CN103549417B - 一种洋葱苦瓜分散片及其生产工艺 - Google Patents
一种洋葱苦瓜分散片及其生产工艺 Download PDFInfo
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Abstract
本发明所述的一种洋葱苦瓜分散片及其生产工艺属于保健品技术领域,其主要成分重量份是:洋葱冻干粉545份,苦瓜提取物粉145份,桑叶提取物粉110份,低取代-羟丙基纤维素150份、微晶纤维素42份,硬脂酸镁8份,乙醇适量。由于原料中有洋葱冻干粉和中药提取物粉,不适于用水作为粘合剂,本发明采用适当浓度的乙醇作为粘合剂,既能保证颗粒的成型,也能保证产品的稳定性。本发明的有益效果是:洋葱、苦瓜、桑叶进行合理配伍并制成分散片,对高血脂、高血糖人群体质的改善将起到积极和有利作用,并且携带服用方便,效果稳定。洋葱苦瓜分散片的生产工艺稳定、合理、可行,适合于工业化生产。
Description
技术领域
本发明涉及洋葱苦瓜分散片的产品配方及生产工艺粉碎、制粒、干燥、整粒、总混、压片的生产技术,属于保健品技术领域。
背景技术
高血脂,严格定义应该为血脂紊乱或血脂异常,是指人体内血清脂质的浓度水平超出了正常范围,包括血清总胆固醇(TC)水平升高,血清甘油三脂(TG)水平升高,血清高密度脂蛋白胆固醇(HDLE)水平异常减低。是心脑血管疾病的主要危险因素之一。高血脂病是随着人们生活条件的改善而来的,生活节奏快、工作压力大,平时应酬多、饮食油腻,再加上缺乏体育锻炼等都是致病因素。有些人是饮食不注意,过分高脂肪、高热量、高胆固醇的饮食,以及抽烟、喝酒等生活方式不合理而导致。另外,也跟家族遗传因素有一定的关系。健康生活方式很重要,这些不注意的人就更容易得高血脂症。不一定胖人才得,当然胖人更容易得高血脂症。高血脂症在我国已不少见,甚至儿童中也有近10%者血脂偏高。另外,国内外冠心病普查资料表明,长期睡眠不佳、精神经常紧张、忧虑及时间紧迫均能影响血脂代谢。高血脂症本身没有临床症状,这也是很多人不重视早期诊断和早期治疗的重要原因。该病对身体的损害是隐匿、逐渐、进行性和全身性的。它的直接损害是加速全身动脉粥样硬化,因为全身的重要器官都要依靠动脉供血、供氧,一旦动脉被粥样斑块堵塞,就会导致严重后果。近年来高血脂患者有向年轻化发展趋势。一般情况下,高血脂的发病率随着年龄的增加有增高的趋势,患者以45-60岁的成年人为主,其中中青年的男性较多,中年以后的女性患者也不少,就目前临床发现,年轻人也有明显增加的趋势,另外,肥胖的人也较易患上高血脂。
糖尿病,是由于机体胰岛素绝对缺乏或胰岛素作用不足而引起血糖异常升高的疾病。实际上,胰岛素不仅掌管着血糖的高低,它还是我们身体其他两大类物质:脂肪和蛋白质代谢的主要调控因素。所以在糖尿病患者中,由于胰岛素的生物调节作用发生障碍,常伴有脂质代谢的紊乱。出现脂质代谢异常。而且近年来,由于我国人民的生活水平明显提高、饮食习惯发生改变等原因,血糖与血脂同时升高者日益增多。糖尿病和高脂血症均增加了冠心病的危险性,为了避免心脑血管病的发生,糖尿病患者除了血糖控制良好外,高脂血症的治疗也是不容忽视的。引起高脂血症的原因很多,但归纳起来主要有三个方面的因素:①遗传因素;②饮食因素;③内分泌或代谢因素。大多数患者的血脂异常是由于饮食不当造成的。饮食因素在高脂血症发病中的作用比较复杂,糖类摄入过多,可影响胰岛素分泌。加速肝脏极低密度脂蛋白的合成,容易引起高甘油三酯血症。胆固醇和动物脂肪摄入过多,与高胆固醇血症的形成有关,因此饮食治疗十分重要。
在我国,改革开放以来,随着人们生活水平的不断提高,高脂血症和糖尿病和发病率呈明显上升趋势,营养素摄人过剩及日常运动量的明显减少,使成人患病率增加。动脉粥样硬化性心脑血管疾病、高血压、糖尿病等疾病占老年人死因的75%,已成为我国城市居民死亡的主要原因。随着人们对亚健康认识的深入和对自身健康状况的关注,有越来越多的人会在身体各项指标稍微偏高或正常情况下,选择服用保健食品来辅助降血脂或辅助降血糖,以达到调整身体健康状况的目的。
洋葱:洋葱为百合科植物洋葱的鳞茎,具强烈的香气;近代医学研究发现,洋葱含有硫化物、类黄酮、苯丙素酚类、甾体皂苷类、含氯化合物、***素类和多糖等多种化学成分,具有消炎抑菌、防癌抗癌、利尿止泻及降血糖、降血脂、降胆固醇、降血压、抗血小板凝聚、预防心脑血管病、抗氧化、美容等多种药理作用。
苦瓜:苦瓜为葫芦科植物苦瓜的果实,性味苦、寒,可清暑涤热,明目,解毒。治热病烦渴引饮,中暑,痢疾,赤眼疼痛,痈肿丹毒,恶疮。作为食用蔬菜,资源广泛,方便易得。苦瓜中的化学成分比较复杂,比较明确的有葫芦索烷型、齐墩果烷型皂苷,以及甾醇及其苷类、生物碱类等。近年来的药理研究表明,苦瓜具有显著的药理活性,尤其是降糖、抗肿瘤和抗病毒方面的活性值得深人研究。
桑叶:桑叶为桑科植物桑的叶,性味苦甘,寒,可祛风清热,凉血明目。治风温发热,头痛,目赤,口渴,肺热咳嗽,风痹,瘾疹,下肢象皮肿。含有以下化学成分:芸香甙、槲皮素、异槲皮素、槲皮素-3-三葡萄甙、微量的β-谷甾醇、菜油甾醇、β-谷甾醇β-D-葡萄甙、蛇麻脂醇、内消旋肌醇、昆虫***激素牛膝甾酮和蜕皮甾酮、溶血素、绿原酸。并含维生素C200~300毫克%,谷胱甘肽140~400毫克%,叶酸105微克%,5-甲酰四氢叶酸22微克%,维生素B1460微克%,维生素B2300~800微克%,腺嘌呤、胆碱、胡芦巴碱,以及铜、锌、硼、锰等微量元素。现代研究发现,桑叶具有抑制血糖值上升作用、降血压作用;降低血清总胆固醇并减少在血管内壁的沉积。
本发明人经过反复研究,并通过多次实验,对以上三种原料进行合理配伍,成功制成洋葱苦瓜分散片,充分发挥每种原料的生理作用,本品具有辅助降血脂和辅助降血糖功能,至今为止,还没有发现任何与本发明类似的工艺的报道。
发明内容
为了降低高脂血症和糖尿病和发病率,本发明提供一种洋葱苦瓜分散片,是针对高血脂、高血糖的亚健康人群,对洋葱、苦瓜、桑叶进行合理配伍,开发出一种功能性保健食品,该产品对高血脂、高血糖人群体质的改善将起到积极和有利作用。
为了实现上述目的本发明采用的技术方案是:一种洋葱苦瓜分散片,其主要成分重量份是:洋葱冻干粉545份,苦瓜提取物粉145份,桑叶提取物粉110份,低取代-羟丙基纤维素150份、微晶纤维素42份,硬脂酸镁8份,乙醇适量。由于原料中有洋葱冻干粉和中药提取物粉,不适于用水作为粘合剂,本发明采用适当浓度的乙醇作为粘合剂,既能保证颗粒的成型,也能保证产品的稳定性。
所述洋葱苦瓜分散片的生产工艺是通过对洋葱冻干粉进行粉碎,苦瓜提取物粉、桑叶提取物粉进行过筛、低取代-羟丙基纤维素、微晶纤维素、硬脂酸镁,按配方比例混匀,用一定浓度的乙醇溶液制粒,烘干后整粒,总混,压制成分散片,制成服用方便的洋葱苦瓜分散片,具体按如下步骤进行:(1)粉碎及过筛,洋葱冻干粉应先进行粉碎,并过40-120目筛,过筛后原料备用;(2)苦瓜提取物粉、桑叶提取物粉粉碎,过40-120目筛,过筛后原料备用;(3)低取代-羟丙基纤维素、微晶纤维素过40-100目筛,过筛后原料备用;(4)投料,按配方量计算各原料的实际投料量;(5)混合及制湿颗粒:将称取好各原料混合10-50分钟,使混合均匀,加入60-95%乙醇适量制软材,过12-30目筛制湿颗粒;(6)烘干,制得湿颗粒在烘箱中,30℃-60℃干燥3-5小时;(7)整粒和总混,过12-30目筛整粒,加入硬脂酸镁混合均匀,得干颗粒;(8)压片:半成品检测后,将颗粒压制成分散片,片重0.4-1.2g/片。
质控指标:总黄酮以芦丁计≥1.0g/100g。
本发明的有益效果是:洋葱、苦瓜、桑叶进行合理配伍并制成分散片,对高血脂、高血糖人群体质的改善将起到积极和有利作用,并且携带服用方便,效果稳定。洋葱苦瓜分散片的生产工艺稳定、合理、可行,适合于工业化生产。
具体实施方式
下面结合具体实施方式进一步加以说明。
实施例1:洋葱冻干粉应先进行粉碎,并过60目筛,过筛后原料备用。苦瓜提取物粉、桑叶提取物粉均过60目筛,未过筛粗颗粒应进行粉碎,过筛后原料备用。低取代-羟丙基纤维素、微晶纤维素过40目筛,过筛后原料备用。按配方量计算各原料的实际投料量。将称取好各原料混合50分钟,使均匀,加入60%乙醇适量制软材,过30-目筛制湿颗粒,制得湿颗粒在烘箱中,60℃干燥3小时。过12目筛整粒,加入硬脂酸镁混合均匀,得干颗粒。将颗粒压制成分散片,片重0.4g/片。
实施例2:洋葱冻干粉应先进行粉碎,并过80目筛,过筛后原料备用。苦瓜提取物粉、桑叶提取物粉均过60目筛,未过筛粗颗粒应进行粉碎,过筛后原料备用。低取代-羟丙基纤维素、微晶纤维素过60目筛,过筛后原料备用。按配方量计算各原料的实际投料量。将称取好各原料混合20分钟,使均匀,加入80%乙醇适量制软材,过20目筛制湿颗粒,制得湿颗粒在烘箱中,60℃干燥5小时。过30目筛整粒,加入硬脂酸镁混合均匀,得干颗粒。将颗粒压制成分散片,片重0.8g/片。
实施例3:洋葱冻干粉应先进行粉碎,并过100目筛,过筛后原料备用。苦瓜提取物粉、桑叶提取物粉均过60目筛,未过筛粗颗粒应进行粉碎,过筛后原料备用。低取代-羟丙基纤维素、微晶纤维素过100目筛,过筛后原料备用。按配方量计算各原料的实际投料量。将称取好各原料混合40分钟,使均匀,加入80%乙醇适量制软材,过12目筛制湿颗粒,制得湿颗粒在烘箱中,40℃干燥3-5小时。过30目筛整粒,加入硬脂酸镁混合均匀,得干颗粒。将颗粒压制成分散片,片重1.2g/片。
洋葱苦瓜分散片的服用方法:一次1粒,日服2次。
洋葱苦瓜分散片的疗效:本产品已经服用近百例,经随访65例,其中高血脂人群体质改善的35例,高血糖人群体质改善的30例,无效0例。从以上分析来看,洋葱苦瓜分散片可达到对高血脂、高血糖人群体质的改善将起到积极和有利作用的目的。
最后应说明的是:显然,上述实施例仅仅是为清楚地说明本发明所作的举例,而并非对实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动,由此所引伸出的显而易见的变化或变动仍处于本发明的保护范围之中。
Claims (3)
1.一种洋葱苦瓜分散片,特征是其主要成分重量份是:洋葱冻干粉545份,苦瓜提取物粉145份,桑叶提取物粉110份,低取代-羟丙基纤维素150份、微晶纤维素42份,硬脂酸镁8份,乙醇适量。
2.根据权利要求1所述的一种洋葱苦瓜分散片,其特征是采用适当浓度的乙醇作为粘合剂。
3.如权利要求1所述洋葱苦瓜分散片的生产工艺,特征是所述洋葱苦瓜分散片的生产工艺按如下步骤进行:(1)粉碎及过筛,洋葱冻干粉应先进行粉碎,并过40-120目筛,过筛后原料备用:(2)苦瓜提取物粉、桑叶提取物粉粉碎,过40-120目筛,过筛后原料备用;(3)低取代-羟丙基纤维素、微晶纤维素过40-100目筛,过筛后原料备用;(4)投料,按配方量计算各原料的实际投料量;(5)混合及制湿颗粒:将称取好各原料混合10-50分钟,使混合均匀,加入60-95%乙醇适量制软材,过12-30目筛制湿颗粒;(6)烘干,制得湿颗粒在烘箱中,30℃-60℃干燥3-5小时;(7)整粒和总混,过12-30目筛整粒,加入硬脂酸镁混合均匀,得干颗粒;(8)压片:半成品检测后,将颗粒压制成分散片,片重0.4-1.2g/片。
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