CN103656361A - Medicine used for treating herpes zoster, and preparation method thereof - Google Patents
Medicine used for treating herpes zoster, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine used for treating herpes zoster, and a preparation method thereof. The medicine is prepared from medical ingredients, such as herba portulacae, semen plantaginis, oldenlandia diffusa, radix gentianae, rheum officinale, herba violae, rulvis glycyrrhizae extractionis sedilis, radix salviae miltiorrhizae, yam rhizome and complete scorpion, according to a certain weight ratio. The medicine is capable of clearing away heat and toxic materials, dispersing blood and diminishing swelling, and diminishing inflammation and killing parasite; and can be used for treating herpes zoster with rapidly realized effects and excellent curative effects; and relapse of herpes zoster is seldom caused.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of herpes zoster and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Herpes zoster is the actute infection dermatoses being caused by varicella zoster virus.After infected without the child of immunity to this virus, there is chickenpox.After some patients were is infected, become carrier and symptom does not occur.Because virus has neurotropism, after infection, can hide for a long time in the neuron of spinal nerves posterior root ganglion, when lower for the resistance or tired, infection, flu, virus can regrow breeding, and move to skin along nerve fiber, make nerve and the skin of being invaded produce strong inflammation.The feature that erythra generally has one-sided property and distributes by nerve segment, is comprised of the herpes that collects bunch property, and with pain; Age is larger, and neuralgia is heavier.Primary disease is apt to occur in adult, and season in spring and autumn is common.Sickness rate increased and is remarkable rising with the age.At present, because Western medicine cannot effectively be treated herpes zoster, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effective treatment herpes zoster.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment herpes zoster, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat herpes zoster.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Portulacae, Semen Plantaginis, Herba Hedyotidis Diffusae, Radix Gentianae, Radix Et Rhizoma Rhei, Herba Violae, Preparatum Glycyrrhizae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Septemlobae, Scorpio, Radix Rhapontici, Folium Isatidis, Squama Manis, Flos Lonicerae, Radix et Caulis Opuntiae Dillenii, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Semen Plantaginis, Fructus Hordei Germinatus, Os Draconis, Herba Lophatheri, the Rhizoma Atractylodis Macrocephalae, Haematitum, Semen Trichosanthis, Herba Cayatiae Japonicae, Indigo Naturalis, Rhizoma Alismatis, Caulis Piperis Kadsurae, Caulis Akebiae, Fructus Crataegi, Rhizoma Corydalis, arnebia medicinal to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of herpes zoster.Wherein select Herba Portulacae to be because its nature and flavor acid is cold, enter large intestine, liver, spleen channel, have heat-clearing and toxic substances removing, the function of loose blood detumescence, controls hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, scrofula.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, there is diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select Herba Hedyotidis Diffusae to be because its property bitter but sweet flavor is cold, enter the heart, liver, spleen three warps, have heat clearing away, dampness removing, the function of removing toxic substances, controls dyspnea and cough due to lung-heat, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom.Select Radix Gentianae to be because its nature and flavor are bitter, cold, enter liver, gallbladder meridian, there is eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Radix Et Rhizoma Rhei to be because its nature and flavor are bitter, cold, enter stomach, large intestine, liver footpath, have the poison of purging heat, removing mass is stagnant, the function of clots absorbing blood, controls excess-heat constipation, and delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Selecting Herba Violae is that GUIXIN, Liver Channel, have heat-clearing and toxic substances removing because of its nature and flavor bitter, acrid, cold, and the function of removing heat from blood detumescence, controls furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Select Preparatum Glycyrrhizae to be because its nature and flavor are sweet, cold, enter the heart, stomach warp, there is heat clearing away, removing heat from blood, the function of removing toxic substances, the cold and heat disease that cures the wound, large hot excessive thirst, maculopapulae due to toxic heat, erysipelas, skin infection.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Rhizoma Dioscoreae Septemlobae to be because its nature and flavor are bitter, flat, enter liver, stomach, urinary bladder channel, dispel the wind, the function of dampness removing, dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, damp and hot sore.Select Scorpio to be because its nature and flavor are salty pungent, flat, poisonous, enter meridian of Foot-JUE YIN, dispel the wind, relieving convulsion, dredging collateral, the function of removing toxic substances, controls convulsion with spasms ， epilepsy, apoplexy, hemiplegia, deviation of the eye and mouth, migraine, rheumatic arthralgia, tetanus, tuberculous lymphadenitis, rubella skin ulcer is swollen.Select Radix Rhapontici to be because its nature and flavor hardship is salty-cold, enter stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of stimulating milk secretion, controls the swollen pain of breast, galactostasis, toxic-heat and blood stasis, arthralgia.Select Folium Isatidis to be because its nature and flavor are bitter, cold, enter liver, the heart, stomach warp, there is heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of the stimulating milk secretion of stimulating the menstrual flow, controls carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Radix et Caulis Opuntiae Dillenii to be because its nature and flavor are bitter, cold, enter the heart, lung, stomach three warps, there is promoting flow of QI and blood, the function of heat-clearing and toxic substances removing, controls heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.Select Rhizoma Osmundae to be because its nature and flavor are bitter, cool, enter liver, stomach warp, kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls anemopyretic cold, and damp and hot skin eruption is spitted blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds malignant boil tinea disease.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, there is diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select Fructus Hordei Germinatus to be because its nature and flavor are sweet, tepor, enters spleen, stomach warp, and have and help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, controls food stagnation and does not disappear, swollen distention and fullness in the abdomen, and inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select Os Draconis to be because its property sweet-puckery flavor is flat, be included into the heart, liver, kidney, large intestine channel, have tranquillizing the mind by relieving convulsion, the function of arresting sweating controlling nocturnal emission with astringent drugs, controls frightened Epilepsy demented, and palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating.Select Herba Lophatheri to be because its property slightly sweet flavor is cold, enter heart kidney two warps, have clearing away heart-fire, heat clearing away and restlessness relieving, the function of diuresis, controls calentura thirsty, vexed, hot urination, stranguria with turbid discharge, erosion of the oral mucosa tongue boil, gingival swelling and pain.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Haematitum to be because its property bitter but sweet flavor is flat, enter liver, stomach, heart born of the same parents warp, have suppressing the hyperactive liver town contrary, the function of cooling blood for hemostasis, controls eructation vomiting, dysphagia and regurgitation, and asthma, frightened Epilepsy, spits blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid flaccidity, bleeding not during menses.Select Semen Trichosanthis to be because its nature and flavor are sweet, cold, return lung, stomach, large intestine channel, there is moistening the lung and resolving phlegm, the function of laxation relieving constipation, controls cough caused by dryness expectorant glutinous, dryness of the intestine constipation.Select Herba Cayatiae Japonicae to be because its nature and flavor picric acid is cold, enter the heart, liver, stomach three warps, have clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls carbuncle, furuncle, mumps, erysipelas, rheumatalgia, jaundice, dysentery, hematuria, nebulousurine.Select Indigo Naturalis to be because its nature and flavor are salty, cold, enter liver, lung, stomach warp, there is heat clearing away, removing heat from blood, the function of removing toxic substances, controls epidemic febrile disease intenseness of heat, and macule is spitted blood, is spat blood, little Jing Epilepsy, skin ulcer is swollen, erysipelas, snake bite and insect sting.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, there is diuretic, eliminating dampness by diuresis, the function expelling the heat-evil, controls dysuria, and edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Caulis Piperis Kadsurae to be because its nature and flavor are arduous, tepor, enters the heart, kidney two warps, has wind-damp dispelling, the meridian dredging, and the function of regulating the flow of vital energy, controls anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.Select Caulis Akebiae to be because its nature and flavor are bitter, cool, enter the heart, small intestinal, urinary bladder channel, have pathogenic fire purging row water, the function of promoting blood circulation, controls hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Select Fructus Crataegi to be because its nature and flavor acid is sweet, tepor, enters spleen, stomach, Liver Channel, has to help digestion long-pendingly, and dissipating blood stasis blood, drives the function of edge worm, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's also eats stagnation.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature, enters liver, stomach warp, invigorates blood circulation, and dissipating blood stasis, regulates the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select Radix Arnebiae (Radix Lithospermi) to be because its nature and flavor earnestly, cold, enter percardium, Liver Channel, have removing heat from blood, invigorate blood circulation, the function of heat-clearing and toxic substances removing, controls warm macule, jaundice due to damp-heat, purpura, tells, nosebleed, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Herba Portulacae 15-25 gram of Semen Plantaginis 15-25 gram of Herba Hedyotidis Diffusae 10-20 gram
Radix Gentianae 10-20 gram of Radix Et Rhizoma Rhei 10-20 gram of Herba Violae 10-20 gram
Preparatum Glycyrrhizae 10-20 gram of Radix Salviae Miltiorrhizae 10-20 Ke Rhizoma Dioscoreae Septemlobae 10-20 gram
Scorpio 5-15 gram of Radix Rhapontici 5-15 gram of Folium Isatidis 5-15 gram
Squama Manis 5-15 gram of Flos Lonicerae 5-15 gram of Radix et Caulis Opuntiae Dillenii 5-15 gram
Rhizoma Osmundae 15-25 gram of Radix Glycyrrhizae 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Semen Plantaginis 15-25 gram of Fructus Hordei Germinatus 15-25 cron bone 15-25 gram
Herba Lophatheri 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram of Haematitum 15-25 gram
Semen Trichosanthis 10-20 gram of Herba Cayatiae Japonicae 10-20 gram of Indigo Naturalis 10-20 gram
Rhizoma Alismatis 15-25 gram of Caulis Piperis Kadsurae 15-25 gram of Caulis Akebiae 15-25 gram
Fructus Crataegi 10-20 gram of Rhizoma Corydalis 10-20 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram
Preferable amount is
15 grams of 20 grams of Herba Hedyotidis Diffusaes of 20 grams of Semen Plantaginiss of Herba Portulacae
15 grams of 15 grams of Herba Violaes of 15 grams of Radix Et Rhizoma Rhei of Radix Gentianae
15 grams of 15 grams of Radix Salviae Miltiorrhizaes of Preparatum Glycyrrhizae, 15 Ke Rhizoma Dioscoreae Septemlobae
10 grams of 10 grams of Folium Isatidiss of 10 grams of Radix Rhapontici of Scorpio
10 grams of 10 grams of Radix et Caulis Opuntiae Dilleniis of 10 grams of Flos Loniceraes of Squama Manis
20 grams of 20 grams of Rhizoma Polygoni Cuspidati of 20 grams of Radix Glycyrrhizaes of Rhizoma Osmundae
20 grams, 20 grams of Fructus Hordei Germinatus of Semen Plantaginis, 20 cron bone
20 grams of 20 grams of Haematitums of 20 grams of Rhizoma Atractylodis Macrocephalaes of Herba Lophatheri
15 grams of 15 grams of Indigo Naturaliss of 15 grams of Herba Cayatiae Japonicaes of Semen Trichosanthis
20 grams of 20 grams of Caulis Akebiaes of 20 grams of Caulis Piperis Kadsuraes of Rhizoma Alismatis
15 grams of 15 grams of Radix Arnebiae (Radix Lithospermi)s of 15 grams of Rhizoma Corydalis of Fructus Crataegi
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Portulacae: choose clean impurity, remove undesirable root, slightly moisten with water, cutting is dried;
2, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
3, Herba Hedyotidis Diffusae: get crude drug, remove impurity, wash quickly is clean, slightly dries in the air, and cutting is dry, sieve dedust bits;
4, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
5, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
6, Herba Violae: get crude drug, remove impurity, clean, slightly dry in the air, cutting, dry;
7, Preparatum Glycyrrhizae: choose decontamination, select dry not mould Preparatum Glycyrrhizae;
8, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
9, Rhizoma Dioscoreae Septemlobae: remove impurity, section, cleans, and soaks, and runs through, dry, and sieve removes chip;
10, Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
11, Radix Rhapontici: choose clean impurity, unhairing is cleaned, and runs through, and section, dries;
12, Folium Isatidis: choose decontamination and dead leaf, clean, slightly moisten, cutting, dries;
13, Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and fry to easily, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
14, Flos Lonicerae: sieve removes silt, chooses clean impurity;
15, Radix et Caulis Opuntiae Dillenii: extract according to quantity fresh Radix et Caulis Opuntiae Dillenii;
16, Rhizoma Osmundae: slightly soak with clear water, take out, each watering sooner or later once, softens, and section, dries;
17, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
18, Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
19, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
20, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;
21, Os Draconis: outwash earth, smash;
22, Herba Lophatheri: choose decontamination and root, cutting, dries;
23, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
24, Haematitum: remove impurity, smash, sieve;
25, Semen Trichosanthis: get crude drug, remove impurity and fruit stem, clean, flatten, shredding or fritter, dry;
26, Herba Cayatiae Japonicae: summer, autumn gather, and dry;
27, Indigo Naturalis: choose decontamination, sieve;
28, Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;
29, Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, takes out and puts profit 16-24 hour in square-bottomed bamboo basket, and section, dries;
30, Caulis Akebiae: water slightly soaks, moistening, to thoroughly, is cut into slices, and dries;
31, Fructus Crataegi: get the Fructus Crataegi that chooses clean, put in pot and fry and be faint yellow taking-up to outside with slow fire, cool;
32, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
33, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries.
Two, preparation
1, by the Herba Portulacae of described weight, Semen Plantaginis, Herba Hedyotidis Diffusae, Radix Gentianae, Radix Et Rhizoma Rhei, Herba Violae, Preparatum Glycyrrhizae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Septemlobae, Scorpio, Radix Rhapontici, Folium Isatidis, Squama Manis, Flos Lonicerae, Radix et Caulis Opuntiae Dillenii, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Semen Plantaginis, Fructus Hordei Germinatus, Os Draconis, Herba Lophatheri, the Rhizoma Atractylodis Macrocephalae, Haematitum, Semen Trichosanthis, Herba Cayatiae Japonicae, Indigo Naturalis, Rhizoma Alismatis, Caulis Piperis Kadsurae, Caulis Akebiae, Fructus Crataegi, Rhizoma Corydalis, arnebia medicinal decocts with water secondary, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, the medicinal residues after filtering are for the first time added to 5 times of amounts of water, decoct boiling, then use slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time.
3, twice decoction liquor mixed, be divided into 6 doses and take.
Medicine of the present invention has heat-clearing and toxic substances removing, loose blood detumescence, and blood circulation and promoting silt, anti-inflammatory anti-itch, the effect of parasite killing, treatment herpes zoster instant effect, short treating period, do not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 173 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation
Before dermexanthesis, can there be slightly the General Symptomies such as weak, low grade fever, poor appetite, the conscious burning sensation of illing skin or neuralgia, that touches has an obvious Hyperalgesia, continues 1～3 day, can absence of prodrome be also dermexanthesis.Predilection site is followed successively by intercostal nerves, cervical nerves, nervi trigeminus and waist sacral nerves domination region.There is flushing speckle in affected part Chang Shouxian, occurs that very soon foxtail millet grain is to the pimple of Semen Glycines size, and bunch shape distributes and do not merge, and then becomes rapidly vesicle, and tonic vesicle wall is shinny, limpid vesicle fluid, and periphery is around with blush, and between each bunch of vesicle group, skin is normal; Skin lesion is banded along a certain peripheral nerve to be arranged, and mostly occurs in a side of health, is generally no more than median line.Neuralgia is one of primary disease feature, can or follow skin lesion to occur at premorbid, and gerontal patient is often comparatively violent.General 2～3 weeks of the course of disease, vesicle is dry, incrustation leaves temporary light red speckle or pigmentation after coming off.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 5 days was a course for the treatment of, took continuously 4 courses for the treatment of.
4, efficacy assessment standard
Effective: herpes zoster is eliminated, observe after half a year without recurrence;
Take a turn for the better: herpes zoster symptom is clearly better;
Invalid: symptom, without improvement, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, by the banded herpes patient of Drug therapy of the present invention 173 examples, effective 161 examples of result, obvious effective rate is 93.06%, 10 examples that take a turn for the better, and improvement rate is 5.78%, invalid 2 examples, total effective rate is 98.84%.
Claims (3)
1. a medicine for the treatment of herpes zoster, is characterized in that: it is to be made by the crude drug in following weight range:
Herba Portulacae 15-25 gram of Semen Plantaginis 15-25 gram of Herba Hedyotidis Diffusae 10-20 gram
Radix Gentianae 10-20 gram of Radix Et Rhizoma Rhei 10-20 gram of Herba Violae 10-20 gram
Preparatum Glycyrrhizae 10-20 gram of Radix Salviae Miltiorrhizae 10-20 Ke Rhizoma Dioscoreae Septemlobae 10-20 gram
Scorpio 5-15 gram of Radix Rhapontici 5-15 gram of Folium Isatidis 5-15 gram
Squama Manis 5-15 gram of Flos Lonicerae 5-15 gram of Radix et Caulis Opuntiae Dillenii 5-15 gram
Rhizoma Osmundae 15-25 gram of Radix Glycyrrhizae 15-25 gram of Rhizoma Polygoni Cuspidati 15-25 gram
Semen Plantaginis 15-25 gram of Fructus Hordei Germinatus 15-25 cron bone 15-25 gram
Herba Lophatheri 15-25 gram of Rhizoma Atractylodis Macrocephalae 15-25 gram of Haematitum 15-25 gram
Semen Trichosanthis 10-20 gram of Herba Cayatiae Japonicae 10-20 gram of Indigo Naturalis 10-20 gram
Rhizoma Alismatis 15-25 gram of Caulis Piperis Kadsurae 15-25 gram of Caulis Akebiae 15-25 gram
Fructus Crataegi 10-20 gram of Rhizoma Corydalis 10-20 gram of Radix Arnebiae (Radix Lithospermi) 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
15 grams of 20 grams of Herba Hedyotidis Diffusaes of 20 grams of Semen Plantaginiss of Herba Portulacae
15 grams of 15 grams of Herba Violaes of 15 grams of Radix Et Rhizoma Rhei of Radix Gentianae
15 grams of 15 grams of Radix Salviae Miltiorrhizaes of Preparatum Glycyrrhizae, 15 Ke Rhizoma Dioscoreae Septemlobae
10 grams of 10 grams of Folium Isatidiss of 10 grams of Radix Rhapontici of Scorpio
10 grams of 10 grams of Radix et Caulis Opuntiae Dilleniis of 10 grams of Flos Loniceraes of Squama Manis
20 grams of 20 grams of Rhizoma Polygoni Cuspidati of 20 grams of Radix Glycyrrhizaes of Rhizoma Osmundae
20 grams, 20 grams of Fructus Hordei Germinatus of Semen Plantaginis, 20 cron bone
20 grams of 20 grams of Haematitums of 20 grams of Rhizoma Atractylodis Macrocephalaes of Herba Lophatheri
15 grams of 15 grams of Indigo Naturaliss of 15 grams of Herba Cayatiae Japonicaes of Semen Trichosanthis
20 grams of 20 grams of Caulis Akebiaes of 20 grams of Caulis Piperis Kadsuraes of Rhizoma Alismatis
15 grams of 15 grams of Radix Arnebiae (Radix Lithospermi)s of 15 grams of Rhizoma Corydalis of Fructus Crataegi.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Herba Portulacae: choose clean impurity, remove undesirable root, slightly moisten with water, cutting is dried;
(2) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
(3) Herba Hedyotidis Diffusae: get crude drug, remove impurity, wash quickly is clean, slightly dries in the air, and cutting is dry, sieve dedust bits;
(4) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(5) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
(6) Herba Violae: get crude drug, remove impurity, clean, slightly dry in the air, cutting, dry;
(7) Preparatum Glycyrrhizae: choose decontamination, select dry not mould Preparatum Glycyrrhizae;
(8) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(9) Rhizoma Dioscoreae Septemlobae: remove impurity, section, cleans, and soaks, and runs through, dry, and sieve removes chip;
(10) Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
(11) Radix Rhapontici: choose clean impurity, unhairing is cleaned, and runs through, and section, dries;
(12) Folium Isatidis: choose decontamination and dead leaf, clean, slightly moisten, cutting, dries;
(13) Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and fry to easily, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
(14) Flos Lonicerae: sieve removes silt, chooses clean impurity;
(15) Radix et Caulis Opuntiae Dillenii: extract according to quantity fresh Radix et Caulis Opuntiae Dillenii;
(16) Rhizoma Osmundae: slightly soak with clear water, take out, each watering sooner or later once, softens, and section, dries;
(17) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly time to eighty per cant, run through section, airing;
(18) Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;
(19) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
(20) Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;
(21) Os Draconis: outwash earth, smash;
(22) Herba Lophatheri: choose decontamination and root, cutting, dries;
(23) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(24) Haematitum: remove impurity, smash, sieve;
(25) Semen Trichosanthis: get crude drug, remove impurity and fruit stem, clean, flatten, shredding or fritter, dry;
(26) Herba Cayatiae Japonicae: summer, autumn gather, and dry;
(27) Indigo Naturalis: choose decontamination, sieve;
(28) Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;
(29) Caulis Piperis Kadsurae: former medicine is put in clear water and soaked 30-60 minute, takes out and puts profit 16-24 hour in square-bottomed bamboo basket, and section, dries;
(30) Caulis Akebiae: water slightly soaks, moistening, to thoroughly, is cut into slices, and dries;
(31) Fructus Crataegi: get the Fructus Crataegi that chooses clean, put in pot and fry and be faint yellow taking-up to outside with slow fire, cool;
(32) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(33) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;
(2) preparation
(1) by the Herba Portulacae of described weight, Semen Plantaginis, Herba Hedyotidis Diffusae, Radix Gentianae, Radix Et Rhizoma Rhei, Herba Violae, Preparatum Glycyrrhizae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae Septemlobae, Scorpio, Radix Rhapontici, Folium Isatidis, Squama Manis, Flos Lonicerae, Radix et Caulis Opuntiae Dillenii, Rhizoma Osmundae, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Semen Plantaginis, Fructus Hordei Germinatus, Os Draconis, Herba Lophatheri, the Rhizoma Atractylodis Macrocephalae, Haematitum, Semen Trichosanthis, Herba Cayatiae Japonicae, Indigo Naturalis, Rhizoma Alismatis, Caulis Piperis Kadsurae, Caulis Akebiae, Fructus Crataegi, Rhizoma Corydalis, arnebia medicinal decocts with water secondary, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time,
(2) medicinal residues after filtering are for the first time added to 5 times of amounts of water, decoct boiling, then use slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time;
(3) twice decoction liquor mixed, be divided into 6 doses and take.
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| CN102357155A (en) * | 2011-10-27 | 2012-02-22 | 潘根起 | Traditional Chinese medicine combination for treating herpes zoster |
| CN102552492A (en) * | 2012-01-12 | 2012-07-11 | 山东省千佛山医院 | Traditional Chinese medicinal composition for treating herpes zoster and preparation method thereof |
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| CN102357155A (en) * | 2011-10-27 | 2012-02-22 | 潘根起 | Traditional Chinese medicine combination for treating herpes zoster |
| CN102552492A (en) * | 2012-01-12 | 2012-07-11 | 山东省千佛山医院 | Traditional Chinese medicinal composition for treating herpes zoster and preparation method thereof |
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