CN103675045A - Novel blood-clotting thrombolysis full-function detection device - Google Patents
Novel blood-clotting thrombolysis full-function detection device Download PDFInfo
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- CN103675045A CN103675045A CN201310653976.4A CN201310653976A CN103675045A CN 103675045 A CN103675045 A CN 103675045A CN 201310653976 A CN201310653976 A CN 201310653976A CN 103675045 A CN103675045 A CN 103675045A
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Abstract
The invention discloses a novel blood-clotting thrombolysis full-function detection device, a solid microelectronic mechanical chip is electrically connected with the lower end of a printed circuit board, the solid microelectronic mechanical chip comprises a rectangular main board and a long striped silicon probe which are formed by cutting a complete silicon wafer, the main board is etched with 1 ~ 7 groups of driving capacitors, the driving capacitors at least contain 1 group of comb driving capacitors, each group of the comb driving capacitors comprises 2 comb driving capacitors arranged side by side, and each group of the driving capacitors is respectively connected with a capacitance read chip. According to the device, a micro torsion meter of the solid microelectronic mechanical chip is used for replace purely-mechanical testing of an original spring hairspring, the instrument stability is enhanced, the precision of obtained force/torque is improved, the whole device is small and compact, at the same time, the current situation that domestic blood-clotting thrombolysis detection is dependent on import for a long term can be changed, and the blood-clotting thrombolysis full-function detection cost is reduced.
Description
Technical field
The present invention relates to a kind of biomedical detecting instrument, be specifically related to a kind of new device that blood coagulation and thrombolysis function are detected.
Background technology
Blood coagulation thrombolysis function detection device comes across 1948 the earliest, and it take spring hairspring as core, detects the grumeleuse elastic force producing in blood coagulation and thrombolysis process, is reflected on drawing instrument, draws out a time dependent curve of thrombus elastic force.Because this curve can provide the most complete blood coagulation thrombolysis overall process parameter, blood coagulation thrombolysis function detection device all has important Research Significance for clinical treatment, pathological research and new drug development.
Commercial blood coagulation thrombolysis Function detection market is mainly monopolized by TEG and these two kinds of import instruments of ROTEM at present, and matched reagent used is also mainly from abroad, thereby price is comparatively expensive.Simultaneously, these instruments for the detection of thrombus elastic force based on spring hairspring, what measure is that blood sample produces one dimension torsional drag force to probe, cannot embody the molten three-dimensional netted crosslinked biophysics feature of blood pool and bolt, thereby testing result is often not accurate enough comprehensively, in addition, the mechanical system of instrument is too meticulous, poor stability, and detection sensitivity is not enough, and be subject to extraneous factor and disturb, the inconvenience that above-mentioned feature all can cause instrument to use.
Summary of the invention
For overcoming the deficiencies in the prior art, the object of the present invention is to provide a kind of easy and simple to handle, highly sensitive, volume is little and compact and blood coagulation thrombolysis global function pick-up unit that can accurate quantitative analysis parameter.
For achieving the above object, the present invention is achieved through the following technical solutions:
A novel blood coagulation thrombolysis global function pick-up unit, is electrically connected with a solid microelectron-mechanical chip in printed circuit board lower end; Described solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and described solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On described mainboard, be etched with 1～7 group and drive electric capacity, at least contain 1 group of pectination and drive electric capacity in described driving electric capacity, every group of pectination drives electric capacity to comprise 2 comb capacitances that are arranged side by side; Every group of driving electric capacity connects respectively an electric capacity and reads chip.
Preferably, described novel blood coagulation thrombolysis global function pick-up unit, on described mainboard, being only etched with 1 group of driving electric capacity and this driving electric capacity is that pectination drives electric capacity, described pectination drives electric capacity to be positioned at the middle part of described mainboard.
Preferably, described novel blood coagulation thrombolysis global function pick-up unit, on described mainboard, being etched with 3 groups drives electric capacity and these 3 groups driving electric capacity to be pectination driving electric capacity, wherein 1 group of pectination drives electric capacity to be positioned at the middle part of described mainboard, and other 2 groups of pectinations drive electric capacity to be set in parallel in respectively the two ends up and down of described mainboard.
Preferably, described novel blood coagulation thrombolysis global function pick-up unit, is etched with 5 groups and drives electric capacity on described mainboard, and wherein 1 group of driving electric capacity is that pectination drives electric capacity; Described pectination drives electric capacity to be positioned at the middle part of described mainboard, and other 4 groups of driving electric capacity lay respectively at four corners of described mainboard.
Preferably, described novel blood coagulation thrombolysis global function pick-up unit, is etched with 6 groups and drives electric capacity on described mainboard, and wherein 2 groups of driving electric capacity are that pectination drives electric capacity; Described 2 groups of pectinations drive electric capacity to be set in parallel in the two ends up and down of described mainboard, and other 4 groups of driving electric capacity lay respectively at four corners of described mainboard.
Preferably, described novel blood coagulation thrombolysis global function pick-up unit, is etched with 7 groups and drives electric capacity on described mainboard, and wherein 3 groups of driving electric capacity are that pectination drives electric capacity; 3 groups of pectinations drive in electric capacity has 2 groups of pectinations to drive electric capacity to be set in parallel in the two ends up and down of described mainboard, and 1 group of pectination drives electric capacity to be positioned at the middle part of described mainboard; Remaining 4 groups four corners that drive electric capacity to lay respectively at described mainboard.
The invention has the beneficial effects as follows: 1) micro-torsionmeter of applying solid microelectron-mechanical chip replaces the pure mechanical detection of spring hairspring originally, strengthened the stability of instrument, greatly improved the precision of institute's acquisition power/moment, also make whole device little and compact simultaneously; 2) change the present situation that state's intravascular coagulation thrombolysis detects long-term dependence on import, reduce the cost that blood coagulation thrombolysis global function detects.
Accompanying drawing explanation
Fig. 1 is the structural representation of solid microelectron-mechanical chip in the novel blood coagulation thrombolysis global function pick-up unit described in one embodiment of the invention.
Embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail, to make those skilled in the art can implement according to this with reference to instructions word.
Refer to Fig. 1, a kind of novel blood coagulation thrombolysis global function pick-up unit of its explanation one embodiment of the invention, this device replaces the spring hairspring dynamometric system of traditional thrombelastogram instrument (TEG) with solid microelectron-mechanical chip, and the molten blood elastic force causing of blood coagulation bolt is changed and is converted into electric signal.
In the printed circuit board lower end of this device, be electrically connected with a solid microelectron-mechanical chip; Solid microelectron-mechanical chip comprises the silicon probe 2 of a rectangular mainboard 1 and a strip, and solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On mainboard, be etched with 1～7 group and drive electric capacity 5, drive in electric capacity 5 and at least contain 1 group of pectination driving electric capacity, every group of pectination drives electric capacity to comprise 2 comb capacitances that are arranged side by side 3; Every group of driving electric capacity 5 connects respectively an electric capacity and reads chip.
In silicon probe 2 blood samples that stretch in sample cup 4, when being subject to micro-torsional moment, silicon probe 2 does the used time, driving in chip drives the spacing of electric capacity 5 to change, also be the change that Detection capacitance value occurs, this signal can adopt electric capacity to read chip and data collecting card reads and digital-to-analog conversion, thereby thrombus stretch parameter is more accurately provided.The driving electric capacity of solid microelectron-mechanical chip can carry out etching as required, can detect multiple directions respectively, can carry out one dimension to three-dimensional micro-force and moment and resolve.The scope of the micro-force and moment of chip detection is between 0～4000 μ N and 0～2600nNm.If detect the power of the x direction of one dimension, in chip, only need pectination of etching to drive electric capacity; If detect two-dimentional x, the power of y direction, needs three pectinations of etching to drive electric capacity in chip; If detect two-dimentional x, the power of z direction, needs pectination of etching to drive electric capacity and four z to electric capacity in chip, and z is preferably common electric capacity to electric capacity; If detect three-dimensional x, y, the power of z direction, needs three pectinations of etching to drive electric capacity and four z to electric capacity in chip.Drive electric capacity quantity more, the dimension of the power that can resolve is just higher, and the power detecting also can be more accurate.
Provide some specific embodiments to describe the present invention in detail below.
In the printed circuit board lower end of this blood coagulation thrombolysis global function pick-up unit, be electrically connected with a solid microelectron-mechanical chip; Solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On mainboard, being only etched with 1 group of driving electric capacity and this driving electric capacity is that pectination drives electric capacity, and it is positioned at mainboard middle part.The chip of this structure can resolve one-dimensional square to force and moment.
In the printed circuit board lower end of this blood coagulation thrombolysis global function pick-up unit, be electrically connected with a solid microelectron-mechanical chip; Solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On mainboard, be etched with 3 groups and drive electric capacity and these 3 groups driving electric capacity to be pectination driving electric capacity, wherein 1 group of pectination drives electric capacity to be positioned at mainboard middle part, and other 2 groups of pectinations drive electric capacity to be set in parallel in respectively the two ends up and down of described mainboard.The chip of this structure can be resolved two-dimentional x, the force and moment of y direction.
In the printed circuit board lower end of this blood coagulation thrombolysis global function pick-up unit, be electrically connected with a solid microelectron-mechanical chip; Solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On mainboard, be etched with 5 groups and drive electric capacity, wherein 1 group of driving electric capacity is that pectination drives electric capacity; Pectination drives electric capacity to be positioned at mainboard middle part, other 4 groups of four corners that drive electric capacity to lay respectively at mainboard.The chip of this structure can be resolved two-dimentional x, the force and moment of z direction.
In the printed circuit board lower end of this blood coagulation thrombolysis global function pick-up unit, be electrically connected with a solid microelectron-mechanical chip; Solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On mainboard, be etched with 6 groups and drive electric capacity, wherein 2 groups of driving electric capacity are that pectination drives electric capacity; 2 groups of pectinations drive electric capacity to be set in parallel in the two ends up and down of mainboard, and other 4 groups of driving electric capacity lay respectively at four corners of mainboard.The chip of this structure can be resolved two-dimentional y, the force and moment of z direction.
In the printed circuit board lower end of this blood coagulation thrombolysis global function pick-up unit, be electrically connected with a solid microelectron-mechanical chip; Solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On mainboard, be etched with 7 groups and drive electric capacity, wherein 3 groups of driving electric capacity are that pectination drives electric capacity; 3 groups of pectinations drive in electric capacity has 2 groups of pectinations to drive electric capacity to be set in parallel in the two ends up and down of mainboard, and 1 group of pectination drives electric capacity to be positioned at the middle part of mainboard; Remaining 4 groups four corners that drive electric capacity to lay respectively at mainboard.The chip of this structure can be resolved three-dimensional x, y, the force and moment of z direction.
Although embodiment of the present invention are open as above, but it is not restricted to listed utilization in instructions and embodiment, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other modification, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend of describing.
Claims (6)
1. a novel blood coagulation thrombolysis global function pick-up unit, is characterized in that, is electrically connected with a solid microelectron-mechanical chip in printed circuit board lower end; Described solid microelectron-mechanical chip comprises the silicon probe of a rectangular mainboard and a strip, and described solid microelectron-mechanical chip is to be formed by a complete silicon wafer cutting; On described mainboard, be etched with 1～7 group and drive electric capacity, at least contain 1 group of pectination and drive electric capacity in described driving electric capacity, every group of pectination drives electric capacity to comprise 2 comb capacitances that are arranged side by side; Every group of driving electric capacity connects respectively an electric capacity and reads chip.
2. novel blood coagulation thrombolysis global function pick-up unit according to claim 1, is characterized in that, on described mainboard, being only etched with 1 group of driving electric capacity and this driving electric capacity is that pectination drives electric capacity, and described pectination drives electric capacity to be positioned at the middle part of described mainboard.
3. novel blood coagulation thrombolysis global function pick-up unit according to claim 1, it is characterized in that, on described mainboard, being etched with 3 groups drives electric capacity and these 3 groups driving electric capacity to be pectination driving electric capacity, wherein 1 group of pectination drives electric capacity to be positioned at the middle part of described mainboard, and other 2 groups of pectinations drive electric capacity to be set in parallel in respectively the two ends up and down of described mainboard.
4. novel blood coagulation thrombolysis global function pick-up unit according to claim 1, is characterized in that, is etched with 5 groups and drives electric capacity on described mainboard, and wherein 1 group of driving electric capacity is that pectination drives electric capacity; Described pectination drives electric capacity to be positioned at the middle part of described mainboard, and other 4 groups of driving electric capacity lay respectively at four corners of described mainboard.
5. novel blood coagulation thrombolysis global function pick-up unit according to claim 1, is characterized in that, is etched with 6 groups and drives electric capacity on described mainboard, and wherein 2 groups of driving electric capacity are that pectination drives electric capacity; Described 2 groups of pectinations drive electric capacity to be set in parallel in the two ends up and down of described mainboard, and other 4 groups of driving electric capacity lay respectively at four corners of described mainboard.
6. novel blood coagulation thrombolysis global function pick-up unit according to claim 1, is characterized in that, is etched with 7 groups and drives electric capacity on described mainboard, and wherein 3 groups of driving electric capacity are that pectination drives electric capacity; 3 groups of pectinations drive in electric capacity has 2 groups of pectinations to drive electric capacity to be set in parallel in the two ends up and down of described mainboard, and 1 group of pectination drives electric capacity to be positioned at the middle part of described mainboard; Remaining 4 groups four corners that drive electric capacity to lay respectively at described mainboard.
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| CN105944774A (en) * | 2016-05-12 | 2016-09-21 | 大连理工大学 | Two-layer microfluidic chip for analysis of in-vitro thrombolytic drug effect and preparation method |
| CN106153439A (en) * | 2016-08-16 | 2016-11-23 | 中国科学院苏州生物医学工程技术研究所 | Hemostasis examination device |
| CN106198943A (en) * | 2016-08-16 | 2016-12-07 | 中国科学院苏州生物医学工程技术研究所 | A kind of Studies on Hemodynamic Changes device |
| CN107024312A (en) * | 2017-05-15 | 2017-08-08 | 深圳麦科田生物医疗技术有限公司 | Detection means with micro- damping structure |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105944774A (en) * | 2016-05-12 | 2016-09-21 | 大连理工大学 | Two-layer microfluidic chip for analysis of in-vitro thrombolytic drug effect and preparation method |
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| CN106153439A (en) * | 2016-08-16 | 2016-11-23 | 中国科学院苏州生物医学工程技术研究所 | Hemostasis examination device |
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| CN106153439B (en) * | 2016-08-16 | 2019-02-01 | 中国科学院苏州生物医学工程技术研究所 | Hemostasis detestion device |
| CN106198943B (en) * | 2016-08-16 | 2019-11-12 | 中国科学院苏州生物医学工程技术研究所 | A kind of Studies on Hemodynamic Changes device |
| CN107024312A (en) * | 2017-05-15 | 2017-08-08 | 深圳麦科田生物医疗技术有限公司 | Detection means with micro- damping structure |
| CN107024312B (en) * | 2017-05-15 | 2023-09-15 | 深圳麦科田生物医疗技术股份有限公司 | Detection device with micro damping structure |
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