CN103550596A - Application of Anerning granules in preparing medicament for treating viral pneumonia - Google Patents
Application of Anerning granules in preparing medicament for treating viral pneumonia Download PDFInfo
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Abstract
The invention discloses application of Anerning granules in preparing a medicament for treating viral pneumonia. The granules have a remarkable curative effect on viral pneumonia caused by respiratory syncytial virus and influenza virus, can be used for remarkably reducing the lung index, and is in dose-effect relationship. The Anerning granules can be used for protecting experimental animal death caused by respiratory syncytial virus (RSV), and has a remarkable inhibition effect on spleen index and thymus index reduction caused by RSV, can be used for reducing animal death cased by viral pneumonia, and can be used for remarkably protecting the immunity of experimental animals.
Description
Technical field
The present invention relates to pacify the application of the peaceful granule of youngster in preparation treatment viral pneumonia medicine, belong to field of medicaments.
Background technology
The pathogenic status of virus in pneumonia occurs caused increasing concern at present.Especially sars coronavirus, bird flu virus A(H5N1), epidemic influenza virus A(H1N1 in 2009) appearance, again caused that people cause the attention of severe pneumonia for respiratory virus infection.According to WHO, estimate, the whole world approximately has 4.5 hundred million patients with pneumonias every year, and wherein approximately 400 die ten thousand deaths in this disease, accounts for 5,700 7% of the populations of dying of dieing ten thousand deaths, and pneumonia has become the third-largest underlying cause of death after ischemic heart desease and cerebrovascular disease.As everyone knows, antibacterial is the main pathogens that causes Adults Community acquired pneumonia (CAP), especially the most common with streptococcus pneumoniae.And in recent years, the effect of Respirovirus in adult CAP occurs is familiar with by people gradually.Most research thinks, influenza virus is to cause the topmost pathogen of adult diseases toxicity CAP, and other common viruses also comprise respiratory syncytial virus (RSV) etc.
The peaceful granule of peace youngster is recorded in Chinese patent medicine provincial standard rising national drug standards part; Standard number: WS-10640 (ZD-0640)-2002, has clearing away heat and expelling wind, the effect of preventing phlegm from forming and stopping coughing.For infantile anemopyretic cold, bring up phlegm when one coughs, heating pharyngalgia, upper respiratory tract infection is shown in above-mentioned patient, and pharmacological effect result of study shows bringing up phlegm when one coughs, and the pharyngalgia of generating heat has good therapeutic effect.Document once reported, the peaceful granule of peace youngster can be used for assistant and controls bronchopneumonia, but the document do not explain this bronchopneumonia and cause for which kind of cause of disease, and to investigate foundation be only course of disease natural law, according to the document, can not get pacifying the enlightenment that the peaceful granule of youngster can be used for viral pneumonia.Further retrieval, also has no the research that the peaceful granule of other peace youngster is used for the treatment of viral pneumonia.
Summary of the invention
The object of this invention is to provide the application of the peaceful granule of a kind of youngster of peace in preparation treatment viral pneumonia medicine.
The application of the peaceful granule of above-mentioned peace youngster in preparation treatment viral pneumonia medicine, described viral pneumonia is the viral pneumonia that respiratory syncytial virus causes.
The application of the peaceful granule of above-mentioned peace youngster in preparation treatment viral pneumonia medicine, described viral pneumonia is the viral pneumonia that influenza virus causes.
The application of the peaceful granule of above-mentioned peace youngster in preparation treatment viral pneumonia medicine, described influenza virus is A type HINI influenza virus, A type H2N2, A type H5N1 or Influenza B virus.
The application in preparation treatment viral pneumonia medicine of the peaceful granule of above-mentioned peace youngster and chemical drugs or Chinese medicine or natural drug.
The peaceful granule of described peace youngster is for meeting the preparation of WS-10640 (ZD-0640)-2002 standard, and its formula is: Flos Carthami 53.3 weight portions, Santalum album 66.7 weight portions, Radix Glycyrrhizae 53.3 weight portions, high mountain Radix Cochleariae officinalis dish 53.3 weight portions, Rhizoma Seu Herba Bergeniae 53.3 weight portions, Concretio Silicea Bambusae 66.7 weight portions, Lagotis brevituba 66.7 weight portions, Tangut aconite 66.7 weight portions, artificial Calculus Bovis's 5.3 weight portions.
Effect of the present invention: experiment is found, pacifies the lung index that the peaceful granule of youngster can significantly reduce viral pneumonia, and the amount of being-effect relationship, high dose group lung index and Normal group are without the significance difference opposite sex, and in body, lung index is greater than 40%.In, the lung index of low dose group is all greater than 20%.Experiment is also found; the laboratory animal that the respiratory syncytial virus (RSV) of can protecting the peaceful granule of peace youngster causes is dead; and the spleen index causing for RSV, thymus index reduction have significant inhibitory action; show to pacify the peaceful granule of youngster and can also reduce the animal dead that viral pneumonia causes, significantly the immunologic function of Protection animal.
The specific embodiment
Test example 1, the peaceful granule resisiting influenza virus of peace youngster pneumonia pharmacodynamics test
One, experiment material
Virus: H1N1, H2N2, H5N1 and Influenza B virus ，Yin Zi Virology Inst., Chinese Academy of Preventive Medical Science.Amplified proliferation in health fertilization ovum gallinaceum allantoic cavity and in Mice Body after virus recovery ,-80 ℃ save backup.
Animal: BALB/c mouse, 5-7 week, male and female half and half, body weight is that 12 ± 2g， SPFJi，You Beijing Vital River Experimental Animals Technology Co., Ltd. provides, the animal quality certification number: SCXK (capital) 2012-2013.
Medicine: the preparation of the peaceful granule You Jinhe of peace youngster Tibetan medicine limited company, lot number 20121119.
Two, experimental technique
1, the toxic action of the peaceful Granules on Mouse of peace youngster and the selection of drug dose
The peaceful granule people of peace youngster consumption is 0.432g/kg every day, and in mice, dosage is according to 11 times of calculating of people's consumption, and every day, dosage was 4.75g/kg; It is low dose of that for middle dosage, half is 2.38g/kg; Heavy dose of is that two times of middle dosage are 9.5g/kg.Therefore peace youngster peaceful granule is used for the treatment of to the high, medium and low dosage of viral pneumonia mice due to influenza virus to be decided to be: 0.1g/ml, 0.2g/ml, 0.4g/ml; Every animals administer amount is 0.2ml, every day 1 time.Get at random 20 BALB/c mouse, be equally divided into administration group and Normal group, administration group gives 0.4g/ml peace youngster peaceful particle solution, through continuous 5 days, give mouse stomach, every day 1 time, each 0.2ml, Normal group gives co-content sterile distilled water gavage, observes 20 days.Mice mental status Non Apparent Abnormality, body weight is the trend that grows steadily, with normal group comparison, no significant difference.The peaceful Granules on Mouse of peace youngster of illustrative experiment concentration does not have toxicity.
2, viral LD
50measure
The lung tissue of getting respectively inoculation H1N1, H2N2, H5N1 and Influenza B virus mice, low-temperature centrifugation, gets supernatant, with blood serum medium, make 10 times of serial dilution 10^0,10^-1,10^-2,10^-3,10^-4,10^-5,10^-6 is totally 7 titres, every kind of viral 10 mices of each titre, via intranasal application is inoculated in Mice Body respectively, every 30 μ l, intact animal's group is set, in 15 days, observes mice symptom body weight change and mortality rate.
The mice that infects influenza A H1N1 influenza virus, the 3rd day starts to occur disease symptom, within 5-6 days, is the peak mortality phase.It is 10^-5.2/ml that Reed-muenchShi method is calculated viral LD50 titre.
The mice that infects A type H2N2 influenza virus, starts to occur disease symptom on the 3rd day, and the 6th day is the peak mortality phase.It is 10^-4.6/ml that Reed-muenchShi method is calculated viral LD50 titre.
The mice that infects A type H5N1 influenza virus, the 2.5th day starts to occur disease symptom, within 5-6 days, is the peak mortality phase.It is 10^-4.2/ml that Reed-muenchShi method is calculated viral LD50 titre.
The mice that infects Influenza B virus, the 5th day starts to occur disease symptom, within 6-7 days, is the peak mortality phase.It is 10^-2.6/ml that Reed-muenchShi method is calculated viral LD50 titre.
3, the effect of the peaceful granule of peace youngster to 4 kinds of viral pneumonias
By mice, divide at random dosage group, the peaceful granule low dose group of peace youngster, H1N1 matched group, H2N2 matched group, H5N1 matched group, influenza B matched group, Normal group in the peaceful granule high dose group of peace youngster, the peaceful granule of peace youngster, male and female half and half, 10 every group.Each organizes mice after the slight anesthesia of ether, uses respectively 4 kinds of influenza virus with 15 times of LD
50concentration, by every 30 μ L collunariums, infect.High, medium and low group of difference gastric infusion of the peaceful granule of peace youngster, every 0.2ml, every day 1 time, Normal group and virus control group give same solvent sterile distilled water gavage.Gavage drug treatment 5d, prohibits water fasting 6h before each gavage continuously.After last administration, mice fasting 8h, weighs, and extracts the de-cervical vertebra of eyeball blood-letting and puts to death animal, opens thoracic cavity and wins full lung, and normal saline washing 2 times, weighs, and calculates one by one lung exponential sum lung index.
4, statistical method date processing
Use SPSS17.0 software to complete, between group, relatively adopt t check.
5, experimental result
In Table 1, arrive table 4.
The impact of the peaceful granule of table 1 peace youngster on H 1 N 1 influenza A virus infection mouse lung index
Wherein, with normal group comparison, * * P<0.01; With the comparison of virus group, ##P<0.01
The impact of the peaceful granule of table 2 peace youngster on A type H2N2 influenza infection mouse lung index
Wherein, with normal group comparison, * * P<0.001; With the comparison of virus group, ##P<0.001
The impact of the peaceful granule of table 3 peace youngster on A type H5N1 influenza infection mouse lung index
Wherein, with normal group comparison, * * P<0.001; With the comparison of virus group, ##P<0.001
The impact of the peaceful granule of table 4 peace youngster on Influenza B virus Lung Index of mice infected by Influenza virus
Wherein, with Normal group comparison, * * P<0.001; With the comparison of virus group, ##P<0.001
6, experiment conclusion
From result, can find out, the lung index that high, medium and low three the dosage groups of the peace peaceful granule of youngster cause for 4 kinds of influenza virus increases all extremely significant inhibitory action (P<0.001), the inhibitory action amount of being-effect relationship, best with high dose group, suppression ratio > 47%.
Effect to respiratory syncytial virus pneumonia in experimental example 2, the peaceful granule of peace youngster
One, experiment material
Virus seed culture of viruses respiratory syncytial virus (RSV) Long Zhu Yinzi Virology Inst., China Academy of Preventive Medicine Sciences's seed culture of viruses chamber, people's Human Laryngeal Cancer Cell (Hep-2 cell), basis microbial room of institute of Shandong Academy of Medical Sciences provides; BALB/c mouse, 5-7 week, male and female half and half, body weight is the raw animal center of 12 ± 1g ，SPF Ji，Yin Zi Shandong University, SPF level animal credit number: SCXX(Shandong) 2012004; Virazole, Yantai No.2 Pharmaceutical Factory, lot number 20110514.The preparation of the peaceful granule You Jinhe of peace youngster Tibetan medicine limited company, lot number 20121119.
Two, experimental technique
1, viral median infective dose (TCID50)
With Hep-2 cell monolayer, cultivate, inoculate 7 concentration of 10 times of virus dilution, observation of cell pathological changes situation after cultivating, the Reed-muenchShi method of take is calculated viral median infective dose TCID50 as 10^-6.3/ml.
2, the toxic action of the peaceful Granules on Mouse of peace youngster and the selection of drug dose
The peaceful granule people of peace youngster consumption is 0.432g/kg every day, and in mice, dosage is according to 11 times of calculating of people's consumption, and every day, dosage was 4.75g/kg; It is low dose of that for middle dosage, half is 2.38g/kg; Heavy dose of is that two times of middle dosage are 9.5g/kg.Therefore peace youngster peaceful granule is used for the treatment of to the high, medium and low dosage of viral pneumonia mice due to RSV to be decided to be: 0.1g/ml, 0.2g/ml, 0.4g/ml; Every animals administer amount is 0.2ml, every day 1 time.Get at random 20 BALB/c mouse, be equally divided into administration group and Normal group, administration group gives 0.4g/ml peace youngster peaceful particle solution, through continuous 5 days, give mouse stomach, every day 1 time, each 0.2ml, Normal group gives co-content sterile distilled water gavage, observes 20 days.Mice mental status Non Apparent Abnormality, body weight is the trend that grows steadily, with normal group comparison, no significant difference.The peaceful Granules on Mouse of peace youngster of illustrative experiment concentration does not have toxicity.
3, the effect to respiratory syncytial virus pneumonia
60 of BALB/C mice, male female half and half, be divided at random 6 groups, be respectively the peace peaceful granule high dose group of youngster (0.4g/ml), middle dosage group (0.2g/ml), low dose group (0.1g/ml), virazole 0.1g/ml, virus-positive and normal saline Normal group, 10 every group.By body weight gastric infusion, positive and Normal group gavage normal saline.After three days, except Normal group, all the other mice per nasal splash into 15 times of RSV suspension TCID50 (TCID50 is 10^-6.3/ml), continue intranasal administration 3,1 times/day, observe mouse survival situation.After last administration 60min, put to death mice, win lungs, spleen and thymic tissue, after surperficial blood stasis is processed totally, the weighed weight of electronic balance, calculates each organ index according to body weight.
4, statistical method date processing
Use SPSS17.0 software to complete, between group, relatively adopt t check.
5, experimental result
Experimental result is as shown in table 5, table 6.
1) impact on lung index
The impact of the peaceful granule of table 5 peace youngster on viral pneumonia lung index due to RSV
Wherein, with normal group comparison, * * P<0.001; With the comparison of virus group, ##P<0.001
2) impact on immune organ (spleen and thymic tissue) index
The impact of the peaceful granule of table 6 peace youngster on viral pneumonia Immune Organs Index due to RSV
Wherein, with Normal group comparison, * * P<0.001; With the comparison of virus group, #P<0.01, ##P<0.001
6, experiment conclusion
The peaceful granule of peace youngster can extremely significantly reduce the lung index (P<0.001) of RSV viral pneumonia, and the amount of being-effect relationship, and in high dose group body, lung index is greater than 40%.In, the lung index of low dose group is all greater than 20%; the laboratory animal that the peaceful granule of peace youngster also can protect RSV to cause is dead; and the spleen index that middle and high dosage causes for RSV, thymus index reduce extremely significant inhibitory action (P<0.001), shows to pacify the significantly immunologic function of Protection animal of the peaceful granule of youngster.
Following examples all can reach described curative effect.
Embodiment 1: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of H1N1 virus pneumonia medicine, each 2 bags, every day 3 times.
Embodiment 2: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of H1N1 virus pneumonia medicine, each 1 bag, every day 3 times.
Embodiment 3: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of H2N2 viral pneumonia medicine, each 1 bag, every day 3 times.
Embodiment 4: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of H2N2 viral pneumonia medicine, each 2 bags, every day 3 times.
Embodiment 5: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of H5N1 virus pneumonia medicine, each 2 bags, every day 3 times.
Embodiment 6: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of H5N1 virus pneumonia medicine, each 1 bag, every day 3 times.
Embodiment 7: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of Influenza B virus pneumonia medicine, each 1 bag, every day 3 times.
Embodiment 8: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of Influenza B virus pneumonia medicine, each 2 bags, every day 3 times.
Embodiment 9: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of respiratory syncytial virus pneumonia medicine, each 2 bags, every day 3 times.
Embodiment 10: the peaceful granule of peace youngster, every bag of 3g, for the preparation of the application for the treatment of respiratory syncytial virus pneumonia medicine, each 1 bag, every day 3 times.
Claims (5)
1. the application of the peaceful granule of peace youngster in preparation treatment viral pneumonia medicine, the peaceful granule of wherein said peace youngster is comprised of following raw material medicaments: Flos Carthami 53.3 weight portions, Santalum album 66.7 weight portions, Radix Glycyrrhizae 53.3 weight portions, high mountain Radix Cochleariae officinalis dish 53.3 weight portions, Rhizoma Seu Herba Bergeniae 53.3 weight portions, Concretio Silicea Bambusae 66.7 weight portions, Lagotis brevituba 66.7 weight portions, Tangut aconite 66.7 weight portions, artificial Calculus Bovis's 5.3 weight portions.
2. the application of the peaceful granule of peace youngster according to claim 1 in preparation treatment viral pneumonia medicine, is characterized in that, described viral pneumonia is the viral pneumonia that respiratory syncytial virus causes.
3. the application of the peaceful granule of peace youngster according to claim 1 in preparation treatment viral pneumonia medicine, is characterized in that, described viral pneumonia is the viral pneumonia that influenza virus causes.
4. the application of the peaceful granule of peace youngster according to claim 3 in preparation treatment viral pneumonia medicine, is characterized in that, described influenza virus is influenza A H1N1 influenza virus, A type H2N2, A type H5N1 or Influenza B virus.
5. according to the peaceful granule of peace youngster described in claim 1-4 any one and chemical drugs or Chinese medicine or the application of natural drug in preparation treatment viral pneumonia medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106913802A (en) * | 2015-12-28 | 2017-07-04 | 山东金诃药物研究开发有限公司 | A kind of Tibetan medicinal composition for viral pneumonia |
| CN112569285A (en) * | 2020-06-10 | 2021-03-30 | 山东汉方制药有限公司 | Application of compound cortex phellodendri composition in preparation of medicines for preventing and treating viral respiratory tract infection |
| CN116785385A (en) * | 2023-06-29 | 2023-09-22 | 济宁滨阳生物科技股份有限公司 | Traditional Chinese medicine composition for preventing and treating viral respiratory diseases |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913802A (en) * | 2015-12-28 | 2017-07-04 | 山东金诃药物研究开发有限公司 | A kind of Tibetan medicinal composition for viral pneumonia |
| CN112569285A (en) * | 2020-06-10 | 2021-03-30 | 山东汉方制药有限公司 | Application of compound cortex phellodendri composition in preparation of medicines for preventing and treating viral respiratory tract infection |
| CN116785385A (en) * | 2023-06-29 | 2023-09-22 | 济宁滨阳生物科技股份有限公司 | Traditional Chinese medicine composition for preventing and treating viral respiratory diseases |
| CN116785385B (en) * | 2023-06-29 | 2024-01-23 | 济宁滨阳生物科技股份有限公司 | Traditional Chinese medicine composition for preventing and treating viral respiratory diseases |
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Application publication date: 20140205 |