CN103623084B - Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition is composed of xanthium sibiricum, radix bupleuri, prunella vulgaris, cortex fraxini, garden balsam, pawpaw, cortex periplocae, magnolia cortex and exocarpium benincasae. By defining the compositions and corresponding ratio of the traditional Chinese medicine composition and employing the preparation method of the traditional Chinese medicine composition, the traditional Chinese medicine composition has substantial effect on treatment of rheumatoid arthritis, has no side effect and is not easy to cause recurrence and low in cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof.
Background technology
The typical performance of rheumatic arthritis is slight or moderate heating, migratory polyarthritis, affected joints mostly is the large joint such as knee joint, ankle, shoulder, elbow wrist, commonly be transferred to another joint by a joint; pathological changes local presents redness, scorching hot, severe pain some patients also has several joint to fall ill simultaneously; atypical patient only has arthralgia and shows without other inflammation, and acute inflammation generally disappears in 2-4 week and do not stay sequela, but normal recurrent exerbation.If active rheumatism affects heart, myocarditis can be there is and even leave over valve disorder.
One is that joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change is usually the large joints of lower limb such as knee joint, hip, ankle, and be secondly shoulder, elbow, carpal joint, the Minor articulus of brothers is rare.Two is that pain migration is indefinite, and a period of time is the outbreak of this joint, and a period of time is that joint is uncomfortable, but durante dolors is not long, within several days, just can disappear.Blood chemical examination erythrocyte sedimentation rate is accelerated, and anti-" 0 " titre raises, rheumatoid factor negative.Seldom recurrence after curing, deformity is not stayed in joint, and some patients can leave over heart change.
Rheumatism is medically the chronic pain of articulations digitorum manus and surrounding soft tissue's unknown cause thereof.Rheumatism then refers to that the different but common ground of a large class cause of disease is for involving joint and surrounding soft tissue, comprises the disease of flesh, ligament, synovial bursa, fascia.Arthropathy has pain outer still with swelling and moving obstacle, in outbreak with the alleviation chronic course of disease alternately.Because the blood circulation of patient is obstructed, cause muscle or the nutrition required for tissue cannot be carried by blood circulation, cause that patient muscle lacks nutrition and accelerated ageing becomes stiff, serious meeting causes patient muscle and blood vessel die back, some patients and can occur disabling and viscera function exhaustion in joint.
Now for rheumatic arthritis, be generally the method taking western medicine, be difficult to be effected a radical cure, easily recur.The general curative effect of existing Chinese medicine composition is not very remarkable.
Summary of the invention
The invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis and preparation method thereof, by limiting composition and the proportioning thereof of Chinese medicine composition, and the preparation method of Chinese medicine composition, the product that the present invention is obtained for rheumatic arthritis treatment has remarkable result, and is free from side effects, be not easy recurrence, cost is low.
The invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthritis, Chinese medicine composition is made up of the raw material of following weight parts: Herba Xanthii grass 25-30g, Radix Bupleuri 20-25g, Spica Prunellae 20-25g, Cortex Fraxini 15-20g, Flos Impatientis 10-15g, Fructus Chaenomelis 25-30g, Cortex Periplocae 20-25g, Cortex Magnoliae Officinalis 10-15g, Exocarpium Benincasae 25-30g.
Preferred scheme is that Chinese medicine composition is made up of the raw material of following weight parts: Herba Xanthii grass 27g, Radix Bupleuri 23g, Spica Prunellae 22g, Cortex Fraxini 18g, Flos Impatientis 13g, Fructus Chaenomelis 26g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 12g, Exocarpium Benincasae 28g.
Preferred scheme is that Chinese medicine composition also comprises Herba Pteridis Multifidae 23g.
Preferred scheme is that Chinese medicine composition also comprises Cortex Cinnamomi 22g.
Preferred scheme is that Chinese medicine composition also comprises Radix Glycyrrhizae 28g.
Present invention also offers a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthritis, comprise the steps:
(1) above-mentioned raw materials is divided into A group and B group, A group is Herba Xanthii grass, Spica Prunellae, Cortex Fraxini, Cortex Periplocae, Cortex Magnoliae Officinalis, and B group is all the other compositions;
(2) A group raw material extracts through conventional water extraction process, makes extractum fine powder;
(3) B group raw material is ground into fine powder, mixes, stir with above-mentioned extractum fine powder, as required, makes Chinese medicinal granule, powder, capsule.
The application of the Chinese medicine composition that the present invention obtains in preparation treatment rheumatoid arthritis agents.
The application in treatment medicine for treating rheumatoid arthritis is being prepared when the Chinese medicine composition that the present invention obtains adds Herba Pteridis Multifidae.
The application in treatment rheumatic fever medicine is being prepared when the Chinese medicine composition that the present invention obtains adds Cortex Cinnamomi.
The application in treatment ankylosing spondylitis medicine is being prepared when the Chinese medicine composition that the present invention obtains adds Radix Glycyrrhizae.
The present invention is suitable for rheumatoid arthritis patients, after adding different compositions, has good curative effect to rheumatoid arthritis, rheumatic fever and ankylosing spondylitis.Product of the present invention have treatment cycle short, be free from side effects, be not easy to recur, feature that cost is low.
Detailed description of the invention
The present invention is further detailed explanation below.
Embodiment 1
Formula 1: Herba Xanthii grass 27g, Radix Bupleuri 23g, Spica Prunellae 22g, Cortex Fraxini 18g, Flos Impatientis 13g, Fructus Chaenomelis 26g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 12g, Exocarpium Benincasae 28g
Formula 2: Herba Xanthii grass 26g, Radix Bupleuri 23g, Spica Prunellae 23g, Cortex Fraxini 17g, Flos Impatientis 12g, Fructus Chaenomelis 28g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 14g, Exocarpium Benincasae 26g
Formula 3: Herba Xanthii grass 28g, Radix Bupleuri 24g, Spica Prunellae 22g, Cortex Fraxini 16g, Flos Impatientis 14g, Fructus Chaenomelis 26g, Cortex Periplocae 24g, Cortex Magnoliae Officinalis 14g, Exocarpium Benincasae 28g
Formula 4: Herba Xanthii grass 27g, Radix Bupleuri 23g, Spica Prunellae 22g, Cortex Fraxini 18g, Flos Impatientis 13g, Fructus Chaenomelis 26g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 12g, Exocarpium Benincasae 28g, Herba Pteridis Multifidae 23g
Formula 5: Herba Xanthii grass 27g, Radix Bupleuri 23g, Spica Prunellae 22g, Cortex Fraxini 18g, Flos Impatientis 13g, Fructus Chaenomelis 26g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 12g, Exocarpium Benincasae 28g, Cortex Cinnamomi 22g
Formula 6: Herba Xanthii grass 27g, Radix Bupleuri 23g, Spica Prunellae 22g, Cortex Fraxini 18g, Flos Impatientis 13g, Fructus Chaenomelis 26g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 12g, Exocarpium Benincasae 28g, Radix Glycyrrhizae 28g
Preparation method is as follows:
(1) raw material in above-mentioned each formula is divided into A group and B group, A group is Herba Xanthii grass, Spica Prunellae, Cortex Fraxini, Cortex Periplocae, Cortex Magnoliae Officinalis, and B group is all the other compositions;
(2) A group raw material extracts through conventional water extraction process, makes extractum fine powder;
(3) B group raw material is ground into fine powder, mixes, stir with above-mentioned extractum fine powder, as required, makes Chinese medicinal granule, powder, capsule.
Embodiment 2
Zhang, man, 43 years old, finds trouble rheumatic arthritis in 2005, and SCID Mice is red and swollen, bitterly, limitation of activity, within 2010, start to take Chinese medicine composition of the present invention after 2 weeks, redness alleviates, pain relief, by the 5th week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 1, a point morning and evening takes for twice, takes clothes every day.
Field, man, 48 years old, finds trouble rheumatic arthritis in 2006, knee joint, ankle, shoulder, elbow joint be red and swollen, bitterly, limitation of activity, within 2010, start to take Chinese medicine composition of the present invention after 3 weeks, redness alleviates, pain relief, by the 5th week, recover normal, do not recur so far.Take the granule that mode is made according to above-mentioned formula 2, a point morning and evening takes for twice, takes clothes every day.
Grandson, female, 55 years old, calendar year 2001 found trouble rheumatic arthritis, and knee joint, shoulder joint are red and swollen, bitterly, limitation of activity, within 2010, start to take Chinese medicine composition of the present invention after 2 weeks, redness alleviates, pain relief, by the 5th week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 3, a point morning and evening takes for twice, takes clothes every day.
As above, observe 100 patients altogether, all take aforesaid way to take medicine, find that cure rate is 62%, effective percentage is 96%, and inefficiency is 4%.
Criterion of therapeutical effect divide following what:
Cure: after treatment, clinical symptom disappearance;
Effective: after treatment, clinical symptoms is to some extent significantly improved.
Invalid: after treatment, clinical symptoms is slightly improved or without improvement.
Embodiment 3
Lu, female, 52 years old, finds trouble rheumatoid arthritis in 2005, interphalangeal joint, metacarpophalangeal joints swelling, pain, not easily activity, within 2010, start to take Chinese medicine composition of the present invention after 2 weeks, redness alleviates, pain relief, by the 6th week, recover normal, do not recur so far.Take the granule that mode is made according to above-mentioned formula 4, a point morning and evening takes for twice, takes clothes every day.
Lin, female, 55 years old, finds trouble rheumatoid arthritis in 2006, interphalangeal joint, carpal joint, toes arthroncus, pain, not easily activity, within 2010, start to take Chinese medicine composition of the present invention after 3 weeks, redness alleviates, pain relief, by the 6th week, recover normal, do not recur so far.Take the granule that mode is made according to above-mentioned formula 4, a point morning and evening takes for twice, takes clothes every day.
As above, altogether observe 20 routine patients, clinical symptom disappearance be 13 example, significantly alleviate be 4 example.Illustrate that formula 4 can be used as treatment rheumatoid arthritis.
Embodiment 4
Lee, female, 51 years old, finds trouble rheumatic fever in 2006, heating, erythra, arthritis, and within 2010, start to take Chinese medicine composition of the present invention after 2 weeks, symptom alleviates, and by the 6th week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 5, a point morning and evening takes for twice, takes clothes every day.
Tang, female, 53 years old, finds trouble rheumatic fever in 2006, heating, erythra, arthritis, and within 2010, start to take Chinese medicine composition of the present invention after 2 weeks, symptom alleviates, and by the 8th week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 5, a point morning and evening takes for twice, takes clothes every day.
As above, altogether observe 20 routine patients, clinical symptom disappearance be 13 example, significantly alleviate be 5 example.Illustrate that formula 5 can be used as treatment rheumatic fever.
Embodiment 5
Lin, female, 51 years old, finds trouble ankylosing spondylitis in 2006, the back of the body, waist, neck pain, arthralgia, and within 2010, start to take Chinese medicine composition of the present invention after 2 weeks, symptom alleviates, and by the 8th week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 6, a point morning and evening takes for twice, takes clothes every day.
Zhang, female, 53 years old, finds trouble ankylosing spondylitis in 2006, the back of the body, waist, neck pain, deformation of spinal column, and within 2010, start to take Chinese medicine composition of the present invention after 3 weeks, symptom alleviates, and by the tenth week, recovers normal, does not recur so far.Take the granule that mode is made according to above-mentioned formula 6, a point morning and evening takes for twice, takes clothes every day.
As above, altogether observe 20 routine patients, clinical symptom disappearance be 14 example, significantly alleviate be 5 example.Illustrate that formula 6 can be used as treatment ankylosing spondylitis.
Above content is the further description done it in conjunction with structure of the present invention and work process, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (4)
1. treat a Chinese medicine composition for rheumatic arthritis, it is characterized in that: described Chinese medicine composition is prepared from by the raw material of following weight parts: Herba Xanthii grass 25-30g, Radix Bupleuri 20-25g, Spica Prunellae 20-25g, Cortex Fraxini 15-20g, Flos Impatientis 10-15g, Fructus Chaenomelis 25-30g, Cortex Periplocae 20-25g, Cortex Magnoliae Officinalis 10-15g, Exocarpium Benincasae 25-30g.
2. the Chinese medicine composition for the treatment of rheumatic arthritis according to claim 1, is characterized in that: described Chinese medicine composition is prepared from by the raw material of following weight parts: Herba Xanthii grass 27g, Radix Bupleuri 23g, Spica Prunellae 22g, Cortex Fraxini 18g, Flos Impatientis 13g, Fructus Chaenomelis 26g, Cortex Periplocae 23g, Cortex Magnoliae Officinalis 12g, Exocarpium Benincasae 28g.
3. a preparation method for the Chinese medicine composition of the treatment rheumatic arthritis described in claim 1 or 2, comprises the steps:
(1) above-mentioned raw materials is divided into A group and B group, A group is Herba Xanthii grass, Spica Prunellae, Cortex Fraxini, Cortex Periplocae, Cortex Magnoliae Officinalis, and B group is all the other compositions;
(2) A group raw material extracts through conventional water extraction process, makes extractum fine powder;
(3) B group raw material is ground into fine powder, mixes, stir with above-mentioned extractum fine powder, as required, makes Chinese medicinal granule, powder, capsule.
4. the application of Chinese medicine composition according to claim 1 and 2 in preparation treatment rheumatoid arthritis agents.
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| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN1985906A (en) * | 2005-12-19 | 2007-06-27 | 张臣 | Specific medicine for treating rheumatism and bone spur |
| EP2070525A1 (en) * | 2007-12-11 | 2009-06-17 | DSM IP Assets B.V. | Compositions comprising Magnolol and/or Honokiol and chondroitin and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
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Patent Citations (4)
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|---|---|---|---|---|
| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN1985906A (en) * | 2005-12-19 | 2007-06-27 | 张臣 | Specific medicine for treating rheumatism and bone spur |
| EP2070525A1 (en) * | 2007-12-11 | 2009-06-17 | DSM IP Assets B.V. | Compositions comprising Magnolol and/or Honokiol and chondroitin and use thereof for the treatment, co-treatment or prevention of inflammatory disorders |
| CN102793729A (en) * | 2011-05-27 | 2012-11-28 | 江西中医学院 | Triptolide and chinese brake herb general flavone combined medicinal composition and preparation and application thereof |
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| 刘塔斯.香加皮.《袖珍中草药彩色图本》.湖南科学技术出版社,2007,(第1版),第186-187页. * |
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Inventor after: Hu Lili Inventor before: Zhang Lei |
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Effective date of registration: 20170907 Address after: 300450, No. 17, building 2002, Hebei Road, Tianjin Binhai New Area Patentee after: Hu Lili Address before: 315010 Zhejiang City, Haishu Province, lion street, Lane 95, room 1, No. 801, room Patentee before: Zhang Lei |
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