CN103550421B - A kind of Chinese medicine composition of fumigation treatment ankylosing spondylitis - Google Patents
A kind of Chinese medicine composition of fumigation treatment ankylosing spondylitis Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition of fumigation treatment ankylosing spondylitis, be prepared from by traditional Chinese medicinal material raw materials and adjuvant, by weight, described traditional Chinese medicinal material raw materials comprises: Folium Artemisiae Argyi 60-80 part, Herba Violae 16-22 part, Radix Aconiti Kusnezoffii 16-22 part, Ramulus Cinnamomi 16-22 part, Fructus Foeniculi 5-10 part, Ramulus Salicis Babylonicae 30-40 part, Magnetitum 30-40 part, Folium Citri tangerinae 30-40 part, Cortex Eucommiae 18-25 part, Radix Gentianae 18-25 part, Semen Litchi 6-12 part, Radix Glycyrrhizae 10-18 part.The fumigation Chinese medicinal composition that the present invention relates to coordinates the recovery of Western medicine to patients with ankylosing spondylitis function to have good therapeutic effect, does not recur more.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine composition of fumigation treatment ankylosing spondylitis.
Background technology
Ankylosing spondylitis belongs to rheumatism category, the one of seronegative spondyloanthropathy.This sick act of violence is still not clear, and take spinal column as the chronic disease of major lesions, involves sacroiliac joint, cause rigid spine and fibrosis, causes eye, lung, muscle, skeleton pathological changes in various degree, belongs to autoimmune disease.Be more common in 16-30 year between twenty and fifty, male is common, and 40 years old is rare with sequela person.Primary disease insidious onset, makes slow progress, and General Symptoms is lighter.Early stage often to have back pain and morning to rise stiff, alleviates after activity, and can with low grade fever, weak, loss of appetite, the symptom such as to become thin.During beginning, pain is intermittent, develops into persistence after several years several months, and later inflammatory pain disappears, and spinal column is from bottom to top partly or entirely tetanic, occurs bow-backed deformity.Female patient periarticular is more common by invading, and progress is comparatively slow, and deformity of spine is lighter.
Doctor trained in Western medicine it is generally acknowledged that ankylosing spondylitis is relevant with heredity, environment, infection etc.Modern medical therapy application nonsteroidal antiinflammatory drug and immune formulation even hormone, though can relief of symptoms, long-term taking easily causes the side effect such as Gastric mucosal lesion, hepatorenal damage, bone marrow depression, and patient is often difficult to tolerance, cause Relapse rate to show effect, and Chinese medicine have some superiority.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacyly not recur, the Chinese medicine composition of the fumigation treatment ankylosing spondylitis of no pain during treatment.
The object of the present invention is achieved like this:
A kind of Chinese medicine composition of fumigation treatment ankylosing spondylitis, be prepared from by stock and adjunct, by weight, described raw material comprises: Folium Artemisiae Argyi 60-80 part, Herba Violae 16-22 part, Radix Aconiti Kusnezoffii 16-22 part, Ramulus Cinnamomi 16-22 part, Fructus Foeniculi 5-10 part, Ramulus Salicis Babylonicae 30-40 part, Magnetitum 30-40 part, Folium Citri tangerinae 30-40 part, Cortex Eucommiae 18-25 part, Radix Gentianae 18-25 part, Semen Litchi 6-12 part, Radix Glycyrrhizae 10-18 part.
Preferably, the Chinese medicine composition of fumigation treatment ankylosing spondylitis described above, by weight, described raw material is made up of following component: Folium Artemisiae Argyi 65-75 part, Herba Violae 18-20 part, Radix Aconiti Kusnezoffii 18-20 part, Ramulus Cinnamomi 18-20 part, Fructus Foeniculi 7-9 part, Ramulus Salicis Babylonicae 33-37 part, Magnetitum 33-37 part, Folium Citri tangerinae 33-37 part, Cortex Eucommiae 20-24 part, Radix Gentianae 20-24 part, Semen Litchi 8-10 part, Radix Glycyrrhizae 13-15 part.
Preferably, the Chinese medicine composition of fumigation treatment ankylosing spondylitis described above, by weight, described traditional Chinese medicinal material raw materials is made up of following component: Folium Artemisiae Argyi 70 parts, Herba Violae 20 parts, Radix Aconiti Kusnezoffii 20 parts, Ramulus Cinnamomi 20 parts, Fructus Foeniculi 8 parts, Ramulus Salicis Babylonicae 35 parts, Magnetitum 35 parts, Folium Citri tangerinae 35 parts, the Cortex Eucommiae 22 parts, Radix Gentianae 22 parts, Semen Litchi 8 parts, 14 parts, Radix Glycyrrhizae.
Further preferably, the Chinese medicine composition of fumigation treatment ankylosing spondylitis as above, it is conditioning liquid.
Further preferably, the Chinese medicine composition of fumigation treatment ankylosing spondylitis as above, wherein said adjuvant comprises antiseptic.
Again further preferably, the Chinese medicine composition of fumigation treatment ankylosing spondylitis as above, wherein said antiseptic is ethyl hydroxybenzoate.
The preparation method of the Chinese medicine composition of fumigation treatment ankylosing spondylitis of the present invention comprises the steps: to take Folium Artemisiae Argyi 60-80 part, Herba Violae 16-22 part, Radix Aconiti Kusnezoffii 16-22 part, Ramulus Cinnamomi 16-22 part, Fructus Foeniculi 5-10 part, Ramulus Salicis Babylonicae 30-40 part, Magnetitum 30-40 part, Folium Citri tangerinae 30-40 part, Cortex Eucommiae 18-25 part, Radix Gentianae 18-25 part, Semen Litchi 6-12 part and Radix Glycyrrhizae 10-18 part, clean roguing, dry, be ground into granule, add the soak by water 1-1.5h of medical material weight 10-15 times amount, filter, collect filtrate; The soak by water 0.5-1h of medical material weight 8-10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate is merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 2, the ethanol then adding 95% routinely carries out precipitate with ethanol, and slow quickening stirs, make the concentration of alcohol of solution reach 70%, put refrigerator cold-storage and spend the night.Within 2nd, by alcohol deposit fluid sucking filtration, collect filtrate, reclaim ethanol, obtaining concentration is liquor capacity: medical material weight=1: the drug extract of 1, and 0.1% adds antiseptic ethyl hydroxybenzoate, last thin up, subpackage by weight percentage.
According to Chinese medicine Historical Data Data About, pharmacologically active and the source of the above-mentioned Chinese crude drug that the present invention selects are as follows:
Folium Artemisiae Argyi: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus, decortication.Select the dried leaves of feverfew Chinese mugwort Artemisia argyi Levl. et Vant..
Herba Violae: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.Select the dry herb of Herba Violae.
Radix Aconiti Kusnezoffii: search wind prevailing over dampness, dispersing cold for relieving pain, opens expectorant, detumescence.Control anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.Select the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb Aconitum kusnezoffii Reichb..
Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Select the dry twig of Lauraceae aiphyllium plant Cortex Cinnamomi.
Fructus Foeniculi: stimulating appetite, cold expelling of regulating the flow of vital energy, has supporing yang road.Cure mainly: cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain; Hernia pain, painful and swollen testis; Stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain.Select the dry mature fruit of samphire Fructus Foeniculi FoeniculumvulgareMill..
Ramulus Salicis Babylonicae: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Select the dry branch of Salicaceous Plants Salix babylonica L..
Magnetitum: suppressing the hyperactive liver and subsiding YANG; Calm the nerves relieving convulsion; Hearing-improing and eyesight improving; Helping inspiration to relieve asthma.Cure mainly: main dizzy; Order flower; Deaf; Tinnitus; Palpitation with fear; Insomnia, dyspnea of suffering from a deficiency of the kidney.Select the Ore of oxide-based mineral magnetic iron ore.
Folium Citri tangerinae: soothing the liver, circulation of qi promoting, reduces phlegm, detumescence poison.Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.Select the leaf of the multiple Fructus Citri tangerinae class such as leaf or Zhu's Fructus Citri tangerinae of rutaceae orange Citrus reticulata Blanco.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension.Select the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver).
Radix Gentianae: heat clearing and damp drying; Eliminating pathogen in the liver is calmed the frightened.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear swells; Hypochondriac pain bitter taste; Calentura convulsion with spasms.Derive from the root welding technology of gentianaceae plant Radix Gentianae (Gentiana scabra Bge.).
Semen Litchi: promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.For colic of cold type stomachache, painful and swollen testis.Select the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select the root and rhizome for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch..
Herbal fumigation is with traditional Chinese medical science traditional theory for instructing, and the dual function absorbed by the warm and Chinese medicine of physics, by the effect of the efficacy of a drug and heating power, percutaneous local penetration, makes medicine go directly disease institute.Research shows, effective Chinese medicine ingredients enters in body by open pore, infiltration acupuncture point, dredging the meridian, thus play dispelling cold by warming the meridian, damp eliminating of dispeling the wind, blood circulation promoting and blood stasis dispelling effect.The present invention adopts the recovery of herb fumigation to patients with ankylosing spondylitis function to have good therapeutic effect, and do not recur more, patient is satisfied with to treatment.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: Folium Artemisiae Argyi 7 kilograms, Herba Violae 2 kilograms, Radix Aconiti Kusnezoffii 2 kilograms, Ramulus Cinnamomi 2 kilograms, Fructus Foeniculi 0.8 kilogram, Ramulus Salicis Babylonicae 3.5 kilograms, Magnetitum 3.5 kilograms, Folium Citri tangerinae 3.5 kilograms, the Cortex Eucommiae 2.2 kilograms, Radix Gentianae 2.2 kilograms, Semen Litchi 0.8 kilogram, 1.4 kilograms, Radix Glycyrrhizae.
Preparation technology: take above-mentioned traditional Chinese medicinal material raw materials, cleans roguing, dries, be ground into granule, add the soak by water 1-1.5h of medical material weight 10-15 times amount, filters, and collects filtrate; The soak by water 0.5-1h of medical material weight 8-10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate is merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 2, the ethanol then adding 95% routinely carries out precipitate with ethanol, and slow quickening stirs, make the concentration of alcohol of solution reach 70%, put refrigerator cold-storage and spend the night.Within 2nd, by alcohol deposit fluid sucking filtration, collect filtrate, reclaim ethanol, obtaining concentration is liquor capacity: medical material weight=1: the drug extract of 1, and 0.1% adds antiseptic ethyl hydroxybenzoate by weight percentage, is finally diluted with water to 10 liters, by every bag of 100 milliliters of subpackages.
Embodiment 2
Crude drug prescription: Folium Artemisiae Argyi 7.8 kilograms, Herba Violae 1.6 kilograms, Radix Aconiti Kusnezoffii 1.6 kilograms, Ramulus Cinnamomi 2 kilograms, Fructus Foeniculi 0.5 kilogram, Ramulus Salicis Babylonicae 3.3 kilograms, Magnetitum 3 kilograms, Folium Citri tangerinae 4 kilograms, the Cortex Eucommiae 2.5 kilograms, Radix Gentianae 1.8 kilograms, Semen Litchi 1.2 kilograms, 1.2 kilograms, Radix Glycyrrhizae.
Preparation technology: take above-mentioned traditional Chinese medicinal material raw materials, cleans roguing, dries, be ground into granule, add the soak by water 1-1.5h of medical material weight 10-15 times amount, filters, and collects filtrate; The soak by water 0.5-1h of medical material weight 8-10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate is merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 2, the ethanol then adding 95% routinely carries out precipitate with ethanol, and slow quickening stirs, make the concentration of alcohol of solution reach 70%, put refrigerator cold-storage and spend the night.Within 2nd, by alcohol deposit fluid sucking filtration, collect filtrate, reclaim ethanol, obtaining concentration is liquor capacity: medical material weight=1: the drug extract of 1, and 0.1% adds antiseptic ethyl hydroxybenzoate by weight percentage, is finally diluted with water to 10 liters, by every bag of 100 milliliters of subpackages.
Embodiment 3
Crude drug prescription: Folium Artemisiae Argyi 6 kilograms, Herba Violae 2 kilograms, Radix Aconiti Kusnezoffii 2.2 kilograms, Ramulus Cinnamomi 1.6 kilograms, Fructus Foeniculi 1 kilogram, Ramulus Salicis Babylonicae 4 kilograms, Magnetitum 4 kilograms, Folium Citri tangerinae 3 kilograms, the Cortex Eucommiae 1.8 kilograms, Radix Gentianae 2.5 kilograms, Semen Litchi 0.8 kilogram, 1.8 kilograms, Radix Glycyrrhizae.
Preparation technology: take above-mentioned traditional Chinese medicinal material raw materials, cleans roguing, dries, be ground into granule, add the soak by water 1-1.5h of medical material weight 10-15 times amount, filters, and collects filtrate; The soak by water 0.5-1h of medical material weight 8-10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate is merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 2, the ethanol then adding 95% routinely carries out precipitate with ethanol, and slow quickening stirs, make the concentration of alcohol of solution reach 70%, put refrigerator cold-storage and spend the night.Within 2nd, by alcohol deposit fluid sucking filtration, collect filtrate, reclaim ethanol, obtaining concentration is liquor capacity: medical material weight=1: the drug extract of 1, and 0.1% adds antiseptic ethyl hydroxybenzoate by weight percentage, is finally diluted with water to 10 liters, by every bag of 100 milliliters of subpackages.
Clinical practice example
Patients with ankylosing spondylitis 49 example, is divided into 2 groups at random, treatment group 25 example, wherein man 21 example, female 4 example; Age 18-48 year, average (32.5 ± 6.9) year; Course of disease 0.5-8, average (4.6 ± 3.1) year.Matched group 24 example, wherein man 20 example, female 4 example; Age 19-48 year, average (32.2 ± 7.0) year; Course of disease 0.5-9, average (4.5 ± 3.3) year.Two groups of physical data, through statistical analysis no significant difference (P > 0.05), have comparability.
Treatment group adopts the treatment of herbal fumigation method; get medicinal liquid one bag prepared by the embodiment of the present invention 1; produce steam after electric heating heating in high-pressure steam container medicinal liquid being poured into fumigating device; the medicinal liquid molecule through overflash sprays to pars affecta skin at a high speed under the effect of the pressure; every day 1 time, each 30min.Herb steam therapy combines Meloxicam Dispersive Tablet 7.5mg simultaneously, every day 2 times.Matched group adopts Meloxicam Dispersive Tablet 7.5 mg, every day 2 times.2 groups of all inactive other drugs of patients.Two groups of patients treat 3 weeks all continuously.Treatment terminate after, by following standard (with reference to " and new Chinese medicine guideline of clinical investigations (try) [M]. Beijing: China Medical Science Press, 2002:115 ~ 119 formulation ") judge curative effect:
Effective: the overall improvement rate > 75%, ESR and CRP of cardinal symptom, sign normal or obvious improvement or close normal;
Take a turn for the better: the overall improvement rate > 50% of cardinal symptom, sign, and≤75%, ESR and CRP be improved;
Effective: the overall improvement rate of cardinal symptom, sign is that 3O%-5O%, ESR and CRP are improved or without improvement;
Invalid: the overall improvement rate < 30%, ESR and CRP of cardinal symptom, sign is without improvement.
Two groups of patient clinical comparitive study are in table 1.
Table 1 liang group Clinical efficacy comparison result (example)
Claims (4)
1. the Chinese medicine composition of a fumigation treatment ankylosing spondylitis, be prepared from by traditional Chinese medicinal material raw materials and adjuvant, it is characterized in that described traditional Chinese medicinal material raw materials is made up of following component: Folium Artemisiae Argyi 70 parts, Herba Violae 20 parts, Radix Aconiti Kusnezoffii 20 parts, Ramulus Cinnamomi 20 parts, Fructus Foeniculi 8 parts, Ramulus Salicis Babylonicae 35 parts, Magnetitum 35 parts, Folium Citri tangerinae 35 parts, the Cortex Eucommiae 22 parts, Radix Gentianae 22 parts, Semen Litchi 8 parts, 14 parts, Radix Glycyrrhizae.
2. the Chinese medicine composition of fumigation treatment ankylosing spondylitis according to claim 1, is characterized in that: described Chinese medicine composition is conditioning liquid.
3. the Chinese medicine composition of fumigation in treating ankylosing spondylitis according to claim 1, is characterized in that: described adjuvant comprises antiseptic.
4. the Chinese medicine composition of fumigation in treating ankylosing spondylitis according to claim 3, is characterized in that: described antiseptic is ethyl hydroxybenzoate.
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| WO2013048235A2 (en) * | 2011-09-27 | 2013-04-04 | Nameta Sdn Bhd | A medicinal herbal ointment |
| CN102813754B (en) * | 2012-07-30 | 2014-03-26 | 汤杰杰 | Traditional Chinese medicine plaster for treating arthritis |
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| CN1146343A (en) * | 1995-09-25 | 1997-04-02 | 石建民 | External compress paste for discopathy |
| CN103316308A (en) * | 2012-03-20 | 2013-09-25 | 于文波 | Traditional Chinese medical liquor for external use |
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| 吴名波,等."中药熏蒸疗法治疗强直性脊柱炎临床疗效观察".《中国中医骨伤科杂志》.2009,第17卷(第3期),第27-28、31页. * |
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