CN103610454A - Blood pressure measurement method and system - Google Patents
Blood pressure measurement method and system Download PDFInfo
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Abstract
The invention discloses a blood pressure measurement method and system. The method comprises the following steps that a blood pressure measurement expression with correction factors is set according to the relationship between shear stress and the blood flow velocity V; characteristic parameters of the blood flow velocity V of a measured object are obtained, meanwhile the blood pressure reference value of the measured object is directly collected through a pressure gauge, and inverse calculation is conducted on the blood pressure measurement expression to obtain a correction factor value; when the practical blood pressure measurement is conducted, the correction factor value of the corresponding measured object is read from a database, and the blood pressure measuring result is calculated on the basis of the blood pressure measurement expression and the characteristic parameters, collected in real time, of the blood flow velocity. The blood pressure measurement method and system are simple, safe, convenient in test, and can achieve remote real-time monitoring of the blood pressure of the user, are good in real-time detection performance, can cope with various accidents of sudden illness of a blood-pressure-disease patient timely, eliminate the damage to the human body by a traditional direct measurement method, store the correction factors and characteristic constant values of the different measured objects for blood pressure calculation, and are high in measurement accuracy.
Description
Technical field
The present invention relates to a kind of blood pressure measuring method and system.
Background technology
Systemic arterial blood pressure is called for short blood pressure (blood pressure, BP).Blood pressure is blood while flowing in blood vessel, the pressure of vasoactive wall, and it is to promote blood mobile power in blood vessel.Ventricular systole, blood flows into tremulous pulse from ventricle, and now blood is the highest to the pressure of tremulous pulse, is called systolic pressure (systolic blood pressure, SBP).Ventricular diastole, arteries elastical retraction, blood still slowly continues to flow forward, but blood pressure drops, pressure is now called diastolic pressure (diastolic blood pressure, DBP).
Along with increasing of Hypertension incidence, sphygomanometer has been come into people's life, becomes one of household implements that a lot of people are indispensable, for early discovery hypertension and monitoring therapeuticing effect offer convenience.The method of Measure blood pressure has direct method and indirect method.The direct method of measurement has been again wound measurement method, namely by puncture, places the blood pressure recording after conduit in blood vessel, such as will monitor patient's invasive blood pressure when doing heart intervention diagnosis and treatment.With there being the direct Measure blood pressure of wound method, different because of surveyed position, method is different, can not reflect the blood pressure of human body completely.The indirect method of measurement is again non-invasive measurement method, namely by puncture in blood vessel, do not place conduit after but by the blood pressure indirectly recording.The indirect method of measurement is people's conventional methods at ordinary times, mainly measures the arteriotony of upper arm, and handling safety, convenience are the methods of Measure blood pressure conventional in Hospitals at Present and family, are divided into auscultation and oscillographic method.Auscultation is again Ke Shi sound method, is also divided into artificial Ke Shi sound method and electronics Ke Shi sound method.The blood pressure recording with auscultation can only be also an approximation, and its levels of precision and measuring technique have certain relation.Oscillographic method is also succusion, is a kind of more advanced electronic measuring method growing up the nineties.Such method of testing develops into the product that nowadays develops into various sphygomanometers.
Traditional blood pressure is in respect of electric sphygmomanometer, mercurial sphygmomanometer (piezometer), spring meter type blood pressure meter (piezometer).Electronic blood pressure in respect of arm-type, wrist formula minute; Its technology has experienced the development of the first generation (the most original arm-type and wrist formula) of " having gaseous core ", the second filial generation (arm-type use) of " without gaseous core " and the third generation (use of wrist formula).Mercurial sphygmomanometer (piezometer) and spring meter type blood pressure meter (piezometer), based on auscultation Measure blood pressure, must coordinate stethoscope, by doctor or nurse, are judged, draw the reading of systolic pressure, diastolic pressure.Wherein, China will be completely forbidden and use hydrargyrum in 2013, and mercurial sphygmomanometer will be withdrawn from the market gradually.On market, existing spring sphygomanometer and electric sphygmomanometer are all to utilize inflating pressures such as cuff, air bag or tracheas, after certain pressure (generally exceeding 30～50 mmHg than systolic pressure), stop pressurization, start venting, when air pressure to a certain extent, blood flow just can pass through blood vessel, and have certain wave of oscillation, the wave of oscillation propagates into pressure transducer by trachea, pressure sensing can detect pressure and the fluctuation in surveyed cuff in real time.Venting gradually, the wave of oscillation is increasing.Exit again because cuff is more loose with contacting of arm, so pressure and fluctuation that pressure transducer detects are more and more less.Selecting the maximum moment of fluctuation is reference point, take this point as basis, and finding is forward the fluctuation point of peak value 0.45, this point is systolic pressure, finding is backward the fluctuation point of peak value 0.75, and the corresponding pressure of this point is diastolic pressure, and the highest corresponding pressure of point of fluctuation is mean pressure.The pressure value degree of accuracy that this method of testing records is higher, but can cause extruding injury to blood vessel; And test has the inflation/deflation of carrying out at every turn, be difficult to frequent measurement or continuous measurement; Inflation/deflation is that general recommendations can not be moved, and also requires gauger to keep certain posture, as measured the back of the hand or wrist, requires sphygomanometer and heart to remain on sustained height horizontal line, therefore can not monitor in real time the blood pressure situation of human body.
Summary of the invention
In order to overcome the weak point of the prior art of above-mentioned indication, the invention provides a kind of blood pressure measuring method and system, safe to realize, convenient, accurately, the blood pressure of monitor user ' in real time.
The present invention is achieved by the following technical solutions:
A blood pressure measuring method, comprises the following steps:
S1, according to shearing stress
and the relation between velocity of blood flow V
, Re is Reynolds number, and ρ is density of blood, and the expression formula of setting blood pressure measurement is systolic pressure
=
, diastolic pressure
=
,
,
for correction factor;
S2, obtain the velocity of blood flow characteristic parameter of measuring object, utilize piezometer directly gather the blood pressure reference value of this measuring object and the expression formula of blood pressure measurement is carried out to reverse calculating after correction factor value simultaneously, correction factor value is stored in the data base who is subordinated to this measuring object;
S3, carry out actual blood pressure while measuring, from data base, reading the correction factor value of corresponding measuring object, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of the expression formula based on blood pressure measurement and Real-time Collection.
In step S1, described reynolds number Re adopts experience constant, or utilizes
calculate gained, the blood viscosity coefficient that η is measuring object, d is blood vessel diameter.
In step S2, available light Power Capacity pulse tracing obtains the velocity of blood flow characteristic parameter of measuring object, comprising:
S21, measurement recording light Power Capacity pulse wave signal obtain the waveform obtaining the real-time AD value of reflection blood flow after AD conversion
;
S22, the quadratic equation of setting up velocity of blood flow V are
, α, β, γ are correction factor, determine velocity of blood flow V=
.
In this embodiment, described step S21 adopts bounce technique or transmission measurement photoelectricity volume pulse wave signal.
Or in step S2, the velocity of blood flow characteristic parameter that obtains measuring object is to adopt ultrasonic Detection Method or laser detection method or pressure sensing detection method to gather velocity of blood flow V.
In described step S2, by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter, directly gather the systolic pressure of measuring object
and diastolic pressure
, recycling systolic pressure
and diastolic pressure
expression formula carry out, after the reverse correction factor value that calculates measuring object, this correction factor value being stored in data base.
Blood pressure measuring method of the present invention also comprises: set up in advance the data base of measuring object, gather density of blood ρ, blood viscosity coefficient η, the blood vessel diameter d of measuring object and be stored in data base as feature constant.
The invention also discloses a kind of blood pressure measuring system, comprising:
Expression formula derivation module, for according to shearing stress
and the relation between velocity of blood flow V
, Re is Reynolds number, and ρ is density of blood, and the expression formula of setting blood pressure measurement is systolic pressure
=
, diastolic pressure
=
,
,
for correction factor;
Data acquisition module, for obtaining the velocity of blood flow characteristic parameter of measuring object, utilize piezometer directly gather the blood pressure reference value of measuring object and the expression formula of blood pressure measurement is carried out to reverse calculating after correction factor value simultaneously, correction factor value is stored in the data base who is subordinated to this measuring object;
Result computing module for when carrying out actual blood pressure measurement, reads the correction factor value of corresponding measuring object, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of the expression formula based on blood pressure measurement and Real-time Collection from data base.
The velocity of blood flow characteristic parameter that described data acquisition module obtains measuring object is to adopt any in photoelectricity volume pulse tracing, ultrasonic Detection Method, laser detection method and pressure sensing detection method.
Blood pressure measuring system of the present invention also comprises a database initialize module, for setting up in advance the data base of measuring object, gathers density of blood ρ, blood viscosity coefficient η, the blood vessel diameter d of measuring object and is stored in data base as feature constant.
Compared with prior art, the present invention has that test is simple, safety, feature easily, by adopting the monitoring devices such as photoelectricity volume pulsation wave, ultrasound wave of portable can realize remote real time monitoring user's blood pressure; Because detection property is strong in real time, reduce the various accidents of blood pressure diseases patient sudden illness; Eliminate the injury of traditional direct measuring method to human body simultaneously; The correction factor and the feature constant calculating blood pressure that store different measuring objects, pointed, certainty of measurement is high.
Accompanying drawing explanation
The realization flow schematic diagram of the blood pressure measuring method that accompanying drawing 1 is an embodiment of the present invention;
Accompanying drawing 2 is the realization flow schematic diagram of the blood pressure measuring method of the another kind of embodiment of the present invention;
Accompanying drawing 3 is the principle schematic of ultrasonic Detection Method measurement velocity of blood flow in the present invention;
The formation schematic diagram of the blood pressure measuring system that accompanying drawing 4 is an embodiment of the present invention;
Accompanying drawing 5 is the formation block diagram of application intelligent wearing equipment of the present invention.
The specific embodiment
For the ease of those skilled in the art's understanding, below in conjunction with drawings and Examples, the invention will be further described.
A blood pressure measuring method, comprises the following steps:
S1, according to shearing stress
and the relation between velocity of blood flow V
, Re is Reynolds number, and ρ is density of blood, and the expression formula of setting blood pressure measurement is systolic pressure
=
, diastolic pressure
=
,
,
for correction factor;
S2, obtain the velocity of blood flow characteristic parameter of measuring object, utilize piezometer directly gather the blood pressure reference value of this measuring object and the expression formula of blood pressure measurement is carried out to reverse calculating after correction factor value simultaneously, correction factor value is stored in the data base who is subordinated to this measuring object;
S3, carry out actual blood pressure while measuring, from data base, reading the correction factor value of corresponding measuring object, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of the expression formula based on blood pressure measurement and Real-time Collection.
According to bernoulli equation in hydrodynamics, can obtain equation 1.: P+ ρ gz+ (1/2) * ρ v
2=C; In formula, P, ρ, v are respectively pressure, density and the speed of fluid; Z is vertical height, and g is acceleration of gravity, and that in formula, show tube wall pressure is exactly P.By Bernoulli equation can clear and definite tube wall pressure and fluid there is certain physical relation, i.e. blood pressure and blood and flow etc. and to have physical relation.
For blood vessel, can think a columniform pipeline.2. the shearing stress at pipe wall place is expressed as equation:
; There is again equation 3.:
; 4. above-mentioned two formulas of simultaneous obtain equation:
.Wherein
for pipe flow loss factor,
for fluid density,
for the mean flow rate on tube section.
For pipe laminar flow,
only relevant to reynolds number Re, be expressed as equation 5.:
.
For turbulent flow, a large amount of experimentation and theoretical researches show, the loss factor of Turbulent Pipe Flow
relevant to reynolds number Re and tube wall relative roughness, be expressed as equation 6.:
.
Reynolds number (Reynolds number) is a kind of dimensionless number that can be used to characterize fluid mobility status, with Re, represents, is expressed as equation 7.:
, wherein V, ρ, η are respectively flow velocity, density and the viscosity coefficient of fluid, and d is a characteristic length.For example fluid flows through circular pipe, and d is pipe diameter.Utilizing Reynolds number can distinguish the mobile of fluid is laminar flow or turbulent flow, also can be used to determine object mobile suffered resistance in fluid.
For the present invention, fluid is blood, and fluid density ρ is the density of blood, and η and μ refer to the viscosity coefficient (or claiming dynamic viscosity) of blood, thickness or the caliber of the blood vessel that d value and L-value can near-sighted be thought, and V is the mean flow rate of blood.When Re≤2000, think flowing for laminar flow in pipe; When Re >=2000, think flowing for turbulent flow in pipe; A large amount of experimentation and theoretical researches show, the Reynolds number representative value of the blood flow in aorta is about Re=1000, think the flowing for laminar flow of blood.Therefore, by equation, 4. 5. drawn with equation
.
In the present invention, described reynolds number Re can adopt experience constant, or utilizes
calculate gained, the blood viscosity coefficient that η is measuring object, d is blood vessel diameter.Described density of blood ρ, blood viscosity coefficient η can and be not limited to obtain by the chemical examination of clinical laboratory's routine blood test or other blood pressures, and the thickness of blood vessel is that blood vessel diameter d can and be not limited to obtain by B ultrasonic.
In step S2, the velocity of blood flow characteristic parameter of measuring object can adopt several different methods directly or indirectly to measure, and comprises that ultrasonic doppler detects, laser-Doppler detects, distance between two points is surveyed velocity of blood flow, infrared photography, pressure sensing detection method etc.In an embodiment of the present invention, adopt photoelectricity volume pulse tracing to obtain the velocity of blood flow characteristic parameter of measuring object, photoelectricity volume pulse tracing is to utilize photoelectric effect to test out blood flow situation, according to different two kinds of transmission beam method and the bounce techniques that are divided in the position of light emission and optical pickup apparatus, use a kind of light of wavelength frequency to measure, also can utilize the light of multi-frequency to be used in conjunction with measurement.The monitoring position of transmission beam method is that the human body limb thickness such as ear lobe or finger are little, blood vessel flows significantly local, in limbs both sides, place respectively the photoelectric receiving arrangement of light-emitting device and respective frequencies, as placed light emitting devices above fingernail, below finger, optical pickup apparatus is placed at fingerprint place.When light-wave irradiation human body limb, the photon of a part, by transmission limbs, is received by photoelectric receiving arrangement, and the photon of another part will be reflected or scattering consumes, or by limbs tissue absorption etc., finally by photoelectric receiving arrangement, do not received.The monitoring position of bounce technique is that any one blood vessel of human body limb is mobile significantly local, as finger, wrist joint place etc. position, in the same side of limbs, place the photoelectric receiving arrangement of light-emitting device and respective frequencies, as placed side by side light emitting devices and optical pickup apparatus at finger print place.When light-wave irradiation human body limb, the photon of a part will be reflected by limbs and blood, by photoelectric receiving arrangement, be received, and the photon of another part will be transmitted or scattering consumes, or by limbs tissue absorption etc., finally by photoelectric receiving arrangement, do not received.In two kinds of methods, method of testing is different, it is all finally to receive the photon of returning by photoelectric receiving arrangement, by circuit conversion, is photoelectric current and is got simulation electronic waveform after the processing of circuit such as amplification, filtering, and the waveform that two kinds of methods are obtained is almost consistent in form.This waveform can reflect the flow condition of blood of human body, and the simulation electronic waveform that medically the method obtains is called pulse wave.
Pulse wave, through methods such as circuit design or wireless transmission, can be input in the chip of operation processing function, as Micro-processor MCV, can calculate the parameters such as flow velocity of blood in MCU through certain algorithm.Pulse wave is the reflection of test position blood flow situation, and the variation of pulse wave is that ventricular systole and diastole are caused.Work as ventricular systole, blood flows into tremulous pulse from ventricle, and now blood is the highest to the pressure of tremulous pulse, is called systolic pressure; Work as ventricular diastole, arteries elastical retraction, blood still slowly continues to flow forward, but blood pressure drops, pressure is now called diastolic pressure.In somewhere, waveform top, it is the reflection that ventricular systole is penetrated blood; In somewhere, waveform bottom, it is diastolic reflection.After utilizing circuit design that the photon obtaining is processed, the Waveform Input drawing is processed waveform to the AD conversion mouthful of microprocessor.At waveform top, the AD value that microprocessor gets is maximum, and the velocity of blood flow that this moment flows through tested place blood vessel is maximum; In waveform bottom, the AD value that microprocessor gets is minimum, and the velocity of blood flow that this moment flows through tested place blood vessel is minimum.In the AD value of waveform top and bottom, illustrate that the flow of length inner blood is different at the same time, microprocessor obtains the reflection that AD value is blood flow.
In step S2, adopt photoelectricity volume pulse tracing to obtain the velocity of blood flow characteristic parameter of measuring object, comprising:
S21, measurement recording light Power Capacity pulse wave signal obtain the waveform obtaining the real-time AD value of reflection blood flow after AD conversion
;
S22, the quadratic equation of setting up velocity of blood flow V are
, α, β, γ are correction factor, determine velocity of blood flow V=
.
In step S22, set up the AD value that microprocessor obtains
following relation with velocity of blood flow V:
.When
time, V=
; Obviously,
the reflection of flow velocity,
certainly exist relation with V, give up this formula.When
time, draw V=
, in two solutions, contain one and do not meet actual value, it is given up.
In this embodiment, with real-time AD value
as the velocity of blood flow characteristic parameter of measuring object, the expression formula of described velocity of blood flow V is with real-time AD value
for variable and comprise correction factor, the velocity of blood flow V drawing through step S22 is updated to formula
in, can show that corresponding shearing stress expression formula is:
Based on shearing stress and systolic pressure
, diastolic pressure
relation, determine systolic pressure
and diastolic pressure
expression formula be respectively:
=
=
。
In another embodiment of the invention, the velocity of blood flow characteristic parameter that described step S2 obtains measuring object is to adopt ultrasonic Detection Method to gather velocity of blood flow V, usings the velocity of blood flow characteristic parameter of velocity of blood flow V as measuring object.Utilize the method for ultrasonic measurement velocity of blood flow to comprise time difference method and frequency-difference method, no matter use which kind of method, it is consistent that the flow velocity waveform of the blood obtaining is described.The principle of the application laser detection method measurement velocity of blood flow in the another kind of embodiment of the present invention is similar to ultrasonic Detection Method.
As shown in Figure 3, the both sides that the ultrasonic transducer P1 that a pair of operating frequency is f and P2 are arranged on blood vessel (in actual applications, ultrasonic transducer can be arranged on the both sides, position such as arm), establishes distance for L, with blood vessel angle is
, the speed of ultrasound wave in blood is c, the flow velocity of blood is V.When P1 sends ultrasonic pulse when being transmitted to P2 and receiving along L, record its following current time t
12; Now along the acoustic speed of propagation of L
(formula a1), wherein
(formula a2); Equally, when P2 sends ultrasonic pulse when being transmitted to P1 and receiving along L, record its adverse current time t
21; Now along the acoustic speed of propagation of L
(formula b1), wherein
(formula b2).
By formula a1, formula a2, formula b1, formula b2, can be obtained
(formula c);
Or, utilize
, obtain
(formula d);
Formula c, formula d all can be used as the expression formula of velocity of blood flow, although the mode of expressing is different, the waveform morphology finally obtaining is consistent.In actual applications, by processor or microprocessor, control in real time transmission ultrasonic pulse, and the time of Real-time Obtaining ultrasonic pulse, through type c or formula d all can obtain real-time velocity of blood flow V.
In described step S2, by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter, directly gather the systolic pressure of measuring object
and diastolic pressure
, recycling systolic pressure
and diastolic pressure
expression formula carry out, after the reverse correction factor value that calculates measuring object, this correction factor value being stored in data base.No matter be normal person or hypertensive patient, blood pressure is all obvious undulatory property.In daily life, along with sleep and clear-headed, day and night, the replacement of having a rest and moving, blood pressure also has the fluctuation of rhythmicity.People's pressure value was change curve in the middle of one day, as various forms such as two peaks types.Normotensive crowd and hyperpietic's change curve is not quite similar.Within the regular hour, the blood vessel thickness of human body and the parameter of density of blood can be thought invariable, utilize traditional electric sphygmomanometer or mercurial sphygmomanometer can record many groups systolic pressure and the diastolic pressure of same person different time points, by the data that record as a reference, the above-mentioned systolic pressure of substitution
and diastolic pressure
expression formula in, the real-time AD value of obtaining in conjunction with microprocessor
or velocity of blood flow V can determine each correction factor etc., thereby complete the calibration of individual constant.For different individuals, will there is different correction factors to answer in contrast, need obtain many group statistical datas as foundation by traditional electric sphygmomanometer or additive method, draw different individuals' correction factors.
Blood pressure measuring method of the present invention also comprises: set up in advance the data base of measuring object, gather density of blood ρ, blood viscosity coefficient η, the blood vessel diameter d of measuring object and be stored in data base as feature constant.Because the density of blood of human body and blood vessel thickness are not constancy, again calibration after needing a period of time, each group constant and correction factor can only correspondence user targetedly, in same equipment, can preserve the different clients' of many groups data, while measuring, need change constant at every turn.
For the acquisition process of described blood pressure, when practical operation, can increase other feature constants as reference foundation and/or for corrected Calculation pressure value.Described other feature constants refer to except the thickness of the density that comprises described blood, blood vessel or caliber, the sticky coefficient of blood are, the flow velocity of blood, other related physiological parameters of human body one or more all in described scope, as HbO2 Oxyhemoglobin ratio in degree of roughness, heart rate and the situation of change thereof of content of hemoglobin, skin in platelet content, blood in body temperature, blood, blood, blood sugar content etc.
Feature constant of the present invention not necessarily obtains by photoelectric effect, can obtain by other means, and as the thickness of blood vessel or caliber can obtain by laser or X-ray, body temperature can obtain by the sensor of semiconductor principle.Described other feature constants, not for main calculating, refer to that both can be used for auxiliary calculating obtains pressure value, the various parameter values that use while also can be used as in reference and/or corrected Calculation process.
As shown in Figure 1, the present invention also provides the blood pressure measuring method based on photoelectricity volume pulsation wave of a kind of embodiment, comprises the following steps:
S101, the data base who sets up measuring object, this data base comprises density of blood ρ, feature constant and the correction factor value such as blood viscosity coefficient η, blood vessel diameter d of measuring object;
S102, measurement recording light Power Capacity pulse wave signal;
S103, the waveform obtaining is obtained after AD conversion to the real-time AD value of reflection blood flow
;
S104, the correction factor value that reads measuring object from data base and feature constant;
S105, by real-time AD value, correction factor value and the feature constant expression formula of substitution blood pressure measurement respectively;
S106, calculating blood pressure measurement result also show.
As shown in Figure 2, the present invention also provides the blood pressure measuring method testing the speed based on ultrasound wave blood of another kind of embodiment, comprises the following steps:
S201, the data base who sets up measuring object, this data base comprises density of blood ρ, feature constant and the correction factor value such as blood viscosity coefficient η, blood vessel diameter d of measuring object;
S202, the ultrasonic transducer that is arranged on the palm both sides of measuring object receive ultrasonic pulse;
S203, calculate real-time velocity of blood flow V according to the reception time difference of two ultrasonic transducers;
S204, the correction factor value that reads measuring object from data base and feature constant;
S205, by real-time velocity of blood flow V, correction factor value and the feature constant expression formula of substitution blood pressure measurement respectively;
S206, calculating blood pressure measurement result also show.
The invention also discloses a kind of blood pressure measuring system,, as shown in Figure 4, comprising:
Expression formula derivation module 41, for according to shearing stress
and the relation between velocity of blood flow V
, Re is Reynolds number, and ρ is density of blood, and the expression formula of setting blood pressure measurement is systolic pressure
=
, diastolic pressure
=
,
,
for correction factor;
Described reynolds number Re of the present invention adopts experience constant, or utilizes
calculate gained, the blood viscosity coefficient that η is measuring object, d is blood vessel diameter.
The velocity of blood flow characteristic parameter of described data acquisition module 32 measuring objects can adopt several different methods directly or indirectly to measure, and comprises that ultrasonic doppler detects, laser-Doppler detects, distance between two points is surveyed velocity of blood flow, infrared photography, pressure sensing detection method etc.In an embodiment of the present invention, described data acquisition module 32 obtains the velocity of blood flow characteristic parameter of measuring object by photoelectricity volume pulse tracing, comprise: for measuring and recording light Power Capacity pulse wave signal, the waveform obtaining is obtained after AD conversion to the real-time AD value of reflection blood flow
; For setting up the quadratic equation of velocity of blood flow V, be
, α, β, γ are correction factor, determine velocity of blood flow V=
.
In this embodiment, adopt bounce technique or transmission measurement photoelectricity volume pulse wave signal.By in the expression formula of velocity of blood flow V substitution blood pressure measurement, obtain systolic pressure
and diastolic pressure
expression formula be respectively:
=
=
。
In another embodiment of the invention, to obtain the velocity of blood flow characteristic parameter of measuring object be to adopt ultrasonic Detection Method to gather velocity of blood flow V to described data acquisition module 42.
Described data acquisition module 42 directly gathers the systolic pressure of measuring object by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter
and diastolic pressure
, recycling systolic pressure
and diastolic pressure
expression formula carry out, after the reverse correction factor value that calculates measuring object, this correction factor value being stored in data base.
Blood pressure measuring system of the present invention also comprises a database initialize module 44, for setting up in advance the data base of measuring object, gathers density of blood ρ, blood viscosity coefficient η, the blood vessel diameter d of measuring object and is stored in data base as feature constant.
In a preferred embodiment of practical application of the present invention, the blood pressure measuring system based on photoelectricity volume pulsation wave is loaded in an intelligent wearing equipment, especially in a wristband type universal serial or watch style intelligence wearing equipment.Described intelligence is dressed integration of equipments photoelectricity blood pressure measuring ability, adopt green-light source, the test of use bounce technique, as shown in Figure 5, comprise that MCU(refers to microprocessor, be any one or more chips with disposal ability, comprise single-chip microcomputer, ARM, CPU, DSP etc.), power supply, pulse wave monitoring part, other parameter detecting parts, wireless communication apparatus and display device.Take intelligent watch as example, can in watch core bottom, place light-emitting device and the photoelectric receiving arrangement of pulse wave monitoring part, by controlling luminous intensity, obtain the pulse wave of human body, through MCU, process the flow velocity that calculates blood in conjunction with feature constant.On the other hand, the sticky coefficient of the density of testee's blood, blood can obtain by the chemical examination of clinical laboratory's routine blood test or other blood.The thickness of blood vessel is that caliber can obtain by B ultrasonic.Intelligent watch has the density of correction factor and blood, the sticky coefficient of blood, the feature constant settings such as thickness of blood vessel, and testee can real-time update relevant parameter.The flow velocity of blood can obtain the processing of pulse wave by microprocessor, can get the change in flow curve of blood flow by algorithm, and then in conjunction with fluctuation point and relevant parameter, by microprocessor, can be calculated pressure value.The pressure value drawing can show or by being wirelessly transmitted to background system, pressure value is analyzed for professional doctor.
In another preferred embodiment of practical application of the present invention, integrated pulse ripple monitoring function (maybe can calculate the flow velocity of blood) and other parameter detecting parts on intelligent watch, numerical value detection being obtained by wireless telecommunications part mails to background monitoring center.The correction factor and the various feature constant that in Surveillance center, have measurand, if the thickness of the sticky coefficient of the density of blood, blood, blood vessel is caliber etc.The pulse wave that Surveillance center obtains by intelligent watch or the flow velocity of blood and other auxiliary physiological parameters, in conjunction with the existing correction factor of Surveillance center and feature constant, then calculate the current blood pressure situation of measured by processor.
Above content is in conjunction with concrete optimal way further description made for the present invention, should not assert that specific embodiment of the invention is confined to above explanation.For those skilled in the art, without departing from the inventive concept of the premise, can also make some simple deduction or replace, within the definite protection domain of the claim that all should be considered as being submitted to by the present invention.
Claims (10)
1. a blood pressure measuring method, comprises the following steps:
S1, according to shearing stress
and the relation between velocity of blood flow V
, Re is Reynolds number, and ρ is density of blood, and the expression formula of setting blood pressure measurement is systolic pressure
=
, diastolic pressure
=
,
,
for correction factor;
S2, obtain the velocity of blood flow characteristic parameter of measuring object, utilize piezometer directly gather the blood pressure reference value of this measuring object and the expression formula of blood pressure measurement is carried out to reverse calculating after correction factor value simultaneously, correction factor value is stored in the data base who is subordinated to this measuring object;
S3, carry out actual blood pressure while measuring, from data base, reading the correction factor value of corresponding measuring object, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of the expression formula based on blood pressure measurement and Real-time Collection.
2. blood pressure measuring method according to claim 1, is characterized in that: in step S1, described reynolds number Re adopts experience constant, or utilizes
calculate gained, the blood viscosity coefficient that η is measuring object, d is blood vessel diameter.
3. blood pressure measuring method according to claim 1, is characterized in that, in step S2, adopts photoelectricity volume pulse tracing to obtain the velocity of blood flow characteristic parameter of measuring object, comprising:
S21, measurement recording light Power Capacity pulse wave signal obtain the waveform obtaining the real-time AD value of reflection blood flow after AD conversion
;
S22, the quadratic equation of setting up velocity of blood flow V are
, α, β, γ are correction factor, determine velocity of blood flow V=
.
4. blood pressure measuring method according to claim 3, is characterized in that: described step S21 adopts bounce technique or transmission measurement photoelectricity volume pulse wave signal.
5. blood pressure measuring method according to claim 1, is characterized in that: in step S2, the velocity of blood flow characteristic parameter that obtains measuring object is to adopt ultrasonic Detection Method or laser detection method or pressure sensing detection method to gather velocity of blood flow V.
6. blood pressure measuring method according to claim 1, is characterized in that, in described step S2, directly gathers the systolic pressure of measuring object by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter
and diastolic pressure
, recycling systolic pressure
and diastolic pressure
expression formula carry out, after the reverse correction factor value that calculates measuring object, this correction factor value being stored in data base.
7. blood pressure measuring method according to claim 1, is characterized in that, also comprises: set up in advance the data base of measuring object, gather density of blood ρ, blood viscosity coefficient η, the blood vessel diameter d of measuring object and be stored in data base as feature constant.
8. a blood pressure measuring system, is characterized in that, comprising:
Expression formula derivation module, for according to shearing stress
and the relation between velocity of blood flow V
, Re is Reynolds number, and ρ is density of blood, and the expression formula of setting blood pressure measurement is systolic pressure
=
, diastolic pressure
=
,
,
for correction factor;
Data acquisition module, for obtaining the velocity of blood flow characteristic parameter of measuring object, utilize piezometer directly gather the blood pressure reference value of measuring object and the expression formula of blood pressure measurement is carried out to reverse calculating after correction factor value simultaneously, correction factor value is stored in the data base who is subordinated to this measuring object;
Result computing module for when carrying out actual blood pressure measurement, reads the correction factor value of corresponding measuring object, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of the expression formula based on blood pressure measurement and Real-time Collection from data base.
9. blood pressure measuring system according to claim 8, is characterized in that: the velocity of blood flow characteristic parameter that described data acquisition module obtains measuring object is to adopt any in photoelectricity volume pulse tracing, ultrasonic Detection Method, laser detection method and pressure sensing detection method.
10. blood pressure measuring system according to claim 8, it is characterized in that: also comprise a database initialize module, for setting up in advance the data base of measuring object, gather density of blood ρ, blood viscosity coefficient η, the blood vessel diameter d of measuring object and be stored in data base as feature constant.
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