CN103584845B - The measuring method of pulse signal transmission time difference - Google Patents
The measuring method of pulse signal transmission time difference Download PDFInfo
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Abstract
The present invention provides the measuring method of a kind of pulse signal transmission time difference, by the first cuff colligation at measured one upper limb position, by the second cuff colligation at measured one lower extremity, determine the time difference between described pulse signal by calculating the time of correlation function maximum between the pulse signal of three or more than three in the pulse signal of in the second cuff three or more than three and the first cuff；The measuring method of this kind of pulse signal transmission time difference, pulse signal transmission time difference can be measured reliably, accurately and quickly, there is advantage simple to operate, that measurement is quick and cost is low, it is possible to ensure that the measurement result of pulse signal transmission time difference is as the reliability judging basis.
Description
Technical field
The present invention relates to the measuring method of a kind of pulse signal transmission time difference.
Background technology
Arteriosclerosis can make ductus arteriosus wall thicken, hardening, follow the string, luminal stenosis.The angiopathy that arteriosclerosis is as age growth and occurs, its rule usually occurs at adolescence, increases the weight of period to person in middle and old age, falls ill.Male is many compared with women, and primary disease increases gradually in China in recent years, becomes one of old people's main cause of death.In recent years, due to the positive correlation of pulse wave transmission speed PWV Yu arteriosclerosis degree, it is simple and easy to do and do not have wound to add its measuring method, so, it is widely used and is used as an index of assessment Degree of arteriosclerosis.
PWV, refers to pulse wave spread speed between two of Arterial system had both pinpointed, and according to Moens-Korteweg equation, PWV is directly proportional to the square root of coefficient of elasticity, and due to the attenuating of arterial elasticity, pulse wave accelerates in the spread speed of Arterial system.In normal situation, PWV increases along with the increase at age.Generally PWV normal value is: less than 45 years old adult's < 9 meter per seconds (m/s)；More than 45 years old < 10m/s.PWV is more high, and prompting Degree of arteriosclerosis is more heavy.
In existing measuring method, owing to pulse wave is very faint by impact and the pulse wave signal itself of measurement system noise, cause that the measurement accuracy of pulse signal transmission time difference is undesirable, have impact on the measurement result of pulse wave transmission speed as the reliability judging basis.
The problems referred to above are the problems should paid attention to and solve in the measurement process of pulse signal transmission time difference.
Summary of the invention
It is an object of the invention to provide the measuring method of a kind of pulse signal transmission time difference and solve in existing measuring method, owing to pulse wave is very faint by impact and the pulse wave signal itself of measurement system noise, cause that the measurement accuracy of pulse signal transmission time difference is undesirable, have impact on the measurement result of the pulse wave transmission speed problem as the reliability judging basis.
The technical solution of the present invention is:
The measuring method of a kind of pulse signal transmission time difference, for measuring the time difference between the arterial pulse signal of different two body part of measured, said method comprising the steps of:
By the first cuff colligation at measured one upper limb position, by the second cuff colligation at measured one lower extremity；
By gas connection part and one, described first cuff and the second cuff being measured main frame be connected, described measurement main frame includes the first pressure transducer, the second pressure transducer, the first gas bleeder valve, the second gas bleeder valve, more than one air pump；
Using microprocessor, process by the pressure signal in the first pressure transducer, the first cuff of the second pressure transducer acquisition, the second cuff and/or pulse signal, described microprocessor performs the process measuring pulse signal time difference comprised the following steps:
A) by described first cuff, the first gas bleeder valve, the first pressure transducer, air pump, measure described artery of upper extremity blood pressure, and measurement makes pulse signal amplitude in the first cuff reach maximum cuff pressure P1A simultaneously；By described second cuff, the second gas bleeder valve, the second pressure transducer, air pump, measure described artery of lower extremity blood pressure, and measurement makes pulse signal amplitude in the second cuff reach maximum cuff pressure P2A simultaneously；
B) force value described first cuff being pressurized on P1A or P1A in next given range by described air pump, by the force value that the second cuff is pressurized on P2A or P2A in next given range by described air pump, then pass through described first and second pressure transducers and measure the pulse signal of in described first and second cufves more than three simultaneously respectively；
C) time difference between the pulse signal of more than three in the pulse signal of in described second cuff more than three and described first cuff is calculated.
Preferably, on described P1A, next given range is P1A ± 10mmHg, and on described P2A, next given range is P2A ± 10mmHg.
Preferably, described step C) for determining the time difference between described pulse signal by calculating the time of correlation function maximum between the pulse signal of more than three in the pulse signal of in described second cuff more than three and described first cuff.
Preferably, described step C) particularly as follows:
If wave function y (t) of n pulse signal C2A of described second cuff, 0≤t≤T, the wave function of n pulse signal C1A of described first cuff is x (t), 0≤t≤T, calculating the correlation function R (τ) of described y (t) and x (t), computing formula isCalculating described correlation function R (τ) again and take τ-value corresponding during maximum, if described τ-value is τ 0, then τ 0 is exactly the pulse signal transmission time difference of measured.
Preferably, described step C) particularly as follows:
If the pulse signal wave function respectively q1 (t) of n pulse signal C2A of described second cuff, q2 (t) ... qn (t), and 0≤t≤T, the pulse signal wave function of n pulse signal C1A of described first cuff is p1 (t), p2 (t) ... pn (t), and 0≤t≤T, calculate the correlation function Ri (τ) of qi (t) and pi (t) respectively, wherein 0≤i≤n and be integer, computing formula isCalculate respectively more described n correlation function R1 (τ) to Rn (τ) take maximum time corresponding τ-value, if described τ-value respectively τ 1, τ 2... τ n, calculating the meansigma methods of described τ 1 to τ n again, described meansigma methods is exactly the pulse signal transmission time difference of measured.
Preferably, calculate a given number in eight to ten six in the pulse signal of a given number in eight to ten six in described second cuff and described first cuff pulse signal between time difference, determine measured's Degree of arteriosclerosis with this.
Preferably, use pressurization measurement method or decompression measurement method, for being detected air pressure P1 (t) and pulse signal A1 (t) of described first cuff by described first pressure transducer, as the pulse signal A1 (t1) three continuous moment of t1, t2 and t3 being detected, A1 (t2), when A1 (t3) meets A1 (t1)<A1 (t2)>A1 (t3) relation, then the air pressure that the t2 moment is corresponding is target pressure P1A.
Preferably, use pressurization measurement method or decompression measurement method, for being detected air pressure P2 (t) and pulse signal A2 (t) of described second cuff by described second pressure transducer, as the pulse signal A2 (t21) three continuous moment of t21, t22 and t23 being detected, A2 (t22), when A2 (t23) meets A2 (t21)<A2 (t22)>A2 (t23) relation, then the air pressure that the t22 moment is corresponding is target pressure P2A.
The invention has the beneficial effects as follows: the measuring method of a kind of pulse signal transmission time difference of the present invention, pulse signal transmission time difference can be measured reliably, accurately and quickly, there is advantage simple to operate, that measurement is quick and cost is low, it is possible to ensure that the measurement result of pulse signal transmission time difference is as the reliability judging basis.
Accompanying drawing explanation
The structure that Fig. 1 is the embodiment of the present invention one illustrates block diagram；
The structure that Fig. 2 is the embodiment of the present invention two illustrates block diagram；
The structure that Fig. 3 is the embodiment of the present invention three illustrates block diagram；
Fig. 4 is the structural representation of the embodiment of the present invention；
Fig. 5 be decompression measurement method the first cuff and the second cuff add, reduce pressure and pulse signal sequential chart；
Fig. 6 is pulse signal enlarged diagram in Fig. 5；
Fig. 7 be pressurization measurement method the first cuff and the second cuff add, reduce pressure and pulse signal sequential chart；
Fig. 8 is pulse signal enlarged diagram in Fig. 7.
Wherein: 1-the first cuff, 2-the second cuff, 3-main frame, 4-the first trachea, 5-the second trachea；
C1-the first cuff inflation or disappointing time pressure signal or pulse signal curve, C2-the second cuff inflation or disappointing time pressure signal or pulse signal curve.
Detailed description of the invention
The preferred embodiments of the present invention are described in detail below in conjunction with accompanying drawing.
As shown in Fig. 4, Fig. 5 or Fig. 7, the measuring method of a kind of pulse signal transmission time difference, for measuring the time difference between the arterial pulse signal of different two body part of measured, said method comprising the steps of:
By the first cuff 1 colligation at measured one upper limb position, by the second cuff 2 colligation at measured one lower extremity；
With one, described first cuff 1 and the second cuff 2 being measured main frame 3 by gas connection part be connected, described measurement main frame 3 includes the first pressure transducer, the second pressure transducer, the first gas bleeder valve, the second disappointing two, more than one air pump；
Use microprocessor, process by the first pressure transducer, second pressure transducer obtain first cuff the 1, second cuff 2 in pressure signal and/or pulse signal, described microprocessor perform comprise the following steps measure pulse signal time difference process:
A) by described first cuff the 1, first gas bleeder valve, the first pressure transducer, air pump, measure described artery of upper extremity blood pressure, and measurement makes pulse signal amplitude in the first cuff 1 reach maximum cuff pressure P1A simultaneously；By described second cuff the 2, second gas bleeder valve, the second pressure transducer, air pump, measure described artery of lower extremity blood pressure, and measurement makes pulse signal amplitude in the second cuff 2 reach maximum cuff pressure P2A simultaneously；
B) force value described first cuff 1 being pressurized on P1A or P1A in next given range by air pump, by the force value that the second cuff 2 is pressurized on P2A or P2A in next given range by air pump, then pass through described first and second pressure transducers and measure the pulse signal of in described first and second cufves 2 more than three simultaneously respectively；
C) time difference between the pulse signal of more than three in the pulse signal of in described second cuff 2 more than three and described first cuff 1 is calculated.
As shown in Figure 1, Figure 2 or shown in Fig. 3, a kind of arteriosclerosis measurement apparatus, including main frame 3, and the first cuff 1 and the second cuff 2 being connected with main frame 3 respectively.First cuff 1 is a upper arm cuff, for being bundled in a tested upper limb, can block the blood flowing of tested artery of upper extremity after inflation completely, and is connected with the upper limb balloon interface of main frame 3 by the first trachea 4.Second cuff 2 is an ankle cuff, for being bundled in tested lower limb, can block the blood flowing of tested artery of lower extremity after inflation completely, and is connected with the lower limb balloon interface of main frame 3 by the second trachea 5.First pressure transducer and the second pressure transducer are connected with the first cuff 1 and the second cuff 2 respectively by gas connection part, described first pressure transducer and the second pressure transducer detect the force value in the first cuff 1 and the second cuff 2 and/or pulse signal simultaneously respectively, according to the pulse signal in described first cuff 1 and the second cuff 2 and atmospheric pressure value, determine contraction pressure and the diastolic pressure of tested artery of upper extremity, and the contraction pressure of artery of lower extremity and diastolic pressure.Contraction pressure according to described artery of upper extremity, diastolic pressure and pulse signal, and the contraction pressure of described artery of lower extremity, diastolic pressure and pulse signal, it is determined that the pulse signal transmission time difference of measured.
Described main frame 3 includes microprocessor, the human-computer interaction interface being connected respectively, the first pressure transducer, the second pressure transducer, gas charging system, system of losing heart and the upper limb balloon interface being connected with the first cuff 1 and the second cuff 2 respectively and lower limb balloon interface with microprocessor.Human-computer interaction interface is the human-computer interaction interface including keyboard, display.Gas charging system includes more than one air pump.Disappointing system includes more than one gas bleeder valve.
Gas connection part is made up of one or more parts in trachea, joint, switch valve, three-way air valve.
Embodiment one
For Fig. 1, there is following two step successively:
The first step, for Fig. 5, has following steps:
1) the first cuff 1 and the second cuff 2 are bundled on a tested upper limb and tested lower limb respectively, and are connected with the upper limb balloon interface on main frame 3 and lower limb balloon interface respectively by the first trachea 4 and the second trachea 5；
2) pressing the start key of main frame 3 keyboard, the first and second gas bleeder valves cut out, and the first and second air pumps are inflated to the first cuff 1 and the second cuff 2 respectively, and the air pressure of the first cuff 1 and the second cuff 2 increases from zero；
3) when the air pressure in the first cuff 1 and the second cuff 2 is respectively greater than contraction pressure, close the first and second air pumps, stop inflation；
4) the first and second gas bleeder valves are controlled, respectively the first cuff 1 and the second cuff 2 are slowly lost heart, in the process that the first cuff 1 and the second cuff 2 slowly lose heart, the air pressure and pulse signal that are continually changing in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine the contraction pressure of tested artery of upper extremity and tested artery of lower extremity respectively；
5) continue the first cuff 1 and the second cuff 2 are slowly lost heart, in the process that the first cuff 1 and the second cuff 2 slowly lose heart, the air pressure and pulse signal that are continually changing in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, according to described pulse signal and atmospheric pressure value, determine a target pressure P1A and P2A of tested artery of upper extremity and tested artery of lower extremity respectively, it is determined that the method following 5-1 respectively of this target pressure P1A and P2A) and 5-2):
5-1) for being detected air pressure and the pulse signal of the first cuff 1 by the first pressure transducer, shown in the P1 (t) and A1 (t) of waveform such as Fig. 5, as the pulse signal A1 (t1) three continuous moment of t1, t2 and t3 being detected, A1 (t2), when A1 (t3) meets A1 (t1)<A1 (t2)>A1 (t3) relation, then the air pressure that the t2 moment is corresponding is target pressure P1A；
5-2) for being detected air pressure and the pulse signal of the second cuff 2 by the second pressure transducer, shown in the P2 (t) and A2 (t) of waveform such as Fig. 5, as the pulse signal A2 (t21) three continuous moment of t21, t22 and t23 being detected, A2 (t22), when A21 (t23) meets A2 (t21)<A2 (t22)>A2 (t23) relation, then the air pressure that the t22 moment is corresponding is target pressure P2A；
6) continue the first cuff 1 and the second cuff 2 are slowly lost heart, in the process that the first cuff 1 and the second cuff 2 slowly lose heart, the air pressure and pulse signal that are continually changing in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine tested artery of upper extremity and the diastolic pressure of tested artery of lower extremity respectively；
7) being increased respectively to by the air pressure of the first cuff 1 and the second cuff 2 within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 7-1) and 7-2):
7-1) close the first and second gas bleeder valves, open the first and second air pumps, respectively the first cuff 1 and the second cuff 2 are pressurizeed, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close the first and second air pumps, stop pressurization；
7-2) open the first and second gas bleeder valves, exit to respectively the first cuff 1 and the second cuff 2, until discharging, then wait for a period of time, turn off the first and second gas bleeder valves, open the first and second air pumps, respectively the first cuff 1 and the second cuff 2 are pressurizeed, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close the first and second air pumps, stop pressurization；
8) pulse signal of more than three in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, the pulse signal according to described first cuff 1 and the second cuff 2, it is determined that the pulse signal transmission time difference of measured.Determine that the method for the pulse signal transmission time difference of measured has two kinds, respectively following 8-1) and 8-2):
nullThe pulse signal of a given number in eight to ten six 8-1) is detected in the first cuff 1 and the second cuff 2 respectively by the first pressure transducer and the second pressure transducer，Calculate described given number in the pulse signal of described given number in the second cuff 2 and the first cuff 1 pulse signal between time difference，Such as given number is 12，Shown in C2A and C1A in its waveform such as Fig. 6，First calculate d1=t26-t6，D2=t27-t7，D3=t28-t8，D4=t29-t9，D5=t30-t10，D6=t31-t11，D7=t32-t12，D8=t33-t13，D9=t34-t14，D10=t35-t15，D11=t36-t16，D12=t37-t17，Calculate the meansigma methods of d1～d12 again，Described meansigma methods is exactly the pulse signal transmission time difference of measured；
8-2) detected the pulse signal of more than three in the first cuff 1 and the second cuff 2 respectively by the first pressure transducer and the second pressure transducer, calculate pulse signal described in the second cuff 2 and between pulse signal described in the first cuff 1 time of correlation function maximum determine the time difference between described pulse signal, such as given number is 12, shown in C2A and C1A in its waveform such as Fig. 6, calculation has two kinds, respectively following 8-2-1) and 8-2-2):
8-2-1) set wave function y (t) of 12 pulse signal C2A of the second cuff 2,0≤t≤T, the wave function of 12 pulse signal C1A of the first cuff 1 is x (t), 0≤t≤T, calculating the correlation function R (τ) of y (t) and x (t), computing formula isCalculating described correlation function R (τ) again and take τ-value corresponding during maximum, if described τ-value is τ 0, then τ 0 is exactly the pulse signal transmission time difference of measured；
null8-2-2) set the pulse signal wave function respectively q1 (t) of 12 pulse signal C2A of the second cuff 2，q2(t)，q3(t)，q4(t)，q5(t)，q6(t)，q7(t)，q8(t)，q9(t)，q10(t)，q11(t)，q12(t)，And 0≤t≤T,The pulse signal wave function of 12 pulse signal C1A of the first cuff 1 is p1 (t)，p2(t)，p3(t)，p4(t)，p5(t)，p6(t)，p7(t)，p8(t)，p9(t)，p10(t)，p11(t)，p12(t)，And 0≤t≤T，Calculate the correlation function Ri (τ) of qi (t) and pi (t) respectively，Wherein 0≤i≤12T and be integer，Computing formula isCalculate respectively again 12 correlation function R1 (τ) to R12 (τ) take maximum time corresponding τ-value, if described τ-value respectively τ 1, τ 2, τ 3, τ 4, τ 5, τ 6, τ 7, τ 8, τ 9, τ 10, τ 11 and τ 12, calculating the meansigma methods of τ 1 to τ 12 again, described meansigma methods is exactly the pulse signal transmission time difference of measured；
9) open the first and second gas bleeder valves, lose heart to the first cuff 1 and the second cuff 2.
The second step, for Fig. 7, has following steps:
1) the first cuff 1 and the second cuff 2 are bundled on a tested upper limb and tested lower limb respectively, and are connected with the upper limb balloon interface on main frame 3 and lower limb balloon interface respectively by the first trachea 4 and the second trachea 5；
2) pressing the start key of main frame 3 keyboard, the first and second gas bleeder valves cut out, and the first and second air pumps are inflated to the first cuff 1 and the second cuff 2 respectively, and the air pressure of the first cuff 1 and the second cuff 2 slowly increases from zero；
3) in the process that the first cuff 1 and the second cuff 2 are slowly pressurizeed, the air pressure and pulse signal that are continually changing in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine tested artery of upper extremity and the diastolic pressure of tested artery of lower extremity respectively；
4) continue the first cuff 1 and the second cuff 2 are slowly pressurizeed, in the process that the first cuff 1 and the second cuff 2 slowly pressurize, the air pressure and pulse signal that are continually changing in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, according to described pulse signal and atmospheric pressure value, determine a target pressure P1A and P2A of tested artery of upper extremity and tested artery of lower extremity respectively, it is determined that the method following 4-1 respectively of this target pressure P1A and P2A) and 4-2):
4-1) for being detected air pressure and the pulse signal of the first cuff 1 by the first pressure transducer, shown in the P1 (t) and A1 (t) of waveform such as Fig. 7, as the pulse signal A1 (t41) three continuous moment of t41, t42 and t43 being detected, A1 (t42), when A1 (t43) meets A1 (t41)<A1 (t42)>A1 (t43) relation, then the air pressure that the t42 moment is corresponding is target pressure P1A；
4-2) for being detected air pressure and the pulse signal of the second cuff 2 by the second pressure transducer, shown in the P2 (t) and A2 (t) of waveform such as Fig. 6, as the pulse signal A2 (t61) three continuous moment of t61, t62 and t63 being detected, A2 (t62), when A2 (t63) meets A2 (t61)<A2 (t62)>A2 (t63) relation, then the air pressure that the t162 moment is corresponding is target pressure P2A；
5) continue the first cuff 1 and the second cuff 2 are slowly pressurizeed, in the process that the first cuff 1 and the second cuff 2 slowly pressurize, the air pressure and pulse signal that are continually changing in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, according to described pulse signal and atmospheric pressure value, utilize oscillographic method principle, determine the contraction pressure of tested artery of upper extremity and tested artery of lower extremity respectively；
6) air pressure of the first cuff 1 and the second cuff 2 being reduced respectively or increased within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 6-1) and 6-2):
6-1) open the first gas bleeder valve and the second gas bleeder valve, respectively the first cuff 1 and the second cuff 2 are lost heart, the air pressure of the first cuff 1 and the second cuff 2 is reduced to respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is reduced respectively and press P1A and P2A to target, close the first gas bleeder valve and the second gas bleeder valve, stop losing heart；
6-2) open the first gas bleeder valve and the second gas bleeder valve, exit to respectively the first cuff 1 and the second cuff 2, until discharging, then wait for a period of time, turn off the first gas bleeder valve and the second gas bleeder valve, open the first air pump and the second air pump, respectively the first cuff 1 and the second cuff 2 are pressurizeed, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close the first air pump and the second air pump, stop pressurization；
7) pulse signal of more than three in the first cuff 1 and the second cuff 2 is detected respectively by the first pressure transducer and the second pressure transducer, the pulse signal according to described first cuff 1 and the second cuff 2, it is determined that the pulse signal transmission time difference of measured.Determine that the method for the pulse signal transmission time difference of measured has two kinds, respectively following 7-1) and 7-2):
nullThe pulse signal of a given number in eight to ten six 7-1) is detected in the first cuff 1 and the second cuff 2 respectively by the first pressure transducer and the second pressure transducer，Calculate described given number in the pulse signal of described given number in the second cuff 2 and the first cuff 1 pulse signal between time difference，Such as given number is 12，Shown in C2A and C1A in its waveform such as Fig. 8，First calculate d21=t66-t46，D22=t67-t47，D23=t68-t48，D24=t69-t49，D25=t70-t50，D26=t71-t51，D27=t72-t52，D28=t73-t53，D29=t74-t54，D30=t75-t55，D31=t76-t56，D32=t77-t57，Calculate the meansigma methods of d21～d32 again，Described meansigma methods is exactly the pulse signal transmission time difference of measured；
7-2) detected the pulse signal of more than three in the first cuff 1 and the second cuff 2 respectively by the first pressure transducer and the second pressure transducer, calculate pulse signal described in the second cuff 2 and between pulse signal described in the first cuff 1 time of correlation function maximum determine the time difference between described pulse signal, such as given number is 12, shown in C2A and C1A in its waveform such as Fig. 8, calculation has two kinds, respectively following 7-2-1) and 7-2-2):
7-2-1) set wave function y (t) of 12 pulse signal C2A of the second cuff 2,0≤t≤T, the wave function of 12 pulse signal C1A of the first cuff 1 is x (t), 0≤t≤T, calculating the correlation function R (τ) of y (t) and x (t), computing formula isCalculating described correlation function R (τ) again and take τ-value corresponding during maximum, if described τ-value is τ 0, then τ 0 is exactly the pulse signal transmission time difference of measured；
null7-2-2) set the pulse signal wave function respectively q1 (t) of 12 pulse signal C2A of the second cuff 2，q2(t)，q3(t)，q4(t)，q5(t)，q6(t)，q7(t)，q8(t)，q9(t)，q10(t)，q11(t)，q12(t)，And 0≤t≤T,The pulse signal wave function of 12 pulse signal C1A of the first cuff 1 is p1 (t)，p2(t)，p3(t)，p4(t)，p5(t)，p6(t)，p7(t)，p8(t)，p9(t)，p10(t)，p11(t)，p12(t)，And 0≤t≤T，Calculate the correlation function Ri (τ) of qi (t) and pi (t) respectively，Wherein 0≤i≤12 and be integer，Computing formula isCalculate respectively again 12 correlation function R1 (τ) to R12 (τ) take maximum time corresponding τ-value, if described τ-value respectively τ 1, τ 2, τ 3, τ 4, τ 5, τ 6, τ 7, τ 8, τ 9, τ 10, τ 11 and τ 12, calculating the meansigma methods of τ 1 to τ 12 again, described meansigma methods is exactly the pulse signal transmission time difference of measured；
8) open the first gas bleeder valve and the second gas bleeder valve, lose heart to the first cuff 1 and the second cuff 2.
Embodiment two
As in figure 2 it is shown, there is following a kind of step:
For Fig. 5, it is only necessary to use Fig. 1 the first step, and by the step 2 in described step), 3) and 7) respectively by following steps 2), 3) and 7) replace:
2) start key of main frame 3 keyboard is pressed, first gas bleeder valve and the second gas bleeder valve are closed, timesharing opens the first switch valve, close second switch valve, open air pump inflates and opens second switch valve to the first cuff 1, close the first switch valve, open air pump and inflate to the second cuff 2, and the air pressure of the first cuff 1 and the second cuff 2 increases from zero；
3) when the air pressure in the first cuff 1 and the second cuff 2 is respectively greater than contraction pressure, close air pump, stop inflation；
7) being increased respectively to by the air pressure of the first cuff 1 and the second cuff 2 within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 7-1) and 7-2):
7-1) close the first gas bleeder valve and the second gas bleeder valve, timesharing opens the first switch valve, close second switch valve, open air pump inflates and opens second switch valve to the first cuff 1, close the first switch valve, open air pump and inflate to the second cuff 2, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close air pump, stop pressurization；
7-2) open the first gas bleeder valve and the second gas bleeder valve, exit to respectively the first cuff 1 and the second cuff 2, until discharging, then wait for a period of time, turn off the first gas bleeder valve and the second gas bleeder valve, the first switch is opened in timesharing, close second switch valve, open air pump and inflate and open second switch valve to the first cuff 1, close the first switch valve, open air pump to inflate to the second cuff 2, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close air pump, stop pressurization.
Embodiment three
As it is shown on figure 3, there is following a kind of step:
For Fig. 5, it is only necessary to use Fig. 1 the first step, and by the step 2 in described step), 3) and 7) respectively by following steps 2), 3) and 7) replace:
2) start key of main frame 3 keyboard is pressed, first gas bleeder valve and the second gas bleeder valve are closed, three-way air valve connected air pump and the first cuff 1 by timesharing, open air pump to the first cuff 1 inflates and connects air pump and the second cuff 2 with by three-way air valve, opens air pump and inflate to the second cuff 2, and the air pressure of the first cuff 1 and the second cuff 2 increases from zero；
3) when the air pressure in the first cuff 1 and the second cuff 2 is respectively greater than contraction pressure, close air pump, stop inflation；
7) being increased respectively to by the air pressure of the first cuff 1 and the second cuff 2 within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, this step has two kinds of embodiments, respectively following 7-1) and 7-2):
7-1) close the first gas bleeder valve and the second gas bleeder valve, three-way air valve connected air pump and the first cuff 1 by timesharing, open air pump to the first cuff 1 inflates and connects air pump and the second cuff 2 with by three-way air valve, opens air pump and inflate to the second cuff 2, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close air pump, stop pressurization；
7-2) open the first gas bleeder valve and the second gas bleeder valve, exit to respectively the first cuff 1 and the second cuff 2, until discharging, then wait for a period of time, turn off the first gas bleeder valve and the second gas bleeder valve, three-way air valve is connected air pump and the first cuff 1 by timesharing, open air pump to inflate to the first cuff 1 and connect air pump and the second cuff 2 with by three-way air valve, open air pump to inflate to the second cuff 2, the air pressure of the first cuff 1 and the second cuff 2 is increased respectively within the scope of target pressure P1A or P1A ± 10mmHg and within the scope of P2A or P2A ± 10mmHg, such as the air pressure of the first cuff 1 and the second cuff 2 is increased respectively to target pressure P1A and P2A, close air pump, stop pressurization.
Above content be in conjunction with concrete preferred implementation made for the present invention convert in detail further bright, it is impossible to assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention; make some equivalent replacements or obvious modification without departing from the inventive concept of the premise; and performance or purposes are identical, all should be considered as belonging to patent protection model that the present invention determines by submitted claims with.
Claims (5)
1. a measuring method for pulse signal transmission time difference, for measuring the time difference between the arterial pulse signal of different two body part of measured, it is characterised in that said method comprising the steps of:
By the first cuff colligation at measured one upper limb position, by the second cuff colligation at measured one lower extremity；
By gas connection part and one, described first cuff and the second cuff being measured main frame be connected, described measurement main frame includes the first pressure transducer, the second pressure transducer, the first gas bleeder valve, the second gas bleeder valve, more than one air pump；
Using microprocessor, process by the pressure signal in the first pressure transducer, the first cuff of the second pressure transducer acquisition, the second cuff and/or pulse signal, described microprocessor performs the process measuring pulse signal time difference comprised the following steps:
A) by described first cuff, the first gas bleeder valve, the first pressure transducer, air pump, measure described artery of upper extremity blood pressure, and measurement makes pulse signal amplitude in the first cuff reach maximum cuff pressure P1A simultaneously；By described second cuff, the second gas bleeder valve, the second pressure transducer, air pump, measure described artery of lower extremity blood pressure, and measurement makes pulse signal amplitude in the second cuff reach maximum cuff pressure P2A simultaneously；
B) by described air pump described first cuff is pressurized to a force value within the scope of P1A ± 10mmHg, by described air pump described second cuff is pressurized to a force value within the scope of P2A ± 10mmHg, then passes through described first and second pressure transducers and measure the pulse signal of in described first and second cufves more than three simultaneously respectively；
C) time difference between the pulse signal of more than three in the pulse signal of in described second cuff more than three and described first cuff is calculated, particularly as follows: determine the time difference between described pulse signal by calculating the time of correlation function maximum between the pulse signal of more than three in the pulse signal of in described second cuff more than three and described first cuff.
2. the measuring method of pulse signal transmission time difference as claimed in claim 1, it is characterized in that, described computational methods are particularly as follows: set wave function y (t) of n pulse signal C2A of described second cuff, 0≤t≤T, the wave function of n pulse signal C1A of described first cuff is x (t), 0≤t≤T, calculates the correlation function R (τ) of described y (t) and x (t), and computing formula isCalculating described correlation function R (τ) again and take τ-value corresponding during maximum, if described τ-value is τ 0, then τ 0 is exactly the pulse signal transmission time difference of measured.
3. the measuring method of pulse signal transmission time difference as claimed in claim 1, it is characterised in that described computational methods particularly as follows:
If the pulse signal wave function respectively q1 (t) of n pulse signal C2A of described second cuff, q2 (t) ... qn (t), and 0≤t≤T, the pulse signal wave function of n pulse signal C1A of described first cuff is p1 (t), p2 (t) ... pn (t), and 0≤t≤T, calculate the correlation function Ri (τ) of described qi (t) and pi (t) respectively, wherein 0≤i≤n and be integer, computing formula isCalculate respectively more described n correlation function R1 (τ) to Rn (τ) take maximum time corresponding τ-value, if described τ-value respectively τ 1, τ 2... τ n, calculating the meansigma methods of described τ 1 to τ n again, described meansigma methods is exactly the pulse signal transmission time difference of measured.
4. the measuring method of the pulse signal transmission time difference as described in any one of claim 1-3, it is characterized in that: use pressurization measurement method or decompression measurement method, for being detected air pressure P1 (t) and pulse signal A1 (t) of described first cuff by described first pressure transducer, as the pulse signal A1 (t1) three continuous moment of t1, t2 and t3 being detected, A1 (t2), when A1 (t3) meets A1 (t1)<A1 (t2)>A1 (t3) relation, then the air pressure that the t2 moment is corresponding is target pressure P1A.
5. the measuring method of the pulse signal transmission time difference as described in any one of claim 1-3, it is characterized in that: use pressurization measurement method or decompression measurement method, for being detected air pressure P2 (t) and pulse signal A2 (t) of described second cuff by described second pressure transducer, as the pulse signal A2 (t21) three continuous moment of t21, t22 and t23 being detected, A2 (t22), when A2 (t23) meets A2 (t21)<A2 (t22)>A2 (t23) relation, then the air pressure that the t22 moment is corresponding is target pressure P2A.
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| US4245648A (en) * | 1978-09-20 | 1981-01-20 | Trimmer Gordon A | Method and apparatus for measuring blood pressure and pulse rate |
| JP2001321347A (en) * | 2000-05-16 | 2001-11-20 | Nippon Koden Corp | Blood pressure monitoring device |
| CN1325285A (en) * | 1998-08-24 | 2001-12-05 | 马丁·C·巴鲁克 | Apparatus and method for measuring pulse transit time |
| KR20090127517A (en) * | 2008-06-09 | 2009-12-14 | (주)아이베이지디쓰리 | Heart monitoring system |
| CN102223837A (en) * | 2008-11-20 | 2011-10-19 | 欧姆龙健康医疗事业株式会社 | Blood pressure information measuring device for measuring pulse wave velocity as blood pressure information |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4245648A (en) * | 1978-09-20 | 1981-01-20 | Trimmer Gordon A | Method and apparatus for measuring blood pressure and pulse rate |
| CN1325285A (en) * | 1998-08-24 | 2001-12-05 | 马丁·C·巴鲁克 | Apparatus and method for measuring pulse transit time |
| JP2001321347A (en) * | 2000-05-16 | 2001-11-20 | Nippon Koden Corp | Blood pressure monitoring device |
| KR20090127517A (en) * | 2008-06-09 | 2009-12-14 | (주)아이베이지디쓰리 | Heart monitoring system |
| CN102223837A (en) * | 2008-11-20 | 2011-10-19 | 欧姆龙健康医疗事业株式会社 | Blood pressure information measuring device for measuring pulse wave velocity as blood pressure information |
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