CN103628167A - Method of preparing medical polypropylene monofilaments with improved biocompatibility - Google Patents
Method of preparing medical polypropylene monofilaments with improved biocompatibility Download PDFInfo
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- CN103628167A CN103628167A CN201310566933.2A CN201310566933A CN103628167A CN 103628167 A CN103628167 A CN 103628167A CN 201310566933 A CN201310566933 A CN 201310566933A CN 103628167 A CN103628167 A CN 103628167A
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Abstract
The invention relates to a method of preparing medical polypropylene monofilaments with improved biocompatibility and discloses a novel method of preparing medical polypropylene monofilaments with improved biocompatibility. The method comprises the following steps of: by adopting medical-level polypropylene slices and pearl powder as materials, fusing and extruding out monofilament fine flow by adopting a novel screw extruder after kneading by a kneading machine; winding and forming to obtain the modified polypropylene monofilaments containing pearl powder after water-bath cooling, solidifying, stretching and heat-setting. The monofilaments has diameters of 0.07 mm-0.20 mm, fineness of 35 dtex-300 dtex, breaking strength of 3.0 cN/dtex-5.0 cN/dtex and elongation at break of 15%-30%. The pearl powder content is 1%-5%, and cytotoxicity is graded as grade 0 through an MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method test. The product has good stability and uniformity, various mechanical performances reaching the level of the common medical-level polypropylene monofilaments, and biocompatibility superior to the common medical-level PP (Polypropylene) monofilaments.
Description
Technical field
The present invention relates to a kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement.
Background technology
Along with the development of material science, increasing material enters damaged as bio-medical material reparation partes corporis humani position of medical domain, and medical patch and suspender belt are exactly one of them.Medical patch and the suspender belt of current pure monofilament braiding obtain important application in department of general surgery.Be mainly used in the repairing of all kinds of hernias, female pelvic is rebuild and stress incontinence.Raw material as sticking patch and suspender belt has polypropylene type, polyesters, polytetrafluoroethylene (PTFE) class and glycolic acid class etc. at present.Wherein at present most widely used is polypropylene monofilament.But sticking patch and the suspender belt of polypropylene monofilament braiding exist some problems in application, and it can cause the stronger foreign body reaction of organizing, and causes some potential harm, such as chronic inflammation etc.In order effectively to solve sticking patch and the suspender belt of virgin pp monofilament establishment, there is inflammation problem, also there is no at present the exsertile modified polypropylene monofilaments of a kind of anti-inflammatory.
Modern pharmacological research shows that pearl powder contains 18 seed amino acids such as leucine, methionine, alanine, the calcium carbonate of aragonite structure, 20 various trace elements and Cobastab.Its effect is as follows respectively: threonine: the constituent of multiple enzyme; Serine: enhanced machine body immunity function; Glutamic acid: allergic dermatitis, insomnia; Glycine: beauty treatment, the cytothesis of promotion skin collagen; Cysteine: relevant with immunologic function, knot propylhomoserin: anti-ageing; Methionine: strengthen skin elasticity; Isoleucine: relevant with the growth of hair; Leucine: enhancing development; Taurine: there is good effects of tranquilizing and allaying excitement.Studies show that in addition pearl powder can also promote the growth of collagenocyte in human body, pearl powder also has more significant antiinflammation simultaneously, can inflammation-inhibiting cytothesis, prevent that wound from further worsening.Pearl powder is outer can fill tissue space for wound, is adhered vascular tissue, brings into play its anti-inflammatory, promotes the effect that collagenocyte is grown, and impels body cell regeneration.Studies show that in addition pearl powder can improve the ratio of periphery blood T lymphocyte significantly, strengthen the phagocytic function of peripheral blood neutrocyte and the ratio of raising hemolysin, this shows that pearl powder has the effect of certain enhancing immunologic function.
In known patent " Nano pearl powder polypropylene superfine Denier fibre and preparation method thereof ", the pearl powder that it relates to and polypropylene mixed process comprise: first will first make pearl powder aqueous dispersions, add again stabilizing agent, obtain nano-pearl flour complexes, then after compound and compatilizer are mixed together with polypropylene chip in double screw extruder granulation.Its process is quite numerous and diverse, and adds the additive except pearl powder, has improved to a certain extent cost.Owing to not mediating this process, what said method made contains in pearl powder polypropylene fibre, and pearl powder is present in fibrous inside in a large number, relatively less in fiber surface existence, has wasted to a certain extent pearl powder.And pearl powder and polypropylene fibre are not received the pressure producing in kneading process, the active force between pearl powder and polypropylene molecule is little, easily causes coming off of fiber surface pearl powder.
Summary of the invention
The object of this invention is to provide a kind of method of being prepared the polypropylene monofilament of bio-compatible property improvement by medical grade polypropylene pellet and pearl powder blend, require its mechanical property suitable with common medical grade polypropylene monofilament, by pearl powder modification polypropylene for medical article monofilament cytotoxicity, detecting this monofilament of proof has than the better cell compatibility of common medical grade polypropylene monofilament.The present invention adopts direct kneading mode in polypropylene, to sneak into pearl powder, method is simply efficient, and cost is lower, and pearl powder is present in polypropylene monofilament surface in a large number after mediating, make in use pearl powder directly act on surface, antimicrobial antiphlogistic effect is better.
A kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement of the present invention, comprises the following steps:
(1) blend of acrylic resin section and pearl powder;
Acrylic resin section is mediated to the blend that makes acrylic resin and pearl powder through kneader by weight 95-99:5-1 with pearl powder; Mediate temperature and be controlled at 50-100 ℃, kneading speed is controlled at 10-60r/min, and kneading time is controlled at 0.5-3h.
(2) melt extruding of blend prepared to monofilament;
The above-mentioned blend making is added to screw extruder, screw zones temperature is controlled at 210-270 ℃, filament spinning component temperature is controlled at 250-270 ℃, blend melt is controlled extruded velocity by measuring pump, it is cooling that melt thread after spinneret orifice enters water-bath, chilling temperature 20-40 ℃, in hot bath, stretch subsequently, temperature is at 85-95 ℃, draw ratio 3-7 doubly, shapes after stretching in hot-air, setting temperature 110-140 ℃, then the single fiber of take carries out coiling and molding, winding speed 120-140m/min as unit;
The fracture strength of the polypropylene for medical article monofilament of prepared bio-compatible property improvement is 3.0-5.0cN/dtex, elongation at break is 15-30%, hot water shrinkage is at 4-10%, and cytotoxicity is rated 0 grade, and under the same terms, cell proliferation is than the many 5-20% of conventional polypropylene monofilament.
As preferred technical scheme:
A kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement as above, the flow index MFI of described acrylic resin section
230 ℃/2.16kgfor 8-16g/10min.It is not high enough that melt melt index is greater than the resin fluid viscosity of 16g/10min, is unfavorable for that pearl powder mixes in polypropylene matrix; The shortcoming that melt melt melt index is less than 8g/10min is that spinning temperature is too high, can affect to a certain extent the biologically active of pearl powder.
A kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement as above, the particle diameter of described pearl powder is controlled at 100-1000nm.Pearl powder particle diameter is excessive, and blend melt pearl powder particle in the process by filter screen may be tackled by filter screen, can not get on the one hand the polypropylene for medical article monofilament of pearl powder modification, may cause on the other hand spinning machine internal pressure excessive, damages machine.The too little particle diameter of pearl powder particle diameter because of surface can too highly cause disperseing more difficult, moreover too small commodity are difficult to buy on market.
A kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement as above, the diameter of the polypropylene for medical article monofilament of described bio-compatible property improvement is 0.07-0.20mm, being equivalent to fiber number is 35-300dtex.
A kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement as above, describedly through kneader, mediate and to refer to the polypropylene for medical article of special ratios and pearl powder are put into clean kneader, with certain rotating speed, be uniformly mixed material, utilize interaction force between pearl powder and polypropylene granules surface to make pearl powder evenly be coated on polypropylene granules surface.
The invention has the beneficial effects as follows:
The pearl powder modification polypropylene for medical article monofilament of preparing in the present invention adds pearl powder in polypropylene for medical article monofilament to first, and pearl powder is evenly distributed in polypropylene for medical article monofilament surface.In addition, such polypropylene, after adding pearl powder, does not affect the mechanical property of polypropylene for medical article monofilament, and cytotoxicity is rated 0 grade, and the unit interval inner cell rate of increase is better than plain polypropylene monofilament.
Accompanying drawing explanation
Fig. 1 is blending single filament spinning line figure
Fig. 2 is that pearl powder is in blending single filament distribution of surface
Fig. 3 is modified polypropylene monofilaments leaching liquor L929 cellular morphology
1. melt spinning machine 2. head 3. bosh 4. first drawing roller 5. hot-stretch tank 6. second drawing roller wherein
7. air HEAT SETTING casing 8. coiler devices
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.In addition should be understood that those skilled in the art can make various changes or modifications the present invention after having read the content of the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1
With melt flow index (MFI)
230 ℃/2.16kgfor the medical grade polypropylene pellet of 8g/10min is raw material.The pearl powder of the polypropylene granules of 2kg and 30g (particle diameter 100nm) is put into kneader mediates at every turn.Mixing pellet (pearl powder content approximately 1.48%) after mediating directly adds to incorporate and in spinning machine 1, carries out spinning.Fig. 1 is blending single filament spinning line figure, by melt spinning machine 1, head 2, bosh 3, the first drawing roller 4, hot-stretch tank 5, the second drawing roller 6, air HEAT SETTING casing 7, coiler device 8. 8 major parts, formed, in spinning process, raw material is after melt spinning machine 1, through spinnerets, enter bosh 3, drawing and setting makes required pearl powder modified polypropylene monofilaments after reeling.
Kneading condition
Mediate temperature: 50 ℃
Kneading speed: 60r/min
Kneading time: 0.5h
Spinning condition
Screw rod 1-5 district temperature: 210/230/250/250/265/270 ℃
Filament spinning component temperature: 270 ℃
The hole diameter of spinneret: 3mm
85 ℃ of hot-stretch tank 5 temperature
Draw ratio: 3 times
Air HEAT SETTING casing 7 temperature: 110 ℃
This pearl powder modification polypropylene for medical article filament properties test result is as follows: fiber number is 70dtex, and fracture strength is 5.0cN/dtex, and elongation at break is 23.7%.
The distribution of pearl powder in monofilament: pearl powder is evenly distributed in this polypropylene surface.[Fig. 2]
By document mtt assay, evaluating the cytotoxicity of medical macromolecular materials evaluates the cytotoxicity of the polypropylene monofilament obtaining, the Growth of Cells situation test of this modified polypropylene monofilaments as shown in Figure 3, in the situation that this pearl powder monofilament exists, L-929 Growth of Cells form is good, L-929(l cell) cultivate Isosorbide-5-Nitrae, 7 days is 108% with respect to not containing the relative rate of increase of pearl powder polypropylene monofilament, 109%, 108%.
By 2 kilograms of melt index, being 12g/10min medical grade polypropylene pellet makes blend pellet through kneader, kneading condition respectively at 80 pearl powder (400nm)
Mediate temperature: 80 ℃
Kneading speed: 30r/min
Kneading time: 2h
Spinning condition
Screw rod 1-5 district temperature: 210/230/240/250/255/260 ℃
Filament spinning component temperature: 260 ℃
The hole diameter of spinneret: 3mm
90 ℃ of hot-stretch tank 5 temperature
Draw ratio: 7 times
Air HEAT SETTING casing 7 temperature: 140 ℃
Be spun into pearl powder content and be 4% modified polypropylene monofilaments.
Properties test demonstration, this modification polypropylene for medical article filament number is 200dtex, the fracture strength of monofilament is 4.5cN/dtex, elongation at break 27%.
Mtt assay cytotoxicity test result shows, this pearl powder modification polypropylene for medical article monofilament is more conducive to the growth of cell, biologically active is fine, cytotoxicity is rated 0 grade, biologically active is also improved to some extent, and is more beneficial to L-929(l cell and PIEC(pig endothelial cell) growth.
The pearl powder modified polypropylene monofilaments of preparing by the present invention is applicable to produce medical patch and suspender belt.
By 3 batches of 2 kilograms of melt index be 16g/10min medical grade polypropylene pellet respectively at 20g, 60g, the pearl powder of 100g (1000nm) makes blend pellet through kneader, kneading condition
Mediate temperature: 100 ℃
Kneading speed: 10r/min
Kneading time: 3h
Spinning condition
Screw rod 1-5 district temperature: 210/230/240/240/245/250 ℃
Filament spinning component temperature: 250 ℃
The hole diameter of spinneret: 3mm
95 ℃ of hot-stretch tank 5 temperature
Draw ratio: 7 times
Air HEAT SETTING casing 7 temperature: 140 ℃
Be spun into the pearl powder modified polypropylene monofilaments (approximately 1%, 3%, 5%) of three kinds of specifications.
Properties is tested in Table 1, in table 1, shows, three kinds of modification polypropylene for medical article filament numbers are the same, and along with the increase of pearl powder content, the fracture strength of monofilament and elongation at break significantly do not change, respectively within the scope of 4.0-4.3cN/dtex and 15-30%.
Mtt assay cytotoxicity test [table 2-5] result shows, polypropylene for medical article monofilament after pearl powder modification is more conducive to the growth of cell, biologically active is fine, cytotoxicity is rated 0 grade, and within the specific limits, along with the raising of pearl powder content, biologically active is also improved to some extent, and is more beneficial to L-929(l cell and PIEC(pig endothelial cell) growth.The pearl powder modified polypropylene monofilaments of preparing by the present invention is applicable to produce medical patch and suspender belt.
Table 1 pearl powder blend PP monofilament mechanical property
| Pearl powder content % | 0% | 1 | 3 | 5 |
| Fiber number dtex | 150 | 150 | 150 | 150 |
| Ultimate strength cN | 637 | 641 | 633 | 638 |
| Elongation at break % | 25 | 24 | 22 | 26 |
| Intensity cN/dtex | 4.2 | 4.3 | 4.2 | 4.3 |
The table 2 pearl powder blend PP monofilament relative rate of increase of leaching liquor L929 (492nm)
The table 3 pearl powder blend PP monofilament relative rate of increase of leaching liquor L929 (570nm)
The table 4 pearl powder blend PP monofilament relative rate of increase of leaching liquor PIEC (492nm)
The table 5 pearl powder blend PP monofilament relative rate of increase of leaching liquor PIEC (570nm)
Claims (5)
1. a method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement, is characterized in that comprising the following steps:
(1) blend of acrylic resin section and pearl powder;
Acrylic resin section and pearl powder are mediated through kneader by weight 95-99:5-1, made the blend of acrylic resin and pearl powder; Mediate temperature and be controlled at 50-100 ℃, kneading speed is controlled at 10-60r/min, and kneading time is controlled at 0.5-3h;
(2) melt extruding of blend prepared to monofilament;
The above-mentioned blend making is added to screw extruder, screw zones temperature is controlled at 210-270 ℃, blend melt is controlled extruded velocity at 10r/min-30r/min by measuring pump, it is cooling that melt thread after spinneret orifice enters water-bath, filament spinning component temperature is controlled at 250-270 ℃, chilling temperature 20-40 ℃, in hot bath, stretch subsequently, temperature is at 85-95 ℃, draw ratio 3-7 doubly, shapes after stretching in hot-air, setting temperature 110-140 ℃, then the single fiber of take carries out coiling and molding, winding speed 120-140m/min as unit; The fracture strength of the polypropylene for medical article monofilament of prepared bio-compatible property improvement is 3.0-5.0cN/dtex, and elongation at break is 15-30%, and cytotoxicity is rated 0 grade.
2. a kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement according to claim 1, is characterized in that, the flow index MFI of described acrylic resin section
230 ℃/2.16kgfor 8-16g/10min.
3. a kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement according to claim 1, is characterized in that, the particle diameter of described pearl powder is controlled at 100-1000nm.
4. a kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement according to claim 1, is characterized in that, the diameter of the polypropylene for medical article monofilament of described bio-compatible property improvement is 0.07-0.20mm.
5. a kind of method of preparing the polypropylene for medical article monofilament of bio-compatible property improvement according to claim 1, it is characterized in that, describedly through kneader, mediate and to refer to the polypropylene for medical article of special ratios and pearl powder are put into clean kneader, with certain rotating speed, be uniformly mixed material, utilize interaction force between pearl powder and polypropylene granules surface to make pearl powder evenly be coated on polypropylene granules surface.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109680361A (en) * | 2018-12-25 | 2019-04-26 | 摩登大道时尚集团股份有限公司 | A kind of dedicated hot melting cohesion antibacterial monofilament of seamless hot pressing clothes and preparation method thereof |
| CN112011844A (en) * | 2020-08-04 | 2020-12-01 | 南通新帝克单丝科技股份有限公司 | Medical polypropylene monofilament, product and preparation method thereof |
| CN113679875A (en) * | 2021-08-31 | 2021-11-23 | 长春圣博玛生物材料有限公司 | Absorbable medical operation line and preparation method thereof |
| CN115094531A (en) * | 2022-08-11 | 2022-09-23 | 青岛融美发制品集团有限公司 | Preparation process of antibacterial shape memory simulation hair |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109680361A (en) * | 2018-12-25 | 2019-04-26 | 摩登大道时尚集团股份有限公司 | A kind of dedicated hot melting cohesion antibacterial monofilament of seamless hot pressing clothes and preparation method thereof |
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| CN113679875A (en) * | 2021-08-31 | 2021-11-23 | 长春圣博玛生物材料有限公司 | Absorbable medical operation line and preparation method thereof |
| CN115094531A (en) * | 2022-08-11 | 2022-09-23 | 青岛融美发制品集团有限公司 | Preparation process of antibacterial shape memory simulation hair |
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