CN103550796A - Method for preparing iodine-125 sealed seed source core - Google Patents
Method for preparing iodine-125 sealed seed source core Download PDFInfo
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- CN103550796A CN103550796A CN201310444386.0A CN201310444386A CN103550796A CN 103550796 A CN103550796 A CN 103550796A CN 201310444386 A CN201310444386 A CN 201310444386A CN 103550796 A CN103550796 A CN 103550796A
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Abstract
The invention discloses a method for preparing an iodine-125 sealed seed source core, comprising the following steps of: in a reaction container, adding 100 silver rods in proportion, adding a citrate solution and a vanadyl sulfate solution, mixing, reacting, and then adding a bromide solution, an iodized salt solution and an sodium iodide-125 solution; regulating pH value; oscillating for reaction, removing liquid supernatant, and cleaning with acetone, deionized water or ethanol, to obtain the iodine-125 sealed seed source core. The method can rapidly and simply fix radioactive iodine-125 on a silver rod, prepares iodine-125 source core with advantages of uniform dosage, firmness, compactness, one step method completion, and simple and easy control of operation process, greatly raising production efficiency, and reducing labor intensity and radiation dose of a worker. The method has advantages of rapidness, simpliness, low production cost, and high iodine-125 utilization rate.
Description
Technical field
The invention belongs to the medicinal preparation technical field containing radioactive substance, particularly, relate to a kind of preparation method of iodine-125 sealing seed source core.
Background technology
Iodine-125 sealed seed source implanted treatment tumor is by around iodine-125 sealed seed source implantation tumour or tumor, utilizes the low-energyγ-ray that iodine-125 sealing seed source core is emitted to kill tumor cell, reaches the object for the treatment of and alleviation disease.This technology is adapted to the implanted treatment of various entity tumors, as carcinoma of prostate, breast carcinoma, hepatocarcinoma, cerebroma and ovarian cancer etc., has obtained and surgical operation, therapeutic effect that outer radiotherapy is identical, and toxic and side effects is little.Iodine-125 sealed seed source implanted treatment tumor mode is divided into temporary implanted treatment tumor and permanent implanted treatment tumor, permanent implanted referring to no longer taken out iodine-125 sealed seed source implantation tumour position, and temporary implantation refers to iodine-125 sealed seed source implantation tumour position, after treatment a period of time, take out.
Compare with other radionuclide, radionuclide iodo-125 has good nulcear properties, and the iodine-125 half-life is 59.43 days, and electron capture decay is attended by characteristic X-ray and internal-conversion electron.The Ti wall that electronics is Iodine-125 Seed is absorbed, and main Te-KX characteristic X-ray is 27.4,31.4KeV and 35.5KeV gamma-rays, also has from the fluorescent X-ray of 22.1 and 25.2KeV of Ag rod transmitting.Because the gamma-rays energy of iodine-125 is low, easily shielding, the above ray of plumbous maskable 99% that 0.25mm is thick, organizing range is 17mm, and the radiation injury of normal structure is little, and entourage and medical personnel's exposure dosage is little.The long half time of iodine-125 sealed seed source, long shelf-life, clinical easy to use.Iodine-125 has good chemical property, can form stable iodate precipitated metal with many metal ions (Au, Ag, Cu etc.), the general fixedly support rod of iodine-125 of silver conduct of selecting, because silver ion can not only form silver iodide precipitation with iodine, and be the mark of x ray, while being convenient to implanted treatment, iodine-125 sealed seed source is carried out the estimation of accurate location and therapeutic dose.
Iodine-125 sealed seed source is to have the silver rod (also claiming radioactivity iodine-125 source core) of iodine-125 to pack in titanium pipe or stainless steel tube absorption, with laser welding technology sealing two ends, makes, and Fig. 1 is shown in by structure chart.
Radionuclide iodo-125 is fixed on the technology of silver rod, also claims that iodine-125 source core technology of preparing is the important technology that iodine-125 sealed seed source is manufactured, and the technology of preparing of iodine-125 source core has galvanoplastic, chemical auto-deposition method and physical deposition method conventionally.Compare with other two kinds of methods; chemistry auto-deposition method has that technological process is simple, the utilization rate of iodine-125 is high, equipment easily obtains, preparation process has been controlled and easily large-scale production; become the main stream approach of preparing iodine-125 source core both at home and abroad, associated patent is more.For example U.S. Patent number 4323055 and the disclosed preparation method of China Patent Publication No. CN1307907 are all to using silver as the fixing carrier of iodine-125, the halate (hypochlorite and chlorite) of take is oxidized and chlorination reaction as oxidant under 6mol/L hydrochloric acid condition, silver rod after chlorination carries out ion-exchange reactions 18～22 hours with iodine-125 sodium water solution in pH10～12, make the source core of iodine-125 sealed seed source.The main deficiency of said method is that the response time is long, and a large amount of chlorine that has penetrating odor of course of reaction generation, and personnel and environment are caused to adverse effect, and hypochlorous acid is not conventional reagent, is difficult to buy.A kind of chemiadsorption that China Patent Publication No. CN1265924A discloses is also to take hydrogen peroxide under hydrochloric acid condition, to be oxidized and chlorination reaction as oxidant, silver rod after chlorination carries out ion-exchange reactions 18 hours with iodine-125 sodium water solution under pH=5, make the source core of iodine-125 sealed seed source, although solved the generation of chlorine in preparation process, but the response time is still long, and in chlorination reaction process, produce a large amount of oxygen, for the cleaning operation of silver chloride rod brings certain difficulty.The disclosed preparation method of China Patent Publication No. CN101401944A is first to use 20%～80% sodium hypochlorite and silver-colored excellent oscillating reactions 1 hour, make silver rod surface form the AgCl layer of one deck densification, then it is reacted 1 hour with the mixed liquor of iodine-125 sodium water solution at hac buffer, make iodine-125 source core, although very big Reaction time shorten, but complete by two-step method (iodate after first chlorination), complicated operation, process is wayward, and also can produce a small amount of chlorine at chlorination process, personnel and environment are had to adverse effect, therefore need be improved.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide that a kind of cost is low, environmentally safe, easily control, a kind of preparation method of iodine-125 sealing seed source core fast.
Technical scheme of the present invention is summarized as follows:
A preparation method for iodine-125 sealing seed source core, is comprised of following steps:
In reaction vessel, putting in proportion 100 diameters is the silver rod that 0.1～0.7mm, length are 2.0～3.5mm, adding 0.05～0.5mL concentration is that citrate aqueous solution and the 0.15～1.5mL concentration of 0.01～3mol/L is 0.25～10mol/L vanadium oxysulfate aqueous solution, mix, react 2～5 minutes, then to add 0.10～1.5mL concentration be that 0.005mol/L～1mol/L Bromide aqueous solution, 0.02～0.5mL concentration are that 0.001mol/L～4mol/L iodized salt aqueous solution, 0.04～1.5mL concentration are 100-1000mCi/mL iodine-125 sodium water solution; Regulate pH=8～12; Oscillating reactions 3～20min, abandons supernatant, with acetone, deionized water or ethanol, cleans 2～4 times, obtains iodine-125 sealing seed source core.
Described citrate optimization citric acid sodium or potassium citrate.
The preferred sodium bromide of described Bromide or potassium bromide or cesium bromide.
The preferred sodium iodide of described iodized salt or potassium iodide or cesium iodide.
Advantage of the present invention:
1, the present invention can fast and conveniently be fixed on radioactivity iodine-125 on silver-colored rod, prepare iodine-125 source core dosage even, firm and fine and close, whole preparation process needs 25 minutes at most, one-step method completes, operation sequence is simple and easy to control, greatly improve production efficiency, reduced staff's labor intensity and radiation dose.
2, the present invention adopts silver rod to carry out pre-reaction with vanadium oxysulfate aqueous solution under the effect of citrate, add again radioactivity iodine-125, minimizing iodine-125 ion in course of reaction is oxidized to iodine-125 molecule, and the volatilization of minimizing radioactivity iodine-125, improved the utilization rate of radioactivity iodine-125, save cost, reduced the environmental pollution that production process causes.
3, the present invention prepares the mixed precipitation layer that iodine-125 source core is Silver monobromide and silver iodide, improve the stability of iodine-125 source core under daylight, reduce the photolysis of iodine-125 source core, improve the utilization rate of iodine-125, reduce production costs, the pollution risk of reduction to environment, the safety of raising subsequent operation.
4, the chemical reagent that the present invention uses is conventional commercial reagent, and buying is convenient, low price.
Accompanying drawing explanation
Fig. 1 is iodine-125 sealed seed source structural representation.
In figure, 1 is titanium pipe or stainless steel tube, and 2 is iodine-125 source core.
The specific embodiment
Below in conjunction with concrete enforcement, the present invention is further illustrated.
The chemical reagent using in all embodiment is analytical pure.
After 100 silver rods (Φ 0.3 * 3mm) are cleaned with acetone, the square quartzy bottle that packs 15mL into, add 0.25mL0.2mol/L sodium citrate aqueous solution and 0.20mL0.5mol/L vanadium oxysulfate aqueous solution, reaction 2min, add again 0.5mL0.10mol/L aqueous sodium bromide, 0.04mL0.005mol/L sodium iodide aqueous solution and 1mL100mCi/mL iodine-125 sodium water solution, mix homogeneously, regulate pH=10, speed oscillation with 20 turn/min is reacted 15 minutes, abandon supernatant, by washed with de-ionized water 3 times, dry, obtain iodine-125 sealing seed source core.After reaction, in solution, the activity of iodine-125 is 0.5mCi, and the utilization rate of iodine-125 is 99.5%, and the average radioactivity of iodine-125 source core is 0.625mCi.
The utilization rate of iodine-125=(activity of iodine-125 in the rear solution of activity-reaction of input iodine-125) ÷ drops into activity * 100% of iodine-125
After 100 silver rods (Φ 0.3 * 3mm) are cleaned with acetone, the square quartzy bottle that packs 15mL into, add 0.15mL0.5mol/L potassium citrate aqueous solution and 0.45mL0.25mol/L vanadium oxysulfate aqueous solution, reaction 3min, add again 0.5mL0.10mol/L kbr aqueous solution, 0.04mL0.005mol/L potassium iodide aqueous solution and 1mL160mCi/mL iodine-125 sodium water solution, mix homogeneously, regulate pH=8, rotating speed rotational oscillation with 20 turn/min reacts 10 minutes, abandon supernatant, by washed with de-ionized water 3 times, dry, obtain iodine-125 sealing seed source core.After reaction, in solution, the activity of iodine-125 is 0.95mCi, and the utilization rate of iodine-125 is 99.4%, and the average radioactivity of iodine-125 source core is 1.03mCi.
Embodiment 3
After 200 silver rods (Φ 0.3 * 3mm) are cleaned with acetone, the square quartzy bottle that packs 15mL into, add 0.40mL0.2mol/L sodium citrate aqueous solution and 0.40mL0.5mol/L vanadium oxysulfate aqueous solution, mix, reaction 2min, add again 0.5mL0.15mol/L aqueous sodium bromide, 0.04mL0.01mol/L sodium iodide aqueous solution and 1mL320mCi/mL iodine-125 sodium water solution, mix homogeneously, rotating speed rotational oscillation with 40 turn/min reacts 20 minutes, abandon supernatant, by washed with de-ionized water 3 times, dry, obtain iodine-125 sealing seed source core.After reaction, in solution, the activity of iodine-125 is 0.65mCi, and the utilization rate of iodine-125 is 99.8%, and the average radioactivity of iodine-125 source core is 1.06mCi.
Embodiment 4
After 100 silver rods (Φ 0.1 * 2mm) are cleaned with acetone, the square quartzy bottle that packs 15mL into, add 0.05mL3mol/L sodium citrate aqueous solution and 0.15mL10mol/L vanadium oxysulfate aqueous solution, mix, reaction 2min, add again 0.10mL1mol/L aqueous sodium bromide, 0.02mL4mol/L sodium iodide aqueous solution and 0.07mL1000mCi/mL iodine-125 sodium water solution, mix homogeneously, regulate pH=10, speed oscillation with 20 turn/min is reacted 3 minutes, abandons supernatant, with acetone, cleans 2 times, dry, obtain iodine-125 sealing seed source core.
After reaction, in solution, the activity of iodine-125 is 0.4mCi, and the utilization rate of iodine-125 is 99.6%, and the average radioactivity of iodine-125 source core is 0.638mCi.
Embodiment 5
After 100 silver rods (Φ 0.7 * 3.5mm) are cleaned with acetone, the square quartzy bottle that packs 15mL into, add 0.5mL0.01mol/L sodium citrate aqueous solution and 1.5mL0.25mol/L vanadium oxysulfate aqueous solution, mix, reaction 5min, add again 1.5mL0.005mol/L cesium bromide aqueous solution, 0.5mL0.001mol/L cesium iodide aqueous solution and 0.5mL400mCi/mL iodine-125 sodium water solution, mix homogeneously, regulate pH=12, speed oscillation with 20 turn/min is reacted 20 minutes, abandons supernatant, with ethanol, cleans 4 times, dry, obtain iodine-125 sealing seed source core.
After reaction, in solution, the activity of iodine-125 is 0.5mCi, and the utilization rate of iodine-125 is 99.5%, and the average radioactivity of iodine-125 source core is 1.250mCi.
Claims (4)
1. the preparation method of an iodine-125 sealing seed source core, by following steps, formed: in reaction vessel, putting in proportion 100 diameters is 0.1～0.7mm, length is the silver rod of 2.0～3.5mm, adding 0.05～0.5mL concentration is that citrate aqueous solution and the 0.15～1.5mL concentration of 0.01～3mol/L is 0.25～10mol/L vanadium oxysulfate aqueous solution, mix, react 2～5 minutes, adding 0.10～1.5mL concentration is 0.005mol/L～1mol/L Bromide aqueous solution again, 0.02～0.5mL concentration is 0.001mol/L～4mol/L iodized salt aqueous solution, 0.04～1.5mL concentration is 100-1000mCi/mL iodine-125 sodium water solution, regulate pH=8～12, oscillating reactions 3～20min, abandons supernatant, with acetone, deionized water or ethanol, cleans 2～4 times, obtains iodine-125 sealing seed source core.
2. according to the preparation method of a kind of iodine-125 sealing seed source core of claim 1, it is characterized in that described citrate is sodium citrate or potassium citrate.
3. the preparation method of a kind of iodine-125 sealing seed source core according to claim 1, is characterized in that described Bromide is sodium bromide or potassium bromide or cesium bromide.
4. the preparation method of a kind of iodine-125 sealing seed source core according to claim 1, is characterized in that described iodized salt is sodium iodide or potassium iodide or cesium iodide.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106139175A (en) * | 2016-07-13 | 2016-11-23 | 江苏华益科技有限供公司 | A kind of Novel silver-based absorption iodine [125i] preparation method of sealed seed source |
Citations (7)
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|---|---|---|---|---|
| US4323055A (en) * | 1980-04-08 | 1982-04-06 | Minnesota Mining And Manufacturing Company | Radioactive iodine seed |
| CN1265924A (en) * | 2000-02-28 | 2000-09-13 | 中国原子能科学研究院 | Preparation process of iodine-125 seed source carrier rod |
| CN1307907A (en) * | 2001-01-18 | 2001-08-15 | 中国科学院上海原子核研究所 | Iodine-125 seed medicine for intervention treatment and its preparation |
| CN1593666A (en) * | 2004-07-12 | 2005-03-16 | 天津赛德生物制药有限公司 | Preparation method of therapy used iodine-125 sealed seed source core |
| CN101397659A (en) * | 2007-09-26 | 2009-04-01 | 王沄涛 | Technique for preparing coating of iodine-125 sealed seed source silver carrier rod |
| CN101401944A (en) * | 2008-10-30 | 2009-04-08 | 成都云克药业有限责任公司 | Method of preparing iodine-125 sealing seed source core |
| CN101905028A (en) * | 2010-07-08 | 2010-12-08 | 北京智博高科生物技术有限公司 | Method for preparing iodine [1251] sealed seed source core |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323055A (en) * | 1980-04-08 | 1982-04-06 | Minnesota Mining And Manufacturing Company | Radioactive iodine seed |
| CN1265924A (en) * | 2000-02-28 | 2000-09-13 | 中国原子能科学研究院 | Preparation process of iodine-125 seed source carrier rod |
| CN1307907A (en) * | 2001-01-18 | 2001-08-15 | 中国科学院上海原子核研究所 | Iodine-125 seed medicine for intervention treatment and its preparation |
| CN1593666A (en) * | 2004-07-12 | 2005-03-16 | 天津赛德生物制药有限公司 | Preparation method of therapy used iodine-125 sealed seed source core |
| CN101397659A (en) * | 2007-09-26 | 2009-04-01 | 王沄涛 | Technique for preparing coating of iodine-125 sealed seed source silver carrier rod |
| CN101401944A (en) * | 2008-10-30 | 2009-04-08 | 成都云克药业有限责任公司 | Method of preparing iodine-125 sealing seed source core |
| CN101905028A (en) * | 2010-07-08 | 2010-12-08 | 北京智博高科生物技术有限公司 | Method for preparing iodine [1251] sealed seed source core |
Non-Patent Citations (3)
| Title |
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| CHUNFU ZHANG ET AL.: "Preparation of iodine-125 seed Part I: Iodination of the silver rod", 《JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY》 * |
| IZABELA CIESZYKOWSKA ET AL.: "An approach to the preparation of iodine-125 seed-type sources", 《NUKLEONIKA》 * |
| 何佳恒等: "碘在银丝上的吸附工艺研究", 《核化学与放射化学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106139175A (en) * | 2016-07-13 | 2016-11-23 | 江苏华益科技有限供公司 | A kind of Novel silver-based absorption iodine [125i] preparation method of sealed seed source |
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