CN103637349B - Functional beverage capable of removing dampness and tonifying deficiency and preparation method thereof - Google Patents

Functional beverage capable of removing dampness and tonifying deficiency and preparation method thereof Download PDF

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CN103637349B
CN103637349B CN201310697557.0A CN201310697557A CN103637349B CN 103637349 B CN103637349 B CN 103637349B CN 201310697557 A CN201310697557 A CN 201310697557A CN 103637349 B CN103637349 B CN 103637349B
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mesona herb
chinese mesona
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CN103637349A (en
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许淑清
王静芝
黄永文
莫桂坚
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Guangxi Shuangqian Health Industry Co ltd
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DOUBLE COINS Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention discloses a functional beverage capable of removing dampness and tonifying deficiency and a preparation method thereof. The functional beverage is prepared from following raw materials in parts by weight: Chinese mesona herb powder, tortoise plastrons, poria cocos, angelica sinensis, jujubes, rhizoma zingiberis, cassia twigs, amomum tsao-ko, pericarpium citri reticulatae, white hyacinth beans and glycyrrhiza uralensis. The functional beverage is simple to manufacture, convenient to drink and fresh in mouth feel; the functional beverage is easily favored by people and can be used as daily health protection tea to be usually drunk.

Description

Drinks of a kind of clearing damp qi-restoratives and preparation method thereof
Technical field
The present invention relates to field of medicaments, be specifically related to drinks of a kind of clearing damp qi-restoratives and preparation method thereof.
Background technology
Chinese should be food with five cereals, but Modern human populations is after life condition improvement, and carnivorous excessive, amount of exercise is few, strongly fragrant in health overabundant YIN leading to insufficient YANG, damp evil, for a long time like this, injury be taste.Insufficiency of the spleen then loose stool, makes moisture in body pent up simultaneously and does not fall apart.
Cold-dampness is overweight is the source of ten thousand diseases, and at the wind caused a disease, cold, heat, wet, dry, in fiery this " six evil ", the traditional Chinese medical science is afraid of damp evil most.The most easily permeate because wet.Damp evil never fights a lone battle, and always will act in collusion with each other with other perverse trend.Meet to tremble with fear when moisture and then become cold-dampness, moisture heat then becomes damp and hot, and moisture meets wind then becomes rheumatism.In body, moisture is overweight, can allow people feels sleepy, health four is heavy, not have appetite, trick is ice-cold, skin plays rash, glutinous greasy uncomfortable on the face, and even occur enterogastritis phenomenon, Oral symptoms is obvious, and tongue fur is thick in vain.Stomach is not good, lassitude, four limbs are heavy, skin plays measles, freckle increases the weight of this five kinds of symptoms, is the most typical performance that in body, moisture is overweight.
Theory of traditional Chinese medical science is thought: cold-dampness person, and gas phase that is wet and cold water is fought also, and the wet water of lid is similar, and it is rain and dew when YANG in universe, and be frost and snow time cloudy, be water at rivers, be wet in soil, and this source of body, is easy to be harmonious, the yang-energy of speaking sarcastically most.Accumulate in water paddy, the deficiency syndrome of the lung can not change gas, insufficiency of the spleen Tianjin of can not faling apart, or the cold drink of shape is cold, or empty in wine visitor.Inside and outside be harmonious, objective heresy both from show into, and lie prostrate heresy from interior also.Impairment of the spleen sun, in then not transport ruffian full, descend, stomachache is let out in hole.Injure one's stomach sun, then vomiting and regurgitation, pectoralgia that diaphragm is swollen.Two impairment of the spleens, existing spleen card, has again stomach to demonstrate,prove also.Damp being a kind of YIN pathogen, its sun of hurting sb.'s feelings also, obtain reason just, therefore many and common.Its moon of hurting sb.'s feelings also, is the change of gesture, Gu Han and rare.Controlling wet person must examine at what dirty through what, cold heat of holding concurrently of holding concurrently, and gas divides blood system, and go out Xin Liang, Xin Wen, Gan Wen, bitter temperature, lightly to ooze, hardship is oozed controls, multitudinous throw and must imitate.Control if general mixed, taste regardless of, negative and positive fever and chills are not distinguished, by seeing swelling, jaundice, hole are let out, bleeding from five sense organs or subcutaneous tissue, have blood in stool, all cards come in great numbers.
Guangdong, Guangxi one are with a kind of Traditional health care food--Guiling Jelly, it is the sliding lotion of perfume (or spice) made for raw material with Chinese mesona herb, tortoise, smilax, dandelion, eel grass, honeysuckle etc., have the good clearing heat and expelling damp effect of effect, and mouthfeel is good, sales range widens northern market gradually from south.But the Chinese medicine used due to traditional Guiling Jelly is how partially cold, it is wet to be mainly used in treatment heat, for crowd that is weakness of the spleen and the stomach, weaker, the poor appetite of physique at ordinary times, can cause increasing the weight of the symptoms such as trick is ice-cold, stomach cold, the deficiency of yang, diarrhoea after taking.
In order to adapt to the needs of different crowd, be necessary that a kind of Eradicates being applicable to cold-dampness crowd of exploitation wets qi-restoratives beverage, to meet the clearing damp needs of weakness of the spleen and the stomach crowd, make oral liquid formulations or other formulations can facilitate and take at any time simultaneously, make oral liquid formulations, when taking as beverage, have the function of quenching one's thirst concurrently.
Summary of the invention
The object of this invention is to provide a kind of drinks of clearing damp qi-restoratives;
Another object of the present invention is to provide a kind of preparation method of clearing damp qi-restoratives drinks.
The object of the invention is by following technical scheme realize:
The drinks of clearing damp qi-restoratives of the present invention is prepared from by the raw material comprising following weight portion: Chinese mesona herb 700-1200 part, tortoiseshell 10-30 part, Poria cocos 300-500 part, Radix Angelicae Sinensis 100-300 part, date 60-100 part, rhizoma zingiberis 50-100 part, cassia twig 30-80 part, tsaoko 30-80 part, Semen Lablab Album 80-150 part, dried orange peel 80-150 part, Radix Glycyrrhizae 120-200 part.
The drinks of clearing damp qi-restoratives of the present invention, its preferred version is prepared from by the raw material comprising following weight portion: Chinese mesona herb 800-1000 part, tortoiseshell 15-25 part, Poria cocos 400-500 part, date 70-90 part, rhizoma zingiberis 60-80 part, cassia twig 40-70 part, tsaoko 40-70 part, dried orange peel 90-120 part, Radix Glycyrrhizae 150-180 part.
The drinks of clearing damp qi-restoratives of the present invention, its further preferred version is prepared from by the raw material comprising following weight portion: Chinese mesona herb 800-1000 part, tortoiseshell 15-25 part, Poria cocos 400-500 part, Radix Angelicae Sinensis 150-200 part, date 70-90 part, rhizoma zingiberis 60-80 part, cassia twig 40-70 part, tsaoko 40-70 part, dried orange peel 90-120 part, Semen Lablab Album 100-120 part, Radix Glycyrrhizae 150-180 part.
The Chinese medicine details adopted in the present invention is as follows:
Chinese mesona herb: lip plant Chinese mesona herb platymiscium Mesona Chinensis Benth herb.
Tortoise: be Testudinidae animal tortoise.Return liver, kidney channel.The effect such as tortoise meat and tortoiseshell have nourishing and strengthening vital, removing toxic substances of drying, beneficial liver moistening lung, Yi Yin enrich blood.
Poria cocos: be the dry sclerotia of On Polyporaceae Poria cocos Poria Cocos (Schw.) Wolf.Gui Jing: thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Effect: sharp water medicine; Diuretics with the action of eliminating dampness.
Radix Angelicae Sinensis: umbelliferae angelica Angelica sinensis(Oliv.) root of Diels.Gui Jing: return liver, the heart, the spleen channel.Effect: enrich blood, invigorate blood circulation, moisturize laxation.
Date: this product is Rhamnaceae zizyphus jujube Ziziphus zizyphus..Have the effects such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach, red date has good therapeutic effect to illnesss such as chronic hepatitis, cirrhosis, anaemia, anaphylactoid purpuras; Red date contains triterpene compound and CAMP, has stronger anticancer, anti-allergic effects.Date can moisten cardiopulmonary, cough-relieving, tonifying five zang organs, it is deficient to control, except stomach addiction gas, support spleen, flat stomach Qi, logical nine orifices in can also pacifying, help 12 through etc.
Rhizoma zingiberis: ginger refers to the block rhizome of ginger, calls purple ginger, ginger, fresh ginger, old ginger.Warm in nature, its distinctive " gingerol " energy stimulating gastrointestinal mucous membrane, make gastrointestinal redness, digestion power strengthens, and effectively can treat the abdominal distension, stomachache, diarrhoea, vomiting etc. of eating cold and cool food and too much causing.
Cassia twig: be the dry spray of Lauraceae aiphyllium plant Chinese cassia tree CassiaTwig.Expelling cold and relieving exterior syndrome; Warming meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Numbness and ache of cold dampness; Peripheral coldness; Through closing stomachache; Abdominal mass lumps; The obstruction of qi in the chest; Palpitaition; Difficult urination.For anemofrigid cold, coldness and pain in the epigastrium, blood is cold through closing, joint pain, phlegm and retained fluid retaining, oedema, palpitaition.
Tsaoko: Zingiber Amomum plant Amomum tsaoko, another name SEMEN TSAOKO, SEMEN TSAOKO.Nature and flavor: taste is pungent, warm in nature, nontoxic.Gui Jing: enter the spleen channel, stomach warp.Function: eliminating dampness is except cold, and eliminate the phlegm preventing malaria, and help digestion helping digestion.
Dried orange peel: be the dry mature skin of rutaceae orange and variety thereof.Bitter, pungent, temperature.Return lung, the spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm.For chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum.
Semen Lablab Album: French beans taste sweet flavour enters the spleen stomach warp.Be tonifying spleen simply and do not grow greasy, dehumidifying and not dry strong invigorating the spleen for eliminating dampness good medicine, its nature and flavor are sweet micro-wet, enter taste two warp, have tonifying spleen and stomach, and middle dampness elimination, effect of relieve summer heating Detoxication,
Radix Glycyrrhizae: the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., glycyrrhiza inflate bat Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..Gas is micro-, and taste is sweet and special.Function cures mainly clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc.
Another aspect of the present invention there is provided the preparation method of inventive compound, and active ingredient of Chinese herbs of the present invention is by following preparation method's gained: Chinese mesona herb adds alcohol extract, and all the other 10 taste medicinal material extracting in waters, merge two kinds of extracts, to obtain final product.Concrete preparation method is as follows:
Get Chinese mesona herb and add alcohol extract 2-3 time that percent by volume is 50-80%, ethanol consumption is medicinal material weight 8-12 times amount, each 1-3 hour, merges extract, reclaims ethanol extremely without alcohol taste, add withdrawal liquid and amass the 1-5 water yield doubly, mixing, leaves standstill 12-48 hour, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.10-1.20, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2-3 time, add at every turn and be equivalent to medicinal material gross weight 8-12 water doubly, extract 1-3 hour, merge extract, filter, when being concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.05-1.10, add Chinese mesona herb alcohol extracting gained medicinal extract, mixing, obtains described active component.
The preparation method of inventive compound is preferably as follows:
Get Chinese mesona herb and add the alcohol extract 2 times that percent by volume is 60%, ethanol consumption is medicinal material weight 8-10 times amount, each 1-3 hour, merges extract, reclaims ethanol extremely without alcohol taste, add withdrawal liquid and amass the 2-4 water yield doubly, mixing, leaves standstill 16-36 hour, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.10-1.20, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2 times, add at every turn and be equivalent to medicinal material gross weight 8-10 water doubly, extract 1-3 hour, merge extract, filter, when being concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.05-1.10, add Chinese mesona herb alcohol extracting gained medicinal extract, mixing, obtains described active component.
The present invention program the formula based on traditional Guiling Jelly improves and obtains, and in order to keep the local flavor of Guiling Jelly, remains primary raw material tortoiseshell, Poria cocos, the Chinese mesona herb of Guiling Jelly.Owing to being rich in Chinese mesona herb polysaccharide in Chinese mesona herb, when getting by water extraction, Chinese mesona herb polysaccharide extracts in a large number from Chinese mesona herb, Chinese mesona herb polysaccharide is colloid, gel is condensed into after meeting starch, supernatant liquid cannot be prepared into, therefore Chinese mesona herb needs independent alcohol extract, and all the other medicinal material water extractions mix with Chinese mesona herb alcohol extract after getting again, then phenomenon of condensing can not occur.
The traditional Chinese medical science thinks that cold-dampness comprises diseases caused by external factors cold-dampness and Nei Sheng cold-dampness two aspects.Diseases caused by external factors cold-dampness: diseases caused by external factors pathogenic cold-damp, QI-blood circulation is obstructed, and take joint, arthralgia and myalgia as the syndrome of common disease; Interior raw cold-dampness: tired and damage spleen sun in cold-dampness, or the insufficiency of both the spleen and the kindey and stopping in cold-dampness, with aversion to cold and cold limbs, stomachache is had loose bowels, or edema is the syndrome of common disease.Rawly mostly be insufficiency of the spleen and cause.If cold that there was dampness in the air external just can cause human body insufficiency of the spleen and occur raw card, just has raw heresy in human body.
In side of the present invention, Poria cocos is sharp water Be very effective; Containing abundant Chinese mesona herb polysaccharide in Chinese mesona herb, after starch chain bond, the lotion of smooth in taste can be formed, and Chinese mesona herb there are heat, antipyretic sharp water function clearly, monarch drug in a prescription in the above two medicine sides of being; Radix Angelicae Sinensis has the effect of enriching blood, invigorating blood circulation; Jiang Xinwen, the warming intestines and stomach that can warmly fall apart are cold; Cassia twig warming meridian, activating YANG and prormoting functioning of QI; Tsaoko is drying damp and strengthening spleen, and dried orange peel can enter internal organs, change the heresy staying in the cold-dampness of internal organs; Semen Lablab Album enters taste two warp, has tonifying spleen and stomach, and middle dampness elimination, effect of relieve summer heating Detoxication, is to dehumidify and not dry strong invigorating the spleen for eliminating dampness good medicine, and above six medicine strengthening spleen and nourishing stomach, help loose cold-dampness, are ministerial drug in side; Tortoiseshell has the detoxicating functions that dries, and for insufficiency of vital energy and blood, malnutrition, date qi-restoratives benefit gas, strengthening the spleen and stomach, Radix Glycyrrhizae tonifying Qi, share to control from different medicine and cold cough wet phlegm.All medicines share above, invigorating the spleen qi-restoratives, clearing damp of dispeling cold, and mend the yang-energy of internal organs, many symptom spontaneous regressions that cold-dampness is caused.
The drinks of a kind of clearing damp qi-restoratives provided by the invention has the following advantages:
1, the present invention remove cause because of cold-dampness canker sore repeatedly, flow clear nasal mucus, diarrhoea, the on the face symptom such as long acne and spot have significant curative effect, clearing damp qi-restoratives Be very effective.
2, the oral liquid comfortable taste of this product, conveniently takes, and is easy to for crowd likes, can be used as daily health products and often eat, the fastness of not taking medicine, and can be beneficial in time and maintenance is taken, and drug effect is played better.
3, clinical test results shows, Chinese medicine of the present invention compares with Guiling Jelly on the market, and the successful for the treatment of cold-dampness is better than control group, and after treatment group and control group two groups of patient therapy, somatic feature score compares P value and is less than 0.05, has significant difference.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted.
Embodiment 1
Chinese mesona herb 700g, tortoiseshell 10g, Poria cocos 300g, Radix Angelicae Sinensis 300g, date 60g, rhizoma zingiberis 50g, cassia twig 30g, tsaoko 30g, dried orange peel 80g, Semen Lablab Album 150g, Radix Glycyrrhizae 120g.Get Chinese mesona herb and add the alcohol extract 2 times that percent by volume is 60%, each extraction ethanol consumption is respectively 12 times, 8 times amount of medicinal material weight, each extraction time is respectively 3 hours, 2 hours, merges extract, reclaims ethanol extremely without alcohol taste, add the water yield that withdrawal liquid amasss 5 times, mixing, leaves standstill 12 hours, filters, when filtrate is concentrated into 60 DEG C, relative density is the medicinal extract of 1.20, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2 times, add respectively at every turn and be equivalent to medicinal material gross weight 12 times, the water of 8 times, each extraction time is respectively 3 hours, 2 hours, merge extract, filter, when being concentrated into 60 DEG C, relative density is the medicinal extract of 1.10, adds Chinese mesona herb alcohol extracting gained medicinal extract, mixing, with rock sugar 27kg, adding water to gross weight is 450kg, obtains oral liquid of the present invention.
Embodiment 2
Chinese mesona herb 1200g, tortoiseshell 30g, Poria cocos 500g, Radix Angelicae Sinensis 100g, date 100g, rhizoma zingiberis 100g, cassia twig 80g, tsaoko 80g, dried orange peel 150g, Semen Lablab Album 80g, Radix Glycyrrhizae 200g.Get Chinese mesona herb and add the alcohol extract 3 times that percent by volume is 80%, each extraction ethanol consumption is respectively 12 times, 10 times, 8 times amount of medicinal material weight, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract, reclaims ethanol extremely without alcohol taste, add the water yield that withdrawal liquid amasss 1 times, mixing, leaves standstill 48 hours, filters, when filtrate is concentrated into 80 DEG C, relative density is the medicinal extract of 1.10, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 3 times, add respectively at every turn and be equivalent to medicinal material gross weight 12 times, the water of 10 times, 8 times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merge extract, filter, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.05, adds Chinese mesona herb alcohol extracting gained medicinal extract, mixing, with rock sugar 57kg, adding water to gross weight is 720kg, obtains oral liquid of the present invention.
Embodiment 3
Chinese mesona herb 800g, tortoiseshell 15g, Poria cocos 400g, Radix Angelicae Sinensis 150g, date 70g, rhizoma zingiberis 60g, cassia twig 40g, tsaoko 40g, dried orange peel 90g, Semen Lablab Album 100g, Radix Glycyrrhizae 150g.Get Chinese mesona herb and add the alcohol extract 3 times that percent by volume is 70%, each extraction ethanol consumption is respectively 10 times, 8 times, 8 times amount of medicinal material weight, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract, reclaims ethanol extremely without alcohol taste, add the water yield that withdrawal liquid amasss 2 times, mixing, leaves standstill 24 hours, filters, when filtrate is concentrated into 70 DEG C, relative density is the medicinal extract of 1.15, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 3 times, add respectively at every turn and be equivalent to medicinal material gross weight 10 times, the water of 10 times, 8 times, each extraction time is respectively 2 hours, 2 hours, 1 hour, merge extract, filter, when being concentrated into 70 DEG C, relative density is the medicinal extract of 1.05, adds Chinese mesona herb alcohol extracting gained medicinal extract, mixing, add white sugar 24.8kg, adding water to gross weight is 496kg, obtains oral liquid of the present invention.
Embodiment 4
Chinese mesona herb 1000g, tortoiseshell 25g, Poria cocos 500g, Radix Angelicae Sinensis 200g, date 90g, rhizoma zingiberis 80g, cassia twig 70g, tsaoko 70g, dried orange peel 120g, Semen Lablab Album 120g, Radix Glycyrrhizae 180g.Get Chinese mesona herb and add the alcohol extract 2 times that percent by volume is 60%, each extraction ethanol consumption is respectively 10 times, 8 times amount of medicinal material weight, each extraction time is respectively 3 hours, 1 hour, merges extract, reclaims ethanol extremely without alcohol taste, add the water yield that withdrawal liquid amasss 4 times, mixing, leaves standstill 36 hours, filters, when filtrate is concentrated into 80 DEG C, relative density is the medicinal extract of 1.10, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2 times, each adding respectively is equivalent to medicinal material gross weight 10 times, the water of 8 times, and each extraction time is respectively 3 hours, 1 hour, merges extract, filter, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.05, adds Chinese mesona herb alcohol extracting gained medicinal extract, mixing, adding water to gross weight is 650kg, obtains oral liquid of the present invention.
Embodiment 5
Chinese mesona herb 900g, tortoiseshell 20g, Poria cocos 450g, Radix Angelicae Sinensis 150g, date 80g, rhizoma zingiberis 70g, cassia twig 60g, tsaoko 60g, dried orange peel 100g, Semen Lablab Album 100g, Radix Glycyrrhizae 160g.Get Chinese mesona herb and add the alcohol extract 2 times that percent by volume is 70%, each extraction ethanol consumption is respectively 10 times, 8 times amount of medicinal material weight, each extraction time is respectively 2 hours, 2 hours, merges extract, reclaims ethanol extremely without alcohol taste, add the water yield that withdrawal liquid amasss 3 times, mixing, leaves standstill 16 hours, filters, when filtrate is concentrated into 60 DEG C, relative density is the medicinal extract of 1.10, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2 times, adds respectively at every turn and is equivalent to medicinal material gross weight 10 times, the water of 8 times, each extraction time is respectively 2 hours, 2 hours, merges extract, filters, when being concentrated into 60 DEG C, relative density is the medicinal extract of 1.20, adds Chinese mesona herb alcohol extracting gained medicinal extract, mixing, obtain active component of the present invention, crushed after being dried, add appropriate amount of starch and dextrin, mixing, granulates, dry, compressing tablet, obtains tablet of the present invention.
Embodiment 6
Chinese mesona herb 1000g, tortoiseshell 20g, Poria cocos 450g, Radix Angelicae Sinensis 150g, date 90g, rhizoma zingiberis 60g, cassia twig 70g, tsaoko 40g, dried orange peel 90g, Semen Lablab Album 110g, Radix Glycyrrhizae 180g.Get Chinese mesona herb and add the alcohol extract 3 times that percent by volume is 60%, each extraction ethanol consumption is respectively 10 times, 8 times, 8 times amount of medicinal material weight, each extraction time is respectively 2 hours, 2 hours, 1 hour, merges extract, reclaims ethanol extremely without alcohol taste, add the water yield that withdrawal liquid amasss 4 times, mixing, leaves standstill 18 hours, filters, when filtrate is concentrated into 80 DEG C, relative density is the medicinal extract of 1.20, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2 times, adds respectively at every turn and is equivalent to medicinal material gross weight 12 times, the water of 10 times, each extraction time is respectively 2 hours, 2 hours, merges extract, filters, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.20, adds Chinese mesona herb alcohol extracting gained medicinal extract, mixing, obtain active component of the present invention, crushed after being dried, adds appropriate amount of starch, silica, dolomol, makes particle, incapsulate, obtain capsule of the present invention.
Embodiment 7
Chinese mesona herb 900g, tortoiseshell 20g, Poria cocos 430g, Radix Angelicae Sinensis 160g, date 80g, rhizoma zingiberis 60g, cassia twig 70g, tsaoko 40g, dried orange peel 90g, Semen Lablab Album 90g, Radix Glycyrrhizae 180g, above 11 tastes, clean rear pulverizing, cross 80-100 mesh sieve, obtain pulvis of the present invention.
Clinical testing
Clinical observation is carried out to the curative effect of clearing damp qi-restoratives of the present invention, by observing the situation of change for the treatment of Patients Before And After curative effect and safety indexes, relatively treat the difference of efficacy and saferry between front and back and group for two groups, preliminary objective evaluation the present invention treats the Clinical efficacy and safety of cold-dampness type recurrent oral ulceration.
1 Standards of Chinese Medical Syndrome Differentiation: " traditional Chinese medical science throat stomatology ", " combination of Chinese tradiational and Western medicine ear,nose & throat ability to speak science "
1.1 primary symptoms: the mucous membrane at the places such as the lip in oral cavity, cheek, soft palate or gums occurs single or number is less, the circle differed in size or oval ulcer, Mild edema around, sore look dark red is or dim in canescence, local cusalgia is light, and duration of seizure is longer, indolence.
1.2 diseases: after food or afternoon abdominal distension, continuous and dull pain in the abdomen, meets warm must subtracting or disappear, and food is few indigestion and loss of appetite, and large loose stool or first hard rear half congealed, spiritlessness and sparing of words, sallow complexion, aversion to cold and cold limbs, mouth is light dull, and poor appetite, thirsty hot drink preference, n and V, urinates clearly.
1.3 tongue pictures: tongue is light fatly tenderly has indentation, white,slippery and moist fur.
1.4 pulse conditions: slow and sunken pulse or slow weak unable.
2 inclusive criterias
2.1 diagnostic criteria meeting doctor trained in Western medicine recurrent oral ulceration;
2.2 Chinese medical discriminations are spleen-stomach deficiency-cold;
2.3 ulcer at least every three months occur more than 1 time, these ulcer generation course of disease≤2 day;
Other Chinese medicines and corticosteroid, immunodepressant etc. is not taken in 2.43 months;
2.5 patient ages are between 18 years old to 65 years old.
2.6 voluntarily as study subject, and can accept to observe medicine, has ensured overall process.
3 exclusion standards
3.1 diagnostic criteria and the traditional Chinese medical science spleen-stomach deficiency-cold CM syndrome differentiation criterion not meeting doctor trained in Western medicine RAU, as traumatic ulcer, cancerous ulcer, infectious stomatitis, Behcet's disease and other ulcer persons;
3.2 merge the serious organic diseases of important organ such as cardiovascular and cerebrovascular disease, liver, kidney, hemopoietic system severe primary disease, mental patient, peptic ulcer, clone disease, acute infectious diseases, autoimmune disease, tumour etc.;
Use antalgesic in 3.324 hours, in January, use antibiotic, antiphlogistic, in March, use corticosteroid, immunodepressant;
3.4 allergic constitutions and to multi-medicament allergy sufferers;
3.5 purpose gestation or pregnant woman women breast-feeding their children.
4 tcm symptom classifications, standards of grading
With reference to related content in RAU in 2002 editions " new Chinese medicine guideline of clinical investigations " and syndrome of deficient cold of spleen and stomach Syndrome Scale quantization table, be mainly divided into light, in, weigh three grades.
Table 1 RAU Syndrome Scale quantitative criteria
The computational methods of ulcer area are the product of ulcer maximum gauge and its perpendicular diameter, add up its areal calculation with mm, and ulcer selects maximum and easy observer in oral cavity, chooses from big to small and is no more than at most 5.Pain is for feel ulcer place pain without patient in any stimulation situation.
5 RAU curative effect determinate standards: with reference to 2002 editions " new Chinese medicine guideline of clinical investigations "
Recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear, symptom, somatic feature score reduce >=95%.
Effective: tcm clinical practice symptom, sign all have clear improvement, symptom, somatic feature score reduce >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, symptom, somatic feature score reduce >=30%.
Invalid: tcm clinical practice symptom, sign are substantially without improvement, and symptom, somatic feature score reduce < 30%.
Note: symptom, somatic feature score reduce computing formula (Nimodipine method): [before (before treatment the rear integration of integration-treatment)/treatment integration] × 100%.
6 medicines
Experimental group: the embodiment of the present invention 5
Control group: Guiling Jelly, Guangxi Wuzhou Doublecoins Industry Co., Ltd.
7 clinical grouping and methods of treatments
Enter to organize the routine patient of case 100, man 48 example, female 52 example; All patients all meet traditional Chinese medical science spleen-stomach deficiency-cold canker sore diagnostic criteria, and case is divided into two groups at random.
Methods for the treatment of:
Experimental group: the embodiment of the present invention 5, drinks 200ml at every turn, one day twice, serve on 5 days;
Control group: Guiling Jelly, each serving with 250g, one day twice, serve on 5 days.
8 results
Result for the treatment of: grouping clinical treatment is carried out to 100 patients, treatment group and each 50 of control group, before and after treatment, RAU somatic feature score is compared as follows table:
Before and after table 2 treatment group and treatment of control group, oral cavity partial somatic feature score compares
Note: P value compares income value for somatic feature score after treatment group and control group two groups of patient therapy.
Table 2 result is pointed out: after two groups of patient therapy, oral cavity local disease damage, constitutional symptom and sign are all improved before comparatively treating, treatment group patient is obviously better than control group (P < 0.05) in treatment oral cavity partial symptom and sign, embodies the present invention and improves global advantage to treatment cold-dampness type recurrent oral ulceration after formula.
Model case:
The concrete Clinical practice case of Chinese medicine of the present invention:
1, Chen, man, 51 years old, main suit: two knees soreness, malaise, canker sore recurrent exerbation was difficult to recovery from illness.After diagnosing, it is empty that tcm syndrome belongs to taste two, asthenic fire floating upward.Answer warmly invigorating spleen and stomach, nourishing Yin and falling fire.Give the embodiment of the present invention 1, every day 2 times, each 200ml.After taking three days, ulcer is gradually good, has no new and sends out ulcer.After two weeks, two knees soreness, there is not canker sore repeatedly in malaise transference cure.Follow up a case by regular visits to one month, ulcer has no recurrence, is judged as recovery from illness.
2, Hu, female, 28 years old, main suit: easily cause canker sore to be shown effect during excessive fatigue, cold limbs is unable.After diagnosing, it is empty that tcm syndrome belongs to taste two, canker sore caused by insufficiency of vital energy and blood.Answer blood-enrich, nourishing Yin and falling fire.Give the embodiment of the present invention 3, every day 2 times, each 200ml.After taking three days, ulcer is good greatly, has no new and sends out ulcer.After two weeks, four limbs are gradually warm, and weak transference cure does not also occur canker sore repeatedly during excessive fatigue once in a while.Follow up a case by regular visits to one month, ulcer has no recurrence, is judged as recovery from illness.

Claims (6)

1. a drinks for clearing damp qi-restoratives, is characterized in that it is prepared from by the raw material of following weight portion: Chinese mesona herb 700-1200 part, tortoiseshell 10-30 part, Poria cocos 300-500 part, Radix Angelicae Sinensis 100-300 part, date 60-100 part, rhizoma zingiberis 50-100 part, cassia twig 30-80 part, tsaoko 30-80 part, Semen Lablab Album 80-150 part, dried orange peel 80-150 part, Radix Glycyrrhizae 120-200 part.
2. the drinks of clearing damp qi-restoratives as claimed in claim 1, is characterized in that it is prepared from by the raw material of following weight portion: Chinese mesona herb 800-1000 part, tortoiseshell 15-25 part, Poria cocos 400-500 part, Radix Angelicae Sinensis 150-200 part, date 70-90 part, rhizoma zingiberis 60-80 part, cassia twig 40-70 part, tsaoko 40-70 part, dried orange peel 90-120 part, Semen Lablab Album 100-120 part, Radix Glycyrrhizae 150-180 part.
3. the drinks of clearing damp qi-restoratives as claimed in claim 2, is characterized in that it is prepared from by the raw material of following weight portion: Chinese mesona herb 900 parts, tortoiseshell 20 parts, 450 parts, Poria cocos, Radix Angelicae Sinensis 150 parts, 80 parts, date, rhizoma zingiberis 70 parts, cassia twig 60 parts, tsaoko 60 parts, dried orange peel 100 parts, Semen Lablab Album 100 parts, 160 parts, Radix Glycyrrhizae.
4. the drinks of the clearing damp qi-restoratives as described in one of claim 1-3, is characterized in that it is prepared from by the following method: Chinese mesona herb adds alcohol extract, and all the other 10 taste medicinal material extracting in waters, merge two kinds of extracts, to obtain final product.
5. the drinks of clearing damp qi-restoratives as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get Chinese mesona herb and add alcohol extract 2-3 time that percent by volume is 50-80%, ethanol consumption is medicinal material weight 8-12 times amount, each 1-3 hour, merges extract, reclaims ethanol extremely without alcohol taste, add withdrawal liquid and amass the 1-5 water yield doubly, mixing, leaves standstill 12-48 hour, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.10-1.20, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2-3 time, add at every turn and be equivalent to medicinal material gross weight 8-12 water doubly, extract 1-3 hour, merge extract, filter, when being concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.05-1.10, add Chinese mesona herb alcohol extracting gained medicinal extract, mixing, obtains described active component.
6. the drinks of clearing damp qi-restoratives as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get Chinese mesona herb and add the alcohol extract 2 times that percent by volume is 60%, ethanol consumption is medicinal material weight 8-10 times amount, each 1-3 hour, merges extract, reclaims ethanol extremely without alcohol taste, add withdrawal liquid and amass the 2-4 water yield doubly, mixing, leaves standstill 16-36 hour, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.10-1.20, for subsequent use; All the other 10 taste medicinal materials except Chinese mesona herb, extracting in water 2 times, add at every turn and be equivalent to medicinal material gross weight 8-10 water doubly, extract 1-3 hour, merge extract, filter, when being concentrated into 60-80 DEG C, relative density is the medicinal extract of 1.05-1.10, add Chinese mesona herb alcohol extracting gained medicinal extract, mixing, obtains described active component.
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