CN103611005B - Medicine for treating chronic pharyngitis and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating chronic pharyngitis and a preparation method thereof. The medicine is mainly prepared from the following medicinal materials in a certain weight ratio: astragalus, bighead atractylodes rhizome, Chinese parsnip root, cocklebur fruit, silkworm larva, radix angelicae, fructus forsythiae, liquorice and platycodon grandiflorum. The medicine has the effects of clearing away heat and toxic materials, reducing phlegm and resolving masses and dispelling the wind and relieving pain, is fast in effectiveness in treatment of chronic pharyngitis and has a good curative effect, and the chronic pharyngitis does not reoccur.

Description

A kind of medicine for the treatment of chronic pharyngitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic pharyngitis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Chronic pharyngitis is under pharyngeal mucosa, mucosa and adenoid diffuse inflammation.Mainly due to acute pharyngolaryngitis treatment thorough recurrent exerbation, transfer to chronic, or because suffer from various cacorhinia, nose key blocks, long-term mouth breathing, and physics, chemical factor, neck radiotherapy etc. often stimulate pharyngeal caused by.The various chronic disease of whole body, as anemia, constipation, lower respiratory tract chronic inflammatory disease, cardiovascular disease etc. also can secondary primary disease.Because Western medicine effectively cannot treat chronic pharyngitis, and take Western medicine and have more side effect, costly, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment chronic pharyngitis, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment chronic pharyngitis, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment chronic pharyngitis.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Fructus Xanthii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Glycyrrhizae, Radix Platycodonis, Radix Scrophulariae, Radix Sophorae Tonkinensis, Radix Achyranthis, Calyx seu Fructus physalis, Semen Coicis, Pericarpium Citri Reticulatae, Semen Oroxyli, Rhizoma Dioscoreae medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat chronic pharyngitis.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Fructus Xanthii is selected to be that temperature, poisonous, enter lung, Liver Channel, have loose wind, pain relieving, damp eliminating, the function of parasite killing, controls headche due to wind-cold, nasal sinusitis, toothache, anemofrigid-damp arthralgia, four foot spasm and pain, mange, pruritus because its nature and flavor are sweet.Bombyx Batryticatus is selected to be because its nature and flavor are pungent salty, flat, enter liver, lung, stomach warp, have expelling wind to relieve convulsion, the function of dissipating phlegm and resolving masses, control apoplectic aphasia ， Jing Epilepsy, wind syndrome of head, acute throat trouble, sore throat, scrofula tuberculosis, wind skin ulcer urticaria, erysipelas, mastitis.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Fructus Forsythiae to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat clearing away, removing toxic substances, eliminating stagnation, the function of detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Select Radix Scrophulariae to be because its nature and flavor hardship is salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Radix Sophorae Tonkinensis to be because its nature and flavor are bitter, cold, enter the heart, lung, large intestine three warp, relieve inflammation or internal heat, removing toxic substances, detumescence, the function of pain relieving, controls retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, and heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.Select Radix Achyranthis to be because its property mildly bitter flavor, cool, return liver, kidney channel, have heat clearing away, removing toxic substances, the function of diuresis, cure cold heating, laryngopharynx swelling and pain, urinary system calculus, oedema due to nephritis.Select Calyx seu Fructus physalis to be because its nature and flavor acid, cold, enter liver, spleen two warp, have heat clearing away, removing toxic substances, the function of diuresis, controls hectic fever due to YIN-deficiency consumptive fever, cough, laryngopharynx swelling and pain, jaundice, edema, sky bubble eczema.Semen Coicis is selected to be that cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea because its property slightly sweet flavor.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Semen Oroxyli is selected to be that cold, enter lung, Liver Channel, have lung moistening, soothing liver-QI, stomach function regulating, the function of granulation promoting, controls cough, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach, and the open sore part is not held back because its nature and flavor are bitter.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, have spleen invigorating, tonifying the lung, reinforce the kidney, the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Radix Astragali 10-20 gram of Rhizoma Atractylodis Macrocephalae 8-18 gram of Radix Saposhnikoviae 10-18 gram

Fructus Xanthii 8-15 gram of Bombyx Batryticatus 8-15 gram of Radix Angelicae Dahuricae 10-20 gram

Fructus Forsythiae 10-22 gram of Radix Glycyrrhizae 5-15 gram of Radix Platycodonis 5-12 gram

Radix Scrophulariae 10-20 Keshan Radix Sophorae Tonkinensis 10-20 gram of Radix Achyranthis 10-20 gram

Calyx seu Fructus physalis 5-15 gram of Semen Coicis 12-25 gram of Pericarpium Citri Reticulatae 8-16 gram

Semen Oroxyli 5-12 Keshan medicine 10-20 gram

Be preferably

The Radix Astragali 15 grams of Rhizoma Atractylodis Macrocephalaes 12 grams of Radix Saposhnikoviaes 10 grams

Fructus Xanthii 12 grams of Bombyx Batryticatus 10 grams of Radixs Angelicae Dahuricae 10 grams

Fructus Forsythiae 12 grams of Radix Glycyrrhizaes 6 grams of Radix Platycodoniss 6 grams

Radix Scrophulariae 12 Keshan Radix Sophorae Tonkinensis 12 grams of Radix Achyranthis 12 grams

Calyx seu Fructus physalis 6 grams of Semen Coiciss 15 grams of Pericarpium Citri Reticulataes 10 grams

Semen Oroxyli 6 Keshan medicine 12 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

2, Rhizoma Atractylodis Macrocephalae (parched): first wheat bran is spread in hot pot, when time cigarette is emerged, Rhizoma Atractylodis Macrocephalae sheet is poured into micro-stir-fry to faint yellow, take out, cool after sieve removes wheat bran, every Rhizoma Atractylodis Macrocephalae sheet 100 jin, with 10 jin, wheat bran;

3, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

4, Fructus Xanthii: pick most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;

5, Bombyx Batryticatus (parched): be spread in hot pot with wheat bran, waits cigarette and rises, pour Bombyx Batryticatus into, fries to yellow, takes out sieve and removes wheat bran, cool, every Bombyx Batryticatus 100 jin, with 10 jin, wheat bran;

6, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

7, Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

8, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

9, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

10, Radix Scrophulariae: pick clean impurity, cleans and runs through, and section, dries;

11, Radix Sophorae Tonkinensis: pick clean impurity, thickness stepping, is soaked in water, and pulls out, runs through rear section, dries;

12, Radix Achyranthis: removing impurity, cleans, runs through, go reed, cutting, and dry, sieve removes chip;

13, Calyx seu Fructus physalis: autumn fruit maturation, Constellation calyx take on a red color or reddish yellow time take, remove fruit or dry together with fruit;

14, Semen Coicis (parched): get and pick clean Semen Coicis and put in pot and fry to micro-yellow with slow fire, take out, cool, or with wheat bran with frying, every Semen Coicis 100 jin, with 10 jin, wheat bran;

15, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

16, Semen Oroxyli: 10-12 month harvesting ripe fruit, takes out seed, dries or dry;

17, Rhizoma dioscoreae (parched): first by even for wheat bran spreading in hot pot, treat that cigarette rises, add yam slice and stir to faint yellow, take out, sieve remove wheat bran, cool, every yam slice 100, with 10 jin, wheat bran.

Two, prepare

1, the Radix Astragali of described weight, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Fructus Xanthii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Glycyrrhizae, Radix Platycodonis, Radix Scrophulariae, Radix Sophorae Tonkinensis, Radix Achyranthis, Calyx seu Fructus physalis, Semen Coicis, Pericarpium Citri Reticulatae, Semen Oroxyli, Rhizoma Dioscoreae are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.

2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.

3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 2 doses to take.

Medicine of the present invention has the function of heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, wind-expelling pain-stopping, is used for the treatment of chronic pharyngitis instant effect, good effect, does not recur.Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment, less than 30 years old 36 age example, 31-50 year 41 examples, more than 51 years old 23 is routine.

2, diagnostic criteria

Chronic pharyngitis is more common in adult, and child also can occur.General Symptoms is all not obvious, based on local symptom.As pharyngeal sense of discomfort, foreign body sensation, the not easily expectoration of pharyngeal secretions, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also hypodynia sense can be had.Because pharynx rear wall is usually because pharyngeal chronic inflammatory disease causes comparatively thick secretions to adhere to, and cause mouth breathing at night due to nose, nasal sinuses, nasopharynx pathological changes, occur irritable cough when morning of being everlasting rises and feel sick.Frequently swallow because foreign body in pharynx sense can show as.Pharyngeal secretions few and not easily expectoration person often show as habitually dry cough and action of coughing up phlegm of clearing one's throat, pharyngeal mucosa hemorrhage can be caused if firmly cough or clear one's throat, cause in secretions and be with blood.

3, Therapeutic Method

Selecting above-mentioned medicament, take to patient, every day 2 times, each 1 dose, decoction being taken warmly at twice, 15 days is a course for the treatment of, takes two courses for the treatment of continuously.

4, efficacy assessment standard

Effective: chronic pharyngitis symptom is fully recovered, recover normal;

Take a turn for the better: chronic pharyngitis symptom alleviates, and the state of an illness progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy patients with chronic pharyngitis 100 example of the present invention, effective 92 examples of result, obvious effective rate is 92%, and take a turn for the better 3 examples, and improvement rate is 3%, and invalid 5 examples, total effective rate is 95%.

Claims (3)

1. treat a medicine for chronic pharyngitis, it is characterized in that: it is made up of the crude drug in following weight range:

Radix Astragali 10-20 gram of Rhizoma Atractylodis Macrocephalae 8-18 gram of Radix Saposhnikoviae 10-18 gram

Fructus Xanthii 8-15 gram of Bombyx Batryticatus 8-15 gram of Radix Angelicae Dahuricae 10-20 gram

Fructus Forsythiae 10-22 gram of Radix Glycyrrhizae 5-15 gram of Radix Platycodonis 5-12 gram

Radix Scrophulariae 10-20 Keshan Radix Sophorae Tonkinensis 10-20 gram of Radix Achyranthis 10-20 gram

Calyx seu Fructus physalis 5-15 gram of Semen Coicis 12-25 gram of Pericarpium Citri Reticulatae 8-16 gram

Semen Oroxyli 5-12 Keshan medicine 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

The Radix Astragali 15 grams of Rhizoma Atractylodis Macrocephalaes 12 grams of Radix Saposhnikoviaes 10 grams

Fructus Xanthii 12 grams of Bombyx Batryticatus 10 grams of Radixs Angelicae Dahuricae 10 grams

Fructus Forsythiae 12 grams of Radix Glycyrrhizaes 6 grams of Radix Platycodoniss 6 grams

Radix Scrophulariae 12 Keshan Radix Sophorae Tonkinensis 12 grams of Radix Achyranthis 12 grams

Calyx seu Fructus physalis 6 grams of Semen Coiciss 15 grams of Pericarpium Citri Reticulataes 10 grams

Semen Oroxyli 6 Keshan medicine 12 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;

(2) Rhizoma Atractylodis Macrocephalae (parched): first wheat bran is spread in hot pot, when time cigarette is emerged, Rhizoma Atractylodis Macrocephalae sheet is poured into micro-stir-fry to faint yellow, take out, cool after sieve removes wheat bran, every Rhizoma Atractylodis Macrocephalae sheet 100 jin, with 10 jin, wheat bran;

(3) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(4) Fructus Xanthii: pick most impurity, deburring, sieve dedust bits, micro-stir-fry is to yellow, and taking-up cools;

(5) Bombyx Batryticatus (parched): be spread in hot pot with wheat bran, waits cigarette and rises, pour Bombyx Batryticatus into, fries to yellow, takes out sieve and removes wheat bran, cool, every Bombyx Batryticatus 100 jin, with 10 jin, wheat bran;

(6) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

(7) Fructus Forsythiae: pick clean impurity, stranding is opened, except discarding stalk;

(8) Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through section, dry;

(9) Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

(10) Radix Scrophulariae: pick clean impurity, cleans and runs through, and section, dries;

(11) Radix Sophorae Tonkinensis: pick clean impurity, thickness stepping, is soaked in water, and pulls out, runs through rear section, dries;

(12) Radix Achyranthis: removing impurity, cleans, runs through, go reed, cutting, and dry, sieve removes chip;

(13) Calyx seu Fructus physalis: autumn fruit maturation, Constellation calyx take on a red color or reddish yellow time take, remove fruit or dry together with fruit;

(14) Semen Coicis (parched): get and pick clean Semen Coicis and put in pot and fry to micro-yellow with slow fire, take out, cool, or with wheat bran with frying, every Semen Coicis 100 jin, with 10 jin, wheat bran;

(15) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

(16) Semen Oroxyli: 10-12 month harvesting ripe fruit, takes out seed, dries or dry;

(17) Rhizoma dioscoreae (parched): first by even for wheat bran spreading in hot pot, treat that cigarette rises, add yam slice and stir to faint yellow, take out, sieve remove wheat bran, cool, every yam slice 100, with 10 jin, wheat bran;

(2) prepare

(1) Radix Astragali of described weight, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae, Fructus Xanthii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, Fructus Forsythiae, Radix Glycyrrhizae, Radix Platycodonis, Radix Scrophulariae, Radix Sophorae Tonkinensis, Radix Achyranthis, Calyx seu Fructus physalis, Semen Coicis, Pericarpium Citri Reticulatae, Semen Oroxyli, Rhizoma Dioscoreae are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;

(2) add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;

(3) merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 2 doses to take.