CN103592782B - Nano biological light tweezer based on light miniflow ring resonator - Google Patents
Nano biological light tweezer based on light miniflow ring resonator Download PDFInfo
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- CN103592782B CN103592782B CN201310505909.8A CN201310505909A CN103592782B CN 103592782 B CN103592782 B CN 103592782B CN 201310505909 A CN201310505909 A CN 201310505909A CN 103592782 B CN103592782 B CN 103592782B
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Abstract
The invention belongs to optical technical field, be specifically related to a kind of nano biological light tweezer based on light miniflow ring resonator. The present invention is made up of silicon base chip formula annular micro-cavity and Y beam splitter or Multimode interference splitter, use tunable laser source that light field is coupled in annular micro-cavity and in microcavity and is formed Echo Wall standing wave mode by beam splitter, the optical gradient forces of utilizing standing wave mode to produce realizes nano particle localization and handles. This device is broken through the nonlocality of existing configuration and is handled this technical bottleneck, in conjunction with the feature of miniflow and high-quality-factor optical microcavity, possesses low-power consumption, the advantages such as the biomolecule localization manipulation in 100 nanoscales.
Description
Technical field
The invention belongs to optical technical field, be specifically related to a kind of nano biological light tweezer based on light miniflow ring resonator.
Background technology
Optical tweezer technology is as the tool of a kind of not damaged operation biologic grain, since the eighties in last centuryBe widely used in the fields such as cell biology, molecular biology and medical science. But, along with biomedical research object chiThe reducing gradually of degree (by micron dimension to nanometer scale), traditional focused beam light tweezer cannot produce enough gradient forces and goManipulation nano particle. Researcher's body art overcame this difficulty by near field optic manipulation technology in recent years. So-called near field opticHandle, the evanscent field that utilizes exactly light to produce at device interfaces place in the resonance of total reflection or metallic plasma excimer catch orHandle the target particles of nanometer scale. Because evanscent field decays to zero conventionally in hundred nanoscales, the spatial variations rate of light intensityVery large, therefore, it is enough strong that light field can provide, for retraining the gradient force of nano particle. At present, handle former based near field opticThe device of reason mainly contains three kinds: fiber waveguide device, optical resonator device and plasmon type device. Wherein optics annularResonator is considered to one of the most potential near field optic manipulation device.
The research main advantage that utilizes optics ring resonator to carry out particle manipulation is: (1) is compared with fiber waveguide, annularResonator has high Q value conventionally, therefore only need the input light of lower-wattage can in microcavity, form enough strong inBuild light field, generation can fetter the gradient force of small scale particle; (2) preparation technology and integrated optics technology mutually compatible (3) be convenient toPrepare light miniflow integrated device, a kind of trace, high flux optical manipulation mode are fast provided. But, ring resonator at presentOptical manipulation technology also cannot really be applied, because ring resonator configuration is all non-localized maneuverability pattern now. Due toPhoton in chamber is only towards a direction around the movement, and its tangential momentum can only provide one-way pushing power for target particles, causesGrain is forced to do directional circle motion, cannot be static or move to other positions.
Summary of the invention
The object of the invention is to propose one is convenient to, at ring resonator, nanometer scale biomolecule is implemented to localization behaviourVertical nano biological light tweezer.
The nano biological light tweezer that the present invention proposes, uses the Standing Light Wave in miniflow substrate optics ring resonator to replace rowThe light tweezer of glistening light of waves field, handles nanometer scale particle thereby realize localization.
The nano biological light tweezer of the light miniflow ring resonator that the present invention proposes, is constituted successively by following part: Y typeBeam splitter or multimode beam splitter 1, phase adjusted electrode 2, ring resonator 3, microfluidic chambers 4. Phase adjusted electrode 2 is positioned at Y beam splittingOn an arm of device or multimode beam splitter 1, ring resonator 3 is between two arms of Y beam splitter or multimode beam splitter 1; Y dividesBundle device or multimode beam splitter 1, phase adjusted electrode 2, ring resonator 3 threes are integrated on silicon chip, are packaged in microfluidic chambers 4In, form portable lab-on-chip device; Microfluidic chambers two ends are connected with Teflon flexible pipe, logical containing the solution of being handled particleCrossing flexible pipe is input in microfluidic chambers.
In the present invention, ring resonator 3 adopts bidirectional couple microcavity configuration.
In the present invention, beam splitter waveguide and ring resonator can be made up of SiN film or polymer thin-film material.
In the present invention, the resonant ring diameter of ring resonator can be 1 micron to 200 microns.
In the present invention, phase adjusted electrode can be made up of electricity, heat or light-sensitive material.
The principle of the invention is as follows: handle in order to realize localization, require the Whispering-gallery-mode photon in ring resonatorMust be two-way to the tangential motive force of target particles. Therefore, can use bidirectional couple microcavity configuration as shown in Figure 2, logicalCross beam splitter two arms by two bundle coherent light reverse coupled in same microcavity, excited two-way Whispering-gallery-mode. Due to lightAll there is tangential momentum in son, target particles has the tangential motive force that both direction is contrary, works as microcavity on positive and negative both directionWhen interior formation Echo Wall standing wave mode, its stable optical field distribution just can provide the gradient force of localization target acquisition particle, logicalCross and control the wherein phase place of an incident beam and can change the optical field distribution of standing wave, thus the tangential positional operand of realize target particleVertical, and excite the radial location that the Whispering-gallery-mode light field of different rank can realize target particle to handle.
The present invention, by integrated to beam splitter and toroidal cavity resonator, enters microcavity by beam splitter by two bundle coherent light reverse coupledIn, in chamber, form Whispering-gallery-mode Standing Light Wave, input the phase place of light and excite the pattern of different rank to come real by adjustingNow the localization of particle is handled. The present invention handles new thinking is provided near field optic, can solve ring resonator to nanometerThe localization of magnitude biomolecule is handled a difficult problem, and makes it towards biomedical practical application direction further. The present invention breaks through existingThere is the nonlocality of configuration to handle this technical bottleneck, in conjunction with the feature of miniflow and high-quality-factor optical microcavity, possess low meritConsumption, the advantages such as the biomolecule localization manipulation in 100 nanoscales.
Brief description of the drawings
Fig. 1 is the nano biological light tweezer structural diagrams based on light miniflow ring resonator. Wherein, (a) silica-based smooth miniflow ringShape resonator floor map, (b) silica-based smooth miniflow ring resonator light tweezer schematic diagram.
Fig. 2 is bidirectional couple microcavity configuration schematic diagram and Echo Wall standing wave mode.
Fig. 3 is silica-based smooth miniflow ring resonator light tweezer preparation flow schematic diagram.
Number in the figure: 1 is Y type beam splitter or multimode beam splitter, quartz ampoule, 2 is phase adjusted electrode, 3 is optics annularResonator, 4 is PDMS microfluidic chambers.
Detailed description of the invention
Further describe the present invention below by specific embodiment:
Embodiment: the manipulation experiment of micron-scale polystyrene (polystyrene, PS) bead.
1. sample making and setting parameter: preparation scheme as shown in Figure 3, first, to there is thick SiO2Thin layer (d > 2 μ are m)Silicon chip be substrate, by preparation SiN film or polymer SU-8 film as ducting layer; Recycling ultraviolet photolithographic technology and dryMethod or wet etching technique are prepared annular micro-cavity structure; Prepare low-refraction (mixing fluorine compounds, as CYTOP etc.) upper caldding layer,And prepare the phase controlling electrode in single mode waveguide region; By cover lithography, the microchannel of etching microcavity region; Finally, usePDMS is packaged into microfluidic cartridge.
2. measuring method: first, the polystyrene sphere aqueous solution of micron-scale is transported in microchannel; Adopt1550 nanometers or 850 nano narrow band tunable laser sources, enter micro chamber device by optical fiber by laser coupled, measures the humorous of microcavityThe wavelength that shakes, then the output wavelength of light source is fixed near resonance wavelength; By the microscopic system Real Time Observation PS with CCDThe bound state of bead on microcavity; There is bead in the phase place that the voltage by control phase electrode changes Whispering-gallery-mode againMobile. By above experimental procedure, can systematically study this configuration the localization of target particles is handled.
Claims (5)
1. a nano biological light tweezer for light miniflow ring resonator, is characterized in that being constituted successively by following part: Y typeBeam splitter or multimode beam splitter, phase adjusted electrode, ring resonator, microfluidic chambers; Wherein, phase adjusted electrode (2) is positioned at Y and dividesOn an arm of bundle device or multimode beam splitter, ring resonator is between two arms of Y beam splitter or multimode beam splitter; Y dividesBundle device or multimode beam splitter, phase adjusted electrode, ring resonator (3) three are integrated on silicon chip, be packaged in microfluidic chambers,Form portable lab-on-chip device.
2. the nano biological light tweezer of smooth miniflow ring resonator according to claim 1, is characterized in that ring resonatorAdopt bidirectional couple microcavity configuration.
3. the nano biological light tweezer of smooth miniflow ring resonator according to claim 1, is characterized in that beam splitter waveguideFormed by SiN film or polymer thin-film material with ring resonator.
4. the nano biological light tweezer of smooth miniflow ring resonator according to claim 1, is characterized in that ring resonatorResonant ring diameter be 1 micron to 200 microns.
5. the nano biological light tweezer of smooth miniflow ring resonator according to claim 1, is characterized in that phase adjusted electricityThe utmost point is made up of electricity, heat or light-sensitive material.
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| CN103592782B true CN103592782B (en) | 2016-05-11 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105044847B (en) * | 2015-05-20 | 2018-04-24 | 哈尔滨工程大学 | Optical fiber splitter based on drop coupling |
| CN105182521A (en) * | 2015-07-21 | 2015-12-23 | 大连理工大学 | Method for tunably capturing and screening topological insulator particles above substrate through utilizing linearly polarized planar light waves |
| CN107272116B (en) * | 2017-08-16 | 2024-01-05 | 深圳大学 | Echo wall mode resonator and preparation method thereof |
| CN108267815B (en) * | 2018-02-09 | 2019-12-13 | 哈尔滨工业大学 | micro-nano optical motor based on coupling of waveguide and resonant cavity and driving method thereof |
| CN108646350B (en) * | 2018-03-30 | 2019-10-25 | 中国科学技术大学 | Mechanical vibrator microcavity coupling body and the optical circulators for using it |
| CN108760704A (en) * | 2018-06-01 | 2018-11-06 | 北京工业大学 | A kind of unicellular interior substance detecting method based on Whispering-gallery-mode |
| CN112635094B (en) * | 2021-03-11 | 2021-05-07 | 中国人民解放军国防科技大学 | Chip-type microparticle optical suspension device and microparticle capturing method |
| CN113358142B (en) * | 2021-05-21 | 2022-11-18 | 复旦大学 | Optical fiber interference light path based on optical unidirectional transmission and construction method thereof |
| CN113514179B (en) * | 2021-08-11 | 2021-12-10 | 之江实验室 | Force field gradient measuring device and method based on double-vibrator suspension optomechanics system |
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| US20080316575A1 (en) * | 2002-08-01 | 2008-12-25 | The University Of Chicago., | Aberration correction of optical traps |
| US7149396B2 (en) * | 2003-06-16 | 2006-12-12 | The Regents Of The University Of California | Apparatus for optical measurements on low-index non-solid materials based on arrow waveguides |
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Patent Citations (3)
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| CN1588177A (en) * | 2004-08-04 | 2005-03-02 | 中国科学院上海光学精密机械研究所 | Device for regulating light tweezers |
| CN101236275A (en) * | 2008-02-19 | 2008-08-06 | 哈尔滨工程大学 | Optical forceps based on ring -shaped multi- core optical fibre |
| CN101852890A (en) * | 2010-01-08 | 2010-10-06 | 电子科技大学 | Single fiber optical tweezers manufacturing method based on corroded graded-index multimode fiber |
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