CN103611189B - A kind of bacteria inhibiting composition, embedded material and preparation method thereof - Google Patents
A kind of bacteria inhibiting composition, embedded material and preparation method thereof Download PDFInfo
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- CN103611189B CN103611189B CN201310593928.0A CN201310593928A CN103611189B CN 103611189 B CN103611189 B CN 103611189B CN 201310593928 A CN201310593928 A CN 201310593928A CN 103611189 B CN103611189 B CN 103611189B
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Abstract
The invention discloses a kind of bacteria inhibiting composition, the embedded material being coated with described bacteria inhibiting composition and preparation method thereof, described bacteria inhibiting composition comprises expanded PTFE and antibacterial.Described bacteria inhibiting composition is coated in embedded material by high-voltage electrostatic spinning technology and forms fungistatic coating, obtain the embedded material with bacteria resistance function.In bacteria inhibiting composition of the present invention, expanded PTFE effectively can fix antibacterial." duricrust " that utilize high-voltage electrostatic spinning to be formed is even if also can not there is swelling leakage under complex environment in vivo in structure, more effectively can fix antibacterial, antibacterial wherein is firmly combined with material, can not be released, bio-toxicity is low and have good biocompatibility.Preparation method of the present invention, technique is simple, be easy to operation, with low cost, be convenient to realize large-scale production.
Description
Technical field
The present invention relates to embedded material technical field, particularly relate to a kind of bacteria inhibiting composition, embedded material and preparation method thereof.
Background technology
Biomaterial and artificial organ are applied to clinical medicine more and more widely.In the society that science and technology constantly improves, almost everyone is at likely forever or temporarily implantable bioartificial material or artificial organ in vivo in life.As surgery sewing material, various invasive conduit, various tissue and organ for articles for use: artificial joint, Cardiac valve prosthesis, artificial intraocular lenses and even artificial heart-lung kidney etc.And the most important reason restricting these biomaterials of broader applications and artificial organ is the infection (Biomaterial-centeredinfection, BCI) centered by biomaterial.Therefore, about the research of the pathogenesis of BCI, Clinical symptoms, pathophysiological change and prevention, seemed more and more important.
BCI key factor is caused to be exactly bacteria planting.Various microorganism (antibacterial etc.) often falls human body from varying environment, and can settle down at certain position and constantly grow, raise up seed, and this phenomenon is commonly referred to " bacteria planting ".In general, be namely as the microorganism such as antibacterial or yeast forms biomembrane---the i.e. infectiousness cellular layer of stick-slip, glue sample.The microorganism of field planting must rely on human body constantly to supply nutrient substance ability Growth and reproduction, and then has an impact (infecting as caused) to human body.In order to prevent post-operative infection, usually first using the broad ectrum antibiotic of various brute force in the preoperative to patient, attempting to perform the operation under " absolutesterility " condition, to ensure successful surgery.Also can adopt narrow-spectrum antibiotic, remove a certain bacterioid targetedly.Embedded material, as a kind of foreign body, once infect, in most cases needs to be taken out, and particularly for the long period after implantation, the infected occurs, generally bacteria planting causes all slowly, and established fibrous capsule can hinder the performance of antibiotic effect.
Implantation material surface or structure are anticipated and microorganism cannot be adhered at implantation material surface, as one more widely means enjoy people to pay close attention to.Such as, the embedded material of script fine pore is made macrovoid size, as the PP hernia paster of macropore, macrophage can be entered effectively and between hole, to engulf the microorganism causing infecting, but this kind of method is for baroque orthopaedics implant or need the embedded material of high support strength to be inapplicable.And for example, implantation material surface applies some antibacterial material, as degradable chitosan, thus prevent antibacterial and yeast parasitic on a surface, hinder its field planting on a surface, but owing to belonging to bio-extract because of chitosan, be easy to there is foreign protein, therefore anaphylactic patient numbers increases, in addition, chitosan degradation speed is in vivo very fast, is disadvantageous for what prevent bacteria planting for a long time; Or, directly apply some antibacterial at implantation material surface thus stop bacteria planting, but these antibacterial also have cytotoxicity to a certain degree or bio-toxicity, release in various degree can be there is while antibacterial, antibacterial may be caused poisoning.Therefore, select rational fungistatic coating, stop Microorganism colonization to be have very much actual clinical meaning long-term effectively.
Summary of the invention
The object of the present invention is to provide a kind of bacteria inhibiting composition, the embedded material being coated with described bacteria inhibiting composition and preparation method thereof, this bacteria inhibiting composition is coated in implantation material surface and forms fungistatic coating, and antibacterial is wherein combined with material firmly, can not be released, bio-toxicity is low and have good biocompatibility; This preparation method can at implantation material surface homogeneous film formation, and it is combined with embedded material firmly, difficult drop-off, therefore good to the fixed effect of antibacterial.
For reaching this object, the present invention by the following technical solutions:
In first aspect, the invention provides a kind of bacteria inhibiting composition, comprise expanded PTFE and antibacterial.
Expanded PTFE (the expendedpolytetrafluoroethylene that the present invention adopts, ePTFE) there is complete biologically inert, the test of the biochemistry corrosion being exposed to aqueous environment, body temperature, blood and body fluid can be stood, and some complication that can effectively stop embedded material to cause, as the leaching of blood coagulation, rejection, infection and cytotoxic chemical thing, therefore ratified for the manufacture of long-term embedded material by food and drug administration (FoodandDrugAdministration, FDA).Described expanded PTFE is medical grade material, and the residual quantities such as heavy metal all should meet embedded material standard; Wherein, heavy metal total content (in lead) answers≤300 μ g/g, and monomer residue answers <2%, and catalyst residue answers <200 μ g/g.
Preferably, the weight average molecular weight of described expanded PTFE is 50,000 ~ 500,000, such as 50,000,60,000,80,000,100,000,120,000,150,000,180,000,200,000,240,000,250,000,270,000,300,000,320,000,350,000,380,000,400,000,420,000,450,000,480,000,490,000 or 500,000.
Preferably, described antibacterial is selected from solution-type antibacterial, parabens, cationic surfactant, alcohols antibacterial and metal species antibacterial.
More preferably, described solution-type antibacterial is selected from chlorhexidine acetate, A.SAP; Described parabens is selected from methyl hydroxybenzoate and ethyl hydroxybenzoate; Described cationic surfactant is selected from benzalkonium chloride and benzalkonium bromide; Described alcohols antibacterial is selected from chlorobutanol; Described metal species antibacterial is selected from nanometer silver and Nano-Zinc.
Above-mentioned antibacterial can be used alone one, also can combinationally use two or more, typical but the example combinations of indefiniteness comprises: chlorhexidine acetate and A.SAP, methyl hydroxybenzoate and ethyl hydroxybenzoate, benzalkonium chloride and benzalkonium bromide, benzalkonium chloride, benzalkonium bromide and chlorobutanol, nanometer silver and Nano-Zinc, chlorhexidine acetate and methyl hydroxybenzoate, ethyl hydroxybenzoate and benzalkonium chloride, benzalkonium bromide and chlorobutanol, etc.
Preferably, in described bacteria inhibiting composition, the weight of antibacterial is with expanded PTFE weighing scale 0.1%-1%, such as 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1.0%.
Preferably, described bacteria inhibiting composition also comprises dicyandiamide solution, and described dicyandiamide solution comprises chlorine trifluoride and/or chlorine pentafluoride.In the present invention, solvent can vapor away in final electrostatic spinning process, so bacteria inhibiting composition of the present invention can be the compositions comprising or do not comprise dicyandiamide solution.
In second aspect, the invention provides the preparation method of bacteria inhibiting composition as described in relation to the first aspect, described method comprises: be dissolved in dicyandiamide solution by described expanded PTFE, be mixed with solution, add described antibacterial, ultrasonic disperse also stirs and obtains described bacteria inhibiting composition.
Preferably, described dicyandiamide solution comprises DMF, described dicyandiamide solution also optionally comprise in oxolane (Tetrahydrofuran, THF), butanone and NaCl aqueous solution one or more.
Preferably, the concentration of expanded PTFE described in described solution is 5-20%(w/v), such as 6%(w/v), 8%(w/v), 10%(w/v), 12%(w/v), 14%(w/v), 16%(w/v), 18%(w/v) or 19%(w/v), wherein weight (w) is in unit of gram (g), volume is (v) in unit milliliter (mL), and weight/volume (w/v) is in unit grams per milliliter (g/mL).
Preferably, the time of described ultrasonic disperse is 10-20min, such as 12min, 14min, 16min, 18min or 19min.
Preferably, the time of described stirring is 2-5h, such as 2h, 2.5h, 3h, 3.5h, 4h, 4.5h or 5h.
By bacteria inhibiting composition prepared by said method, described expanded PTFE mixes with antibacterial is full and uniform, homogeneous film formation when being beneficial to high-voltage electrostatic spinning.
In the third aspect, the invention provides the embedded material that a kind of surface-coated has bacteria inhibiting composition as described in relation to the first aspect.
Preferably, described bacteria inhibiting composition is coated in its surface by high-voltage electrostatic spinning and obtains by described embedded material.
Expanded PTFE is due to its good biological and chemical stability, and optional dissolution solvent is less, and traditional solution plated film can cause coating uneven.The adhesion of this material and antibacterial is also more weak, utilize high-voltage electrostatic spinning, its special film-forming process is that fibrous external first solidifies, and " duricrust " of formation, even if structure also swelling leakage can not occur under complex environment in vivo, can fix antibacterial effectively; At the material surface homogeneous film formation of arbitrary shape, due to its nonwoven in form continuous film forming, thus can well can be combined with embedded material, difficult drop-off by adjustment electric field, injection stream.
Preferably, described embedded material is artificial joint, Cardiac valve prosthesis, artificial intraocular lenses, the artificial heart, artificial lung or artificial kidney.
In fourth aspect, the invention provides the preparation method of the embedded material as described in the third aspect, described method comprises:
Described bacteria inhibiting composition is injected syringe, add rustless steel syringe needle, voltage is adopted to be 10 ~ 30KV positive electric field high voltage power supply, maintenance solution flow rate is 1 ~ 5mL/h, receiving range is 5 ~ 25cm, connecting needing the embedded material of coating the negative electric field high voltage power supply that voltage is 100-800V, applying, finally by dry for embedded material room temperature in vacuo complete for coating 24-48h.
In the preparation method of above-mentioned embedded material, the voltage of positive electric field high voltage power supply can be 12KV, 15KV, 18KV, 22KV, 25KV, 27KV or 29KV; Solution flow rate can be 1.5mL/h, 2mL/h, 2.5mL/h, 3mL/h, 3.5mL/h, 4mL/h or 4.5mL/h; Receiving range can be 6cm, 7cm, 9cm, 11cm, 13cm, 15cm, 17cm, 19cm, 21cm, 23cm or 24cm; Negative electric field high voltage power supply can be 100V, 200V, 300V, 400V, 500V, 600V, 700V or 800V; The vacuum drying time can be 25h, 27h, 29h, 31h, 35h, 38h, 40h, 42h, 44h or 46h.
As an optimal technical scheme of the present invention, described method comprises:
(1) described expanded PTFE is dissolved in described dicyandiamide solution, being mixed with concentration is 5-20%(w/v) solution, add the antibacterial that weight content is the 0.1%-1% of described expanded PTFE weight content, ultrasonic disperse 10-20min, and stir 2-5h in 80-100 DEG C, obtain described bacteria inhibiting composition;
(2) solution of described bacteria inhibiting composition is injected syringe, add rustless steel syringe needle, voltage is adopted to be 10 ~ 30KV positive electric field high voltage power supply, maintenance solution flow rate is 1 ~ 5mL/h, receiving range is 5 ~ 25cm, connecting needing the embedded material of coating the negative electric field high voltage power supply that voltage is 100-800V, applying, finally by dry for embedded material room temperature in vacuo complete for coating 24-48h.
In the 5th, the invention provides the embedded material that the preparation method as described in fourth aspect obtains.
Beneficial effect of the present invention is: bacteria inhibiting composition of the present invention adopts expanded PTFE and antibacterial to combine, and wherein expanded PTFE effectively can fix antibacterial.In addition, utilize high-voltage electrostatic spinning, its special film-forming process is that fibrous external first solidifies, " duricrust " that formed is even if also can not there is swelling leakage under complex environment in vivo in structure, more effectively can fix antibacterial, in antibacterial insert material wherein, be not released completely, bio-toxicity is low and have good biocompatibility; Utilize high-voltage electrostatic spinning can at the implantation material surface homogeneous film formation of arbitrary shape, it be combined with embedded material firmly, difficult drop-off, therefore fabulous to the fixed effect of antibacterial; Preparation method of the present invention, technique is simple, be easy to operation, with low cost, be convenient to realize large-scale production.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail.It will be understood to those of skill in the art that following examples are only the preferred embodiments of the present invention, so that understand the present invention better, thus should not be considered as limiting scope of the present invention.For a person skilled in the art, the present invention can have various modifications and variations, within the spirit and principles in the present invention all, and any amendment done, equivalent replacement or improvement etc., all should be included within protection scope of the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method; Experiment material used, if no special instructions, is and is purchased available from routine biochemistry chemical reagent work.
Embodiment 1
Be prepared as follows the embedded material coating with bacteria resistance function:
(1) mixed solution of expanded PTFE and antibacterial is prepared: the expanded PTFE (ePTFE) of 200,000 molecular weight is dissolved in chlorine trifluoride, being mixed with concentration is 15%(W/V) mixed solution 20ml, add the chlorhexidine acetate solution 0.06ml that concentration is 10% wherein, calculate according to effective bacteriostatic ingredients, antibacterial weight content is with polymer weight 0.2%; Make it dispersed after ultrasonic 20 minutes, 80 DEG C are stirred 4 hours.
(2) prepare compound fungistatic coating: by above-mentioned mixed solution, inject 5ml glass mould syringe, add No. 5 rustless steel syringe needles, employing voltage is the positive electric field high voltage power supply of 25KV, and solution flow rate is 2mL/h, and receiving range is 18cm; In the rotatable metal conductor rod be connected needing the hernia paster of coating to be placed in voltage to be the negative electric field high voltage power supply of 100V, rotary speed is 100r/min, after spinning 10 meters, will apply complete material room temperature vacuum drying 24 hours, removing residual solvent, and preserve in 4 DEG C of drying baker.
According to ISO11737(2009) carry out bacteriostatic experiment, the fungistatic coating of above-mentioned preparation carried out antibacterial culturing after 3 days, and viable count can not be detected in surface, and surperficial bacteriostasis rate reaches more than 99.99%.In addition, be placed on half a year in the phosphate buffer (PBS solution) of 37 DEG C, the release of chlorhexidine acetate do not detected.According to GBT16886.5(2003) in BiologicalEvaluationofMedicalDevice the 5th part carry out vitro cytotoxicity test, in 3T6 cell culture experiments, 3T6 cell can not in coating material surface adhesion, well-grown in the cell culture fluid containing coating, well adherent with culture dish, prove the fungistatic coating obtained, can effectively stop biomembrane to be formed at implantation material surface, and have good biocompatibility.
Embodiment 2
Be prepared as follows the embedded material coating with bacteria resistance function:
(1) mixed solution of expanded PTFE and antibacterial is prepared: the expanded PTFE (ePTFE) of 50,000 molecular weight is dissolved in chlorine pentafluoride, being mixed with concentration is 20%(W/V) mixed solution 20ml, add the chlorhexidine acetate solution 0.04ml that concentration is 10% wherein, calculate according to effective bacteriostatic ingredients, antibacterial weight content is with polymer weight 0.1%; Make it dispersed after ultrasonic 10 minutes, 80 DEG C are stirred 3 hours.
(2) prepare compound fungistatic coating: by above-mentioned mixed solution, inject 5ml glass mould syringe, add No. 5 rustless steel syringe needles, employing voltage is the positive electric field high voltage power supply of 10KV, and solution flow rate is 5mL/h, and receiving range is 5cm; In the rotatable metal conductor rod be connected needing the hernia paster of coating to be placed in voltage to be the negative electric field high voltage power supply of 100V, rotary speed is 100r/min, after spinning 10 meters, will apply complete material room temperature vacuum drying 36 hours, removing residual solvent, and preserve in 4 DEG C of drying baker.
According to ISO11737(2009) carry out bacteriostatic experiment, the fungistatic coating of above-mentioned preparation carried out antibacterial culturing after 3 days, and viable count can not be detected in surface, and surperficial bacteriostasis rate reaches more than 99.99%.In addition, be placed on half a year in the phosphate buffer (PBS solution) of 37 DEG C, the release of chlorhexidine acetate do not detected.According to GBT16886.5(2003) in BiologicalEvaluationofMedicalDevice the 5th part carry out vitro cytotoxicity test, in 3T6 cell culture experiments, 3T6 cell can not in coating material surface adhesion, well-grown in the cell culture fluid containing coating, well adherent with culture dish, prove the fungistatic coating obtained, can effectively stop biomembrane to be formed at implantation material surface, and have good biocompatibility.
Embodiment 3
Be prepared as follows the embedded material coating with bacteria resistance function:
(1) mixed solution of expanded PTFE and antibacterial is prepared: the mixed solvent (wherein the volume ratio of chlorine trifluoride and chlorine pentafluoride the is 2:1) expanded PTFE (ePTFE) of 500,000 molecular weight being dissolved in chlorine trifluoride and chlorine pentafluoride, being mixed with concentration is 5%(W/V) mixed solution 20ml, add the Benza 0.1ml that concentration is 10% wherein, calculate according to effective bacteriostatic ingredients, antibacterial weight content is 1% of polymer weight content; Make it dispersed after ultrasonic 20 minutes, 100 DEG C are stirred 5 hours.
(2) prepare compound fungistatic coating: by above-mentioned mixed solution, inject 5ml glass mould syringe, add No. 5 rustless steel syringe needles, employing voltage is the positive electric field high voltage power supply of 30KV, and solution flow rate is 1mL/h, and receiving range is 25cm; In the rotatable metal conductor rod be connected needing the hernia paster of coating to be placed in voltage to be the negative electric field high voltage power supply of 800V, rotary speed is 100r/min, after spinning 10 meters, will apply complete material room temperature vacuum drying 48 hours, removing residual solvent, and preserve in 4 DEG C of drying baker.
According to ISO11737(2009) carry out bacteriostatic experiment, the fungistatic coating of above-mentioned preparation carried out antibacterial culturing after 3 days, and viable count can not be detected in surface, and surperficial bacteriostasis rate reaches more than 99.99%.In addition, be placed on half a year in the phosphate buffer (PBS solution) of 37 DEG C, the release of benzalkonium chloride do not detected.According to GBT16886.5(2003) in BiologicalEvaluationofMedicalDevice the 5th part carry out vitro cytotoxicity test, in 3T6 cell culture experiments, 3T6 cell can not in coating material surface adhesion, well-grown in the cell culture fluid containing coating, well adherent with culture dish, prove the fungistatic coating obtained, can effectively stop biomembrane to be formed at implantation material surface, and have good biocompatibility.
Embodiment 4
Be prepared as follows the embedded material coating with bacteria resistance function:
(1) mixed solution of expanded PTFE and antibacterial is prepared: the expanded PTFE (ePTFE) of 350,000 molecular weight is dissolved in chlorine trifluoride, being mixed with concentration is 10%(W/V) mixed solution 20ml, add the A.SAP solution 0.5ml that concentration is 1% wherein, calculate according to effective bacteriostatic ingredients, antibacterial weight content is with polymer weight 0.25%; Make it dispersed after ultrasonic 20 minutes, 90 DEG C are stirred 5 hours.
(2) prepare compound fungistatic coating: by above-mentioned mixed solution, inject 5ml glass mould syringe, add No. 5 rustless steel syringe needles, employing voltage is the positive electric field high voltage power supply of 20KV, and solution flow rate is 2mL/h, and receiving range is 18cm; In the rotatable metal conductor rod be connected needing the hernia paster of coating to be placed in voltage to be the negative electric field high voltage power supply of 100V, rotary speed is 100r/min, after spinning 10 meters, will apply complete material room temperature vacuum drying 24 hours, removing residual solvent, and preserve in 4 DEG C of drying baker.
According to ISO11737(2009) carry out bacteriostatic experiment, the fungistatic coating of above-mentioned preparation carried out antibacterial culturing after 3 days, and viable count can not be detected in surface, and surperficial bacteriostasis rate reaches more than 99.99%.In addition, be placed on half a year in the phosphate buffer (PBS solution) of 37 DEG C, the release of A.SAP do not detected.According to GBT16886.5(2003) in BiologicalEvaluationofMedicalDevice the 5th part carry out vitro cytotoxicity test, in 3T6 cell culture experiments, 3T6 cell can not in coating material surface adhesion, well-grown in the cell culture fluid containing coating, well adherent with culture dish, prove the fungistatic coating obtained, can effectively stop biomembrane to be formed at implantation material surface, and have good biocompatibility.
Applicant states, the present invention illustrates detailed features of the present invention and method detailed by above-described embodiment, but the present invention is not limited to above-mentioned detailed features and method detailed, namely do not mean that the present invention must rely on above-mentioned detailed features and method detailed could be implemented.Person of ordinary skill in the field should understand, any improvement in the present invention, to equivalence replacement and the interpolation of auxiliary element, concrete way choice etc. that the present invention selects component, all drops within protection scope of the present invention and open scope.
Claims (5)
1. a bacteria inhibiting composition, is characterized in that, described bacteria inhibiting composition comprises expanded PTFE and antibacterial; The preparation method of described bacteria inhibiting composition comprises: be dissolved in dicyandiamide solution by described expanded PTFE, and being mixed with concentration is 5-20% (w/v) solution, adds described antibacterial, and ultrasonic disperse also stirs and obtains described bacteria inhibiting composition; Described dicyandiamide solution comprises chlorine trifluoride and/or chlorine pentafluoride; The time of described ultrasonic disperse is 10-20min; The time of described stirring is 2-5h; The weight average molecular weight of described expanded PTFE is 60,000 ~ 480,000;
Described antibacterial is selected from chlorhexidine acetate, parabens, cationic surfactant, alcohols antibacterial or metal species antibacterial; In described bacteria inhibiting composition, the weight content of antibacterial is with expanded PTFE weighing scale 0.2%-0.9%.
2. bacteria inhibiting composition as claimed in claim 1, it is characterized in that, described parabens is selected from methyl hydroxybenzoate and ethyl hydroxybenzoate; Described cationic surfactant is selected from benzalkonium chloride and benzalkonium bromide; Described alcohols antibacterial is selected from chlorobutanol; Described metal species antibacterial is selected from nanometer silver and Nano-Zinc.
3. a surface-coated is just like the embedded material of the bacteria inhibiting composition described in any one of claim 1-2.
4. embedded material according to claim 3, is characterized in that, described bacteria inhibiting composition is coated in its surface by high-voltage electrostatic spinning and obtains by described embedded material;
Described embedded material is artificial joint, Cardiac valve prosthesis, artificial intraocular lenses, the artificial heart, artificial lung or artificial kidney.
5. the preparation method of embedded material according to claim 4, is characterized in that, described method comprises:
Described bacteria inhibiting composition is injected syringe, add rustless steel syringe needle, voltage is adopted to be 10 ~ 30KV positive electric field high voltage power supply, maintenance solution flow rate is 1 ~ 5mL/h, receiving range is 5 ~ 25cm, by needing the negative electric field high voltage power supply that the embedded material of coating and voltage are 100-800V to be connected, apply, finally by dry for embedded material room temperature in vacuo complete for coating 24-48h.
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| CN104389106A (en) * | 2014-11-12 | 2015-03-04 | 无锡中科光远生物材料有限公司 | Polytetrafluoroethylene superfine fiber film and preparation method thereof |
| CN104645943B (en) * | 2014-12-26 | 2017-02-01 | 张红梅 | Method for preparing renewable anti-bacteria fiber for adsorbing heavy metal motes |
| CN107158483A (en) * | 2017-07-12 | 2017-09-15 | 上海微特生物技术有限公司 | A kind of sterile working method for improving biodegradable stent systematic function |
| CN108641506B (en) * | 2018-04-19 | 2021-02-26 | 苏州诺升功能高分子材料股份有限公司 | Preparation method of polytetrafluoroethylene-based composite nano antibacterial dispersant |
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