Pregnancy period vulval eczema nursing is loose and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to pregnancy period vulval eczema nursing and fall apart and preparation method thereof.
Background technology
Vulval eczema is a kind of common non-infectious dermatosis; pathological changes is confined to perineum and clitoris more, also even have spread to buttocks, can there is erythema, erythema, erosion in local; ooze out, form a scab, desquamation; the course of disease is long, and perineum surrounding skin often thickens, and color is greyish white or dark red; coarse; so that chap, ooze out, and pruritus, recurrent exerbation are main feature, and any age all can fall ill.Pathogenesis, a kind of delayed allergy that vulval eczema is mainly caused by motivating factor inside and outside complexity.But its cause of disease and the character of allergen, immunoreactive feature and whether relevant with the late response that IgE mediates, illustrate not yet completely.
Pregnancy period hormone in vivo level produces great variety, local nerve function sensitive improves thereupon, Weidner etc. have confirmed that local nerve function sensitive improves and have occurred clearly relevant to vulval eczema, its inherent approach is: nerve fiber and mastocyte are contacted directly by Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, can mast cell degranulation releasing histamine be made, cause pruritus.So be different from other allergic eczemas, even if pregnancy period eczema removes some sensitizing factor, eczema pathological changes can not disappear very soon, so existing eczema treatment means are unsatisfactory for pregnancy period vulval eczema effect.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the nursing of the little meeting vaginal eczema of side effect is loose and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: a kind of nursing for pregnancy period vulval eczema is fallen apart, and it is characterized in that being prepared from by the crude drug of following weight proportion: Herba Bulbophylli inconspicui 10 ~ 30 parts, Radix Tylophorae arenicolae 6 ~ 12 parts, Retinervus Luffae Fructus 3 ~ 10 parts, alizarin 6 ~ 12 parts of sea, Herba Moslae 3 ~ 10 parts, gelatinum oxhide 6 ~ 12 parts, go back 6 ~ 12 parts, bobbin, Cortex Ponciri trifoliatae 6 ~ 12 parts, stir-fried kidney beans 6 ~ 12 parts, Cortex Betulae Luminiferae 1 ~ 5 part, Rhizoma Fagopyri Dibotryis stem and leaf 3 ~ 10 parts, Bulbus Allii Fistulosi 10 ~ 25 parts.
Chinese medicine of the present invention can be prepared from by following method:
(1) bobbin, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Cortex Ponciri trifoliatae coarse powder, Bulbus Allii Fistulosi will be gone back and extract volatile oil with vapor distillation respectively, and mixing for standby use after collecting, for subsequent use after the medicinal residues mixing after extraction;
(2) gelatinum oxhide, stir-fried kidney beans are pulverized 150 mesh sieves respectively, become fine powder mixing for standby use;
(3) gained medicinal residues mixing in Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 is added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray is dry, obtains just material;
(4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained mixing fine powders mixing in step 2, cross 100 mesh sieves, sterilizing subpackage forms.
Wherein said: Herba Bulbophylli inconspicui is the orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui BulbophylluminconspicuumMaxim., with all herbal medicine.Nature and flavor are sweet; Pungent; Cool; Nontoxic.Return lung; Stomach warp.Merit can heat clearing away YIN nourishing; Nourishing the lung to arrest cough.
Radix Tylophorae arenicolae, for the spirit of asclepiadaceae plant bamboo disappears the root of Cynanchuminamoenum (Maxim.) Loes. or aerial parts.Nature and flavor are bitter; Micro-pungent; Property is put down.Return lung meridian.Merit can the kidney invigorating, spleen invigorating, removing toxic substances.
Retinervus Luffae Fructus is cucurbitaceous plant Fructus Luffae Luffacylindrica(L.) vascular bundle of the dry mature fruit of Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, dispels the wind.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves SargassumenerveC.Ag., Sargassum henslowianum SargassumhenslowianumC.Ag., sargassum thunbergii Sargassumthunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassumhorneri(Turn.) frond of C.Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Herba Moslae is the dry aerial parts of labiate Mosla chinensis Maxim..Nature and flavor are pungent, tepor.Attach to the lung and stomach meridians.Merit can relieving the exterior syndrome by diaphoresis, and middle dampness removing.
Gelatinum oxhide is the glue that the gelatinum oxhide skin that is bovid cattle BostaurusdomesticusGmelin is made.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Merit can be nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae GastrodiaelataBl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head is had a headache; Weak breath consumption of essence; Early whitening of beard and hair.
Cortex Ponciri trifoliatae is rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirustuifoliata(L.) bark of Raf. bits or peel bits.Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Stir-fried kidney beans is the dry mature seed of pulse family Dolichos plant Seem Lablab Album, and fry to micro-yellow, the used time smashs to pieces.Nature and flavor are sweet, tepor.Return spleen, stomach warp.Merit can invigorating the spleen for eliminating dampness, and in relieve summer heat.
Cortex Betulae Luminiferae is Betulaceae betula luminifera BetulaluminiferaH.Win Flos jasmini. bark.Nature and flavor are sweet; Pungent; Slightly warm in nature.Merit can damp eliminating cold expelling; Disappear stagnant and in, removing toxic substances.
Rhizoma Fagopyri Dibotryis stem and leaf is polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrumdibotrys(D.Don) stem and leaf of Hara.Nature and flavor are bitter, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.
Bulbus Allii Fistulosi, be the cauloid of Liliaceae allium Herba Alii fistulosi, merit can be delivered and activate yang, removing toxic substances parasite killing.
Composition principle: vulval eczema, the traditional Chinese medical science thinks that its cause of disease is wind, wet, pathogenic heat is detained skin or wind syndrome due to blood-deficiency dryness-transformation, caused by failure of skin and muscle to be nourished.Mostly choose " removing dampness removing toxic substances " medicines such as Rhizoma Smilacis Glabrae, Rhizoma Coptidis, Cortex Phellodendri, Herba Taraxaci, Alumen, Radix Sophorae Flavescentis, Cortex Dictamni, or Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra " blood enriching and dryness moistening " Drug therapy.But pregnancy period vulval eczema is then that local nerve function sensitive improves, and then mediating mast cell forms because pregnancy period hormone in vivo level produces great variety thereupon.And the pregnancy period uses dispelling the damp pathogen with drugs of bitter in taste and cold in nature medicine also easily to cause local skin to lose foster atrophy, blood circulation promoting medicine too much can cause again the untoward reaction such as local telangiectasis.Inventor's clinical research finds that pregnancy period local nerve function hypersensitivity is also that network of diving with cold-evil is relevant, both can illustrate, Pregnant Women, under cold stimulation, can bring out vulval eczema recurrence.
Compared with prior art, the present invention has following characteristics:
1, prescription is unique: get Herba Bulbophylli inconspicui in side, Radix Tylophorae arenicolae is monarch, the cooperation of described Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, the two is lung meridian medication, the main skin of lung, so the two can enter skin network; The feature of Herba Bulbophylli inconspicui is heat clearing away, but nature and flavor are sweet cool; The vulval eczema of recurrent exerbation does not also lie in " dampness ", so the result of clinical dampness often causes protracted course of disease, and local skin lichenization, dryization, Herba Bulbophylli inconspicui has the merit of sweet profit, simultaneously can YIN nourishing, is suitable for the pregnancy period to use; For in rat inflammatory pain model, the Herba Bulbophylli inconspicui Aqueous extracts of 1mg/kg can reduce localized heat shock protein (HSP) expresses; Radix Tylophorae arenicolae toil, for rat eczema skin lesion model, the glycoside extract local of 1mg/kg uses, and local mast cell activity can be made to reduce, then resist local nerve hypersensitive state excitation;
2, getting Herba Moslae in side is minister, the outer dampness of Herba Moslae solution Intradermal film, and Herba Moslae volatile oil can weaken rabbit local inflammation response strength;
3, get Retinervus Luffae Fructus promoting blood circulation to remove obstruction in the collateral, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, extra large alizarin dissipating phlegm and resolving masses be minister, and inventor for many years Clinical and experimental study show, Cortex Ponciri trifoliatae, extra large madder can alleviate rapidly the pruritus sense of discomfort that local nerve high sensitive strip is come; Get and go back bobbin tonify deficiency subduing the wind syndrome, gelatinum oxhide is nourshing Yin and drynsessmoistening prescription to nourish blood, auxiliary Radix Tylophorae arenicolae kidney and spleen invigorating;
4, make medication pair: Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, the two heat one is trembled with fear, and forms medicine pair, jointly reaching the effect of drying and unbiased, and having effect of removing toxic substances;
5, gelatinum oxhide is rich in colloidality, stir-fried kidney beans rich in starch, and the two local uses and contributes to alleviating local mucous membrane stimulation;
6, Bulbus Allii Fistulosi merit can be delivered and activate yang, and the effect in we increases the overall transdermal absorption factor of medicine;
7, medicine material survival dose of the present invention is groped to sum up to draw through inventor in a large number, and each crude drug consumption is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Bulbophylli inconspicui 20 parts, Radix Tylophorae arenicolae 10 parts, Retinervus Luffae Fructus 6 parts, alizarin 10 parts of sea, Herba Moslae 6 parts, gelatinum oxhide 10 parts, go back 10 parts, bobbin, Cortex Ponciri trifoliatae 10 parts, stir-fried kidney beans 10 parts, Cortex Betulae Luminiferae 2 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 parts, Bulbus Allii Fistulosi 20 parts.
The preparation method of embodiment 1 is: by Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Herba Moslae, gelatinum oxhide, go back bobbin, Cortex Ponciri trifoliatae, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, the decoction of Bulbus Allii Fistulosi mixing and water adding, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and gets local wet dressing around appropriate perineum sooner or later every day.
Embodiment 2, crude drug weight proportion: Herba Bulbophylli inconspicui 10 parts, Radix Tylophorae arenicolae 6 parts, Retinervus Luffae Fructus 3 parts, alizarin 6 parts of sea, Herba Moslae 3 parts, gelatinum oxhide 6 parts, go back 6 parts, bobbin, Cortex Ponciri trifoliatae 6 parts, stir-fried kidney beans 6 parts, Cortex Betulae Luminiferae 1 part, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Bulbus Allii Fistulosi 10 parts.
Embodiment 3, crude drug weight proportion: Herba Bulbophylli inconspicui 20 parts, Radix Tylophorae arenicolae 10 parts, Retinervus Luffae Fructus 6 parts, alizarin 10 parts of sea, Herba Moslae 6 parts, gelatinum oxhide 10 parts, go back 10 parts, bobbin, Cortex Ponciri trifoliatae 10 parts, stir-fried kidney beans 10 parts, Cortex Betulae Luminiferae 2 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 parts, Bulbus Allii Fistulosi 20 parts.
Embodiment 4, crude drug weight proportion: Herba Bulbophylli inconspicui 30 parts, Radix Tylophorae arenicolae 12 parts, Retinervus Luffae Fructus 10 parts, alizarin 12 parts of sea, Herba Moslae 10 parts, gelatinum oxhide 12 parts, go back 12 parts, bobbin, Cortex Ponciri trifoliatae 12 parts, stir-fried kidney beans 12 parts, Cortex Betulae Luminiferae 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 10 parts, Bulbus Allii Fistulosi 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) bobbin, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Cortex Ponciri trifoliatae coarse powder, Bulbus Allii Fistulosi will be gone back and extract volatile oil with vapor distillation respectively, and mixing for standby use after collecting, for subsequent use after the medicinal residues mixing after extraction;
(2) gelatinum oxhide, stir-fried kidney beans are pulverized 150 mesh sieves respectively, become fine powder mixing for standby use;
(3) gained medicinal residues mixing in Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 is added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray is dry, obtains just material;
(4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained mixing fine powders mixing in step 2, cross 100 mesh sieves, sterilizing subpackage forms.
During use, the hot water of about 50 DEG C tunes to open, and gets every day and spreads on local around perineum in right amount.
The efficient combination of said medicine, coordinates mutually, effectively reach the object being applicable to pregnancy period vulval eczema use, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in June, 2012 ~ 2013 are diagnosed as vulval eczema 133 example year June, and be outpatient, 20 ~ 42 years old age, pregnant week is 5 ~ 38 weeks.
1.1.2 diagnostic criteria: " Chinese medical disease Standardization of diagnosis and curative effect " that vulval eczema diagnostic criteria is promulgated by State Administration of Traditional Chinese Medicine performs.Symptom: perineum humidity, pruritus, twinge discomfort, night more so.Training checks: pimple, erythema, erosion, sepage appear in acute person's perineum place; Chronic person's perineum place skin is canescence, thickens thicker, in lichenification and the shallow breach of radial table.
1.1.3 divide into groups: be divided into matched group 40 example at random, soak group 48 example, dresses group 45 example.Three groups of cases no significant difference (P>0.05) in age, pregnant week distribution, has comparability.
1.2 method.
1.2.1 Therapeutic Method: matched group 1:1000 potassium permanganate soak, 2 times/d; Soak group with local wet dressing around gained decoction perineum in the embodiment of the present invention 1,2 times/d; Dress group to dress after melting with gained medicated powder hot water in the embodiment of the present invention 2,2 times/d.Above case was all 1 course for the treatment of with 2 weeks, and the course for the treatment of, interval 2d, judged curative effect after 2 courses for the treatment of.
1.2.2 criterion of therapeutical effect: recovery from illness: clinical symptoms, sign disappear; Effective: clinical symptoms, sign turn for the better by and large, vulval eczema range shorter more than 1/2; Effective: clinical symptoms, sign alleviate, vulval eczema scope reduces less than 1/2 before comparatively treating; Invalid: clinical symptoms, sign, vulval eczema scope are unchanged.
1.2.3 statistical analysis: SPSS13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of Comprehensive Clinical comparitive study: soak group organizes cure rate and matched group difference extremely obviously (soak group χ with dressing
2=16.97, P<0.05; Dress group χ
2=14.42, P<0.05), soak group organizes total effective rate apparently higher than matched group (soak group χ with dressing
2=12.46, P<0.001; Dress group χ
2=16.03, P<0.001), see the following form.
Group |
Number of cases |
Cure |
Effective |
Effectively |
Invalid |
Total effective rate |
Matched group |
40 |
2(5.00%) |
13(32.50%) |
9(22.50%) |
16(40.00%) |
60.00% |
Soak group |
48 |
21(43.75%) |
15(31.25%) |
8(16.67%) |
4(8.33%) |
91.67% |
Dress group |
45 |
18(40.00%) |
17(37.78%) |
8(17.78%) |
2(4.44%) |
95.56% |
2.2 3 groups of adverse reactions of patients incidence rates compare: three groups have been obvious adverse reaction report.
3. conclusion.
This result of study shows, soak group of the present invention organizes cure rate, total effective rate apparently higher than matched group with dressing, and the incidence rate of untoward reaction is low, and can relapse rate be reduced, illustrate that the present invention has the advantage that untoward reaction is comparatively light, safety is higher in treatment pregnancy period vulval eczema.