CN103585454B - A kind of anti-oxidant Cordyceps sinensis composition with strengthening immunity - Google Patents
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The present invention discloses a kind of Cordyceps sinensis composition, and described composition comprises Herba Cistanches, sealwort, Radix Angelicae Sinensis, Poria cocos, mulberries, Rose, wolfberry fruit, Stigma Croci, the root of herbaceous peony and Cordyceps sinensis. Prove that this Cordyceps sinensis composition can strengthen mice serum SOD vigor through experimentation on animals, it is to increase GSH content, reduce MDA content; Improve thymus index and B lymphocyte proliferation rate, have better anti-oxidant compared with Cordyceps sinensis and strengthen immune effect, effectively reduce costs.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically, it relates to a kind of can the Cordyceps sinensis composition of strengthening immunity and anti-oxidant activity.
Background technology
The research of free radical in recent years has become biology, the research emphasis of the subjects such as medicine and pharmacology, and free radical causes lipid peroxidation injury to cause the concern of a lot of scholar as a new paathogenic factor. Generally, life is too busy to get away free radical activity. Free radical is the intermediate product of eubolism, radical pair human body is harmless under normal circumstances, also has free radical in human body, and they both can help to transmit the energy maintaining vitality, kill bacteria and parasite can also be used to, moreover it is possible to participate in getting rid of toxin. But if free radical is movable out of hand, exceedes certain amount, the normal order of life will be destroyed, and disease possibility will be following. The aging course of organism is the free radical accumulation result that the histocyte of body constantly produces, and free radical can cause DNA damage thus cause sudden change, and induced tumor is formed. The multiple material in cell can be made to be oxidized, and infringement microbial film, causes the impaired generation some diseases of cell function, as damaged nerve cell causes hypomnesis, and senile dementia etc. The macromolecules cross-linking such as protein, nucleic acid can also be made, affect its normal function. Such as the lipoprotein in free-radical oxidn blood, cholesterol deposits is caused to cause cardiovascular and cerebrovascular diseases. Free radical can discharge various inflammatory factor by exciting human, causes inflammatory reaction, it is also possible to attacks immunity system and causes human body cell immunity and humoral immune function decline. Normal memory cell is at Free-radical ring opening polymerization, and such as antioxidase and antioxidant, the former is such as superoxide-dismutase (SOD), catalase, Selenoperoxidase etc., the latter is such as gsh, carotene, vitamin-E, vitamins C etc. These Free-radical ring opening polymerization can effectively stop harmful free radicals to the injury of body, and maintenance interior free yl produces and removing is in equilibrium state. But with advancing age, antioxidant system is not enough to the free radical in purged body, equilibrium state is destroyed, and causes the accumulation of interior free yl to cause the oxidative damage of body. Reduce the harm of radical pair human body, except relying on interior free yl scavenge system, also to be found and to excavate exogenous free radical scavenging agent, utilize these materials as scapegoat, allowed them before free radical enters human body with regard to elder generation and combined with radical, to block the attack of extraneous free radical, make human body from injury.
Cordyceps sinensis, it is that section ergot fungus cordyceps sinensis colonizes in the stroma on bat moth section insect larvae and larva cadaveric complex, it is a kind of traditional famous and precious tonic Chinese medicine material, has immunity moderation system function, antitumor, antifatigue, the multiple efficacies such as reducing blood-fat. In pharmacology modern study result, Cordyceps sinensis contains cordycepic acid about 7%, carbohydrate 28.9%, fat about 8.4%, protein about 25%, in fat, 82.2% is unsaturated fatty acids, in addition, still containing vitamin B12, ergot fat alcohol, hexose alcohol, alkaloid etc. Cordyceps extract can improve subacute mouse aging red corpuscle, and in liver and brain, SOD is active, and improves the activity of catalase and Selenoperoxidase in blood. In addition, immunity system is also had good regulating effect by Cordyceps sinensis, and Cordyceps extract can strengthen the weight of normal mouse immune organ, promotes spleen macrophage proliferation, it is to increase liver, spleen activate the phagocytic capacity. But, the resource scarcity of Cordyceps sinensis own, expensive, effect of simple Chinese caterpillar fungus health-care effect is limited, therefore how by Cordyceps sinensis and other traditional Chinese medicine ingredients conbined usage, it is to increase the health-care effect of Cordyceps sinensis is technical problem urgently to be resolved hurrily to one skilled in the art.
Summary of the invention
It is an object of the invention to provide a kind of anti-oxidant and Cordyceps sinensis composition that is strengthening immunity of having, the composition of the present invention is to have the Cordyceps sinensis of health-care effect as main component, and other traditional Chinese medicine ingredients of compatibility is made, the Cordyceps sinensis of fictitious hosts costliness.
In a preferred embodiment of the present invention, the Cordyceps sinensis composition of the present invention mainly comprises following bulk drug (calculating by weight percentage); Cordyceps sinensis 30 60%, wolfberry fruit 5 20%, sealwort 5 20%, mulberries 5 20%, Herba Cistanches 5 15%, Stigma Croci 1-8%, Radix Angelicae Sinensis 3 10%, the root of herbaceous peony 3 10%, Poria cocos 2 10%, Rose 1-10%.
The preparation method of the present composition mainly comprises: Herba Cistanches in formula, sealwort, Radix Angelicae Sinensis, Poria cocos, mulberries, Rose 70% alcohol reflux three times, and is reduced pressure by extracting solution, concentrated, dry, sieves; Wolfberry fruit, Stigma Croci and root of herbaceous peony water extraction 3 times, and extracting solution is reduced pressure, concentrated, dry, sieve. Add Cordyceps powder after being mixed by extract, make 10 20 order powder, filling capsule, 5000Rad sterilizing under 60Co source after packing. .
Prove that this Cordyceps sinensis composition can strengthen mice serum SOD vigor through experimentation on animals, it is to increase 6SH content, reduce MDA content; Improve thymus index and B lymphocyte proliferation rate, have better anti-oxidant compared with Cordyceps sinensis and strengthen immune effect, effectively reduce costs.
Embodiment
Embodiment 1 has anti-oxidant and preparation that is strengthening immunity effect Cordyceps sinensis composition
By Herba Cistanches 10g, sealwort 10g, Radix Angelicae Sinensis 5g, Poria cocos 5g, mulberries 10g, Rose 3g 70% alcohol reflux three times, and extracting solution is reduced pressure, concentrated, dry, sieve; Wolfberry fruit 10g, root of herbaceous peony 5g and Stigma Croci 3g water extraction 3 times, and extracting solution is reduced pressure, concentrated, dry, sieve. By extract mix after add Cordyceps powder 40g, make 10 20 order powder, filling capsule, after packing in605000Rad sterilizing under Co source.
Embodiment 2 Cordyceps sinensis composition anti-oxidation efficacy
Healthy ICR mouse, SPF level, male, body weight 18 22g, animal uses preadaptation environment 1��2d, is divided into 3 groups at random, i.e. Chinese caterpillar fungus composition group, Chinese caterpillar fungus group and normal group after rejecting defective animal, often organizes 16. First gavage gives 200mg/ (kg.d) Chinese caterpillar fungus composition 15 days, then with 100mg/ (kg.d) dosage gavage 15 days (hereinafter referred to as composition group); The first gavage of Chinese caterpillar fungus group gives the micro-powder of 250mg/ (kg.d) Chinese caterpillar fungus 15 days, then with 125mg/ (kg.d) dosage gavage 15 days (hereinafter referred to as Chinese caterpillar fungus group); Normal group gavage gives 10ml/ (kg.d) 0.5% Xylo-Mucine 30 days (hereinafter referred to as normal group). Each group of mouse carries out after last administration mda (MDA), superoxide-dismutase (SOD), reduced glutathion (GSH) etc. respectively measure.
Table 1 Chinese caterpillar fungus composition product is on the impact of normal mouse oxidation index
| Group | MDA (nmol/ml) | SOD (U/ml) | GSH (umol/L) |
| Composition group | 3.16��1.07* | 70.46��9.47* | 14.38��5.51* |
| Chinese caterpillar fungus group | 3.99��0.89 | 72.56��15.98* | 9.57��4.44 |
| Normal group | 4.39��1.69 | 58.29��18.82 | 8.71��4.74 |
Result is as shown in table 1, and compared with control group, Chinese caterpillar fungus group SOD is active significantly raises (P��0.05). Cordyceps sinensis composition group mice serum MDA content significantly reduces (P��0.05); Mice serum superoxide-dismutase (SOD) vigor significantly raises (P��0.05); Mice serum GSH content significantly raises (P��0.05). Cordyceps sinensis composition can strengthen SOD in Mice vigor, it is to increase GSH content, reduces MDA content; It is better than Chinese caterpillar fungus group in the ability in MDA and rising GSH that reduces, and points out it may have certain anti-oxidant function.
Embodiment 3 Cordyceps sinensis composition strengthening immunity effect
Healthy ICR mouse, SPF level, male, body weight 18 22g, animal uses preadaptation environment 1��2d, is divided into 3 groups at random, i.e. Chinese caterpillar fungus composition group, Chinese caterpillar fungus group and normal group after rejecting defective animal, often organizes 16. First gavage gives 200mg/ (kg.d) Chinese caterpillar fungus composition 15 days, then with 100mg/ (kg.d) dosage gavage 15 days (hereinafter referred to as composition group); The first gavage of Chinese caterpillar fungus group gives the micro-powder of 250mg/ (kg.d) Chinese caterpillar fungus 15 days, then with 125mg/ (kg.d) dosage gavage 15 days (hereinafter referred to as Chinese caterpillar fungus group); Normal group gavage gives 10ml/ (kg.d) 0.5% Xylo-Mucine 30 days (hereinafter referred to as normal group). After last administration, each group of mouse being dissected mouse respectively, aseptically get thymus gland, spleen, calculate Thymus and spleen index, spleen is for measuring NK cytoactive and lymphocytic proliferation rate;
Table 2 Chinese caterpillar fungus composition product is on the impact of normal mouse immune index
| Group | Thymus index (%) | Spleen index (%) | B cell proliferation rate (%) | T cell proliferation rate (%) |
| Composition group | 0.166��0.0388** | 0.354��0.0726 | 130��4.9* | 97��20.0 |
| Chinese caterpillar fungus group | 0.159��0.0486* | 0.419��0.1173 | 135��12.0* | 116��31.7 |
| Normal group | 0.128��0.0389 | 0.382��0.0851 | 100��39.2 | 100��16.3 |
Result is as shown in table 2, and compared with normal group, Chinese caterpillar fungus composition group mouse thymus index and B lymphocyte proliferation rate significantly raise (P��0.05). Chinese caterpillar fungus powder can improve thymus index and B lymphocyte proliferation rate, and its effect is similar to Chinese caterpillar fungus composition group, and prompting Chinese caterpillar fungus composition may have certain strengthening immunity function.
Should be understood that; the specific embodiment of the present invention is only the object for exemplary illustration; it limits protection scope of the present invention never in any form; the technician of this area can be improved according to the above description or be converted, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (6)
1. an anti-oxidant Cordyceps sinensis composition with strengthening immunity, the bulk drug of described composition is calculated by weight percentage and is comprised Cordyceps sinensis 30 60%, wolfberry fruit 5 20%, sealwort 5 20%, mulberries 5 20%, Herba Cistanches 5 15%, Stigma Croci 1-8%, Radix Angelicae Sinensis 3 10%, the root of herbaceous peony 3 10%, Poria cocos 2 10%, Rose 1-10%, all bulk drug component sums are 100%; Do not comprise other Chinese medicine and/or western medicine composition.
2. Cordyceps sinensis composition according to claim 1, wherein bulk drug weight percent is respectively Cordyceps sinensis 30 50%, wolfberry fruit 8 12%, sealwort 8 12%, mulberries 8 12%, Herba Cistanches 8 12%, Stigma Croci 1-3%, Radix Angelicae Sinensis 4 6%, the root of herbaceous peony 4 6%, Poria cocos 4 6%, Rose 2 4%, all bulk drug component sums are 100%.
3. Cordyceps sinensis composition according to claim 1 and 2, combination dosage form described in it is capsule.
4. Cordyceps sinensis composition according to claim 3, it is characterised in that described capsule prepares by the following method: Herba Cistanches in formula, sealwort, Radix Angelicae Sinensis, Poria cocos, mulberries, Rose 60 80% alcohol reflux 24 times, and extracting solution is reduced pressure, concentrated, dry, sieve; Wolfberry fruit, Stigma Croci and root of herbaceous peony water extraction 24 times, and extracting solution is reduced pressure, concentrated, dry, sieve; Add Cordyceps powder after being mixed by extract, make 10 20 order powder, filling capsule, pack rear sterilizing.
5. Cordyceps sinensis composition according to claim 1-4 any one is in the application prepared in anti-oxidation medicine or healthcare products.
6. Cordyceps sinensis composition according to claim 1-4 any one improves the application in immunizing power medicine or healthcare products in preparation.
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| CN1091968A (en) * | 1993-03-06 | 1994-09-14 | 管益君 | A kind of medicine and preparation method thereof |
| CN1304688A (en) * | 2000-12-12 | 2001-07-25 | 李江 | Se-enriched cordyceps militaris powder and its preparing process |
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| CN1091968A (en) * | 1993-03-06 | 1994-09-14 | 管益君 | A kind of medicine and preparation method thereof |
| CN1304688A (en) * | 2000-12-12 | 2001-07-25 | 李江 | Se-enriched cordyceps militaris powder and its preparing process |
Non-Patent Citations (2)
| Title |
|---|
| 冬虫夏草的化学成分及药理作用;胡敏等;《时珍国医国药》;20081231;第19卷(第11期);2804－2806 * |
| 冬虫夏草的药理功能研究进展(综述);陈东河;《中国城乡企业卫生》;20080229(第01期);92－94 * |
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