completely, renal function and uroscopy are normal, and it is healing without recidivist that drug withdrawal is observed 3 months; Clinical symptoms and sign disappear, normal renal function, uroscopy urine protein (±～+) or erythrocyte (±～+) be effective; Clinical symptoms and sign disappear substantially, normal renal function, and uroscopy urine protein (+) or erythrocyte (+) are for taking a turn for the better; Invalid without transferring to well through treating 2 weeks all diseases.

(4) therapeutic outcome; Patient's 60 examples, cure 55 examples, effective 2 examples, 1 example that takes a turn for the better, invalid 2 examples, cure rate 91.67%, effective percentage 96.66%.

good effect of the present invention is:medicament composing prescription is pure Chinese medicinal preparation, take clearing away heat and cooling blood, eliminating blood stasis and removing ecchymoses as main, can regulate immunity simultaneously, strengthening the body resistance, thereby obtain good effect.Treatment anaphylactoid purpura determined curative effect.In treatment, do not find apparent side effect.

The specific embodiment

embodiment 1

Take Rhizoma Imperatae 15g, Radix Rubiae 15g, Radix Arnebiae (Radix Lithospermi) 15g, Fructus Gardeniae 10g, Radix Gentianae 10g, Radix Sanguisorbae 10g, Cortex Phellodendri 10g, Semen Plantaginis 10g, Herba Xanthii grass 10g, Flos Carthami 10g, Flos Sophorae 10g, Radix Scutellariae 12g, Fructus Forsythiae 12g, Cortex Mori 12g, Rhizoma Coptidis 8g, Radix Sophorae Flavescentis 8g, Radix Codonopsis 10g, Radix Rehmanniae 10g, Radix Paeoniae Rubra 8g, Radix Glycyrrhizae 10g, removes impurity, being decocted in water for oral dose of 3 ~ 5 times of doses, fried 3 times, each 60 ~ 120 minutes fried completing, collecting decoction and get final product.

embodiment 2

Take Rhizoma Imperatae 15g, Radix Rubiae 15g, Radix Arnebiae (Radix Lithospermi) 10g, Fructus Gardeniae 15g, Radix Gentianae 15g, Radix Sanguisorbae 8g, Cortex Phellodendri 15g, Semen Plantaginis 15g, Herba Xanthii grass 15g, Flos Carthami 8g, Flos Sophorae 12g, Radix Scutellariae 12g, Fructus Forsythiae 15g, Cortex Mori 15g, Rhizoma Coptidis 10g, Radix Sophorae Flavescentis 10g, Radix Codonopsis 12g, Radix Rehmanniae 12g, Radix Paeoniae Rubra 10g, Radix Glycyrrhizae 15g, removes impurity, being decocted in water for oral dose of 3 ~ 5 times of doses, fried 3 times, each 60 ~ 120 minutes fried completing, collecting decoction and get final product.

embodiment 3

Take Rhizoma Imperatae 10g, Radix Rubiae 10g, Radix Arnebiae (Radix Lithospermi) 10g, Fructus Gardeniae 10g, Radix Gentianae 10g, Radix Sanguisorbae 10g, Cortex Phellodendri 10g, Semen Plantaginis 10g, Herba Xanthii grass 10g, Flos Carthami 10g, Flos Sophorae 15g, Radix Scutellariae 15g, Fructus Forsythiae 15g, Cortex Mori 12g, Rhizoma Coptidis 8g, Radix Sophorae Flavescentis 8g, Radix Codonopsis 15g, Radix Rehmanniae 15g, Radix Paeoniae Rubra 8g, Radix Glycyrrhizae 15g, removes impurity, being decocted in water for oral dose of 3 ~ 5 times of doses, fried 3 times, each 60 ~ 120 minutes fried completing, collecting decoction and get final product.

the therapeutic effect that further shows medicine of the present invention by following model case:

case 1:

Wang, man 18 years old, first visit.Main suit: purpura shows effect more than 1 year repeatedly.Disease is seen: extremity skin purpura, and obvious with two lower limb, be speckle mound sample, differ in size, color purple is black, is distributed symmetrically, that presses is colour-fast, and this heals that, companion's pruritus scratch, companion's double knee joint pain, tired mind, limbs fatigue, time have hematuria, purplish tongue is dark, point has petechia, stringy and hesitant pulse, repeatedly have a blood test platelet and coagulation function are all normal.Be diagnosed as: anaphylactoid purpura.

Treatment: take medicine of the present invention (embodiment 1) and serve on two courses for the treatment of, purpura is all disappeared, and simultaneous phenomenon all disappears; Follow up a case by regular visits to half a year, have no recurrence.

case 2:

Lee, female, 15 years old.There is purpura in front two lower limb, color and luster is scarlet, and erythra is intensive, needle point is big or small to Semen Viciae fabae, xerostomia, constipation with dry stool, red tongue with yellow fur, floating and rapid pulse.Be diagnosed as: anaphylactoid purpura.

Treatment: control suitable clearing away heat and cooling blood, eliminating blood stasis and removing ecchymoses, take medicine of the present invention (embodiment 2).Take medicine after 1 week, skin lesion obviously alleviates, and xerostomia, constipation with dry stool disappear.The symptom and sign after 2 weeks of taking medicine all disappears, and continues to take medicine within 1 week, to consolidate curative effect.Follow up a case by regular visits to half a year, have no recurrence.

case 3:

Side certain, man, 12 years old, to suffer from abdominal pain, be paroxysmal, companion feels sick, black stool matter is rare, extremity are dispersed in the granular petechia of foxtail millet, partial fusion is in blocks, that touches is in the way.Without heating, without arthralgia.Have a medical check-up: mind is clear, lassitude, extremity are dispersed in symmetry petechia, and lower limb are especially many, and bilateral bulbar conjunctiva is congested.Cardiopulmonary check that abdomen is soft without abnormal, all tenderness of umbilicus, and without rebound tenderness, Shuan Shen district is without percussion pain.Neurologic check is not drawn pathologic reflex.Red tongue, yellow, greasy and thin fur, stringy and tense pulse.Lab testing: routine blood test WBC 14.5 * 109/L, N 0.83, Hb 138g/L, PLT 220 * 109/L, bleeding time 2min, clotting time 4min; Urine is conventional: urine protein (++), erythrocyte (+), stool blood (++); B ultrasonic shows: two kidney forms are full slightly to be increased, irregular low echo in kidney, prompting excess of the kidney matter mild damage.Be diagnosed as: anaphylactoid purpura.

Treatment: take medicine of the present invention (embodiment 3) stomachache on the same day and alleviate, can tolerate.7d, erythra goes down, stomachache disappears, only two lower limb are shown in and are dispersed in remote hemorrhage point, deflorescence after 14d, diet can, defecation chemical examination is normal, routine blood test WBC8.6 * 109/L, N 0.69, L 0.33, Hb 145g/L, PLT170 * 109/L.Advise the two yellow stuff first quarter moons of following the service, follow up a case by regular visits to half a year, have no recurrence.

Claims (3)

1. treating a Chinese medicine preparation for anaphylactoid purpura, is to be made by the crude drug of following weight portion:

Rhizoma Imperatae 10～15, Radix Rubiae 10～15, Radix Arnebiae (Radix Lithospermi) 10～15, Fructus Gardeniae 10～15, Radix Gentianae 10～15, Radix Sanguisorbae 8～10, Cortex Phellodendri 10～15, Semen Plantaginis 10～15, Herba Xanthii grass 10～15, Flos Carthami 5～10, Flos Sophorae 10～15, Radix Scutellariae 12～15, Fructus Forsythiae 12～15, Cortex Mori 12～15, Rhizoma Coptidis 8～10, Radix Sophorae Flavescentis 8～10, Radix Codonopsis 10～15, the Radix Rehmanniae 10～15, Radix Paeoniae Rubra 8～10, Radix Glycyrrhizae 10～15.

2. the Chinese medicine preparation for the treatment of anaphylactoid purpura as claimed in claim 1 is to be made by the crude drug of following weight portion:

Rhizoma Imperatae 15, Radix Rubiae 15, Radix Arnebiae (Radix Lithospermi) 15, Fructus Gardeniae 10, Radix Gentianae 10, Radix Sanguisorbae 10, Cortex Phellodendri 10, Semen Plantaginis 10, Herba Xanthii grass 10, Flos Carthami 10, Flos Sophorae 10, Radix Scutellariae 12, Fructus Forsythiae 12, Cortex Mori 12, Rhizoma Coptidis 8, Radix Sophorae Flavescentis 8, Radix Codonopsis 10, the Radix Rehmanniae 10, Radix Paeoniae Rubra 8, Radix Glycyrrhizae 10.

3. the Chinese medicine preparation preparation method for the treatment of anaphylactoid purpura according to claim 1 and 2, is characterized in that:

Take in proportion said medicine, remove impurity, being decocted in water for oral dose of 3 ~ 5 times of doses, fried 3 times, each 60 ~ 120 minutes fried completing, collecting decoction and get final product.